Translational journal of the American College of Sports Medicine最新文献

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Remote Exercise for Adults with Down Syndrome. 成人唐氏综合症的远程运动。
Lauren T Ptomey, Amanda N Szabo, Erik A Willis, J Leon Greene, Jessica C Danon, Richard A Washburn, Daniel E Forsha, Joseph E Donnelly
{"title":"Remote Exercise for Adults with Down Syndrome.","authors":"Lauren T Ptomey,&nbsp;Amanda N Szabo,&nbsp;Erik A Willis,&nbsp;J Leon Greene,&nbsp;Jessica C Danon,&nbsp;Richard A Washburn,&nbsp;Daniel E Forsha,&nbsp;Joseph E Donnelly","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose: </strong>Adults with Down syndrome are less physically active than their typically developed peers. The purpose of this study was to assess the feasibility of delivering moderate-to- vigorous exercise sessions, led by a trained health educator using real-time video conferencing, to groups of young adults with Down syndrome in their homes.</p><p><strong>Methods: </strong>Participants were randomized to 30-minute group exercise sessions either 1 or 2 times a week delivered on an iPad mini tablet computer using the Zoom video conferencing application, and were asked to attend individual support/education sessions once a week using FaceTime<sup>®</sup> on the iPad, for 12 weeks. Minutes of MVPA during all group sessions were assessed using a Fitbit Charge HR activity/heart rate monitor. Participants were also asked to complete weekly homework assignments involving MVPA.</p><p><strong>Results: </strong>Twenty-seven participants (n = 14,1 session·wk<sup>-1</sup>, n =13, 2 sessions·wk<sup>-1</sup>), mean age 27.9 ± 7.1 yrs., ~ 41% female, enrolled in and completed the 12-wk. intervention. Attendance at group exercise and individual support/education sessions did not differ significantly between those randomized to 1 (exercise sessions =89.9 ± 8.8%, support/education sessions = 81.2 ±18.7%) or 2 sessions·wk<sup>-1</sup> (exercise sessions = 88.8 ± 7.7%; <i>p</i>=0.79, support/education sessions= 86.0 ± 20.9%; <i>p</i>=0.87). Participants averaged 27.7 ± 5.7 mins·session<sup>-1</sup> of MVPA with no significant difference between the 1 (26.6 ± 3.0 mins·session<sup>-1</sup>) and 2 session·wk<sup>-1</sup> groups (28.8 ± 7.7 mins·session<sup>-1</sup>, <i>p</i>=0.16). The completion rate for homework assignments did not differ significantly between the 1 (21.4 ± 26.3%) and 2 session·wk<sup>-1</sup> groups (37.7 ± 21.7%, <i>p</i>=0.28).</p><p><strong>Conclusion: </strong>Exercise delivered by group video conferencing may be a feasible and potentially effective approach for increasing MVPA in adults with Down syndrome.</p>","PeriodicalId":75243,"journal":{"name":"Translational journal of the American College of Sports Medicine","volume":"3 8","pages":"60-65"},"PeriodicalIF":0.0,"publicationDate":"2018-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6005664/pdf/nihms926576.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36246597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Warrior Wellness Study: A Randomized Controlled Exercise Trial for Older Veterans with PTSD. 战士健康研究:一项针对患有PTSD的老年退伍军人的随机对照运动试验。
Translational journal of the American College of Sports Medicine Pub Date : 2018-03-15 DOI: 10.1249/TJX.0000000000000056
Katherine S Hall, Miriam C Morey, Jean C Beckham, Hayden B Bosworth, Michelle M Pebole, Carl F Pieper, Richard Sloane
{"title":"The Warrior Wellness Study: A Randomized Controlled Exercise Trial for Older Veterans with PTSD.","authors":"Katherine S Hall,&nbsp;Miriam C Morey,&nbsp;Jean C Beckham,&nbsp;Hayden B Bosworth,&nbsp;Michelle M Pebole,&nbsp;Carl F Pieper,&nbsp;Richard Sloane","doi":"10.1249/TJX.0000000000000056","DOIUrl":"https://doi.org/10.1249/TJX.0000000000000056","url":null,"abstract":"<p><p>Posttraumatic stress disorder (PTSD) affects up to 30% of military veterans. Older veterans, many of whom have lived with PTSD symptoms for several decades, report a number of negative health outcomes. Despite the demonstrated benefits of regular exercise on physical and psychological health, no studies have explored the impact of exercise in older veterans with PTSD. This paper describes the development, design, and implementation of the Warrior Wellness exercise pilot study for older veterans with PTSD. Veterans aged ≥60 with a Diagnostic and Statistical Manual of Mental Disorders (DSM-V) diagnosis of PTSD will be recruited and randomized to (a) Warrior Wellness, a 12-week supervised, facility-based exercise intervention, or (b) usual care for 12 weeks. Warrior Wellness is a theory- and evidence-based behavioral intervention that involves 3 sessions per week of multi-component exercise training that targets strength, endurance, balance, and flexibility. Warrior Wellness focuses on satisfaction with outcomes, self-efficacy, self-monitoring, and autonomy. Factors associated with program adherence, defined as the number of sessions attended during the 12 weeks, will be explored. Primary outcomes include PTSD symptoms and cardiovascular endurance, assessed at baseline and 12 weeks. Compared to those in usual care, it is hypothesized that those in the Warrior Wellness condition will improve on these efficacy outcomes. The Warrior Wellness study will provide evidence on whether a short-term exercise intervention is feasible, acceptable, and effective among older veterans with PTSD, and explore factors associated with program adherence. ClinicalTrials.gov <i>Identifier</i>: NCT02295995.</p>","PeriodicalId":75243,"journal":{"name":"Translational journal of the American College of Sports Medicine","volume":"3 6","pages":"43-51"},"PeriodicalIF":0.0,"publicationDate":"2018-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1249/TJX.0000000000000056","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35990549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Motor Control-based Group Exercise: Can It be Delivered as Effectively by Lay Leaders? 运动控制为基础的小组练习:外行领导能有效地进行吗?
Translational journal of the American College of Sports Medicine Pub Date : 2018-02-01 DOI: 10.1249/TJX.0000000000000053
David M Wert, Subashan Perera, Jean F Nutini, Edmund M Ricci, Leslie Coffman, Rachael Turnquist, Jessie VanSwearingen, Jennifer Brach
{"title":"Motor Control-based Group Exercise: Can It be Delivered as Effectively by Lay Leaders?","authors":"David M Wert,&nbsp;Subashan Perera,&nbsp;Jean F Nutini,&nbsp;Edmund M Ricci,&nbsp;Leslie Coffman,&nbsp;Rachael Turnquist,&nbsp;Jessie VanSwearingen,&nbsp;Jennifer Brach","doi":"10.1249/TJX.0000000000000053","DOIUrl":"https://doi.org/10.1249/TJX.0000000000000053","url":null,"abstract":"<p><strong>Purpose: </strong>On the Move (OTM), a motor control-based group exercise program for community-dwelling older adults, has produced greater gains in mobility than a standard group exercise program when delivered by research leaders. The purposes of this study were:1) to examine the effectiveness of OTM versus a standard program when delivered by lay leaders and 2) to compare the outcomes of OTM when delivered by research versus lay leaders.</p><p><strong>Methods: </strong>Community-dwelling, medically stable older adults who could walk household distances participated. OTM consisted of warm-up, timing and coordination, strengthening, and stretching exercises. The seated standard program consisted of warm-up, aerobic, strengthening and stretching exercises. The primary outcome(s) of function and disability was the Late Life Function and Disability Instrument (LLFDI), and for walking ability were the Six Minute Walk Test and gait speed.</p><p><strong>Results: </strong>126 participants (mean age = 80.7±7.8 years, gait speed = 0.91 m/s) were randomized to OTM (n=49) or standard (n=77) programs. When taught by lay leaders, there were no significant between-intervention group differences in any of the outcomes (p>0.10). Comparing OTM outcomes between leaders, there was a statistical but not clinically meaningful difference in LLFDI disability (1.87±0.89, p=0.04) when taught by research versus lay leader, and moderate differences (p=0.06) in LLFDI overall function (1.89±1.02) and gait speed (0.05±0.03). Qualitative interview responses suggest that instructor-related concerns may have impacted program outcomes.</p><p><strong>Conclusion: </strong>When delivered by lay leaders OTM was not more effective than a standard program for improving function, disability, and mobility in older adults. Health promotion programs designed to improve mobility in community-dwelling older adults and based on a motor control theoretical background, may be best taught by rehabilitation professionals.</p>","PeriodicalId":75243,"journal":{"name":"Translational journal of the American College of Sports Medicine","volume":"3 3","pages":"19-27"},"PeriodicalIF":0.0,"publicationDate":"2018-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1249/TJX.0000000000000053","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10549840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Active Learning Increases Children's Physical Activity across Demographic Subgroups. 主动学习增加儿童在人口分组中的身体活动。
Translational journal of the American College of Sports Medicine Pub Date : 2018-01-01 DOI: 10.1249/TJX.0000000000000051
John B Bartholomew, Esbelle M Jowers, Gregory Roberts, Anna-Mária Fall, Vanessa L Errisuriz, Sharon Vaughn
{"title":"Active Learning Increases Children's Physical Activity across Demographic Subgroups.","authors":"John B Bartholomew,&nbsp;Esbelle M Jowers,&nbsp;Gregory Roberts,&nbsp;Anna-Mária Fall,&nbsp;Vanessa L Errisuriz,&nbsp;Sharon Vaughn","doi":"10.1249/TJX.0000000000000051","DOIUrl":"https://doi.org/10.1249/TJX.0000000000000051","url":null,"abstract":"<p><strong>Purpose: </strong>Given the need to find more opportunities for physical activity within the elementary school day, this study was designed to asses the impact of I-CAN!, active lessons on: 1) student physical activity (PA) outcomes via accelerometry; and 2) socioeconomic status (SES), race, sex, body mass index (BMI), or fitness as moderators of this impact.</p><p><strong>Methods: </strong>Participants were 2,493 fourth grade students (45.9% male, 45.8% white, 21.7% low SES) from 28 central Texas elementary schools randomly assigned to intervention (n=19) or control (n=9). Multilevel regression models evaluated the effect of I-CAN! on PA and effect sizes were calculated. The moderating effects of SES, race, sex, BMI, and fitness were examined in separate models.</p><p><strong>Results: </strong>Students in treatment schools took significantly more steps than those in control schools (β = 125.267, SE = 41.327, p = .002, d = .44). I-CAN! had a significant effect on MVPA with treatment schools realizing 80% (β = 0.796, SE =0.251, p = .001; d = .38) more MVPA than the control schools. There were no significant school-level differences on sedentary behavior (β = -0.177, SE = 0.824, p = .83). SES, race, sex, BMI, and fitness level did not moderate the impact of active learning on step count and MVPA.</p><p><strong>Conclusion: </strong>Active learning increases PA within elementary students, and does so consistently across demographic sub-groups. This is important as these sub-groups represent harder to reach populations for PA interventions. While these lessons may not be enough to help children reach daily recommendations of PA, they can supplement other opportunities for PA. This speaks to the potential of schools to adopt policy change to require active learning.</p>","PeriodicalId":75243,"journal":{"name":"Translational journal of the American College of Sports Medicine","volume":"3 1","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1249/TJX.0000000000000051","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36109586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 31
Translating Basic Science to Clinical/Real-World Applications: Relevance for Exercise Science 将基础科学转化为临床/现实世界的应用:运动科学的相关性
Translational journal of the American College of Sports Medicine Pub Date : 2017-11-15 DOI: 10.1249/tjx.0000000000000048
S. Bloomfield
{"title":"Translating Basic Science to Clinical/Real-World Applications: Relevance for Exercise Science","authors":"S. Bloomfield","doi":"10.1249/tjx.0000000000000048","DOIUrl":"https://doi.org/10.1249/tjx.0000000000000048","url":null,"abstract":"\u0000 Among the thousands of American College of Sports Medicine members, many are basic science researchers. Although most are physiologists, cognitive/neuroscience specialists are also contributing to the literature with important new findings about the physical and mental health effects of regular exercise. Although experimental work in cell culture or isolated tissue models can rapidly identify potential cellular and molecular mechanisms, basic scientists must work with appropriate animal models to confirm that mechanisms identified in the highly controlled environment of the petri dish still pertain when the tissue of interest is also exposed to the multiple neural, endocrine, and paracrine signals that pertain to the intact living organism. One form of translational research this journal seeks to publish are intervention trials testing whether earlier results gleaned from appropriate animal models will “translate” to human physiology.","PeriodicalId":75243,"journal":{"name":"Translational journal of the American College of Sports Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43535215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Study Protocol for a Home-based Obesity Prevention Program in Latino Preschool Children. 拉丁裔学龄前儿童家庭肥胖预防项目研究方案。
Translational journal of the American College of Sports Medicine Pub Date : 2017-07-15 DOI: 10.1249/TJX.0000000000000038
Sharon E Taverno Ross, Patricia I Documet, Russell R Pate, Ivonne Smith-Tapia, Lisa M Wisniewski, Bethany B Gibbs
{"title":"Study Protocol for a Home-based Obesity Prevention Program in Latino Preschool Children.","authors":"Sharon E Taverno Ross,&nbsp;Patricia I Documet,&nbsp;Russell R Pate,&nbsp;Ivonne Smith-Tapia,&nbsp;Lisa M Wisniewski,&nbsp;Bethany B Gibbs","doi":"10.1249/TJX.0000000000000038","DOIUrl":"https://doi.org/10.1249/TJX.0000000000000038","url":null,"abstract":"<p><strong>Purpose: </strong>This paper describes the study design for ANDALE Pittsburgh, a culturally-appropriate, family-based intervention to promote a healthy weight in Latino preschool children.</p><p><strong>Methods/design: </strong>The study was organized into two major phases: Phase I: Conduct focus groups with 30 Latino parents of preschool children to inform the development of a culturally-appropriate intervention; Phase II: Test the feasibility and effectiveness of the intervention with 50 families. Participants were recruited from an emerging Latino community through community gatherings, flyers, and word of mouth. Six <i>promotoras</i> (females >18 years, active in community) received 25 hours of training using the intervention curriculum finalized after Phase I. Promotoras delivered the home-based intervention to families over 10, 90-minute weekly sessions that included education, practice, and action (i.e., goal setting). Behavior modification constructs and strategies (e.g., goal setting, problem solving, social support), and building of self-efficacy through healthy recipe preparation and physical activity breaks, were also included. Outcomes (e.g., child BMI) were assessed pre- and post-intervention. Process evaluation assessed fidelity, dose, reach, recruitment, and contextual factors using multiple data sources and mixed methods.</p><p><strong>Discussion: </strong>The ANDALE Pittsburgh study will expand the body of knowledge on interventions to promote a healthy weight in Latino preschool children living in an emerging Latino community. If successful, this approach will be evaluated in a future, larger-scale intervention and provide a potential model to help to address and prevent obesity in this population.</p>","PeriodicalId":75243,"journal":{"name":"Translational journal of the American College of Sports Medicine","volume":"2 14","pages":"85-91"},"PeriodicalIF":0.0,"publicationDate":"2017-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5654603/pdf/nihms873723.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35556942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Nonworksite Interventions to Reduce Sedentary Behavior among Adults: A Systematic Review. 非工作场所干预减少成年人久坐行为:一项系统综述。
Translational journal of the American College of Sports Medicine Pub Date : 2017-06-15 DOI: 10.1249/TJX.0000000000000036
Keith M Thraen-Borowski, Laura D Ellingson, Jacob D Meyer, Lisa Cadmus-Bertram
{"title":"Nonworksite Interventions to Reduce Sedentary Behavior among Adults: A Systematic Review.","authors":"Keith M Thraen-Borowski,&nbsp;Laura D Ellingson,&nbsp;Jacob D Meyer,&nbsp;Lisa Cadmus-Bertram","doi":"10.1249/TJX.0000000000000036","DOIUrl":"https://doi.org/10.1249/TJX.0000000000000036","url":null,"abstract":"<p><strong>Purpose: </strong>Sedentary behavior has been identified as a major health risk. While interventions to reduce time spent sedentary have become increasingly prevalent, the vast majority of this work in adults has been focused on workplace sedentary behavior, and often pairs sedentary reduction interventions with increasing physical activity. As research designed to specifically decrease sedentary time that is not limited to the workplace becomes available, identifying strategies and approaches, along with feasibility and efficacy of these interventions, is warranted.</p><p><strong>Methods: </strong>Electronic databases were searched for sedentary interventions with eligibility criteria including: (a) interventions designed to explicitly reduce sedentary behavior that were not limited to the workplace, (b) outcomes specific to sedentary behavior, (c) adults aged at least 18 years, and (d) written in English.</p><p><strong>Results: </strong>A total of 767 full-text manuscripts were identified, with thirteen studies meeting all eligibility criteria. While intervention characteristics and methodological quality varied greatly among studies, ten of the thirteen studies observed a significant reduction in objectively measured sitting time post-intervention. In those studies that collected participant feasibility/acceptability data, all reported that the intervention was viewed as \"favorable to very favorable,\" would use again, and that participant burden was quite low, suggesting that these interventions were feasible.</p><p><strong>Conclusion: </strong>Sedentary behavior interventions not limited to the workplace appear to be largely efficacious. While results varied with respect to the magnitude of the decrease in time spent sedentary, they are encouraging. However, due to the small body of evidence and the variability of study designs, our ability to make overarching statements regarding \"best practices\" at this time is limited. Well-controlled trials of longer duration with larger samples, using theoretically-based interventions with consistent prescriptions for limiting sedentary time are needed.</p>","PeriodicalId":75243,"journal":{"name":"Translational journal of the American College of Sports Medicine","volume":"2 12","pages":"68-78"},"PeriodicalIF":0.0,"publicationDate":"2017-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5630153/pdf/nihms865597.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35585423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
Surveys to Sidewalks: Translating Physical Activity Research into Policy and Environmental Change 人行道调查:将体育活动研究转化为政策和环境变化
Translational journal of the American College of Sports Medicine Pub Date : 2017-04-01 DOI: 10.1249/tjx.0000000000000031
A. Eyler
{"title":"Surveys to Sidewalks: Translating Physical Activity Research into Policy and Environmental Change","authors":"A. Eyler","doi":"10.1249/tjx.0000000000000031","DOIUrl":"https://doi.org/10.1249/tjx.0000000000000031","url":null,"abstract":"","PeriodicalId":75243,"journal":{"name":"Translational journal of the American College of Sports Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45989696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Physical Activity and Mortality: The Potential Impact of Sitting 体育活动与死亡率:久坐的潜在影响
Translational journal of the American College of Sports Medicine Pub Date : 2017-03-15 DOI: 10.1249/tjx.0000000000000030
P. Katzmarzyk, R. Pate
{"title":"Physical Activity and Mortality: The Potential Impact of Sitting","authors":"P. Katzmarzyk, R. Pate","doi":"10.1249/tjx.0000000000000030","DOIUrl":"https://doi.org/10.1249/tjx.0000000000000030","url":null,"abstract":"Over the past few years, numerous studies of sedentary behavior (sitting) have documented significant associations with chronic disease and mortality outcomes (6). These results have significant implications for workplace health and associated policies, because long-term trends in occupational data suggest that sedentary occupations have increased significantly in the United States between 1960 and 2008 (1). Self-reported levels of sitting in the United States average approximately 4.7 h·d (3); however, this estimate is likely conservative because individuals tend to underreport their sitting behavior. For example, a study among Australian adults using an objective assessment (inclinometer) reported an average of 8.8 h of sitting per day (4). Furthermore, objective data collected by accelerometry in the U.S. National Health and Nutrition Examination Survey indicate that children and adults spend approximately 7.7 h·d being sedentary (5). Thus, a large proportion of the U.S. population is exposed to excessive levels of sedentary behavior and is at increased health risk because of this exposure. A topic of interest that has been addressed in this arena is whether the observed associations of sedentary behavior and increased chronic disease and mortality risk are modified or moderated by physical activity (light, moderate, vigorous, or total). Studies typically statistically “adjust” for a measure of physical activity by including it in a statistical model as a covariate or by stratifying the analysis by level of physical activity (i.e., active vs inactive). Using this approach, Ekelund et al. (2) recently reported the results of a meta-analysis of data from 1,005,791 participants from 13 studies who were followed for all-cause mortality between 2 and 18 yr. A total of 8.4% of the participants died during follow-up, and the hazardous","PeriodicalId":75243,"journal":{"name":"Translational journal of the American College of Sports Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1249/tjx.0000000000000030","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42033292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
Translation Goes Both Ways: The Power of Reverse Translation from Human Trials into Animal Models 翻译是双向的:从人体试验到动物模型的反向翻译的力量
Translational journal of the American College of Sports Medicine Pub Date : 2017-03-01 DOI: 10.1249/tjx.0000000000000029
J. T. Lightfoot, M. Bamman, F. Booth
{"title":"Translation Goes Both Ways: The Power of Reverse Translation from Human Trials into Animal Models","authors":"J. T. Lightfoot, M. Bamman, F. Booth","doi":"10.1249/tjx.0000000000000029","DOIUrl":"https://doi.org/10.1249/tjx.0000000000000029","url":null,"abstract":"\u0000 Much attention has been given to “translational research” with the assumption that such models follow a stepwise progression from basic/discovery science at the bench to application at the bedside. This practice ignores the valuable reverse aspect of translational research (i.e., “reverse translation”) where discoveries or observations at the bedside can inform and stimulate more mechanistic, basic work back at the bench, which in turn should expedite clinical applicability. This commentary reflects on the current thinking regarding reverse translation, with particular emphasis on the value of reverse translational design in understanding acute responses and chronic adaptations to exercise. Overall, we conclude that reverse translational designs offer a powerful avenue of investigation that should be fully leveraged to maximize impact on the understanding and treatment of human disease.","PeriodicalId":75243,"journal":{"name":"Translational journal of the American College of Sports Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1249/tjx.0000000000000029","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43833666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
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