Aktuelle Urologie最新文献

{"title":"Kommentar.","authors":"","doi":"10.1055/a-2909-9691","DOIUrl":"https://doi.org/10.1055/a-2909-9691","url":null,"abstract":"","PeriodicalId":7513,"journal":{"name":"Aktuelle Urologie","volume":"57 5","pages":"434-438"},"PeriodicalIF":0.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148863438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MRT-geleitete Prostata-Abklärung: 5-Jahres-Ergebnisse der RAPID-Strategie.","authors":"","doi":"10.1055/a-2812-7513","DOIUrl":"https://doi.org/10.1055/a-2812-7513","url":null,"abstract":"","PeriodicalId":7513,"journal":{"name":"Aktuelle Urologie","volume":"57 5","pages":"434"},"PeriodicalIF":0.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148863408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Giant Scrotal Elephantiasis as a Septic Focus in Generalized Lymphedema: Radical Resection Following Initial Suspicion of Malignancy].","authors":"Julia Peter-Schiller, Julio Rodas Garzaro, Anton Kravchuk, Stefanie Herrmann, Fabian Eder, Christian Gilfrich, Matthias May, Stephan Siepmann","doi":"10.1055/a-2901-8298","DOIUrl":"https://doi.org/10.1055/a-2901-8298","url":null,"abstract":"<p><strong>Abstract: </strong>This case report describes a rare and clinically highly complex constellation of massive scrotal elephantiasis, generalized lymphedema, and septic deterioration, which initially raised the suspicion of a malignant soft tissue tumor. The report highlights the diagnostic pitfalls associated with extreme scrotal enlargement, the nuanced decision-making regarding timing and extent of surgical intervention in a persistent septic setting, and the urological, pathological, and reconstructive implications of radical resection under extraordinary anatomical conditions. Reports of scrotal elephantiasis presenting as a primary septic focus in non-endemic regions remain rare and are largely limited to isolated case descriptions. This case illustrates clinically relevant diagnostic and therapeutic decision-making in the management of this unusual constellation.</p>","PeriodicalId":7513,"journal":{"name":"Aktuelle Urologie","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148757286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Sex-Specific Treatment Outcomes in Clinical Trials and Subsequent Real-World Data on Systemic Therapies for Urothelial Carcinoma: A Systematic Review.","authors":"Marie Christine Roesch, Lea Sophie Lütje, Marten Müller, Axel S Merseburger, Daniar Osmonov, Nils Gilbert","doi":"10.1055/a-2897-1443","DOIUrl":"https://doi.org/10.1055/a-2897-1443","url":null,"abstract":"<p><strong>Background/context: </strong>Treatment outcomes after systemic cancer therapies exhibit sex-specific differences. Real-world data do not necessarily reflect the results of randomized clinical trials (RCTs).</p><p><strong>Objective: </strong>To compare sex-specific outcomes between RCTs and subsequent real-world data in patients with urothelial cancer (UC) receiving systemic therapies.</p><p><strong>Methods: </strong>A systematic literature search on systemic therapies for UC was conducted in Embase, PubMed, MEDLINE, and Scopus up to February 2025. Eligible studies included phase II/III trials, RCTs, prospective non-interventional studies, retrospective studies, and case series. Extracted parameters comprised hazard ratios for overall survival and progression-free survival (or disease-free survival for adjuvant therapies), sex-specific enrollment rates, and discontinuation rates due to adverse effects. This review is registered with PROSPERO and was conducted in accordance with PRISMA guidelines.</p><p><strong>Results: </strong>A total of 52 articles were included. The proportion of female patients enrolled in UC RCTs did not reflect epidemiologic data, and only a few real-world studies reached the expected benchmark. The following approval studies showed a survival benefit for men compared with women: JAVELIN Bladder 100 (Avelumab), Keynote 045 (Pembrolizumab), EV-301 (Enfortumab Vedotin), CheckMate 901 (Gemcitabine + Cisplatin + Nivolumab), and CheckMate 274 (adjuvant Nivolumab). Only a limited number of real-world studies reported sex-specific outcome analyses, and none demonstrated a clear benefit for either sex. No sex-specific toxicity analyses were published.</p><p><strong>Conclusion: </strong>Several approval studies investigating therapies for urothelial cancer suggest a survival benefit for male patients. However, this finding was not confirmed in real-world data. Female patients remain underrepresented in approval trials for UC, and sex-specific toxicity analyses are lacking. Such analyses should be mandatory in future RCTs.</p>","PeriodicalId":7513,"journal":{"name":"Aktuelle Urologie","volume":" ","pages":""},"PeriodicalIF":0.5,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148700582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Folgelinientherapie nach NHA-Versagen beim kastrationsresistenten metastasierten Prostatakarzinom (mCRPC).","authors":"","doi":"10.1055/a-2861-2725","DOIUrl":"https://doi.org/10.1055/a-2861-2725","url":null,"abstract":"","PeriodicalId":7513,"journal":{"name":"Aktuelle Urologie","volume":"57 4","pages":"340-341"},"PeriodicalIF":0.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148629270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Transition of Patients with Neurogenic Bladder Dysfunction: Challenges and Unmet Needs in Adult Care].","authors":"Raimund Stein, Luisa Weil, Malin Nientiedt, Nina Younsi","doi":"10.1055/a-2875-4321","DOIUrl":"10.1055/a-2875-4321","url":null,"abstract":"<p><strong>Abstract: </strong>Transition describes the structured process by which adolescents are transferred from pediatric and family-centered, and thus predominantly externally determined, care to patient-centered, self-determined adult care. In patients with spina bifida (SB), transition is particularly relevant from a urological perspective, as neurogenic bladder and bowel dysfunction frequently require chronic pharmacological treatment, permanent bladder management (including intermittent self-catheterization), and lifelong monitoring of kidney and bladder function. At the same time, physical limitations and frequently impaired cognitive executive and planning abilities may hamper the development of self-management skills and treatment adherence. As people with SB exhibit considerable variability in their individual capabilities and needs, they require an individualized transition plan. They benefit from continuous and reliable follow-up at a dedicated center. Only such continuity of care can ensure a safe transition to adult-oriented follow-up care. Ideally, this should be provided by the Medical Centers for Adults with Disabilities (MZEB) in collaboration with urological centers specializing in SB patients.</p>","PeriodicalId":7513,"journal":{"name":"Aktuelle Urologie","volume":" ","pages":"360-365"},"PeriodicalIF":0.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148262904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erstlinientherapie des nicht resektablen lokal fortgeschrittenen oder metastasierten Urothelkarzinoms.","authors":"","doi":"10.1055/a-2890-2409","DOIUrl":"https://doi.org/10.1055/a-2890-2409","url":null,"abstract":"","PeriodicalId":7513,"journal":{"name":"Aktuelle Urologie","volume":"57 4","pages":"342-343"},"PeriodicalIF":0.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148629193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Lifelong Urological Follow-up in Patients with Anorectal Malformations: Continence, Urinary Tract Infections, Renal and Sexual Function].","authors":"Luisa Weil, Michael Boettcher, Marietta Jank","doi":"10.1055/a-2883-3894","DOIUrl":"https://doi.org/10.1055/a-2883-3894","url":null,"abstract":"<p><strong>Abstract: </strong>Anorectal malformations (ARM) present with a wide clinical spectrum in severity, with associated anomalies in up to 70% of cases. An increasing number of patients now reach adulthood, resulting in a shift in focus towards long-term function beyond the reconstructive period and securing transition of care. Urological morbidity is common and persists into adult life. Reported rates of urinary incontinence vary considerably depending on the severity of the malformation as well as associated sacral and spinal anomalies. Further sequelae include recurrent urinary tract infections, a retained remnant of the original fistula (ROOF), iatrogenic urogenital injury, chronic kidney disease, and impaired fertility.This narrative review proposes a risk-adapted follow-up scheme based on a structured history (voiding and bowel diaries), ultrasound, laboratory and microbiological assessment, as well as functional testing (uroflowmetry, urodynamics). These findings guide conservative treatment (urotherapy, bowel management, intermittent catheterization) and the decision for surgery. To date, no standardized follow-up recommendations exist for adult care. Risk-stratified interdisciplinary monitoring and initiation of transition at the onset of puberty are essential.</p>","PeriodicalId":7513,"journal":{"name":"Aktuelle Urologie","volume":"57 4","pages":"380-391"},"PeriodicalIF":0.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148629240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapiestrategien beim metastasierten hormonsensiblen Prostatakarzinom.","authors":"","doi":"10.1055/a-2803-8081","DOIUrl":"https://doi.org/10.1055/a-2803-8081","url":null,"abstract":"","PeriodicalId":7513,"journal":{"name":"Aktuelle Urologie","volume":"57 4","pages":"332-334"},"PeriodicalIF":0.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148629282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kommentar.","authors":"","doi":"10.1055/a-2850-1958","DOIUrl":"https://doi.org/10.1055/a-2850-1958","url":null,"abstract":"","PeriodicalId":7513,"journal":{"name":"Aktuelle Urologie","volume":"57 4","pages":"330-332"},"PeriodicalIF":0.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148629233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}