American journal of clinical pathology最新文献

Assessing the process reproducibility of meta-analyses published in the top 20 pathology journals: A cross-sectional study. 评估前20名病理学期刊上发表的荟萃分析的过程可重复性：一项横断面研究。

IF 1.9 4区医学

American journal of clinical pathology Pub Date : 2025-10-06 DOI: 10.1093/ajcp/aqaf103

Griffin Hughes, Cameron Barton, Matt Vassar

{"title":"Assessing the process reproducibility of meta-analyses published in the top 20 pathology journals: A cross-sectional study.","authors":"Griffin Hughes, Cameron Barton, Matt Vassar","doi":"10.1093/ajcp/aqaf103","DOIUrl":"https://doi.org/10.1093/ajcp/aqaf103","url":null,"abstract":"Objective: The objective of this study is to investigate the rigor of reporting and the potential for process reproducibility of meta-analyses published within top pathology journals.Methods: This cross-sectional, meta-research study assessed eligible systematic reviews with meta-analysis indexed in MEDLINE through PubMed. We included those studies that were published within the top 20 pathology journals (h-5 index) from inception to March 21, 2024. We extracted proper reporting variables across 4 key quantitative synthesis domains: (1) primary study eligibility, (2) search strategy, (3) screening and extraction methods, and (4) quantitative synthesis approach.Results: We found 282 studies eligible for masked duplicate data extraction. Less than half of studies (40.8% ± 2.9%) reported whether unpublished literature was eligible for inclusion, while less than 20% reported the date of their database search (18.8% ± 2.3%). Similarly, less than 20% reported a full, reproducible search strategy (19.1% ± 2.3%). Not all studies reported primary study effects (92.9% ± 1.5%). The reported use or mention of a relevant synthesis reporting guideline was associated with significant improvement in reporting of search factors (P < .001) and screening factors (P < .001). Nine meta-analyses (9 of 282; 3.2%) were deemed potentially process-reproducible.Conclusions: Fewer than 10 meta-analyses from top pathology journals were potentially process-reproducible without reasonable effort. Most individual summary estimates were reproducible due to the presence of forest plots. Nevertheless, reproducibility factors related to search strategies are the single largest hindrance to reproducible meta-analyses published within our sample.","PeriodicalId":7506,"journal":{"name":"American journal of clinical pathology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Implementation of a next-generation sequencing and PD-L1 immunohistochemistry reflex testing protocol for non-small cell lung cancers improves turnaround time. 实施下一代测序和PD-L1免疫组织化学反射检测方案，非小细胞肺癌改善周转时间。

IF 1.9 4区医学

American journal of clinical pathology Pub Date : 2025-10-06 DOI: 10.1093/ajcp/aqaf107

C Kendall Major, Chiara J Cocelli, Polina Khrizman, David D Shersher, Kathryn C Behling, Tina B Edmonston

{"title":"Implementation of a next-generation sequencing and PD-L1 immunohistochemistry reflex testing protocol for non-small cell lung cancers improves turnaround time.","authors":"C Kendall Major, Chiara J Cocelli, Polina Khrizman, David D Shersher, Kathryn C Behling, Tina B Edmonston","doi":"10.1093/ajcp/aqaf107","DOIUrl":"https://doi.org/10.1093/ajcp/aqaf107","url":null,"abstract":"Objective: Targeted therapy in non-small cell lung cancer (NSCLC) is now often included as first-line treatment in the neoadjuvant and adjuvant settings. Delays in optimizing treatments based on biomarker status can affect outcomes. Therefore, we assessed the turnaround time (TAT) of reflex biomarker testing for all NSCLCs clinical stage 1B and greater.Methods: A next-generation sequencing (NGS) and PD-L1 immunohistochemistry reflex protocol for NSCLC clinical stage 1B and greater was implemented. Turnaround time intervals between procedure date, pathology sign-out, date received in the molecular laboratory, and date of NGS sign-out were calculated. Median and IQR of each interval before and after implementation of the reflex protocol were calculated and compared using the Mann-Whitney U test.Results: In total, 492 lung cancer NGS cases were identified, 351 before and 141 after implementation of the reflex protocol. The prereflex cases, after exclusion of biomarker testing ordered on older blocks and outside consults (n = 165), demonstrated a 22-day median time from procedure to NGS sign-out (range, 11-70 days; IQR, 9; mean, 24 days), compared to a 20-day median time (range, 13-54 days; IQR, 4.5; mean, 21 days) postimplementation (n = 120) (P < .000103).Conclusions: Reduction in median TAT from procedure to NGS sign-out was statistically significant after implementation of reflex biomarker testing in NSCLC samples.","PeriodicalId":7506,"journal":{"name":"American journal of clinical pathology","volume":" ","pages":""},"PeriodicalIF":1.9,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vascular outflow obstruction changes and low prevalence of advanced fibrosis characterize the liver pathology in orthotopic heart transplant recipients. 血管流出梗阻改变和晚期纤维化发生率低是原位心脏移植受者肝脏病理的特征。

IF 1.9 4区医学

American journal of clinical pathology Pub Date : 2025-10-04 DOI: 10.1093/ajcp/aqaf092

Bethany Freeland LeClair, John Yablonski, Wei Chen, Chanjuan Shi, Kara Wegermann, Avani A Pendse

{"title":"Vascular outflow obstruction changes and low prevalence of advanced fibrosis characterize the liver pathology in orthotopic heart transplant recipients.","authors":"Bethany Freeland LeClair, John Yablonski, Wei Chen, Chanjuan Shi, Kara Wegermann, Avani A Pendse","doi":"10.1093/ajcp/aqaf092","DOIUrl":"10.1093/ajcp/aqaf092","url":null,"abstract":"Objective: The number of orthotopic heart transplants (OHTs) performed each year continues to increase, as does the post-transplant survival rate. Little is known, however, about the morphologic changes in the liver after the patient has undergone an OHT. In this study, we retrospectively reviewed liver pathology in patients following OHT to comprehensively describe the histopathologic changes, particularly fibrosis.Methods: Three pathologists retrospectively reviewed liver biopsy samples in patients who had undergone OHT using a standardized checklist format.Results: In our cohort of 19 biopsies, the morphologic features of hepatic injury noted were in the form of vascular outflow obstruction (9 biopsies), portal inflammation (13 biopsies), cholestasis (8 biopsies), and steatosis/steatohepatitis (5 biopsies). There was no evidence of nodular regenerative hyperplasia. Five of 9 patients with vascular outflow obstruction had sinusoidal fibrosis. Of 8 patients with clinical suspicion of portal hypertension and cirrhosis, only 3 demonstrated advanced fibrosis.Conclusions: This is the first comprehensive account of histopathologic changes in the liver following OHT. This information will be beneficial for clinical decision-making when monitoring hepatic function and fibrosis in patients with OHT.","PeriodicalId":7506,"journal":{"name":"American journal of clinical pathology","volume":" ","pages":"620-625"},"PeriodicalIF":1.9,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Technical features and analytical performances of the Stago Expert Preanalytical Check module for hemolysis, icterus, and lipemia measurement. 技术特点和分析性能的Stago专家分析前检查模块溶血，黄疸，和血脂测量。

IF 1.9 4区医学

American journal of clinical pathology Pub Date : 2025-10-04 DOI: 10.1093/ajcp/aqaf086

Pascale Laroche, Joffrey Feriel, Geneviève Tanala Marolahy, Odile Chachlica, François Depasse

{"title":"Technical features and analytical performances of the Stago Expert Preanalytical Check module for hemolysis, icterus, and lipemia measurement.","authors":"Pascale Laroche, Joffrey Feriel, Geneviève Tanala Marolahy, Odile Chachlica, François Depasse","doi":"10.1093/ajcp/aqaf086","DOIUrl":"10.1093/ajcp/aqaf086","url":null,"abstract":"Objective: Interference caused by hemolysis, icterus, and lipemia (HIL) are a common source of preanalytical errors during coagulation testing. Stago has developed a specific module on its coagulation analyzers to standardize the detection of HIL.Methods: The aims of this study were to evaluate the accuracy, carryover, and cross-interference of HIL measurement and compare results with those obtained on cobas 8000 modular analyzer series devices (Roche Diagnostics). These evaluations were carried out using Clinical and Laboratory Standards Institute guidance and regulatory study requirements.Results: We demonstrated the absence of sample carryover through the HIL measurement chamber and excellent accuracy between HIL theoretical and measured concentrations, with an R2 above 0.99 in all cases. We did not detect any cross-interference of bilirubin and lipids to hemoglobin, of hemoglobin and lipids to bilirubin, or for hemoglobin and bilirubin to lipids. We found excellent agreement between HIL on the Stago STA R Max3 and cobas 8000 platforms, with κ coefficients ranging from 0.928 to 0.963.Conclusions: These results support the implementation of the Stago Expert Preanalytical Check module for HIL interference measurement in routine coagulation laboratory testing.","PeriodicalId":7506,"journal":{"name":"American journal of clinical pathology","volume":" ","pages":"524-529"},"PeriodicalIF":1.9,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12495518/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mutational signature analysis of chronic lymphocytic leukemia uncovering genomic patterns and prognostic implications. 慢性淋巴细胞白血病的突变特征分析揭示了基因组模式和预后意义。

IF 1.9 4区医学

American journal of clinical pathology Pub Date : 2025-10-04 DOI: 10.1093/ajcp/aqaf059

Ali AlJabban, Roberta S Azevedo, Katherine Antel, Allison Arnette, Elizabeth F Cohen, David M Meredith, Mark A Murakami, Lynette M Sholl, Michael Y Tolstorukov, Harrison K Tsai, Jonathan M Tsai, David Zemmour, Neal I Lindeman, Elizabeth Garcia, Jennifer R Brown, Annette S Kim

{"title":"Mutational signature analysis of chronic lymphocytic leukemia uncovering genomic patterns and prognostic implications.","authors":"Ali AlJabban, Roberta S Azevedo, Katherine Antel, Allison Arnette, Elizabeth F Cohen, David M Meredith, Mark A Murakami, Lynette M Sholl, Michael Y Tolstorukov, Harrison K Tsai, Jonathan M Tsai, David Zemmour, Neal I Lindeman, Elizabeth Garcia, Jennifer R Brown, Annette S Kim","doi":"10.1093/ajcp/aqaf059","DOIUrl":"10.1093/ajcp/aqaf059","url":null,"abstract":"Objective: To identify the mutational signature(s) for patients with diagnosed chronic lymphocytic leukemia (CLL) and their correlation with clinical and genetic classifications.Methods: All CLL samples sequenced on several versions of OncoPanel, from 2013 to 2022, were examined (n = 209). All variants produced by the next-generation sequencing pipeline, before review, were obtained for these samples. After the exclusion of likely germline polymorphisms, mutational signatures were generated. De novo mutational signatures were extracted and correlated with clinical and genetic data.Results: Most somatic mutations were found in chromosome 14 (within ADAM6). Somatic mutation signatures analysis revealed a prominent endogenous mutational process, which predominantly led to C-to-T single base substitutions (SBSs). Two novel de novo SBS signatures were identified, weighted by the SBS84 signature, that correlated with somatically hypermutated and unmutated status, respectively, with significant disease heterogeneity. A notable 13.3% of the cohort exhibited the SBS42 signature, suggesting a link to occupational haloalkane exposure, representing a potential new environmental risk factor for CLL.Conclusions: The de novo SBS signatures were identified as being associated with IGHV status, highlighting significant disease heterogeneity that belies the more categorical and limited traditional risk stratification methods. Also, a novel association was made between haloalkane exposure signature and CLL.","PeriodicalId":7506,"journal":{"name":"American journal of clinical pathology","volume":" ","pages":"530-544"},"PeriodicalIF":1.9,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144854216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

History matters: Preventing severe allergic transfusion reactions. 历史问题：预防严重的过敏性输血反应。

IF 1.9 4区医学

American journal of clinical pathology Pub Date : 2025-10-04 DOI: 10.1093/ajcp/aqaf093

Edina A Wappler-Guzzetta, Asad Shafiq, Umaima Asad, Tushar Chakravarty, Elena G Nedelcu

{"title":"History matters: Preventing severe allergic transfusion reactions.","authors":"Edina A Wappler-Guzzetta, Asad Shafiq, Umaima Asad, Tushar Chakravarty, Elena G Nedelcu","doi":"10.1093/ajcp/aqaf093","DOIUrl":"10.1093/ajcp/aqaf093","url":null,"abstract":"Objective: Prior studies have shown that pretransfusion medication is not effective in preventing allergic transfusion reactions (ATRs), but these studies did not consider the patient's history of ATR. This study evaluated whether pretransfusion antiallergy medications decrease the chance of ATRs in patients with a history of severe ATR.Methods: This single-center, retrospective study investigated the effect of pretransfusion medications on preventing ATRs in patients with a history of at least 1 severe ATR between March 2018 and January 2024. Patient demographics as well as clinical and transfusion reaction data were collected from our electronic health record (EHR) system. Data were analyzed using SPSS (IBM Corp) and machine learning in Python, version 3.12.4.Results: In our cohort, 53 patients aged 5 weeks to 94 years with 2767 analyzable transfusion encounters had experienced 88 lifelong mild and severe ATRs. Premedication (P = .021), regular antiallergy medication (P < .001), and washing/volume reduction (P = .032) were associated with a statistically significantly lower chance of developing ATRs in our patient population.Conclusions: Patients with at least 1 severe ATR benefit from pretransfusion administration of antiallergy medications.","PeriodicalId":7506,"journal":{"name":"American journal of clinical pathology","volume":" ","pages":"626-633"},"PeriodicalIF":1.9,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12495513/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Selecting high-throughput scanners for clinical use: A multicenter institution experience. 为临床使用选择高通量扫描仪：多中心机构经验。

IF 1.9 4区医学

American journal of clinical pathology Pub Date : 2025-10-04 DOI: 10.1093/ajcp/aqaf083

Joice Soliman, Karen Weiser, Iman Ahmed, Charlotte Carment-Baker, Michael Hockley, Ioannis Prassas, Shaza Zeidan, Christine Bruce, Blaise Clarke, George M Yousef

{"title":"Selecting high-throughput scanners for clinical use: A multicenter institution experience.","authors":"Joice Soliman, Karen Weiser, Iman Ahmed, Charlotte Carment-Baker, Michael Hockley, Ioannis Prassas, Shaza Zeidan, Christine Bruce, Blaise Clarke, George M Yousef","doi":"10.1093/ajcp/aqaf083","DOIUrl":"10.1093/ajcp/aqaf083","url":null,"abstract":"Objective: To evaluate and implement whole-slide imaging (WSI) scanners for a fully digital pathology workflow at the University Health Network (UHN) in Canada, a multicenter institution. The goal was to optimize clinical diagnosis, education, telepathology, consultation, and artificial intelligence (AI) applications. Given the competitive digital pathology market, a thorough assessment was conducted to select the most suitable scanners for UHN's primary diagnosis at main and satellite sites, remote teleconsultation, intraoperative consultation, and multidisciplinary education.Methods: A request for proposal was issued to evaluate WSI scanners based on technical specifications, compatibility, previous performance, implementation strategy, operational excellence, and postinstallation support. A multidisciplinary committee scored vendors, and the highest-scoring scanners were further assessed for image accuracy, loading and offloading efficiency, scanning speed, throughput, and artifact handling.Results: The UHN selected a fleet of WSI scanners with varying functionality from multiple vendors. Successful implementation included seamless integration with the image management system, laboratory information system, hospital information system, and digital storage. This transition enhanced workflow efficiency, streamlined telepathology services, and supported AI-driven applications.Conclusions: Despite high costs, WSI scanners substantially improved slide accessibility, reduced turnaround times, and enhanced workflow flexibility. Their integration supports AI advancements, facilitates second opinions, improves access to educational materials, and facilitates proficiency testing.","PeriodicalId":7506,"journal":{"name":"American journal of clinical pathology","volume":" ","pages":"589-599"},"PeriodicalIF":1.9,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pathologic sampling of the omentum for neoplasms that involve the female genital tract: A retrospective analysis of 1055 cases. 涉及女性生殖道肿瘤的网膜病理取样：1055例回顾性分析。

IF 1.9 4区医学

American journal of clinical pathology Pub Date : 2025-10-04 DOI: 10.1093/ajcp/aqaf082

Neil Allen Maglalang, Oluwole Fadare

{"title":"Pathologic sampling of the omentum for neoplasms that involve the female genital tract: A retrospective analysis of 1055 cases.","authors":"Neil Allen Maglalang, Oluwole Fadare","doi":"10.1093/ajcp/aqaf082","DOIUrl":"10.1093/ajcp/aqaf082","url":null,"abstract":"Objective: We sought to assess the number of blocks that should routinely be submitted for microscopic examination of omentectomy specimens associated with neoplasms that involve the female genital tract.Methods: Clinicopathologic data were retrospectively reviewed in 1055 cases wherein the omentum was resected for possible gynecologic cancer staging. We investigated any associations between the microscopic positivity rate (MPR) and the number of blocks submitted, block groups (categorized as 1-2 blocks, 3-4 blocks, 5-6 blocks, and >6 blocks), and block to size ratio (the number of blocks submitted to the widest specimen dimension, classified as approximate deciles).Results: Of the 1055 cases we studied, 536 (50.8%) were grossly normal, and 519 (49.2%) were abnormal. Within the grossly normal group, there were no statistically significant differences in MPR between the block groups and between cases with 1, 2, 3, 4, 5, or 6 blocks submitted (P > .50 for all pairwise comparisons). Cochran-Armitage tests for trend did not show any linear trend between increasing block groups (P = .88) or increasing block to size ratios (P = .39) and MPR; a binomial logistic regression analysis confirmed that neither block groups (odds ratio, 1.144 [95% CI, 0.794-1.648]; P = .47) nor block to size ratio (odds ratio, 1.022 [95% CI, 0.770-1.358]; P = .88) showed a statistically significant linear relation to MPR. For diffusely or multifocally abnormal cases, the highest MPR (95.5%) was reached at the 1 to 2 blocks group level, and MPR did not statistically significantly increase with higher levels of sampling.Conclusions: Submitting 1 to 2 block sections of the omentum in the studied setting results in an MPR that is not statistically significantly lower than the MPR associated with higher levels of sampling.","PeriodicalId":7506,"journal":{"name":"American journal of clinical pathology","volume":" ","pages":"581-588"},"PeriodicalIF":1.9,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144833624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PRAME immunohistochemistry distinguishes breast secondary angiosarcoma from benign and atypical vascular lesions of the breast. PRAME免疫组织化学区分乳腺继发性血管肉瘤与乳腺良性和非典型血管病变。

IF 1.9 4区医学

American journal of clinical pathology Pub Date : 2025-10-04 DOI: 10.1093/ajcp/aqaf084

Haley N Corbin, Azfar Neyaz, Terri E Jones, Beth Z Clark, Jing Yu, Jeffrey L Fine, Ivy John, Rohit Bhargava

{"title":"PRAME immunohistochemistry distinguishes breast secondary angiosarcoma from benign and atypical vascular lesions of the breast.","authors":"Haley N Corbin, Azfar Neyaz, Terri E Jones, Beth Z Clark, Jing Yu, Jeffrey L Fine, Ivy John, Rohit Bhargava","doi":"10.1093/ajcp/aqaf084","DOIUrl":"10.1093/ajcp/aqaf084","url":null,"abstract":"Objective: We examined the utility of preferentially expressed antigen in melanoma (PRAME) immunohistochemistry (IHC) in distinguishing breast angiosarcoma from benign or atypical vascular lesions (AVLs) of the breast.Methods: There were 26 breast angiosarcomas (24 radiation related and 2 primary), 6 radiation-related AVLs of the breast, and 16 other benign vascular lesions of the breast retrieved from our institutional archive and stained with PRAME IHC.Results: Twenty-four of 26 (92%) breast angiosarcomas were positive for PRAME with moderate to strong staining intensities (median HScore, 255 [range, 90-300]), while 0 of 22 benign or atypical vascular lesions of the breast were PRAME positive (sensitivity, 92.3% [95% CI, 75.9%-98.6%]; specificity, 100% [95% CI, 85.1%-100%]); c-MYC was positive in all angiosarcoma cases but showed weak staining in several cases (median HScore, 155 [range, 30-280]). PRAME was negative in 1 of 2 primary angiosarcomas and negative in only 1 of 24 secondary angiosarcomas of the breast. None of the benign or atypical vascular lesions was stained with PRAME.Conclusions: It appears that PRAME expression occurs in a high proportion of radiation-related angiosarcomas and not in benign breast vascular lesions or AVLs. PRAME IHC is diagnostically useful in distinguishing benign from malignant vascular proliferations in patients with a history of radiation to the breast.","PeriodicalId":7506,"journal":{"name":"American journal of clinical pathology","volume":" ","pages":"600-607"},"PeriodicalIF":1.9,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of system and scanner downtime in a digital pathology-predominant institution: A 6-year experience. 一个以数字病理学为主的机构的系统和扫描仪停机时间分析：一个6年的经验。

IF 1.9 4区医学

American journal of clinical pathology Pub Date : 2025-10-04 DOI: 10.1093/ajcp/aqaf094

Ryan Reagans, Lokman Cevik, Himani Kumar, David Kellough, Abberly Lott Limbach, Giovanni Lujan, Anil Parwani, Hamza N Gokozan

{"title":"Analysis of system and scanner downtime in a digital pathology-predominant institution: A 6-year experience.","authors":"Ryan Reagans, Lokman Cevik, Himani Kumar, David Kellough, Abberly Lott Limbach, Giovanni Lujan, Anil Parwani, Hamza N Gokozan","doi":"10.1093/ajcp/aqaf094","DOIUrl":"10.1093/ajcp/aqaf094","url":null,"abstract":"Objective: To determine trends in system and scanner downtime in our institution's digital pathology pipeline since its implementation.Methods: Scanner and system downtime data were tabulated from a period beginning in 2017 and ending in 2022. Downtime events were categorized based on their etiology, such as image management system related for the overall system or hardware vs software related for the scanner.Results: The maximum scanner downtime consisted of 36 events and occurred in the first quarter of 2019; most of this downtime was attributed to hardware issues. The average scanner downtime per quarter was 350.7 hours. Multifactorial events tended to last longer than single events. System downtime was mostly due to the image management system. Full-system downtime occurred from 2017 through 2019; since then, full-system downtime has essentially been replaced with partial downtime.Conclusions: Scanner downtime was mostly due to hardware, while system downtime was mostly caused by issues with the image management system. With experience, our institution mitigated the impact of technological difficulties, significantly reducing the number of downtime events since the implementation of digital pathology in 2017.","PeriodicalId":7506,"journal":{"name":"American journal of clinical pathology","volume":" ","pages":"634-638"},"PeriodicalIF":1.9,"publicationDate":"2025-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0