Translational biophotonics最新文献_第2页

Development of a portable Raman device with artificial intelligence method for the detection and staging of endometrial cancer 用于子宫内膜癌检测和分期的便携式人工智能拉曼仪的研制

Translational biophotonics Pub Date : 2022-09-18 DOI: 10.1002/tbio.202200014

Manu Krishnan Krishnan Nambudiri, A. Rajanbabu, Indu Ramachandran Nair, Anandita, Shantikumar V Nair, Manzoor Koyakutty, Girish Chundayil Madathil

{"title":"Development of a portable Raman device with artificial intelligence method for the detection and staging of endometrial cancer","authors":"Manu Krishnan Krishnan Nambudiri, A. Rajanbabu, Indu Ramachandran Nair, Anandita, Shantikumar V Nair, Manzoor Koyakutty, Girish Chundayil Madathil","doi":"10.1002/tbio.202200014","DOIUrl":"https://doi.org/10.1002/tbio.202200014","url":null,"abstract":"The success of a Raman spectroscopy device in cancer detection lies in its ability to acquire high‐quality Raman signals from samples and to employ efficient classification algorithms in analysing spectral data. Portable Raman systems enabled with artificial intelligence tools are well adaptable to clinical settings and for accuracy for community‐level rapid screening. Here, we developed a robotic Raman device with a high‐efficiency Raman probe, validating it against endometrial cancers detecting high‐grade, low‐grade cancers and normal classes. Algorithms like principal component analysis‐discriminant analysis, and support vector machine were compared against the deep learning methodology; convolutional neural network (CNN) with and without data augmentation. Eventually, the system could classify high‐grade, low‐grade and normal tissues with an F1‐score of 91%, 94% and 97%, respectively. CNN with data augmentation proved to be the most dependable classifier that works well even in the presence of high background noise. Thus, we demonstrate a unique portable Raman device with AI tools for high‐sensitivity Raman analysis of endometrial cancer.","PeriodicalId":75242,"journal":{"name":"Translational biophotonics","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47698496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application of Raman spectroscopy in the hospital environment 拉曼光谱在医院环境中的应用

Translational biophotonics Pub Date : 2022-09-04 DOI: 10.1002/tbio.202200011

Aikaterini Pistiki, Markus Salbreiter, Salwa Sultan, P. Rösch, J. Popp

{"title":"Application of Raman spectroscopy in the hospital environment","authors":"Aikaterini Pistiki, Markus Salbreiter, Salwa Sultan, P. Rösch, J. Popp","doi":"10.1002/tbio.202200011","DOIUrl":"https://doi.org/10.1002/tbio.202200011","url":null,"abstract":"The hospital environment is a field with unique microbiological characteristics. Pathogens evolve and spread in different areas of the hospital affecting patients and staff. In addition, a constant circulation of pathogens between the hospital and the outer environment is ongoing. In this context, an extensive management is required in order to minimize the harmful effect of hospital flora on humans as well as the natural environment. Raman spectroscopy has been shown to be an effective tool for this purpose since it is applicable in a variety of biological samples ranging from the patient samples to the hospital's wastewater. It enables the detection of infection, bacterial species identification, antimicrobial resistance determination, epidemiological typing as well as infection control, mandatory for hospital management. The biggest advantages of this analytical method are the limited time and minimal resources required in its workflow. In the current review the Raman‐based analytical methods that have been developed over years in the field of microbiology are presented and their applicability in the different areas of the hospital environment is discussed.","PeriodicalId":75242,"journal":{"name":"Translational biophotonics","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46821481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A cable‐driven soft robotic end‐effector actuator for probe‐based confocal laser endomicroscopy: Development and preclinical validation 用于基于探针的共焦激光显微镜的电缆驱动软机器人末端执行器：开发和临床前验证

Translational biophotonics Pub Date : 2022-08-15 DOI: 10.1002/tbio.202200015

Charles DeLorey, Joseph Davids, João Cartucho, Chi Xu, Alfie Roddan, Amr Nimer, H. Ashrafian, A. Darzi, Alexander J. Thompson, S. Akhond, M. Runciman, G. Mylonas, Stamatia Gianarrou, James Avery

{"title":"A cable‐driven soft robotic end‐effector actuator for probe‐based confocal laser endomicroscopy: Development and preclinical validation","authors":"Charles DeLorey, Joseph Davids, João Cartucho, Chi Xu, Alfie Roddan, Amr Nimer, H. Ashrafian, A. Darzi, Alexander J. Thompson, S. Akhond, M. Runciman, G. Mylonas, Stamatia Gianarrou, James Avery","doi":"10.1002/tbio.202200015","DOIUrl":"https://doi.org/10.1002/tbio.202200015","url":null,"abstract":"Soft robotics is becoming a popular choice for end‐effectors. An end‐effector was designed that has various advantages including ease of manufacturing, simplicity and control. This device may have the advantage of enabling probe‐based devices to intraoperatively measure cancer histology, because it can flexibly and gently position a probe perpendicularly over an area of delicate tissue. This is demonstrated in a neurosurgical setting where accurate cancer resection has been limited by lack of accurate visualisation and impaired tumour margin delineation with the need for in‐situ histology. Conventional surgical robotic end‐effectors are unsuitable to accommodate a probe‐based confocal laser endomicroscopy (p‐CLE) probe because of their rigid and non‐deformable properties, which can damage the thin probe. We have therefore designed a new soft robotic platform, which is advantageous by conforming to the probe's shape to avoid damage and to facilitate precision scanning.","PeriodicalId":75242,"journal":{"name":"Translational biophotonics","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44431531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Superficial shaving combined with photodynamic therapy is effective as a treatment for condyloma acuminatum 表面剃须结合光动力疗法是有效的治疗尖锐湿疣

Translational biophotonics Pub Date : 2022-08-09 DOI: 10.1002/tbio.202200007

Jie Pan, Mingliang Chen, Shuang Zhao, Juan Su

引用次数: 0

Management of patients with giant basal cell carcinoma during SARS COV2 outbreak in Italy. 意大利SARS - COV2暴发期间巨基底细胞癌患者的管理

Translational biophotonics Pub Date : 2022-08-01 Epub Date: 2022-07-26 DOI: 10.1002/tbio.202200009

Carmen Cantisani, Raimondo Rossi, Steven Paul Nisticò, Martina Vitiello, Francesca Farnetani, Luigi Bennaro, Giovanni Pellacani

{"title":"Management of patients with giant basal cell carcinoma during SARS COV2 outbreak in Italy.","authors":"Carmen Cantisani, Raimondo Rossi, Steven Paul Nisticò, Martina Vitiello, Francesca Farnetani, Luigi Bennaro, Giovanni Pellacani","doi":"10.1002/tbio.202200009","DOIUrl":"10.1002/tbio.202200009","url":null,"abstract":"Basal cell carcinoma (BCC) is the most frequently occurring type of all cancers, and represents 80% of all skin cancer. The estimated lifetime risk for BCC in the white population is between 33% and 39% for men and 23% and 28% for women. Its incidence doubles every 25 years and is increasing in the young population. Death is uncommon and seems to decrease in the last years, probably due to early and better diagnosis. BCC arises from abnormal and uncontrolled growth of basal cells. It is a slow-growing tumor, therefore usually curable at an early stage with surgery or alternative treatment, such as cryotherapy, laser, photodynamic therapy, retinoids and topical agent like 5-Fluorouracil cream, imiquimod cream, and so forth. Topical treatment of superficial basocellular carcinoma is a viable option, when surgery is not an advisable treatment, especially in the case of giant basocellular carcinoma. In this subtype, imiquimod 5% cream can be a safe and effective treatment, but there are few reports in available literature. We present our case series of eight patients with superficial giant basocellular carcinoma successfully treated with imiquimod 5% cream, which showed clinical improvement after 8 weeks of treatment.","PeriodicalId":75242,"journal":{"name":"Translational biophotonics","volume":" ","pages":"e202200009"},"PeriodicalIF":0.0,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9350373/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40596688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Fiber-based hand-held RCM-OCT probe for noninvasive assessment of skin lesions and therapy guidance. 基于纤维的手持式RCM-OCT探针用于皮肤病变的无创评估和治疗指导。

Translational biophotonics Pub Date : 2022-08-01 DOI: 10.1002/tbio.202200002

Gopi Maguluri, John Grimble, Mircea Mujat, Jesung Park, Aliana Caron, Nicusor Iftimia

{"title":"Fiber-based hand-held RCM-OCT probe for noninvasive assessment of skin lesions and therapy guidance.","authors":"Gopi Maguluri, John Grimble, Mircea Mujat, Jesung Park, Aliana Caron, Nicusor Iftimia","doi":"10.1002/tbio.202200002","DOIUrl":"https://doi.org/10.1002/tbio.202200002","url":null,"abstract":"Noninvasive assessment of skin lesions, especially of basal cell carcinoma (BCC), has benefited more recently from the use of optical imaging techniques such as optical coherence tomography (OCT) and reflectance confocal microscopy (RCM). While RCM provides submicron scale resolution and thus enables identification of skin morphological changes of the skin, with the downside of limited penetration depth, OCT imaging of the same lesion brings the benefit of better resolving its depth of invasion. OCT and RCM can be used either individually or combined within the same instrument for the noninvasive diagnosis of nonmelanoma skin cancers (NMSCs). Their combined use has shown to provide certain benefits such as better characterization of the lesion's margins, both in depth and laterally, as well as improved sensitivity and specificity, as previously demonstrated by our team. In this paper we report a new \"fiber-based\" implementation of the second-generation RCM-OCT hand-held probe. The fiber-based implementation of both imaging modalities enabled the construction of a smaller footprint/lower weight hand-held probe. Its preliminary evaluation on the skin of healthy volunteers is reported here, demonstrating improved capabilities for resolving sub-cellular structures and image skin morphology with micron-scale resolution to a higher depth than in the previous implementation, while also enabling the construction of angiography maps showing vascular remodeling.","PeriodicalId":75242,"journal":{"name":"Translational biophotonics","volume":"4 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9514145/pdf/nihms-1811900.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10291064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Issue Information 问题信息

Translational biophotonics Pub Date : 2022-08-01 DOI: 10.1002/tbio.202290002

引用次数: 0

A chlorin e6 derivative‐mediated photodynamic therapy for patients with cervical and vaginal low‐grade squamous intraepithelial lesions: a retrospective analysis 氯离子e6衍生物介导的光动力疗法治疗宫颈和阴道低度鳞状上皮内病变患者的回顾性分析

Translational biophotonics Pub Date : 2022-06-21 DOI: 10.1002/tbio.202200006

Hongxia Yao, Jia Yan, Zhongxia Zhou, Shuzhan Shen, Yun Wu, Pei Liu, Haiyan Zhang, Xiuli Wang

{"title":"A chlorin e6 derivative‐mediated photodynamic therapy for patients with cervical and vaginal low‐grade squamous intraepithelial lesions: a retrospective analysis","authors":"Hongxia Yao, Jia Yan, Zhongxia Zhou, Shuzhan Shen, Yun Wu, Pei Liu, Haiyan Zhang, Xiuli Wang","doi":"10.1002/tbio.202200006","DOIUrl":"https://doi.org/10.1002/tbio.202200006","url":null,"abstract":"Cervical and vaginal low‐grade squamous intraepithelial lesions (LSIL) are associated with persistent human papillomavirus infections, and require an efficacious non‐invasive treatment such as photodynamic therapy due to anatomical characteristics. In this study, we evaluated the clinical efficacy and safety of a chlorin e6 derivative named STBF‐mediated photodynamic therapy (STBF‐PDT) for patients with cervical and vaginal LSIL. A total of 18 patients received STBF‐PDT for 3 to 6 times and followed up for 6 to 12 months; among them, 6 had cervical and vaginal LSIL and 1 had vaginal stump LSIL after hysterectomy for cervical cancer. Results showed the complete remission (CR) rates were 72.22% (13/18), and the HPV remission rates and HPV clearance rates were 88.89% (16/18) and 83.33% (15/18), respectively at 1‐month follow‐up. The CR reached 88.89% and HPV remission rates got 94.44% at the 6‐month follow‐up. There were no recurrence cases so far, and no pain, heaving sensation, scar, deformity, and any other obvious adverse reactions occurred during treatment and follow‐up. In conclusion, STBF‐PDT is an effective, safe, and well‐tolerated method for the treatment of cervical and vaginal LSIL. It may have promising potential for applications in the future.","PeriodicalId":75242,"journal":{"name":"Translational biophotonics","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41490836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Side‐viewing handheld confocal Raman probe coupled with an off‐axis parabolic mirror for superficial epithelial Raman measurements of luminal organs 侧视手持式共焦拉曼探针与离轴抛物面镜耦合，用于管腔器官的浅表上皮拉曼测量

Translational biophotonics Pub Date : 2022-06-15 DOI: 10.1002/tbio.202200010

Jianfeng Wang, Gu-ling Zhang

引用次数: 0

Keratoacanthoma‐like squamous cell carcinoma successfully treated by the surgery combined with ALA‐PDT 手术联合ALA - PDT成功治疗角膜棘瘤样鳞状细胞癌

Translational biophotonics Pub Date : 2022-06-14 DOI: 10.1002/tbio.202200005

Jing-fang Shi, Jia Yan, Yang Yutong, Jianhua Huang, Min-Feng Wu, Xiuli Wang, Hong-wei Wang, Lei Shi

引用次数: 0