AIDS最新文献

{"title":"As long-acting HIV prevention options gain momentum, the spotlight shifts to equitable access.","authors":"Iulia Filip","doi":"10.1097/QAD.0000000000004316","DOIUrl":"10.1097/QAD.0000000000004316","url":null,"abstract":"","PeriodicalId":7502,"journal":{"name":"AIDS","volume":" ","pages":"N17-N19"},"PeriodicalIF":3.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144740900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute hepatitis B infections among PWH treated with 2-drug regimen: can we trust the vaccination status?","authors":"Eve Todesco, Marc-Antoine Valantin, Sepideh Akhavan, Rémi Rouget, Marc Wirden, Priscila Passe-Coutrin, Sanaa Saliba, Théophile Cocherie, Roland Tubiana, Antoine Faycal, Hind Stitou, Olivier Vergely, Stéphane Chevaliez, Xavier Amiot, Rachid Agher, Romain Palich, Vincent Calvez, Valérie Pourcher, Anne-Geneviève Marcelin, Sophie Seang","doi":"10.1097/QAD.0000000000004290","DOIUrl":"https://doi.org/10.1097/QAD.0000000000004290","url":null,"abstract":"","PeriodicalId":7502,"journal":{"name":"AIDS","volume":"39 12","pages":"1845-1847"},"PeriodicalIF":3.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The paradox of rising syphilis among MSM living with HIV amid declining HIV infections: a 33-year analysis.","authors":"Massimo Giuliani, Mauro Zaccarelli, Christof Stingone, Laura Gianserra, Maria Gabriella Donà, Eugenia Giuliani, Fulvia Pimpinelli, Alessandra Latini","doi":"10.1097/QAD.0000000000004282","DOIUrl":"https://doi.org/10.1097/QAD.0000000000004282","url":null,"abstract":"<p><p>In an STI/HIV Unit in Italy, the last 33 years saw a significant increase in syphilis diagnoses among MSM, particularly those living with HIV. This increase occurred alongside a recent drastic decline in HIV diagnoses among syphilis patients. These divergent trends likely reflect the success of HIV prevention strategies, yet underscore the need for integrated approaches to manage the risk of syphilis and other STIs in populations where these strategies are increasingly accessible.</p>","PeriodicalId":7502,"journal":{"name":"AIDS","volume":"39 12","pages":"1841-1844"},"PeriodicalIF":3.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Posttraumatic stress disorder and Veterans with HIV: commentary on neurocognition, social cognition, and resilience.","authors":"David E Vance, Shannon Layton","doi":"10.1097/QAD.0000000000004270","DOIUrl":"https://doi.org/10.1097/QAD.0000000000004270","url":null,"abstract":"","PeriodicalId":7502,"journal":{"name":"AIDS","volume":"39 12","pages":"1828-1830"},"PeriodicalIF":3.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of the COVID-19 and mpox outbreaks on behaviours associated with HCV infection among MSM: results from the prerandomisation phase of a clinical trial.","authors":"Kris Hage, Anders Boyd, Udi Davidovich, Ellen Generaal, Elske Hoornenborg, Paul Zantkuijl, Marc van der Valk, Dominique Verhagen, Janneke Stalenhoef, Jan den Hollander, Eliane Leyten, Tania Mudrikova, Hayette Rougier, Thibault Chiarabini, Marc-Antoine Valantin, Gilles Pialoux, Pauline Campa, Janke Schinkel, Karine Lacombe, Maria Prins","doi":"10.1097/QAD.0000000000004265","DOIUrl":"10.1097/QAD.0000000000004265","url":null,"abstract":"<p><strong>Objective: </strong>To assess whether the COVID-19 and mpox outbreaks affected hepatitis C virus (HCV) related behaviours among men who have sex with men (MSM) with a cleared HCV infection.</p><p><strong>Design: </strong>Longitudinal analysis from the international ICECREAM trial (2021-2024).</p><p><strong>Methods: </strong>During the prerandomisation phase (i.e., without any intervention) individuals completed questionnaires on sexual and drug use behaviours and whether the COVID-19 (since start trial) or mpox (shortly after the mpox outbreak in 2022) outbreaks caused changes in these behaviours, all referring to the preceding 6 months. We used mixed-effects logistic regression to model changes in behaviours due to COVID-19 or mpox measures and mixed-effects linear regression to model the average HCV-MOSAIC risk score, as a proxy of HCV-associated risk behaviour, over calendar time.</p><p><strong>Results: </strong>220 MSM ( n  = 117 from the Netherlands, n  = 103 from France) were included. Among 208 that completed the baseline questionnaire, 171 (82.2%) were MSM with HIV. The proportion of individuals reporting any impact of COVID-19 restrictions on risk behaviours, mainly lowering number of partners, decreased from 74.7% in September 2021 to 6.7% in September 2024 ( P  < 0.001) and reporting any impact of mpox from 41.9% in November 2022 to 6.0% in September 2024 ( P  = 0.001). The average HCV-MOSAIC risk score remained constant over time ( P  = 0.59) and was consistently ≥2.0, indicating high reinfection susceptibility.</p><p><strong>Conclusion: </strong>HCV-related behaviours decreased when COVID-19 and mpox measures were in place. However, individuals still engaged in behaviours associated with HCV, highlighting the importance of continued sexual health services and prevention efforts during such outbreaks.</p>","PeriodicalId":7502,"journal":{"name":"AIDS","volume":" ","pages":"1803-1812"},"PeriodicalIF":3.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12404629/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144315721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Under-reporting of HIV and AIDS as an underlying cause of death in South Africa.","authors":"Pam Groenewald, Tracy Glass, Natasha Kallis, Chantelle Holmgren, B Nojilana, Monique Maqungo, Mireille Cheyip, Diane Morof, Nadine Nannan, Debbie Bradshaw","doi":"10.1097/QAD.0000000000004281","DOIUrl":"10.1097/QAD.0000000000004281","url":null,"abstract":"<p><p>Under-reporting of HIV-related and AIDS-related deaths is a major problem in South Africa, with only 27.9% of documented HIV-related deaths in medical records reported as such in the official cause of death data. The legacy of AIDS denialism in South Africa, confidentiality concerns, and anticipated stigma appear to have created a culture of not recording HIV as an underlying cause on the official medical certificate of death. Inaccurate statistics could affect resource allocation for the epidemic.</p>","PeriodicalId":7502,"journal":{"name":"AIDS","volume":"39 12","pages":"1839-1841"},"PeriodicalIF":3.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12404619/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social cognition abilities in people with HIV: the role of stigma and other factors.","authors":"David E Vance, Junghee Lee","doi":"10.1097/QAD.0000000000004254","DOIUrl":"10.1097/QAD.0000000000004254","url":null,"abstract":"<p><p>Social cognition refers to the ability to perceive social stimuli, interpret their meaning, and respond appropriately to navigate dynamic social environments, including various professional and personal relationships to secure interpersonal and external resources for effective social functioning. More basic, social cognition is the complicated ability to interact with others. Known to impact everyday functioning and quality of life, deficits in this essential ability have been well documented in schizophrenia, autism spectrum disorders, depression, and other mental health conditions. Studies in other clinical populations also indicate that even subtle deficits in social cognition can impact social everyday functioning. Such social cognitive abilities include emotional face recognition/perception, prosody, theory of mind, and empathy. This review aims to survey our current knowledge on social cognition in people with HIV (PWH), focusing on the following questions: Do people with HIV show impaired social cognition? Is social cognitive impairment of PWH related to neurocognitive impairment? Are social brain regions compromised in PWH? How is social cognition related to social experiences of PWH (e.g., stigma). These questions and more are explored, from which implications for future research are posited.</p>","PeriodicalId":7502,"journal":{"name":"AIDS","volume":"39 12","pages":"1688-1698"},"PeriodicalIF":3.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12404632/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unit costs of opioid agonist therapy: a global systematic review and cost extrapolation.","authors":"Anh Truc Vo, Adriane Wynn, Marycris Hernandez, Fern Terris-Prestholt, Peter Vickerman, Javier Cepeda, Natasha K Martin","doi":"10.1097/QAD.0000000000004263","DOIUrl":"10.1097/QAD.0000000000004263","url":null,"abstract":"<p><strong>Background: </strong>People who inject drugs (PWID) face elevated risks of HIV and viral hepatitis transmission. Opioid agonist therapy (OAT) like methadone and buprenorphine reduce drug-related harms and improve health outcomes among PWID. Despite effectiveness, global OAT coverage remains suboptimal. This study estimated the global unit cost of OAT provision to inform resource allocation and scale-up of harm reduction services.</p><p><strong>Methods: </strong>We conducted a systematic review to identify cost estimates of OAT provision and cost drivers. Data were extracted from peer-reviewed and grey literature sources. Mixed-effects multivariable regression models, incorporating country-level and program-level covariates, were developed to predict OAT unit costs. The best performing model was used to extrapolate the monthly per person costs of providing OAT in 210 countries.</p><p><strong>Results: </strong>We identified 175 cost estimates across 32 countries. Most estimates were from high-income countries. Higher unit costs were associated with higher country log GDP per capita, more program components, and inclusion of ancillary services in the cost estimations. The best-performing model predicted cost within 95% prediction intervals for 27 out of 32 countries when using the full dataset.</p><p><strong>Conclusion: </strong>The study highlights the scarcity of OAT cost data, particularly in low-income countries, and underscores the need for more research in diverse settings to improve the accuracy and generalizability of cost estimates. This study provides estimates of OAT unit costs, offering insights for policymakers to optimize resource allocation and expand harm reduction efforts.</p>","PeriodicalId":7502,"journal":{"name":"AIDS","volume":" ","pages":"1794-1802"},"PeriodicalIF":3.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144281960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Posttraumatic stress disorder and its associations with morbidity and mortality among veterans with HIV.","authors":"Kartavya J Vyas, Vincent C Marconi, Brian K Agan, Patrick S Sullivan, Jodie L Guest","doi":"10.1097/QAD.0000000000004241","DOIUrl":"10.1097/QAD.0000000000004241","url":null,"abstract":"<p><strong>Objectives: </strong>Posttraumatic stress disorder (PTSD) may increase the risks of adverse clinical outcomes for veterans with HIV (VWH) receiving care in the Department of Veterans Affairs (VA). Objectives were to estimate the associations between PTSD and morbidity and mortality; measure effect modification by number of deployments and combat exposure; and examine how these associations vary over time.</p><p><strong>Design: </strong>In this prospective cohort study of all VWH on antiretroviral therapy (ART) who deployed to Iraq and Afghanistan and receive care in the VA ( n  = 3206), patients entered at HIV diagnosis and were censored in December 2022, totaling 20 121 person-years of follow-up.</p><p><strong>Methods: </strong>Marginal structural Cox models were fitted with a time-dependent exposure, adjusted for time-independent and -dependent confounding and informative censoring.</p><p><strong>Results: </strong>PTSD increased the risks (adjusted hazard ratio, [95% CI]) for AIDS by 11% (1.11 [1.00, 1.23]), chronic kidney disease by 21% (1.21 [1.02, 1.43]), chronic obstructive pulmonary disease by 46% (1.46 [1.10, 1.92]), multimorbidity by 49% (1.49 [1.24, 1.81]), cardiovascular disease by 57% (1.57 [1.25, 1.97]), and arthritis two-fold (1.95 [1.76, 2.15]). PTSD was not associated with asthma, cancer, cerebrovascular disease, diabetes mellitus, liver disease, or all-cause mortality. Associations of PTSD were most pronounced in the first decade postdiagnosis, followed by gradual waning yet still elevated risks.</p><p><strong>Conclusions: </strong>It is recommended that providers who work with VWH consider adopting a trauma-informed model of HIV care and that providers screen Veterans for PTSD, so that their unique trauma history can help guide medical decisions and treatment.</p>","PeriodicalId":7502,"journal":{"name":"AIDS","volume":" ","pages":"1760-1772"},"PeriodicalIF":3.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144126130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are we ending the HIV epidemic among persons who inject drugs?: key findings from 19 US cities.","authors":"Amy R Baugher, Cyprian Wejnert, Dafna Kanny, Dita Broz, Jonathan Feelemyer, Rebecca B Hershow, Janet Burnett, Johanna Chapin-Bardales, Maya Haynes, Teresa Finlayson, Joseph Prejean","doi":"10.1097/QAD.0000000000004249","DOIUrl":"10.1097/QAD.0000000000004249","url":null,"abstract":"<p><strong>Objectives: </strong>National HIV Behavioral Surveillance (NHBS) conducts surveillance among key populations, including persons who inject drugs (PWID). NHBS data can be used to monitor progress toward national goals, including Ending the HIV Epidemic (EHE). EHE strategies include HIV testing (Diagnose), rapid linkage to HIV treatment (Treat), and increasing access to preexposure prophylaxis (PrEP), and syringe services programs (SSPs) (Prevent). This analysis aimed to concisely compare NHBS key findings among PWID to EHE goals.</p><p><strong>Design/methods: </strong>Cross-sectional NHBS data were collected from PWID in 2018 ( n  = 9786) and 2022 ( n  = 6574) in 19 US cities. We compared key findings from 2022 NHBS to specified EHE goals for Diagnose (HIV testing) and Treat (linkage to care, current antiretroviral therapy (ART) use) or 2018 NHBS key findings for Prevent (PrEP and SSP use).</p><p><strong>Results: </strong>In 2022, 45% of PWID were tested for HIV; 45% of PWID with HIV were linked to care within 1 month of diagnosis, and 79% were currently taking ART; 1% of PWID without HIV used PrEP; and approximately half of all PWID received syringes from an SSP. PrEP and SSP use among PWID have not changed since 2018.</p><p><strong>Conclusion: </strong>National HIV strategies are not yet adequately reaching PWID. To end the US HIV epidemic, multilevel solutions are needed to tailor interventions for PWID and dismantle barriers to testing, treatment, and prevention. Structural solutions to improve access to basic needs and SSPs may have downstream benefits across the EHE strategies.</p>","PeriodicalId":7502,"journal":{"name":"AIDS","volume":" ","pages":"1813-1819"},"PeriodicalIF":3.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12424270/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144245683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}