AIDS最新文献

{"title":"Comparison of pregnancy outcomes between people with perinatally acquired HIV, horizontally acquired HIV and those without HIV.","authors":"Shivani Shah, Charlotte-Eve Short, Graham Taylor, Hermione Lyall, Caroline Foster","doi":"10.1097/QAD.0000000000004114","DOIUrl":"10.1097/QAD.0000000000004114","url":null,"abstract":"<p><p>A retrospective case-controlled study compared pregnancy outcomes between people with perinatally acquired HIV (PaHIV), horizontally acquired HIV (HaHIV), and those without HIV. PaHIV were more likely to be viraemic in early pregnancy than HaHIV. When matched for age and ethnicity, babies born to PaHIV were more likely to be premature, small for gestational age, delivered by caesarean section and require enhanced neonatal and social care involvement than infants born to age/ethnically matched HIV-uninfected individuals.</p>","PeriodicalId":7502,"journal":{"name":"AIDS","volume":"39 5","pages":"621-624"},"PeriodicalIF":3.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11949233/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deciphering HIV vaccine-induced Antibody response according to ethnicity.","authors":"Li-Yun Lin, Thomas Ferte, Mkunde Chachage, Celso Casteano, Géraldine Laumond, Sylvie Schmidt, Ouria Tahar, Raphael Carapito, Linda-Gail Bekker, Gavin Churchyard, Michael Keefer, Zoe Moodie, Edna Viegas, Christof Geldmacher, Edouard Lhomme, Christiane Moog","doi":"10.1097/QAD.0000000000004196","DOIUrl":"https://doi.org/10.1097/QAD.0000000000004196","url":null,"abstract":"<p><strong>Objective: </strong>One recurrent question is whether an HIV-1 preventive vaccine requires adaptation to geographic and/or ethnicity background. A recent attempt to improve the Thai RV144 vaccine efficacy in South Africa resulted in non-efficacy. The potential reasons for this disappointing outcome are probably multifactorial; the role of ethnicity could not be investigated given the trials' demographics.</p><p><strong>Design: </strong>To assess the role of ethnicity in the immune responses induced in HIV vaccine trials, we considered the HVTN 204 vaccine trial, which was conducted in the USA and South Africa.</p><p><strong>Methods: </strong>Univariate and multivariate analysis of antibody responses were conducted to assess ethnicity, geographic location, Fc-receptor polymorphism, sex at birth, age and geographic location.</p><p><strong>Results: </strong>We found that Black South Africans displayed higher total Immunoglobulins compared to White Americans. Noteworthy, Black South Africans showed lower HIV-specific binding IgG following vaccination. As they also showed lower background at baseline, differences between ethnic groups were narrowed after baseline background subtraction, referred to as delta values for the vaccine response outcome.</p><p><strong>Conclusions: </strong>The observed modifications of HIV-specific Ab immune responses to the HVTN 204 vaccine according to genetic, geographic location and ethnic background warrants further investigation. Additional studies of immunological differences, especially with vaccine platforms inducing high HIV-specific antibodies that correlate with vaccine efficacy may help decipher the impact of ethnicity on HIV-vaccine efficacy.</p>","PeriodicalId":7502,"journal":{"name":"AIDS","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic review of infodemiology studies using artificial intelligence: social media posts on HIV pre-exposure prophylaxis.","authors":"Emiko Kamitani, Julia B DeLuca, Yuko Mizuno","doi":"10.1097/QAD.0000000000004193","DOIUrl":"https://doi.org/10.1097/QAD.0000000000004193","url":null,"abstract":"<p><strong>Objectives: </strong>To explore how artificial intelligence (AI) can enhance infodemiology, which distributes and scans information in the electronic medium, to process social media posts for HIV pre-exposure prophylaxis (PrEP).</p><p><strong>Design: </strong>Systematic Review.</p><p><strong>Methods: </strong>We searched in the U.S. Centers for Disease Control and Prevention's Prevention Research Synthesis database through June 2024 (PROSPERO: CRD42023458870). We included infodemiology studies published in English and reported using AI to process social media posts on PrEP. Two reviewers independently screened citations, extracted data, and conducted a risk of bias assessment using the Joanna Briggs Institute Critical Appraisal Checklist for Prevalence Studies. Findings are narratively summarized.</p><p><strong>Results: </strong>Of the 135 citations screened, eight infodemiology studies were identified, analyzing over 58.9 million posts. Infodemiology studies found the PrEP topics commonly discussed in communities (e.g., barriers of uptake), rumors that may raise public health concerns (e.g., PrEP is a prevention method against COVID-19 infection), geographic locations where concerns regarding risk of acquiring HIV were raised (e.g., most HIV-related posts were from the 10 states with the highest numbers of new HIV diagnoses), and predicted HIV trends (e.g., HIV-related tweets were negatively correlated with the county-level HIV incidence rate in the following year).</p><p><strong>Conclusions: </strong>Despite the limitations of this review including a small number of studies reviewed, our review suggests social media posts may provide information on real-time PrEP-related concerns, and AI can accelerate and enhance the processing of mass data to identify the information that communities need and the areas/locations that may need HIV prevention intervention.</p>","PeriodicalId":7502,"journal":{"name":"AIDS","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interest and disparities in awareness and uptake of doxyPEP among U.S. MSM living with HIV.","authors":"Tyler Martinson, Megan J Heise, Kevin Sassaman, Hannah R Schmidt, Alexa B D'Angelo, Shivani Mahuvakar, Dustin T Duncan, Keith J Horvath, Sabina Hirshfield, Renessa Williams, Mallory O Johnson, Christian Grov, Adam Carrico, Monica Gandhi, Matthew A Spinelli","doi":"10.1097/QAD.0000000000004192","DOIUrl":"https://doi.org/10.1097/QAD.0000000000004192","url":null,"abstract":"<p><strong>Objective: </strong>The CDC recommends doxycycline post-exposure prophylaxis (doxyPEP) for men who have sex with men (MSM) with a bacterial sexually transmitted infection (bSTI) in the past year. This study explored determinants of doxyPEP awareness and uptake, and associations with HIV care outcomes, among U.S. MSM living with HIV.</p><p><strong>Design: </strong>Cross-sectional study.</p><p><strong>Methods: </strong>From 10/2023-10/2024, we enrolled 827 MSM living with HIV from 46 states, Washington, D.C., and Puerto Rico via a popular geospatial networking app. Adjusted multivariable logistic regression examined determinants of doxyPEP awareness/use and associations with HIV treatment adherence, viral suppression, and care engagement.</p><p><strong>Results: </strong>Among 827 participants, 13% were currently taking doxyPEP, 46% were aware of doxyPEP but not prescribed it, and 41% had not heard of it. Of 360 participants CDC-eligible for doxyPEP, 20% were prescribed it, 49% had heard of it but were not on it, and 31% were unaware, 95% of whom expressed interest. Neither awareness nor use of doxyPEP was associated with HIV care outcomes. Both awareness and uptake of doxyPEP were higher among participants with a recent bSTI (adjusted odds ratio (aOR) = 1.15, 95%CI: 1.06-1.25; aOR = 1.11, 95%CI: 1.05-1.17, respectively) and lower in the U.S. Midwest, Mountain, and South regions (inverse-variance weighted average (IVW-Avg) aOR = 0.81, 95%CI: 0.76-0.86; IVW-Avg aOR = 0.86, 95%CI: 0.82-0.90, respectively) relative to Pacific states.</p><p><strong>Conclusions: </strong>High doxyPEP interest underscores unmet demand in integrated HIV/sexual health care. Sociodemographic and geographic disparities in doxyPEP implementation necessitate targeted interventions for MSM living with HIV to optimize impact on the bSTI epidemic.</p>","PeriodicalId":7502,"journal":{"name":"AIDS","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143750603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microbial translocation and gut damage is associated with hepatic fibrosis but not steatosis in women with and without HIV.","authors":"Maria J Duarte, Phyllis C Tien, Ani Kardashian, Yifei Ma, Peter Hunt, Mark H Kuniholm, Michelle Floris-Moore, Margaret A Fischl, Audrey L French, Elizabeth Topper, Deborah Konkle-Parker, Howard Minkoff, Ighovwerha Ofotokun, Michael Plankey, Anjali Sharma, Jennifer C Price","doi":"10.1097/QAD.0000000000004189","DOIUrl":"https://doi.org/10.1097/QAD.0000000000004189","url":null,"abstract":"<p><strong>Objective: </strong>Metabolic dysfunction-associated steatotic liver disease (MASLD) is highly prevalent in people living with HIV. Gut microbial translocation and gut damage may play a role in MASLD pathogenesis. We determined associations of circulating biomarkers of translocation and gut damage with hepatic steatosis and fibrosis in a large US cohort of women with HIV (WWH) and without HIV.</p><p><strong>Design: </strong>Vibration controlled transient elastography (VCTE) was conducted from 2013-2018 among 854 WWH and 349 women without HIV. Serum biomarkers were measured within 6 months of the VCTE: kynurenine to tryptophan (KT) ratio, intestinal fatty acid binding protein (I-FABP), and immune activation markers soluble CD14 (sCD14) and soluble CD163 (sCD163).</p><p><strong>Methods: </strong>We used multivariable linear regression to evaluate independent associations of each biomarker, HIV serostatus, and demographic, metabolic, and HIV-specific covariates with hepatic steatosis (controlled attenuation parameter [CAP]) and fibrosis (liver stiffness [LS]).</p><p><strong>Results: </strong>In multivariable analysis, increasing in KT ratio was associated with a 6 dB/m lower CAP and 6% higher LS, and sCD14 with a 5 dB/m lower CAP and 8% higher LS. sCD163 was not associated with CAP but was associated with a 12.5% higher LS value. I-FABP was not associated with either CAP or LS values.</p><p><strong>Conclusions: </strong>Higher KT ratio, sCD14, and sCD163 were associated with increased hepatic fibrosis but not steatosis. In fact, higher KT ratio and sCD14 were associated with decreased steatosis. This suggests that microbial translocation and gut damage may contribute to the pathogenesis of fibrosis in WWH in a mechanism unrelated to increased steatosis.</p>","PeriodicalId":7502,"journal":{"name":"AIDS","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143707989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Arterial stiffness in people with HIV: a cross-sectional, comparative study with echocardiographic outcomes in Tanzania.","authors":"Karl Reis, Ponsiano F Stephano, Salama Fadhil, Megan Willkens, Julie Karand, Elias Nyanza, Grace Ruselu, Ayubu Garubindi, Benson Issarow, Myung-Hee Lee, Cody Cichowitz, Robert N Peck","doi":"10.1097/QAD.0000000000004184","DOIUrl":"10.1097/QAD.0000000000004184","url":null,"abstract":"<p><strong>Objectives: </strong>Cardiovascular disease (CVD) is a growing cause of morbidity and mortality in people with HIV (PWH). Arterial stiffness may be an intermediary between HIV-infection and CVD, necessitating holistic assessment of arterial stiffness and correlation with cardiac outcomes.</p><p><strong>Design: </strong>We conducted a cross-sectional study of PWH and HIV-uninfected community controls using multimodal assessment of arterial stiffness and echocardiographic outcomes.</p><p><strong>Methods: </strong>We performed ankle-brachial index (ABI) and pulse-wave velocity (PWV) to characterize arterial stiffness in a cohort of PWH and HIV-uninfected community controls in Tanzania. Regression analysis was used to determine differential risk factors for phenotypes of arterial stiffness and echocardiographic outcomes of these phenotypes.</p><p><strong>Results: </strong>We enrolled 848 participants; 398/848 PWH (46.9%) and 450/848 community controls (53.1%). In multivariable models, elevated ABI was associated with HIV infection (3.29 (1.51, 7.21), p = 0.003), and male sex (2.33 (1.15, 4.71), p = 0.019), whereas elevated PWV was associated with age (1.11 (1.06, 1.17), p < 0.001), systolic blood pressure (1.58 (1.24, 2.01), p < 0.001), and diastolic blood pressure (2.03 (1.38-2.98) p < 0.001). ABI was independently associated with average E:e' (0.74 (0.18, 1.30), p = 0.010). PWV was independently associated with left-ventricular mass index (LVMI) (10.73 (2.69-18.76), p = 0.009).</p><p><strong>Conclusion: </strong>Differential associations between HIV and multiple measures of arterial stiffness suggest that HIV is associated with peripheral but not central arterial stiffness. Arterial stiffness was correlated with cardiac hypertrophy and impaired cardiac filling, suggesting a mechanistic pathway for HIV-related CVD that includes peripheral arterial stiffness. We identified a subpopulation of young, male PWH at risk for early vascular aging.</p>","PeriodicalId":7502,"journal":{"name":"AIDS","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143668677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased frequency of Foxp3+CD8+ T cells are associated with disease progression during HIV infection.","authors":"Leidan Zhang, Na Chen, Xinyue Wang, Juan Du, Di Wang, Ying Liu, Yuqing Wei, Mengyuan Zhang, Meiju Deng, Meiqing Jiang, Yaxian Kong, Hongxin Zhao","doi":"10.1097/QAD.0000000000004185","DOIUrl":"https://doi.org/10.1097/QAD.0000000000004185","url":null,"abstract":"<p><strong>Objectives: </strong>Recent years have witnessed unprecedented strides in comprehending non-CD4 regulatory T cells (Tregs), such as CD8+ Tregs and double negative T cells (DNT cells), and their role in sustaining immune tolerance and restricting immune activation. This study investigates the role of Foxp3+CD8+ T cells during HIV infection and assess the markers associated with CD4+ Tregs.</p><p><strong>Design: </strong>This study was designed as a cross-sectional cohort study, comprising 21 age-matched healthy controls (HCs), 122 treatment-naïve participants (TNs), and 60 people living with HIV (PLWH) receiving successful treatment (ARTs).</p><p><strong>Methods: </strong>The frequency of Foxp3+CD8+ T cells was assessed alongside CD4+ Treg-associated markers and plasma inflammatory factor levels.</p><p><strong>Results: </strong>Foxp3+CD8+ T cells were enriched in PLWH with CD4+ T cell count < 350 cells/μl and persisted after antiretroviral therapy (ART). Besides, the Foxp3+CD8+T cells were correlated with CD4+ T cell count, CD4/CD8 ratio, and the parameters of activation and systematic inflammation in PLWH. Moreover, Foxp3+CD8+ T cells expressed different levels of Tregs related markers compared to CD4+ Tregs and Foxp3+ DNT cells.</p><p><strong>Conclusion: </strong>The Foxp3+CD8+T cells are associated with HIV disease progression and employ distinct mechanisms to exert their functions.</p>","PeriodicalId":7502,"journal":{"name":"AIDS","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143668845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hospitalisation incidence among young children living with HIV in the Western Cape, South Africa.","authors":"Kim Anderson, Brian S Eley, Helena Rabie, Rudzani Muloiwa, James Nuttall, Lisa Frigati, David M Le Roux, Thandi Wessels, Jaco Murray, Vanessa Mudaly, Gayathri Sridhar, Leigh Ragone, Vani Vannappagari, Jonathan Euvrard, Andrew Boulle, Mary-Ann Davies","doi":"10.1097/QAD.0000000000004156","DOIUrl":"10.1097/QAD.0000000000004156","url":null,"abstract":"<p><strong>Introduction: </strong>Studies examining hospitalization among young children with HIV in resource-limited settings, in the context of early infant diagnosis and early antiretroviral therapy (ART) initiation, are limited.</p><p><strong>Methods: </strong>We used routinely collected data to describe hospitalization patterns among children (age ≤5 years), born 2018-2022, who were diagnosed with HIV (Western Cape province, South Africa). We used mixed-effects Poisson models to examine factors associated with overall hospitalization and hospitalization after ART initiation.</p><p><strong>Results: </strong>We included 2219 children, 30% were diagnosed with HIV at birth (≤7 days), an additional 41% before age 1 year, and 29% at age ≥1 year. Median follow-up from birth was 38 months (interquartile range 24-50). Overall, 67% of children were hospitalized, of whom 50% had >1 hospitalization. Excluding birth admissions, 35% of children were hospitalized before ART start (n = 781/2219). Among children who started ART, 38% (n = 747/1990) had admissions after ART start. Compared to children diagnosed with HIV at birth, overall hospitalization rates (excluding birth admissions) increased by 67% [95% confidence interval (CI): 39-101], 74% (95% CI: 45-109) and 29% (95% CI: 9-51%) among those diagnosed at age 1 week to 3 months, >3 to 9 months, and >9 months, respectively. Hospitalization rates after ART start were twice as high (103% increase; 95% CI: 68-146%) among children who had unsuppressed viral load (≥1000 copies/ml) at 4 or 12 months after ART start.</p><p><strong>Conclusions: </strong>High hospitalization rates occur among young children with HIV. Earlier HIV diagnosis, enabling earlier ART initiation, is associated with lower overall hospitalization rates. Unsuppressed viral load is associated with higher post-ART hospitalization rates.</p>","PeriodicalId":7502,"journal":{"name":"AIDS","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143668709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multicenter study of heart failure phenotypes and physician-adjudicated etiologies in people with HIV.","authors":"Nour Beydoun, Robin M Nance, Matthew S Durstenfeld, Alexander P Hoffmann, Bridget M Whitney, Greer A Burkholder, Sonya Health, Priscilla Y Hsue, Michael Saag, Joseph Ac Delaney, Chris T Longenecker, Heidi M Crane, Matthew J Feinstein","doi":"10.1097/QAD.0000000000004182","DOIUrl":"10.1097/QAD.0000000000004182","url":null,"abstract":"<p><strong>Background: </strong>Limited systematic data exist on HF phenotypes in contemporary HIV care, and no prior multicenter studies have investigated physician-adjudicated phenotypes and etiologies of HF in PWH.</p><p><strong>Methods: </strong>We adjudicated HF events and sub-phenotypes occurring between January 1, 2010 and December 31, 2021 at two large urban clinical centers within the CFAR Network of Integrated Clinical Systems (CNICS) cohort. Using Cox proportional hazard regression, hazard ratios were calculated to examine associations of HIV-specific and cardiometabolic risk factors with incident HF among PWH. Exploratory analyses investigated presence of physician-adjudicated ischemic and non-ischemic etiologies of HF.</p><p><strong>Results: </strong>Of 402 individuals with events screened as possible HF, 289 were adjudicated as HF. Of these 289, 77 were prevalent at baseline and 212 were incident. Higher viral load and lower CD4 T cell count were associated with incident HF. In addition, older age, smoking, hypertension, diabetes mellitus, history of myocardial infarction (MI), and renal insufficiency were associated with higher HF risk. Nonischemic HF etiologies were more common than ischemic, and HF with reduced ejection fraction (HFrEF) was more common than preserved ejection fraction (HFpEF). Despite distinct demographic and risk factor compositions between the two sites, HF phenotypes were similar.</p><p><strong>Conclusion: </strong>HIV viremia, low CD4 T cell count, traditional CVD risk factors, and renal insufficiency were associated with higher risk for HF. The predominant HF subtype was non-ischemic HF. While further studies are needed, our findings suggest HF prevention and management in PWH will require addressing complex interactions between HIV-related and traditional CVD risk factors.</p>","PeriodicalId":7502,"journal":{"name":"AIDS","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143655871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Higher non-HIV-comorbidity burden in long-term survivors.","authors":"Thom W Vonder, Tania Mudrikova","doi":"10.1097/QAD.0000000000004054","DOIUrl":"10.1097/QAD.0000000000004054","url":null,"abstract":"<p><strong>Objective: </strong>The possible differences in comorbidity burden were examined between people with longstanding HIV infection and those with shorter HIV duration of the same calendar age.</p><p><strong>Design: </strong>We performed a single-centre retrospective cohort analysis comparing long-term HIV survivors (LTS) diagnosed with HIV before 1996 (pre-HAART), with an age-matched and gender-matched group diagnosed after 2006 [modern ART era (mART)].</p><p><strong>Methods: </strong>Demographic and outcome data up to 1 May 2023 were obtained from electronic health records as well as from digitalized paper charts. Nine comorbidity domains were defined to overlook the comorbidity burden as on 1 May 2023: cardiovascular, musculoskeletal, neurological, oncological, liver, pulmonary, renal, psychiatric/cognitive, and metabolic.</p><p><strong>Results: </strong>Eighty-eight LTS and 88 people diagnosed in the modern ART era were included in the analysis. Median age in both groups was 60 years. LTS had a higher mean number of comorbidity domains than controls (2.6 vs. 1.9; P  = .001). In both LTS and mART groups, metabolic and cardiovascular comorbidity was most prevalent (metabolic 70.5 and 52.3%, respectively, cardiovascular 44.3 and 38.6%, respectively). When stratified according to age, the distribution of the number of comorbidities for LTS roughly resembled the 10 years older mART subgroup. In a multivariate analysis, total ART duration and age were found to be statistically significantly associated with the number of comorbidity domains.</p><p><strong>Conclusion: </strong>Our analysis suggests that LTS have a higher comorbidity burden compared with people diagnosed in the modern ART era of similar calendar age.</p>","PeriodicalId":7502,"journal":{"name":"AIDS","volume":" ","pages":"387-392"},"PeriodicalIF":3.4,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142589804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}