Alzheimer's Research & Therapy最新文献

{"title":"A digital twin methodology using retrospective patient data for sample size reduction in Alzheimer's disease clinical trials.","authors":"Daniel Andrews, Shirin Golchi, D Louis Collins","doi":"10.1186/s13195-026-02024-5","DOIUrl":"10.1186/s13195-026-02024-5","url":null,"abstract":"","PeriodicalId":7516,"journal":{"name":"Alzheimer's Research & Therapy","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Women's reproductive life patterns, intrinsic capacity, and the risk of all-cause and cause-specific dementia: a prospective cohort study.","authors":"Yue Zhang, Qilong Tan, Songtao Wu, Xiaolin Xu","doi":"10.1186/s13195-026-02066-9","DOIUrl":"https://doi.org/10.1186/s13195-026-02066-9","url":null,"abstract":"<p><strong>Background: </strong>Few studies comprehensively examined women's life-course reproductive patterns and the risk of dementia. This study aims to examine the association between women's reproductive life sequence and dementia, and to explore the potential role of intrinsic capacity (IC) on such association.</p><p><strong>Methods: </strong>This study used data of 153,909 women who were post-menopause and free of dementia at baseline from the UK Biobank. We conducted sequence analysis and cluster analysis to identify women's life-course reproductive sequence and its potential patterns based on self-reported single reproductive factors. Women's IC at baseline comprised four functional domains: psychology, sensory, vitality, and locomotion. Participants were followed from baseline to the onset of dementia, death, or the end of follow-up (September 1, 2023). Fine and Gray's subdistribution hazard models were used to examine the associations between reproductive life sequences, IC, and dementia.</p><p><strong>Results: </strong>During a median follow-up of 14.5 years, 2,940 dementia (including 1,509 Alzheimer's disease and 577 vascular dementia) cases were documented. Patterns of reproductive life sequences identified were: standard sequence (46.4%), early childbearing and oophorectomy menopause (6.5%), short reproductive span with natural menopause (17.7%), early childbearing and hysterectomy menopause (11.4%), and high parity with long birth span (18.1%). Compared to the standard sequence, short reproductive span with natural menopause (hazard ratio [HR] = 1.30, 95% confidence interval [CI] = 1.18-1.44), early childbearing and hysterectomy menopause (HR = 1.17, 95% CI = 1.04-1.32), and high parity with long birth span (HR = 1.13, 95% CI = 1.03-1.25) were associated with a higher risk of dementia. These associations would be strengthened when combining with IC impairment. For example, women with the combined sequence of short reproductive span with natural menopause and IC impairment had 2.40-fold (1.77-3.24) increased risk of dementia, compared to those with the standard sequence and no IC impairment. The associations between reproductive life patterns and dementia risk were stronger among women with more impairment items of IC.</p><p><strong>Conclusion: </strong>Our study showed cumulative associations of women's life-course reproductive factors with the risk of dementia in later life, and IC impairment could strengthen such associations. These results suggest the need to prioritize women with high-risk reproductive sequences, with special focus on their IC, in the prevention strategies for dementia.</p>","PeriodicalId":7516,"journal":{"name":"Alzheimer's Research & Therapy","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of N-acetylcysteine in patients with mild cognitive impairment undergoing exercise-based cardiac rehabilitation program: a randomized controlled trial.","authors":"Damien Gallagher, Yejin Kang, Nathan Herrmann, Alex Kiss, Sandra E Black, Paul Oh, Susan Marzolini, Jennifer S Rabin, Ana Andreazza, Joel Ramirez, Fuqiang Gao, Mark Rapoport, Jinghan Jenny Chen, Kate Survilla, Danielle Vieira, Ethan Mah, Walter Swardfager, Krista L Lanctôt","doi":"10.1186/s13195-026-02062-z","DOIUrl":"https://doi.org/10.1186/s13195-026-02062-z","url":null,"abstract":"","PeriodicalId":7516,"journal":{"name":"Alzheimer's Research & Therapy","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic drivers of progression in Alzheimer's disease are distinct from disease risk.","authors":"Celeste E Cohen, Shane Fernandez, Umran Yaman, Ahmad R Ehyaei, Eleftheria Kodosaki, Aydan Askarova, Tenielle Porter, Eleanor O'Brien, Paul Maruff, Alexi Nott, John A Hardy, Simon M Laws, Dervis A Salih, Maryam Shoai","doi":"10.1186/s13195-026-02036-1","DOIUrl":"https://doi.org/10.1186/s13195-026-02036-1","url":null,"abstract":"","PeriodicalId":7516,"journal":{"name":"Alzheimer's Research & Therapy","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between amyloid-β deposition and cognitive function in cognitively normal adults: a multilevel meta-analysis.","authors":"Yanlu Huang, Qiong Gong, Zhuoyi Zhong, Qihao Guo","doi":"10.1186/s13195-026-02061-0","DOIUrl":"https://doi.org/10.1186/s13195-026-02061-0","url":null,"abstract":"","PeriodicalId":7516,"journal":{"name":"Alzheimer's Research & Therapy","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2026-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathways to resilience: relationships between cognitive reserve, psychological debt, and Alzheimer's disease biomarkers.","authors":"Hanna Boscheck, Maxie Luft, René Mauer, Selin Senguel, Ylenia D'elia, Peter Dechent, Klaus Fliessbach, Wenzel Glanz, Stefan Hetzer, Daniel Janowitz, Ingo Kilimann, Luca Kleineidam, Marie Kronmüller, Falk Lüsebrink, Lukas Preis, Boris Rauchmann, Ayda Rostamzadeh, Björn Hendrik Schott, Sebastian Sodenkamp, Eike Spruth, Sophia Stoecklein, Renat Yakupov, Gabriel Ziegler, Frederic Brosseron, Katharina Buerger, Julian Hellmann-Regen, Christoph Laske, Robert Perneczky, Oliver Peters, Josef Priller, Alfredo Ramirez, Anja Schneider, Annika Spottke, Stefan Teipel, Jens Wiltfang, Frank Jessen, Emrah Düzel, Sandra Röske, Michael Wagner, Franka Glöckner, Natalie L Marchant, Olga Klimecki, Miranka Wirth","doi":"10.1186/s13195-026-02054-z","DOIUrl":"https://doi.org/10.1186/s13195-026-02054-z","url":null,"abstract":"","PeriodicalId":7516,"journal":{"name":"Alzheimer's Research & Therapy","volume":"18 1","pages":""},"PeriodicalIF":7.6,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13107903/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of the novel phosphodiesterase 9 inhibitor irsenontrine on CSF proteomics profile in Aβ⁺ and Aβ^- dementia with Lewy bodies patients.","authors":"Marlies Oosthoek, Sjors G J G In 't Veld, Lisa Vermunt, Yuanqing Ye, Manon van Ingen, Marleen Koel-Simmelink, Everard G B Vijverberg, Satya Saxena, Steven Hersch, Michael Irizarry, Pallavi Sachdev, Charlotte E Teunissen","doi":"10.1186/s13195-026-02065-w","DOIUrl":"https://doi.org/10.1186/s13195-026-02065-w","url":null,"abstract":"","PeriodicalId":7516,"journal":{"name":"Alzheimer's Research & Therapy","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Olfactory radiomics signatures link pTau217 to cognitive impairment in probable Alzheimer's disease: a multi-cohort machine learning study.","authors":"Ben Chen, Pengbo Gao, Huanmin Liu, Danyan Xu, Qiang Wang, Mingfeng Yang, Haoye Tan, Zhidai Xiao, Shihan Tian, Zihan Wang, Youxuan Zheng, Xiaomin Zheng, Shuang Liang, Qin Liu, Jiafu Li, Xiaomei Zhong, Yuping Ning","doi":"10.1186/s13195-026-02053-0","DOIUrl":"https://doi.org/10.1186/s13195-026-02053-0","url":null,"abstract":"","PeriodicalId":7516,"journal":{"name":"Alzheimer's Research & Therapy","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma biomarker trajectories across Alzheimer's clinical onset: a 17-year prospective study.","authors":"Siqi Xie, Yumei Liang, Yana Pang, Ying Li, Shuman Cao, Yan Li, Qi Wang, Abhay Moghekar, Marilyn Albert, Jianping Jia","doi":"10.1186/s13195-026-02045-0","DOIUrl":"https://doi.org/10.1186/s13195-026-02045-0","url":null,"abstract":"","PeriodicalId":7516,"journal":{"name":"Alzheimer's Research & Therapy","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global and domain-specific cognitive intraindividual variability associations with neurodegenerative diagnoses and postmortem pathologies.","authors":"Caitlin M Terao, Fareshte Erani, Uriel Urias, Francesca Lopez, Fini Chang, Sarah J Banks, Paul E Gilbert, David G Coughlin, Katherine J Bangen, Kelsey R Thomas","doi":"10.1186/s13195-026-02041-4","DOIUrl":"https://doi.org/10.1186/s13195-026-02041-4","url":null,"abstract":"","PeriodicalId":7516,"journal":{"name":"Alzheimer's Research & Therapy","volume":" ","pages":""},"PeriodicalIF":7.6,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147759737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}