原发性低级别涎腺型导管内癌合并CCDC6::RET融合：病例报告及文献复习。

IF 2.3 4区医学 Q2 PATHOLOGY

American journal of clinical pathology Pub Date : 2025-02-27 DOI:10.1093/ajcp/aqaf014

Bei Wang, Xiaowei Wang, Ziyi Chang, Dingrong Zhong

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引用次数: 0

摘要

目的：唾液腺型导管内癌是一种罕见的低级别唾液腺肿瘤。鉴于原发性肺IC的临床和影像学特征是非特异性的，诊断需要病理分析。方法：我们报告一名63岁女性原发性低级别唾液腺型肺IC，其特征是起源于支气管粘膜下层，导管内或腔内生长的导管上皮，没有间质浸润，并有RET::CCDC6融合。结果：通过病例报告和文献复习，我们讨论了肺涎腺型IC的鉴别诊断和临床处理。结论：分子检测对组织学分型无必要，但有助于IC的鉴别诊断。

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Primary low-grade salivary gland-type intraductal carcinoma of the lung with CCDC6::RET fusion: Case presentation and literature review.

Objectives: Salivary gland-type intraductal carcinoma (IC) is a rare type of low-grade salivary gland neoplasm. Given that the clinical and imaging features of primary lung IC are nonspecific, the diagnosis requires pathologic analysis.

Methods: We report a 63-year-old woman with primary low-grade salivary gland-type IC of the lung, characterized by an origin from the bronchus submucosa, an intraductal or intracavity growth of ductal epithelium, an absence of interstitial infiltration, and harboring an RET::CCDC6 fusion.

Results: Through case presentation and a literature review, we discuss the differential diagnosis and clinical management of salivary gland-type IC of the lung.

Conclusions: Molecular testing is not necessary for histologic subtyping but can aid in the differential diagnosis of IC.

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来源期刊

American journal of clinical pathology 医学-病理学

CiteScore

7.70

自引率

2.90%

发文量

367

审稿时长

3-6 weeks

期刊介绍： The American Journal of Clinical Pathology (AJCP) is the official journal of the American Society for Clinical Pathology and the Academy of Clinical Laboratory Physicians and Scientists. It is a leading international journal for publication of articles concerning novel anatomic pathology and laboratory medicine observations on human disease. AJCP emphasizes articles that focus on the application of evolving technologies for the diagnosis and characterization of diseases and conditions, as well as those that have a direct link toward improving patient care.