American journal of clinical pathology最新文献_第6页

How I diagnose B-cell lymphoproliferative disorders with plasmacytic differentiation. 如何诊断伴有浆细胞分化的b淋巴细胞增生性疾病。

IF 2.3 4区医学

American journal of clinical pathology Pub Date : 2025-04-19 DOI: 10.1093/ajcp/aqae163

Jonathan H Young, Olga Pozdnyakova

{"title":"How I diagnose B-cell lymphoproliferative disorders with plasmacytic differentiation.","authors":"Jonathan H Young, Olga Pozdnyakova","doi":"10.1093/ajcp/aqae163","DOIUrl":"10.1093/ajcp/aqae163","url":null,"abstract":"Objectives: B-cell lymphomas with plasmacytic differentiation is a broad category that includes small and large B-cell lymphomas. In this review, we focus on the small B-cell lymphomas, which include lymphoplasmacytic lymphoma and marginal zone lymphomas, among others. We aimed to review the diagnostic criteria of each entity and the features that distinguish them from each other.Methods: We discuss the clinical presentation, morphology, immunophenotype, molecular features, and potential pitfalls of diagnosing B-cell lymphomas with plasmacytic differentiation and provide 2 illustrative cases.Results: In some instances, small B-cell lymphomas with plasmacytic differentiation, particularly lymphoplasmacytic lymphoma and certain marginal zone lymphomas, have overlapping morphologic and immunophenotypic features. As a result, differentiating them may be difficult.Conclusions: In cases where classification is challenging, integration with clinical, radiologic, and laboratory findings may be helpful in arriving at a specific diagnosis. Instances remain, however, in which classification is difficult.","PeriodicalId":7506,"journal":{"name":"American journal of clinical pathology","volume":" ","pages":"501-510"},"PeriodicalIF":2.3,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143555532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Survey of anatomic and clinical pathology services and infrastructure in Nigeria. 尼日利亚解剖和临床病理服务和基础设施调查。

IF 2.3 4区医学

American journal of clinical pathology Pub Date : 2025-04-19 DOI: 10.1093/ajcp/aqae156

Jonathan Tucci, Jeremy W Jacobs, Zainab U Ibrahim, Aminu A Yusuf, Ali Bala Umar, Danny A Milner, Quentin Eichbaum

{"title":"Survey of anatomic and clinical pathology services and infrastructure in Nigeria.","authors":"Jonathan Tucci, Jeremy W Jacobs, Zainab U Ibrahim, Aminu A Yusuf, Ali Bala Umar, Danny A Milner, Quentin Eichbaum","doi":"10.1093/ajcp/aqae156","DOIUrl":"10.1093/ajcp/aqae156","url":null,"abstract":"Objectives: The paucity of data regarding the availability and extent of diagnostic medical services across sub-Saharan Africa hinders appropriate allocation of resources to improve health care in these regions. We assessed anatomic pathology (AP) and clinical pathology (CP) services in Nigeria, one of the most populous and fastest-growing countries in the world.Methods: Two individual surveys (AP focused and CP focused) were developed by subject matter experts and administered to individuals involved in pathology and laboratory medicine diagnostic services at hospitals and laboratories across Nigeria between June and August 2022 using the American Society for Clinical Pathology email listserv.Results: A total of 75 responses (29 AP and 46 CP) were received from 48 unique laboratories. Twenty-four sites provided AP services and 35 provided CP services. Eleven respondents performed both AP and CP services. Among AP services, basic surgical and cytopathology capabilities were available at most sites; however, the availability of automated technologies (eg, automated sample processing and staining) was more variable. Advanced diagnostic techniques, (eg, immunohistochemistry, human papillomavirus testing, molecular diagnostics) were rarely performed. The most frequently available CP services included hematology, microbiology, and chemistry. Microbiology services appeared to be among the most robust laboratory medicine services, particularly parasitology and bacteriology testing. Similar to AP services, more advanced diagnostic assays, such as flow cytometry, cytogenetics, and molecular testing, were largely unavailable.Conclusions: These findings augment earlier studies and identify gaps that should be prioritized from a policy perspective to improve medical services and the overall health care infrastructure in Nigeria.","PeriodicalId":7506,"journal":{"name":"American journal of clinical pathology","volume":" ","pages":"586-600"},"PeriodicalIF":2.3,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12009665/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142805970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Career pathways into the medical laboratory workforce: Education, exposures, and motivations. 进入医学实验室工作队伍的职业途径：教育、接触和动机。

IF 2.3 4区医学

American journal of clinical pathology Pub Date : 2025-04-19 DOI: 10.1093/ajcp/aqae151

Grace A Guenther, Shahida F Shahrir, Susan M Skillman, Iman Kundu, Edna Garcia, Bianca K Frogner

{"title":"Career pathways into the medical laboratory workforce: Education, exposures, and motivations.","authors":"Grace A Guenther, Shahida F Shahrir, Susan M Skillman, Iman Kundu, Edna Garcia, Bianca K Frogner","doi":"10.1093/ajcp/aqae151","DOIUrl":"10.1093/ajcp/aqae151","url":null,"abstract":"Objectives: The goal of this study was to investigate career pathways into the medical laboratory workforce by examining medical laboratory scientists, medical laboratory technicians, histotechnologists, histotechnicians, cytologists, and phlebotomists.Methods: We collected data through an anonymous online survey (May-June 2023) from a convenience sample of medical laboratory professionals in the United States (N = 1243). We performed descriptive analyses of demographics, current employment characteristics, educational and training history, career exposures, motivations, movement, and outlook (eg, job satisfaction, future career plans).Results: Findings show a diverse range of educational backgrounds and varying career pathways across occupations. A majority of respondents reported hearing about laboratory occupations from friends, family, co-workers, and acquaintances. At least one-third to nearly one-half of respondents had a family member with broader professional health care experience. Respondents viewed their jobs favorably, with at least 75% of respondents answering that they would recommend their occupation or another laboratory occupation.Conclusions: This study found overall positive job experiences and satisfaction, but career pathways into medical laboratory occupations are complex and often unclear. Organizations in the field are undertaking promotional efforts to increase the visibility of these occupations. Future research is needed to monitor and evaluate these efforts.","PeriodicalId":7506,"journal":{"name":"American journal of clinical pathology","volume":" ","pages":"545-580"},"PeriodicalIF":2.3,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142826968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trop-2 and Ephrin B2 expression in urothelial carcinoma with divergent differentiation and aggressive urothelial carcinoma subtypes. Trop-2和Ephrin B2在分化分化分化和侵袭性尿路上皮癌亚型中的表达。

IF 2.3 4区医学

American journal of clinical pathology Pub Date : 2025-04-19 DOI: 10.1093/ajcp/aqae161

Katherine B Case, Dylan J Martini, Melad N Dababneh, Samuel Bidot, Bassel Nazha, Jacqueline Brown, Shreyas Joshi, Vikram Narayan, Vaunita Parihar, Faisal Saeed, Mehmet Asim Bilen, Lara R Harik

{"title":"Trop-2 and Ephrin B2 expression in urothelial carcinoma with divergent differentiation and aggressive urothelial carcinoma subtypes.","authors":"Katherine B Case, Dylan J Martini, Melad N Dababneh, Samuel Bidot, Bassel Nazha, Jacqueline Brown, Shreyas Joshi, Vikram Narayan, Vaunita Parihar, Faisal Saeed, Mehmet Asim Bilen, Lara R Harik","doi":"10.1093/ajcp/aqae161","DOIUrl":"10.1093/ajcp/aqae161","url":null,"abstract":"Objectives: Urothelial carcinomas (UCs) encompass a heterogeneous group of tumors. Several histopathologic features are associated with poor clinical outcomes and limited treatment options. With new rising therapeutic modalities, we aimed to determine the pattern of expression of Trop-2 and ephrin B2 in UC with aggressive subtype histology and/or divergent differentiation (SH/DD).Methods: We performed a retrospective analysis of 113 UC samples with SH/DD at our institution from 2011 to 2021. Immunohistochemical staining for Trop-2 and ephrin B2 expression was performed on all cases. Expression was determined by the percentage of samples with a moderate or strong H-score.Results: Our results show Trop-2 expression was the highest in squamous cell carcinoma and UC with squamous differentiation, adenocarcinoma and UC with glandular differentiation, and plasmacytoid subtype, while ephrin B2 expression was highest in adenocarcinoma, UC with glandular differentiation, and small cell carcinoma.Conclusions: Expression of Trop-2 and ephrin B2 may demonstrate therapeutic possibilities for patients with SH/DD, who usually have limited treatment options, particularly in small cell carcinoma, in which few targets have been identified. Clinical trials to investigate the efficacy of these novel treatments are warranted.","PeriodicalId":7506,"journal":{"name":"American journal of clinical pathology","volume":" ","pages":"618-628"},"PeriodicalIF":2.3,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12009667/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142869280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factors impacting tumor displacement artifact and pseudo-lymphovascular invasion in testicular germ cell tumors. 影响睾丸生殖细胞瘤肿瘤移位假象和假淋巴管侵犯的因素

IF 2.3 4区医学

American journal of clinical pathology Pub Date : 2025-04-19 DOI: 10.1093/ajcp/aqae147

Reem O Ahmed, Debra L Zynger

{"title":"Factors impacting tumor displacement artifact and pseudo-lymphovascular invasion in testicular germ cell tumors.","authors":"Reem O Ahmed, Debra L Zynger","doi":"10.1093/ajcp/aqae147","DOIUrl":"10.1093/ajcp/aqae147","url":null,"abstract":"Objectives: Testicular germ cell tumors are susceptible to tumor displacement artifact (TDA), which produces pseudo-lymphovascular invasion (LVI) and confounds the identification of true LVI. Our study aimed to evaluate tumor displacement artifact and pseudo-LVI in testicular germ cell tumors and determine if prolonged fixation improves histological quality.Methods: A retrospective search identified 121 orchiectomies with slides that were reviewed to assess TDA and pseudo-LVI.Results: Seminoma had more TDA (68% vs 45%, P = .01) and pseudo-LVI (53% vs 19%, P < .001) than mixed germ cell tumor. Seminoma and mixed germ cell tumor with TDA and pseudo-LVI were larger than those without. Mixed germ cell tumor with ≥50% composition of seminoma had a higher rate of TDA (89% vs 38%, P = .008) and pseudo-LVI (44% vs 15%, P = .06) than those with less. TDA was reduced in seminoma with >1 night fixation compared to no fixation (50% vs 82%, P = .046), with a similar trend in mixed germ cell tumor (31% vs 60%, P = .15). A trend in reduction of pseudo-LVI was seen with >1 night fixation compared to no fixation in seminoma (64% vs 39%, P = .12).Conclusions: Seminomas and larger germ cell tumors were more prone to TDA and pseudo-LVI. Prolonged formalin fixation improved histological quality in testicular germ cell tumors. Based on these data, we recommend fixation for at least 2 nights before sectioning orchiectomy specimens, particularly for larger tumors.","PeriodicalId":7506,"journal":{"name":"American journal of clinical pathology","volume":" ","pages":"516-525"},"PeriodicalIF":2.3,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142612170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Use of neuroendocrine immunostains in the evaluation of atrophic gastritis. 神经内分泌免疫染色在萎缩性胃炎诊断中的应用。

IF 2.3 4区医学

American journal of clinical pathology Pub Date : 2025-04-08 DOI: 10.1093/ajcp/aqaf019

Saryn Doucette

引用次数: 0

Expression of CD47 protein in hematolymphoid neoplasms: Implications for CD47-mediated cancer immunotherapy. CD47蛋白在血淋巴肿瘤中的表达：CD47介导的癌症免疫治疗的意义。

IF 2.3 4区医学

American journal of clinical pathology Pub Date : 2025-03-12 DOI: 10.1093/ajcp/aqaf018

Jingjing Zhang, Philip L Bulterys, Sebastian Fernandez-Pol, Sheren F Younes, Shuchun Zhao, Adnan Mansoor, Yasodha Natkunam

{"title":"Expression of CD47 protein in hematolymphoid neoplasms: Implications for CD47-mediated cancer immunotherapy.","authors":"Jingjing Zhang, Philip L Bulterys, Sebastian Fernandez-Pol, Sheren F Younes, Shuchun Zhao, Adnan Mansoor, Yasodha Natkunam","doi":"10.1093/ajcp/aqaf018","DOIUrl":"https://doi.org/10.1093/ajcp/aqaf018","url":null,"abstract":"Objectives: Recent studies show that blocking CD47-SIRPα interactions is a promising target in checkpoint inhibition for cancer immunotherapy. However, to date, the expression of CD47 is not well characterized in various hematolymphoid neoplasms.Methods: This study evaluates CD47 expression in a wide range of hematolymphoid neoplasms using immunohistochemistry on 834 cases.Results: Results show variable but widespread CD47 expression among tumor types and within individual samples in both intensity and percentage. The highest CD47 expressions in both percentage of positive lymphoma cells and intensity was seen in small B-cell lymphomas, particularly chronic lymphocytic leukemia/small lymphocytic lymphoma, mantle cell, marginal zone, and follicular lymphomas. T and B lymphoblastic, diffuse large B-cell, peripheral T-cell, γδ T-cell, angioimmunoblastic T-cell lymphomas and myelodysplastic syndrome showed moderate CD47 expression. Acute and chronic myeloid leukemia as well as classic Hodgkin, anaplastic large cell, and natural killer/T-cell lymphomas showed low expression. Burkitt lymphoma is a notable standout, with little to no CD47 expression in all 14 cases examined.Conclusions: Understanding the prevalence of CD47 expression in hematolymphoid neoplasms is crucial for identifying potential therapeutic targets and selecting patients who may benefit from CD47-targeted therapies. Additionally, CD47 may serve as a valuable diagnostic marker in neoplasms such as Burkitt lymphoma.","PeriodicalId":7506,"journal":{"name":"American journal of clinical pathology","volume":" ","pages":""},"PeriodicalIF":2.3,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143603486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cutaneous lupus erythematosus presenting as a nonhealing ulcer in an African American woman: A case report. 皮肤红斑狼疮表现为非裔美国妇女无法愈合的溃疡：一例报告。

IF 2.3 4区医学

American journal of clinical pathology Pub Date : 2025-03-12 DOI: 10.1093/ajcp/aqaf017

Kevin M Burningham, Mohamad Taha, Seo Won Cho, Mahmud Alkul, Anisha B Patel, Stephen K Tyring

引用次数: 0

The American Society for Clinical Pathology's 2023 wage survey of medical laboratories in the United States. 美国临床病理学会 2023 年美国医学实验室工资调查。

IF 2.3 4区医学

American journal of clinical pathology Pub Date : 2025-03-08 DOI: 10.1093/ajcp/aqae130

Edna Garcia, Iman Kundu, Karen Fong

{"title":"The American Society for Clinical Pathology's 2023 wage survey of medical laboratories in the United States.","authors":"Edna Garcia, Iman Kundu, Karen Fong","doi":"10.1093/ajcp/aqae130","DOIUrl":"10.1093/ajcp/aqae130","url":null,"abstract":"Objectives: To inform the pathology and laboratory field of the most recent national wage data. Historically, the results of this biennial survey have served as a basis for additional research on laboratory professional recruitment, retention, education, marketing, certification, and advocacy.Methods: The 2023 Wage Survey was conducted in collaboration between the American Society for Clinical Pathology's (ASCP's) Institute of Science, Technology, and Policy in Washington, DC, and ASCP Board of Certification in Chicago, Illinois.Results: Compared to 2021, results show that more occupations at the staff level had an increased average hourly wage (pathologists' assistant, molecular biology technologist, phlebotomist, cytogenetic technologist, and medical laboratory technician [MLT]), after adjusting for inflation. Wages by time in current occupational title are significantly higher in 2023 than in 2021. Histotechnicians, histotechnologists, and MLTs show consistent increases in pay rates for a longer length of time in the laboratory. Over half (52.4%) of the respondents feel the pandemic continues to influence their salary and/or well-being.Conclusions: Survey results call for continued efforts in promoting visibility of the profession and greater representation through advocacy. While burnout rates are lower compared to 2021, staffing challenges remain a relevant concern. Efforts to support the workforce have multiplied since the pandemic and have been the forefront focus of the laboratory community. However, continued support and advocacy are needed to increase the promotion and value of laboratory careers for laboratory professionals and patients alike.","PeriodicalId":7506,"journal":{"name":"American journal of clinical pathology","volume":" ","pages":"357-376"},"PeriodicalIF":2.3,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142379885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Use of anatomic pathology tools in global oncology outreach. 在全球肿瘤学推广中使用解剖病理学工具。

IF 2.3 4区医学

American journal of clinical pathology Pub Date : 2025-03-08 DOI: 10.1093/ajcp/aqae134

Harm Veerkamp, Cary Adams

引用次数: 0