Vascular biology (Bristol, England)最新文献_第6页

Vascular dysfunction and pathology: focus on mechanical forces. 血管功能障碍与病理:关注机械力。

Vascular biology (Bristol, England) Pub Date : 2021-06-09 eCollection Date: 2021-01-01 DOI: 10.1530/VB-21-0002

Gloria Garoffolo, Maurizio Pesce

引用次数: 2

microRNAs involved in psoriasis and cardiovascular diseases. 与银屑病和心血管疾病相关的microrna。

Vascular biology (Bristol, England) Pub Date : 2021-06-03 eCollection Date: 2021-01-01 DOI: 10.1530/VB-21-0007

Sara Sileno, Sara Beji, Marco D'Agostino, Alessandra Carassiti, Guido Melillo, Alessandra Magenta

{"title":"microRNAs involved in psoriasis and cardiovascular diseases.","authors":"Sara Sileno, Sara Beji, Marco D'Agostino, Alessandra Carassiti, Guido Melillo, Alessandra Magenta","doi":"10.1530/VB-21-0007","DOIUrl":"https://doi.org/10.1530/VB-21-0007","url":null,"abstract":"Psoriasis is a chronic inflammatory disease involving the skin. Both genetic and environmental factors play a pathogenic role in psoriasis and contribute to the severity of the disease. Psoriasis, in fact, has been associated with different comorbidities such as diabetes, metabolic syndrome, gastrointestinal or kidney diseases, cardiovascular disease (CVD), and cerebrovascular diseases (CeVD). Indeed, life expectancy in severe psoriasis is reduced by up to 5 years due to CVD and CeVD. Moreover, patients with severe psoriasis have a higher prevalence of traditional cardiovascular (CV) risk factors, including dyslipidemia, diabetes, smoking, and hypertension. Further, systemic inflammation is associated with oxidative stress increase and induces endothelial damage and atherosclerosis progression. Different miRNA have been already described in psoriasis, both in the skin tissues and in the blood flow, to play a role in the progression of disease. In this review, we will summarize and discuss the most important miRNAs that play a role in psoriasis and are also linked to CVD.","PeriodicalId":75294,"journal":{"name":"Vascular biology (Bristol, England)","volume":"3 1","pages":"R49-R68"},"PeriodicalIF":0.0,"publicationDate":"2021-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/66/b3/VB-21-0007.PMC8284950.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39207295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12

Bio-chemo-mechanics of the thoracic aorta. 胸主动脉的生化力学。

Vascular biology (Bristol, England) Pub Date : 2021-01-12 eCollection Date: 2021-01-01 DOI: 10.1530/VB-20-0015

Sashini Iddawela, Andrew Ravendren, Amer Harky

引用次数: 0

The aging endothelium. 老化的内皮细胞。

Vascular biology (Bristol, England) Pub Date : 2021-01-12 eCollection Date: 2021-01-01 DOI: 10.1530/VB-20-0013

Ka Ka Ting, Paul Coleman, Yang Zhao, Mathew A Vadas, Jennifer R Gamble

引用次数: 11

SARS-CoV-2 and endothelial cell interaction in COVID-19: molecular perspectives. SARS-CoV-2与内皮细胞在COVID-19中的相互作用:分子视角

Vascular biology (Bristol, England) Pub Date : 2021-01-12 eCollection Date: 2021-01-01 DOI: 10.1530/VB-20-0017

Roberta Giordo, Panagiotis Paliogiannis, Arduino Aleksander Mangoni, Gianfranco Pintus

{"title":"SARS-CoV-2 and endothelial cell interaction in COVID-19: molecular perspectives.","authors":"Roberta Giordo, Panagiotis Paliogiannis, Arduino Aleksander Mangoni, Gianfranco Pintus","doi":"10.1530/VB-20-0017","DOIUrl":"10.1530/VB-20-0017","url":null,"abstract":"SARS-CoV-2 is the agent responsible for the coronavirus disease (COVID-19), which has been declared a pandemic by the World Health Organization. The clinical evolution of COVID-19 ranges from asymptomatic infection to death. Older people and patients with underlying medical conditions, particularly diabetes, cardiovascular and chronic respiratory diseases are more susceptible to develop severe forms of COVID-19. Significant endothelial damage has been reported in COVID-19 and growing evidence supports the key pathophysiological role of this alteration in the onset and the progression of the disease. In particular, the impaired vascular homeostasis secondary to the structural and functional damage of the endothelium and its main component, the endothelial cells, contributes to the systemic proinflammatory state and the multiorgan involvement observed in COVID-19 patients. This review summarizes the current evidence supporting the proposition that the endothelium is a key target of SARS-CoV-2, with a focus on the molecular mechanisms involved in the interaction between SARS-CoV-2 and endothelial cells.","PeriodicalId":75294,"journal":{"name":"Vascular biology (Bristol, England)","volume":"3 1","pages":"R15-R23"},"PeriodicalIF":0.0,"publicationDate":"2021-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/28/c9/VB-20-0017.PMC7923034.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25435790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 24

Aging- and gender-related modulation of RAAS: potential implications in COVID-19 disease. 与年龄和性别相关的RAAS调节:对COVID-19疾病的潜在影响

Vascular biology (Bristol, England) Pub Date : 2020-12-11 eCollection Date: 2021-01-01 DOI: 10.1530/VB-20-0014

Laura Monteonofrio, Maria Cristina Florio, Majd AlGhatrif, Edward G Lakatta, Maurizio C Capogrossi

引用次数: 11

MicroRNA-145 targets in cancer and the cardiovascular system: evidence for common signaling pathways. MicroRNA-145在癌症和心血管系统中的靶点:共同信号通路的证据。

Vascular biology (Bristol, England) Pub Date : 2020-10-23 eCollection Date: 2020-01-01 DOI: 10.1530/VB-20-0012

Dwitiya Sawant, Brenda Lilly

引用次数: 5

The cardiac complications of COVID-19: many publications, multiple uncertainties. COVID-19 的心脏并发症：众多出版物，多种不确定因素。

Vascular biology (Bristol, England) Pub Date : 2020-10-20 eCollection Date: 2020-01-01 DOI: 10.1530/VB-20-0009

Abdallah Al-Mohammad, David G Partridge, Graham Fent, Oliver Watson, Nigel T Lewis, Robert F Storey, Michael Makris, Timothy J Chico

引用次数: 0

The effect of absent blood flow on the zebrafish cerebral and trunk vasculature 无血流对斑马鱼大脑和躯干血管系统的影响

Vascular biology (Bristol, England) Pub Date : 2020-07-24 DOI: 10.1101/2020.07.23.216192

E. Kugler, Ryan O. Snodgrass, George Bowley, K. Plant, J. Serbanovic-Canic, P. Evans, T. Chico, P. Armitage

{"title":"The effect of absent blood flow on the zebrafish cerebral and trunk vasculature","authors":"E. Kugler, Ryan O. Snodgrass, George Bowley, K. Plant, J. Serbanovic-Canic, P. Evans, T. Chico, P. Armitage","doi":"10.1101/2020.07.23.216192","DOIUrl":"https://doi.org/10.1101/2020.07.23.216192","url":null,"abstract":"The role of blood flow is complex and context-dependent. In this study, we quantify the effect of the lack of blood flow on vascular development and compare its impact in two vascular beds, namely the cerebral and trunk vasculature, using zebrafish as preclinical model. We performed this by analysing vascular topology, endothelial cell number, apoptosis, and inflammatory response in animals with normal blood flow or absent blood flow. We find that absent blood flow reduced vascular area and endothelial cell number significantly in both examined vascular beds, but the effect is more severe in the cerebral vasculature. Similarly, while stereotypic vascular patterning in the trunk is maintained, intra-cerebral vessels show altered patterning. Absent blood flow lead to an increase in non-EC-specific apoptosis without increasing tissue inflammation, as quantified by cerebral immune cell numbers and nitric oxide. In conclusion, blood flow is essential for cellular survival in both the trunk and cerebral vasculature, but particularly intra-cerebral vessels are affected by the lack of blood flow, suggesting that responses to blood flow differ between these two vascular beds. Key points We here use zebrafish as a model to quantitatively assess the impact of the lack of blood flow in development and compare its impact in two vascular beds, namely the cerebral to trunk vasculature. In both vascular beds, vascular growth and endothelial cell number are reduced by lack of blood flow, with increasing effect size from 2-5 days post fertilisation. Examination of vascular patterning shows that while stereotypic patterning in the trunk is preserved, the intra-cerebral vasculature patterning is altered. We found non-EC-specific cell death to be increased in both vascular beds, with a larger effect size in the brain, but that this cell death occurs without triggering tissue inflammation.","PeriodicalId":75294,"journal":{"name":"Vascular biology (Bristol, England)","volume":"3 1","pages":"1 - 16"},"PeriodicalIF":0.0,"publicationDate":"2020-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45736012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Infrared thermography for monitoring severity and treatment of diabetic foot infections. 用于监测糖尿病足感染严重程度和治疗的红外热成像技术。

Vascular biology (Bristol, England) Pub Date : 2020-07-21 eCollection Date: 2020-01-01 DOI: 10.1530/VB-20-0003

Kor H Hutting, Wouter B Aan de Stegge, Rombout R Kruse, Jeff G van Baal, Sicco A Bus, Jaap J van Netten

{"title":"Infrared thermography for monitoring severity and treatment of diabetic foot infections.","authors":"Kor H Hutting, Wouter B Aan de Stegge, Rombout R Kruse, Jeff G van Baal, Sicco A Bus, Jaap J van Netten","doi":"10.1530/VB-20-0003","DOIUrl":"10.1530/VB-20-0003","url":null,"abstract":"Monitoring of diabetic foot infections is largely based on clinical assessment, which is limited by moderate reliability. We conducted a prospective study to explore monitoring of thermal asymmetry (difference between mean plantar temperature of the affected and unaffected foot) for the assessment of severity of diabetic foot infections. In patients with moderate or severe diabetic foot infections (International Working Group on the Diabetic Foot infection-grades 3 or 4) we measured thermal asymmetry with an advanced infrared thermography setup during the first 4-5 days of in-hospital treatment, in addition to clinical assessments and tests of serum inflammatory markers (white blood cell counts and C-reactive protein levels). We assessed the change in thermal asymmetry from baseline to final assessment, and investigated its association with infection-grades and serum inflammatory markers. In seven included patients, thermal asymmetry decreased from median 1.8°C (range: -0.6 to 8.4) at baseline to 1.5°C (range: -0.1 to 5.1) at final assessment (P = 0.515). In three patients who improved to infection-grade 2, thermal asymmetry at baseline (median 1.6°C (range: -0.6 to 1.6)) and final assessment (1.5°C (range: 0.4 to 5.1)) remained similar (P = 0.302). In four patients who did not improve to infection-grade 2, thermal asymmetry decreased from median 4.3°C (range: 1.8 to 8.4) to 1.9°C (range: -0.1 to 4.4; P = 0.221). No correlations were found between thermal asymmetry and infection-grades (r = -0.347; P = 0.445), CRP-levels (r = 0.321; P = 0.482) or WBC (r = -0.250; P = 0.589) during the first 4-5 days of hospitalization. Based on these explorative findings we suggest that infrared thermography is of no value for monitoring diabetic foot infections during in-hospital treatment.","PeriodicalId":75294,"journal":{"name":"Vascular biology (Bristol, England)","volume":"2 1","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2020-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/8f/aa/VB-20-0003.PMC7487596.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38483744","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0