Translational biophotonics最新文献

{"title":"Ratiometric Analysis of <i>In Vivo</i> Optical Coherence Tomography Retinal Layer Thicknesses for Detection of Changes in Alzheimer's Disease","authors":"Shonit N. Sharma, Jordan W. Marsh, Michael S. Tsipursky, Stephen A. Boppart","doi":"10.1002/tbio.202300003","DOIUrl":"https://doi.org/10.1002/tbio.202300003","url":null,"abstract":"Abstract We analyzed ophthalmic retinal optical coherence tomography (OCT) images from patients with Alzheimer's disease (AD) to identify retinal layer thickness and ratio changes that may serve as image‐based biomarkers for the disease. One three‐dimensional volume before and one after diagnosis for each of 48 patients were segmented to identify retinal layer and total retinal thicknesses. Between before‐ and after‐diagnosis retinal OCT images, there were significant thickness changes in six of 10 (60%) retinal layers across all 48 patients. Through a comparison with age‐matched healthy subjects, the significant changes were attributed to AD only (NFL and PR2 layers), age only (GCL, IPL, and RPE layers), or both AD and age (OPL layer). Analyzing ratios of retinal layer thicknesses, 53 of 90 (58.89%) ratios had significant changes. The four independently nonsignificant layers were assessed to be affected by neither AD nor age (INL layer) or both AD and age (ELM, PR1, and BM layers). The demonstrated image segmentation, measurement, and ratiometric analysis of retinal layers in AD patients may yield a noninvasive OCT image‐based retinal biomarker that can be used to detect retinal changes associated with this disease.","PeriodicalId":75242,"journal":{"name":"Translational biophotonics","volume":"80 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135666835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep Learning‐based <scp>High‐Dimensional</scp> Multiple Regression Estimator for Chest X‐ray Image Classification in Rapid Cardiomegaly Screening","authors":"Pi‐Yun Chen, Chia‐Hung Lin, Hung‐Yao Peng, Feng‐Zhou Zhang, Chung‐Dann Kan","doi":"10.1002/tbio.202300005","DOIUrl":"https://doi.org/10.1002/tbio.202300005","url":null,"abstract":"Abstract Chest x‐ray (CXR) examination is a common first‐line, non‐invasive, and rapid screening method in clinical examinations. The posteroanterior (PA) and anteroposterior (AP) view modes can both be used to detect related cardiopulmonary diseases, such as pneumonitis, tuberculosis, pulmonary fibrosis, lung tumors, and cardiomegaly. Compared with cardiac computed tomography and cardiac magnetic resonance imaging methods, CXR examination has a short scanning duration and costs less, and is suitable for routine and follow‐up health examinations. Cardiomegaly is an asymptomatic disease in the early stage and cannot be detected through electrocardiography measurements. Thus, early cardiomegaly classes detections, such as cardiac hypertrophy and ventricular dilatation, can help make decisions regarding drug treatments and surgeries. In addition, an automatic assistive tool is required to differentiate between normal individuals and those with cardiomegaly to address the problem of manual inspection and labor shortage. Hence, PA view‐based CXR classification is used to develop a deep learning (DL)‐based high‐dimensional multiple regression analysis (MRA) model for CXR image classification in rapid cardiomegaly screening. This multilayer network model uses a two‐channel three‐layer convolution‐normalization‐pooling process with two‐dimensional (2D) multi convolution operations to enhance images and to extract feature patterns; and then a one‐dimensional feature conversion is used to estimate the four coordinate points of the maximal horizontal cardiac diameter (MHCD) and maximal horizontal thoracic diameter (MHTD), which can be used to estimate cardiothoracic ratio and detect cardiomegaly. For experimental tests, the training and testing datasets are collected from the National Institutes of Health CXR Image Database (Clinical Center, USA), and 10‐fold cross‐validation was used for model evaluation in terms of precision (%), recall (%), accuracy (%), and F1 score. These indexes are used to evaluate the feasibility of the proposed MRA estimator. In addition, the performances of the proposed model are compared with those of conventional DL‐based multilayer classifiers.","PeriodicalId":75242,"journal":{"name":"Translational biophotonics","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135666576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Translation of photodynamic therapy and photodiagnostics into the clinic: Status and obstacles","authors":"A. Rühm, Xiuli Wang, L. Lilge","doi":"10.1002/tbio.202380001","DOIUrl":"https://doi.org/10.1002/tbio.202380001","url":null,"abstract":"Clinical translation of new diagnostic or therapeutic approaches is one of the gate keepers in the evolution of patient management. Photonics-based diagnostic technologies are spearheading clinical translation. In 2021, the publication count for searches of “Photodynamic (-therapy OR -diagnosis) AND clinical translation” started to pick up significantly. Indeed since 2021, 229 works are listed in Clarivate's Web of Science, of which 129 are reviews exemplifying the interest in this topic. In all works, nanotechnology-related investigations are dominant, but other developments in photosensitizer design are also prominent. Over 60% of all listed publications are generated by researchers from the People's Republic of China, reflecting the keen interest in enabling photodynamic therapy as cost-competitive therapy for oncology and other clinical indications. In late 2021, we set out to obtain an update on the translational status of photodynamic diagnostics and therapeutics with a special call for Translational Biophotonics. While only seven manuscripts were accepted for this issue, some of the trends observed during the Web of Science search are also noticed here. The vast majority of the accepted manuscripts originate from the People's Republic of China. Retrospective analyses of previously treated patient cohorts are dominant [1–4], covering keloids, genital warts, port-wine stain (PWS) and condyloma acuminatum treatment, indicating the predominance of these superficial non-oncological indications over oncological therapies in clinical translation. These clinical studies investigated PDT either as an adjuvant to standard therapies (as in the case of surgery for keloid treatment [1]) or as stand-alone therapy vs standard therapies (as in the case of PWS [2], condyloma acuminatum (with prior hair removal) [3] and genital warts [4]). While none of these studies resulted in game-changing advantages of PDT vs standard therapy or of PDT as adjuvant therapy or in combination with adjuvant measures, some reduction in recurrence in keloids, genital warts and port-wine stains were noted. All publications reported an increase in patient satisfaction due to the treatment. Patient acceptance is an often-underappreciated parameter for the widespread adoption of a novel therapy. The port-wine stain study is reporting a 10-year follow-up with stable results. Similar observations were also noted by van Raath et al [5], who reported no improvement in PWS outcome over the past 3 decades. The manuscript by Yao et al [6] reports on an oncological clinical study on chlorin e6 derivative mediated PDT treatments on 18 patients with cervical and vaginal low-grade squamous intraepithelial lesions. Very high rates of complete response and HPV remission were observed at the 6-month follow-up, higher than achieved, for example, with ALA-induced PpIX as reported recently [7, 8]. Shi et al demonstrated that combining surgery and two ALA-induced PpIX-mediated PDT treatments was s","PeriodicalId":75242,"journal":{"name":"Translational biophotonics","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42220410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ten‐year long‐term results following HMME‐PDT therapy for port‐wine stain","authors":"Wenjia Nie, Xue Wang, Yan Liu, J. Tao, Yan Li","doi":"10.1002/tbio.202200004","DOIUrl":"https://doi.org/10.1002/tbio.202200004","url":null,"abstract":"Hematoporphyrin monomethyl Ether‐mediated photodynamic therapy (HMME‐PDT) is an effective and safe treatment option for patients with port‐wine stain (PWS) and might be an alternative approach for treating PWS. The data of long‐term follow‐up of HMME‐mediated PDT are limited.","PeriodicalId":75242,"journal":{"name":"Translational biophotonics","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44514594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Issue Information","authors":"","doi":"10.1002/tbio.202390001","DOIUrl":"https://doi.org/10.1002/tbio.202390001","url":null,"abstract":"","PeriodicalId":75242,"journal":{"name":"Translational biophotonics","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42452113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Issue Information","authors":"","doi":"10.1002/aorn.13721","DOIUrl":"https://doi.org/10.1002/aorn.13721","url":null,"abstract":"","PeriodicalId":75242,"journal":{"name":"Translational biophotonics","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45553043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Topical photodynamic therapy for genital warts: Systematic review and meta‐analysis","authors":"Zhi Cao, Peiru Wang, Haiyan Zhang, Linglin Zhang, Guolong Zhang, Xiuli Wang","doi":"10.1002/tbio.202200008","DOIUrl":"https://doi.org/10.1002/tbio.202200008","url":null,"abstract":"High recurrence rate and adverse effects were common shortcomings in treatments for genital warts, but a number of clinical studies have found that photodynamic therapy (PDT) had some unique superiority compared to other treatments. This study aims to evaluate the efficacy and safety of PDT for genital warts in comparison to alternative treatments. Seven databases and ClinicalTrials.gov were searched and seven randomized controlled trials were finally included. There was no significant difference in clearance rate of urethral lesions between the PDT group and the CO2 laser therapy (CO2‐LT group) (Odds ratio [OR] 0.676, 95% confidence interval [CI] 0.071–6.426, P = 0.734), but the overall clearance rate of all genital warts was slightly lower for PDT (OR 0.574, CI 0.335–0.985, P = 0.044). The recurrence rate after PDT was significantly lower than after CO2‐LT (OR 0.318, CI 0.220–0.460, P < 0.001), and adverse effects were also slighter after PDT (OR 0.015, CI 0.003–0.074, P < 0.001). In addition, a modification of parameters of light irradiation provides the potential to alleviate pain. This study shows that PDT is an effective treatment for genital warts with good tolerability and safety, especially for cavitary lesions. Some modified protocols probably have the potential to reduce adverse effects, but still need further investigation.","PeriodicalId":75242,"journal":{"name":"Translational biophotonics","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47399372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of optical coherence tomography otoscopy to overcome cerumen and other view obstructions during ear examination and assessment","authors":"Ryan G. Porter, Ryan M. Nolan, Michael Novak, Jon Youakim, Ryan L. Shelton","doi":"10.1002/tbio.202200017","DOIUrl":"https://doi.org/10.1002/tbio.202200017","url":null,"abstract":"Childhood ear infections are highly prevalent and diagnosed with the otoscope, a simple tool that illuminates and magnifies the eardrum to subjectively assess color, translucency and presence of any middle ear fluid. Frequently, however, this view is obstructed by cerumen, complicating clinician assessment and appropriate and effective management. An optical coherence tomography (OCT)‐otoscope capable of capturing both depth‐resolved OCT images and digital color surface images was used to compare OCT against otoscopy for imageability and readability despite cerumen obstruction. Image data were collected from 26 human subjects and read by 12 blinded clinicians and 5 blinded OCT experts. An average of 64.6% of otoscopy views were obstructed. For cases with >75% otoscopy view obstruction, OCT imageability was 84.6%, while otoscopy imageability was 37.5%, excluding complete obstruction cases. OCT‐otoscopy is a promising technology to improve practical middle ear assessment despite the presence of obstructions that frequently render current diagnostic assessments ineffective.","PeriodicalId":75242,"journal":{"name":"Translational biophotonics","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47090530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanotechnology and photodynamic therapy from a clinical perspective","authors":"Sara A. Abdel Gaber, M. Fadel","doi":"10.1002/tbio.202200016","DOIUrl":"https://doi.org/10.1002/tbio.202200016","url":null,"abstract":"Photodynamic therapy (PDT) is currently applied clinically in many medical centers worldwide. The clinical outcomes are from one side satisfying and from the other side highlighting the areas of further development. Issues like hydrophobicity of the photosensitizer (PS), uncontrolled distribution and limited tissue penetration of the accompanying light sources triggered the interest of many research groups. Nanotechnology outstood among the various suggested enhancement solutions. In this review, the rationale behind using nanotechnology is discussed. Light is shed on the status of nanotechnology from approval for clinical use. Clinical studies of PS‐loaded nanoparticles are summarized and the challenges facing the progress of those systems are enumerated.","PeriodicalId":75242,"journal":{"name":"Translational biophotonics","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41778766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Robotic large‐area optical biopsy imaging for automated detection of gastrointestinal cancers tested in tissue phantoms and ex vivo porcine bowel","authors":"Fernando B. Avila-Rencoret, G. Mylonas, D. Elson","doi":"10.1002/tbio.202200013","DOIUrl":"https://doi.org/10.1002/tbio.202200013","url":null,"abstract":"Gastrointestinal endoscopy is a subjective procedure that frequently requires tissue samples for diagnosis. Contact optical biopsy (OB) techniques have the aim of providing direct diagnosis of endoscopic areas without excising tissue samples but lack the wide‐area coverage required for locating and resecting lesions. This article presents a large‐area robotically deployed OB imaging platform for endoscopic detection of colorectal cancer as an add‐on for conventional endoscopes. In vitro, in silicon colon phantoms, the platform achieves an optical resolution of 0.5 line pairs per millimeter, while resolving simulated cancer lesions down to 0.75 mm diameter across large‐area images (55‐103 cm2). Large‐area OB images were generated in an ex vivo porcine colon. The platform allows centimeter‐sized large‐area OB imaging in vitro and ex vivo with submillimeter resolution, including automatic data segmentation of simulated cancer areas. The ability for robotic actuation and spectrum collection is also shown for ex vivo animal colon. If successful, this technology could widen access to user‐independent high‐quality endoscopy and early detection of gastrointestinal cancers.","PeriodicalId":75242,"journal":{"name":"Translational biophotonics","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47870715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}