Advances in Urology最新文献

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Analysis of the Learning Curve of Surgeons without Previous Experience in Laparoscopy to Perform Robot-Assisted Radical Prostatectomy. 无腹腔镜手术经验的外科医生进行机器人辅助根治性前列腺切除术的学习曲线分析。
IF 1.4
Advances in Urology Pub Date : 2018-10-29 eCollection Date: 2018-01-01 DOI: 10.1155/2018/9073807
Felipe Monnerat Lott, Deborah Siqueira, Hermano Argolo, Bernardo Lindberg Nóbrega, Franz Santos Campos, Luciano Alves Favorito
{"title":"Analysis of the Learning Curve of Surgeons without Previous Experience in Laparoscopy to Perform Robot-Assisted Radical Prostatectomy.","authors":"Felipe Monnerat Lott,&nbsp;Deborah Siqueira,&nbsp;Hermano Argolo,&nbsp;Bernardo Lindberg Nóbrega,&nbsp;Franz Santos Campos,&nbsp;Luciano Alves Favorito","doi":"10.1155/2018/9073807","DOIUrl":"https://doi.org/10.1155/2018/9073807","url":null,"abstract":"<p><strong>Objective: </strong>To assess the learning curve in robot-assisted radical prostatectomy (RARP) performed by surgeons without previous experience in laparoscopic prostatectomy.</p><p><strong>Materials and methods: </strong>We analyzed 119 patients submitted to RARP performed by two surgeons without previous experience in laparoscopic prostatectomy, with emphasis on the relevant outcomes such as continence, erectile function, and oncologic control with a minimum follow-up of 24 months. We used Fisher's exact test and the chi-square test to investigate the existence of a relationship between the variables and analysis of variance (ANOVA) to verify possible statistically significant differences between groups, at the 5% level.</p><p><strong>Results: </strong>The patients' age varied from 41 to 72 years (mean = 61.09), with 68 (57.14%) cases having intermediate or high risk. There was a consistent decline in operative time. Of the 119 patients, 80.67% were continent 6 months after surgery and 89.07% 12 months afterward, while 35.29% were potent 6 months after surgery and 60.50% 12 months following surgery. Twelve months after surgery, the trifecta outcome rate was 51.26% and the pentafecta rate was 31.09%. There was progressive postoperative improvement and maintenance of continence and sexual potency until the last patient was operated in our sample.</p><p><strong>Conclusions: </strong>Robot-assisted radical prostatectomy does not require previous experience in laparoscopic radical prostatectomy, but the learning curve is not short to achieve the plateau.</p>","PeriodicalId":7490,"journal":{"name":"Advances in Urology","volume":"2018 ","pages":"9073807"},"PeriodicalIF":1.4,"publicationDate":"2018-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2018/9073807","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36747999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Undescended Testes and Laparoscopy: Experience from the Developing World. 隐睾和腹腔镜:来自发展中国家的经验。
IF 1.4
Advances in Urology Pub Date : 2018-10-24 eCollection Date: 2018-01-01 DOI: 10.1155/2018/1620470
Shabir Ahmad Dar, Rajandeep Singh Bali, Yawar Zahoor, Arshad Rashid Kema, Rajni Bhardwaj
{"title":"Undescended Testes and Laparoscopy: Experience from the Developing World.","authors":"Shabir Ahmad Dar,&nbsp;Rajandeep Singh Bali,&nbsp;Yawar Zahoor,&nbsp;Arshad Rashid Kema,&nbsp;Rajni Bhardwaj","doi":"10.1155/2018/1620470","DOIUrl":"https://doi.org/10.1155/2018/1620470","url":null,"abstract":"<p><strong>Background: </strong>Cryptorchidism or undescended testes is the most common disorder of the male endocrine glands in children. With the advancements in laparoscopic techniques and instruments, laparoscopic orchidopexy has become the standard procedure in the management of nonpalpable undescended testes.</p><p><strong>Aim: </strong>To evaluate and determine the therapeutic role, sensitivity, and specificity of laparoscopy in localizing nonpalpable testes and the mean operative time, the conversion rate (and reasons thereof), postoperative wound infection, postoperative stay, and time taken for return to daily activities following laparoscopic orchidopexy or orchidectomy.</p><p><strong>Materials and methods: </strong>This was a prospective study carried out in the Postgraduate Department of Surgery, Government Medical College, Srinagar, J&K, India, from May 2008 to August 2011. All patients who presented to the outpatient department with complaints of absent testes were examined, and the ones with nonpalpable testes were included in the study.</p><p><strong>Results: </strong>The mean operative time for bilateral and unilateral nonpalpable testis was 102.76 and 53.67 minutes, respectively. Minor postoperative wound infections were noted in 4 of our patients. Mean duration of hospital stay was 14.23 hrs for unilateral cases and 16.27 hrs for bilateral cases. Patients who underwent laparoscopic orchidopexy resumed their normal activities within 4 ± 1 days.</p><p><strong>Conclusion: </strong>Laparoscopy clearly demonstrates the anatomy and provides visual information upon which a definitive decision can be made for further management of the undescended nonpalpable testis.</p>","PeriodicalId":7490,"journal":{"name":"Advances in Urology","volume":"2018 ","pages":"1620470"},"PeriodicalIF":1.4,"publicationDate":"2018-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2018/1620470","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36764132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
The Modified Gil-Vernet Antireflux Surgery: A Successful Technique for High-Grade Vesicoureteral Reflux Correction in Children-Long-Term Follow-Up. 改良Gil-Vernet抗反流手术:一种成功的儿童高级别膀胱输尿管反流矫正技术——长期随访。
IF 1.4
Advances in Urology Pub Date : 2018-10-21 eCollection Date: 2018-01-01 DOI: 10.1155/2018/4948165
Mahmoudreza Moradi, Abolhassan Seyedzadeh, Saeed Gharakhloo, Aref Teymourinezhad, Kaveh Kaseb, Haress Rezaee
{"title":"The Modified Gil-Vernet Antireflux Surgery: A Successful Technique for High-Grade Vesicoureteral Reflux Correction in Children-Long-Term Follow-Up.","authors":"Mahmoudreza Moradi,&nbsp;Abolhassan Seyedzadeh,&nbsp;Saeed Gharakhloo,&nbsp;Aref Teymourinezhad,&nbsp;Kaveh Kaseb,&nbsp;Haress Rezaee","doi":"10.1155/2018/4948165","DOIUrl":"https://doi.org/10.1155/2018/4948165","url":null,"abstract":"<p><strong>Introduction: </strong>Vesicoureteral reflux (VUR) is a common urologic anomaly in children. Many techniques have been offered to manage this condition, in which one of them is modified Gil-Vernet antireflux surgery. The study fullfiled to evaluate the efficacy and safety of modified Gil-Vernet antireflux surgery in correction of high-grade VUR.</p><p><strong>Materials and methods: </strong>A retrospective study in which we evaluated efficacy, safety, and complications of modified Gil-Vernet antireflux surgery as a choice procedure for high-grade reflux in all patients who underwent it since 2000 to 2016 at 2 hospitals of Kermanshah University of medical sciences that all of them were done by one surgeon.</p><p><strong>Results: </strong>183 patients with 290 high-grade refluxing units (grade IV or V) were reviewed. 182 refluxing units were grade IV, and 108 units were grade V. There were 76 (41.54%) patients with unilateral and 107 (58.46%) patients with bilateral VUR. Reflux in high-grade group corrected completely in 278 (95.86%) refluxing units and 175 patients (95.62%).</p><p><strong>Conclusions: </strong>Our results are remarkable and compatible with other techniques' results. This simple and safe technique can correct bilateral VURs simultaneously; thus, it is rational to be considered for high-grade VUR correction. According to our results, we suggest the modified Gil-Vernet antireflux procedure for high-grade VUR correction as a simple, safe, and successful technique. This trial is registered with 67145/86/1233.</p>","PeriodicalId":7490,"journal":{"name":"Advances in Urology","volume":"2018 ","pages":"4948165"},"PeriodicalIF":1.4,"publicationDate":"2018-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2018/4948165","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36658921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Germ Cell Tumors: Updates on Epidemiology, Biology, and Treatment Considerations. 生殖细胞肿瘤:流行病学、生物学和治疗方面的最新进展。
IF 1.4
Advances in Urology Pub Date : 2018-08-19 eCollection Date: 2018-01-01 DOI: 10.1155/2018/4821084
Aditya Bagrodia, Costantine Albany, Timothy A Masterson
{"title":"Germ Cell Tumors: Updates on Epidemiology, Biology, and Treatment Considerations.","authors":"Aditya Bagrodia,&nbsp;Costantine Albany,&nbsp;Timothy A Masterson","doi":"10.1155/2018/4821084","DOIUrl":"https://doi.org/10.1155/2018/4821084","url":null,"abstract":"","PeriodicalId":7490,"journal":{"name":"Advances in Urology","volume":"2018 ","pages":"4821084"},"PeriodicalIF":1.4,"publicationDate":"2018-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2018/4821084","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36488211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Efficacy of Transdermal Oxybutynin in the Treatment of Overactive Bladder Syndrome: Does It Make Sense Using It in 2017? 经皮奥施布宁治疗膀胱过度活跃综合征的疗效:2017年是否有意义?
IF 1.4
Advances in Urology Pub Date : 2018-07-29 eCollection Date: 2018-01-01 DOI: 10.1155/2018/6782736
Raúl Vozmediano-Chicharro, Blanca Madurga, Pedro Blasco
{"title":"Efficacy of Transdermal Oxybutynin in the Treatment of Overactive Bladder Syndrome: Does It Make Sense Using It in 2017?","authors":"Raúl Vozmediano-Chicharro,&nbsp;Blanca Madurga,&nbsp;Pedro Blasco","doi":"10.1155/2018/6782736","DOIUrl":"https://doi.org/10.1155/2018/6782736","url":null,"abstract":"<p><strong>Objectives: </strong>Evaluation of changes in symptoms among patients with overactive bladder syndrome treated with transdermal oxybutynin and tolerability after 12 months of follow-up.</p><p><strong>Methods: </strong>This was a multicenter, retrospective, single-cohort, observational study. Changes in symptoms were evaluated primarily with a 3-day voiding diary. Results were compared to baseline. Subgroup analyses were performed in patients previously treated for OAB or not and aged < 65 years versus ≥65 years.</p><p><strong>Results: </strong>Clinical records of 105 patients were examined; 92.4% were women. At 12 months, 58 patients continued to receive transdermal oxybutynin. Changes in symptoms according to the voiding diary were evaluated in 47 patients. Significant improvements from baseline were observed in urinary frequency (-2.6 voids/24 hours (95% CI: -3.5; -1.8), <i>p</i> < 0.001); daily number of urgent episodes (-4.7 episodes/day (95% CI: -6.1; -3.6), <i>p</i> < 0.001); and urge incontinence (-1.9 episodes/day (95% CI: -2.9; -1.3), <i>p</i> < 0.001). No statistically significant differences were found in subgroup analyses. In total, 38.1% of patients had adverse events, primarily in the application site (27.6%). No severe systemic adverse events occurred. Only 6 patients (5.7%) reported dry mouth.</p><p><strong>Conclusions: </strong>Improved symptoms and good tolerability observed after 1 year of treatment with transdermal oxybutynin shows that it currently has a place in the treatment of OAB patients.</p>","PeriodicalId":7490,"journal":{"name":"Advances in Urology","volume":"2018 ","pages":"6782736"},"PeriodicalIF":1.4,"publicationDate":"2018-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2018/6782736","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36434446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
A Review of Outcomes and Technique for the Robotic-Assisted Laparoscopic Retroperitoneal Lymph Node Dissection for Testicular Cancer. 机器人辅助腹腔镜腹膜后淋巴结清扫治疗睾丸癌的效果与技术综述。
IF 1.4
Advances in Urology Pub Date : 2018-05-03 eCollection Date: 2018-01-01 DOI: 10.1155/2018/2146080
Zeyad R Schwen, Mohit Gupta, Phillip M Pierorazio
{"title":"A Review of Outcomes and Technique for the Robotic-Assisted Laparoscopic Retroperitoneal Lymph Node Dissection for Testicular Cancer.","authors":"Zeyad R Schwen,&nbsp;Mohit Gupta,&nbsp;Phillip M Pierorazio","doi":"10.1155/2018/2146080","DOIUrl":"https://doi.org/10.1155/2018/2146080","url":null,"abstract":"<p><strong>Objectives: </strong>The robotic-assisted laparoscopic retroperitoneal lymph node dissection (R-RPLND) represents a new frontier in the surgical management of testicular cancer in the realm of minimally invasive urologic oncology. We aimed to review the early outcomes as compared to the laparoscopic and open approaches as well as describe the operative technique for the R-RPLND.</p><p><strong>Materials and methods: </strong>We reviewed all the literature related to the R-RPLND based on an electronic PubMed search up until July 2017.</p><p><strong>Results and discussion: </strong>Encouraged by favorable early oncologic and safety outcomes for treatment of clinical stage (CS) I nonseminomatous germ cell tumor (NSGCT), the R-RPLND affords the same recovery advantages as the laparoscopic retroperitoneal lymph node dissection (L-RPLND) while offering greater dexterity, superior visualization, and a theoretically shorter learning curve for the surgeon. While R-RPLND has a promising future in the management of patients with primary and postchemotherapy NSGCT, larger and more vigorous prospective studies are needed before supplanting the open RPLND as the gold standard approach for primary low-stage NSGCT or becoming an equivalent surgical modality in the postchemotherapy setting.</p>","PeriodicalId":7490,"journal":{"name":"Advances in Urology","volume":"2018 ","pages":"2146080"},"PeriodicalIF":1.4,"publicationDate":"2018-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2018/2146080","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36182037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 16
Pattern of Ureteric Pathology Presenting to a Fistula Centre in Western Kenya. 输尿管病理模式提出瘘中心在肯尼亚西部。
IF 1.4
Advances in Urology Pub Date : 2018-04-24 eCollection Date: 2018-01-01 DOI: 10.1155/2018/5056049
Anthony Wanjala, Henry Mwangi, Hillary Mabeya
{"title":"Pattern of Ureteric Pathology Presenting to a Fistula Centre in Western Kenya.","authors":"Anthony Wanjala,&nbsp;Henry Mwangi,&nbsp;Hillary Mabeya","doi":"10.1155/2018/5056049","DOIUrl":"https://doi.org/10.1155/2018/5056049","url":null,"abstract":"<p><strong>Background: </strong>Ureteric pathology arises from surgical misadventures, trauma, and congenital anomalies. Early detection and treatment is of the essence.</p><p><strong>Objectives: </strong>To determine the types/etiology and outcome of ureteric pathology presenting to Gynocare Fistula Centre, Eldoret, Kenya.</p><p><strong>Methods: </strong>Descriptive retrospective study that evaluated patients presenting with ureteric pathology at Gynocare between 1st January 2012 and 31st December 2016. We pulled out patient charts and extracted and analyzed relevant data using STATA 13E statistical software.</p><p><strong>Results: </strong>We analyzed 33 charts, and their age ranged from 10 to 58 years. Annual proportion for 2012, 2013, 2014, 2015, and 2016 was 2.5%, 2.8%, 1.2%, 1.4%, and 3.0% respectively among all the fistula patients treated in the hospital. All the patients presented with urinary incontinence, and 7 (21.2%) had flank pain. Iatrogenic injuries contributed 84.8% (28), and 3 (9.1%) were congenital while trauma and infection had 1 each. Of those resulting from surgical misadventures, 17 (60.7%) were from obstetric while 11 (39.2%) were from gynecological surgery. All the injuries were in the distal third of the ureter; 5 were bilateral; and 11 were left sided while 17 were right-sided. Repair and/or reimplantation was successful in 31 (93.93%) of the patients.</p><p><strong>Conclusion: </strong>Highest proportion of ureteric pathologies was accounted for by iatrogenic causes and surgical repair and/or reimplantation has a high success rate.</p>","PeriodicalId":7490,"journal":{"name":"Advances in Urology","volume":"2018 ","pages":"5056049"},"PeriodicalIF":1.4,"publicationDate":"2018-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2018/5056049","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36182039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Use of Modified Templates in Early and Advanced Stage Nonseminomatous Germ Cell Tumor. 改良模板在早期和晚期非半细胞性生殖细胞肿瘤中的应用。
IF 1.4
Advances in Urology Pub Date : 2018-04-05 eCollection Date: 2018-01-01 DOI: 10.1155/2018/6783147
Timothy A Masterson, Clint Cary
{"title":"The Use of Modified Templates in Early and Advanced Stage Nonseminomatous Germ Cell Tumor.","authors":"Timothy A Masterson,&nbsp;Clint Cary","doi":"10.1155/2018/6783147","DOIUrl":"https://doi.org/10.1155/2018/6783147","url":null,"abstract":"<p><p>The surgical management of both early and advanced stage germ cell tumors of the testis remains a complex process of surgical decision making to maximize oncologic control while minimizing morbidity. Over the past 5 decades, the evolution of the surgical template for retroperitoneal lymphadenectomy (RPLND) has resulted in important modifications to achieve these goals. In this review, we will characterize the historical motivating factors that led to the modified template, outline patient and clinical factors in selecting these approaches in both early and advanced stage disease, and briefly discuss future horizons for their implementation.</p>","PeriodicalId":7490,"journal":{"name":"Advances in Urology","volume":"2018 ","pages":"6783147"},"PeriodicalIF":1.4,"publicationDate":"2018-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2018/6783147","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36178243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
Adjuvant Therapy for Stage IB Germ Cell Tumors: One versus Two Cycles of BEP. IB期生殖细胞肿瘤的辅助治疗:一个周期与两个周期的BEP。
IF 1.4
Advances in Urology Pub Date : 2018-04-02 eCollection Date: 2018-01-01 DOI: 10.1155/2018/8781698
Robert A Huddart, Alison M Reid
{"title":"Adjuvant Therapy for Stage IB Germ Cell Tumors: One versus Two Cycles of BEP.","authors":"Robert A Huddart,&nbsp;Alison M Reid","doi":"10.1155/2018/8781698","DOIUrl":"https://doi.org/10.1155/2018/8781698","url":null,"abstract":"<p><p>Testicular germ cell tumours are the commonest tumours of young men and are broadly managed either as pure seminomas or as 'nonseminomas'. The management of Stage 1 nonseminomatous germ cell tumours (NSGCTs), beyond surgical removal of the primary tumour at orchidectomy, is somewhat controversial. Cancer-specific survival rates in these patients are in the order of 99% regardless of whether surveillance, retroperitoneal lymph node dissection, or adjuvant chemotherapy is employed. However, the toxicities of these treatment modalities differ. Undertreating those destined to relapse exposes them to the potentially significant toxicities of 3-4 cycles of bleomycin, etoposide, and cisplatin (BEP) chemotherapy. Conversely, giving adjuvant chemotherapy to all patients following orchidectomy results in overtreatment of a significant proportion. Therefore, the challenge lies in delineating the patient population who require adjuvant chemotherapy and in determining how much chemotherapy to give to adequately reduce relapse risk. This chapter reviews the factors to be considered when adopting a risk-adapted strategy for giving adjuvant chemotherapy in Stage 1B NSGCT sand discusses the data regarding the number of BEP cycles to administer.</p>","PeriodicalId":7490,"journal":{"name":"Advances in Urology","volume":"2018 ","pages":"8781698"},"PeriodicalIF":1.4,"publicationDate":"2018-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2018/8781698","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36139144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 16
Antibiotic Prophylaxis with Trimethoprim-Sulfamethoxazole versus No Treatment after Mid-to-Distal Hypospadias Repair: A Prospective, Randomized Study. 甲氧苄氨嘧啶-磺胺甲恶唑预防尿道下裂中至远端修补术后不治疗:一项前瞻性随机研究。
IF 1.4
Advances in Urology Pub Date : 2018-03-26 eCollection Date: 2018-01-01 DOI: 10.1155/2018/7031906
Elizabeth B Roth, John V Kryger, Charles T Durkee, Melissa A Lingongo, Ruth M Swedler, Travis W Groth
{"title":"Antibiotic Prophylaxis with Trimethoprim-Sulfamethoxazole versus No Treatment after Mid-to-Distal Hypospadias Repair: A Prospective, Randomized Study.","authors":"Elizabeth B Roth,&nbsp;John V Kryger,&nbsp;Charles T Durkee,&nbsp;Melissa A Lingongo,&nbsp;Ruth M Swedler,&nbsp;Travis W Groth","doi":"10.1155/2018/7031906","DOIUrl":"https://doi.org/10.1155/2018/7031906","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the impact of prophylactic antibiotics after distal hypospadias repair on postoperative bacteriuria, symptomatic urinary tract infection, and postoperative complications in a prospective, randomized trial.</p><p><strong>Materials and methods: </strong>Consecutive patients aged 6 months to 2 years were enrolled at our institution between June 2013 and May 2017. Consenting patients were randomized to antibiotic prophylaxis with trimethoprim-sulfamethoxazole versus no antibiotic. Patients had catheterized urine samples obtained at surgery and 6-10 days postoperatively. The primary outcome was bacteriuria and pyuria at postoperative urine collection. Secondary outcomes included symptomatic urinary tract infection and postoperative complications.</p><p><strong>Results: </strong>70 patients consented to the study, of which 35 were randomized to receive antibiotics compared to 32 who did not. Demographics, severity of hypospadias, and type of repair were similar between the groups. Patients in the treatment group had significantly less pyuria (18%) and bacteriuria (11%) present at stent removal compared to the nontreatment group (55% and 63%; <i>p</i>=0.01 and <i>p</i> < 0.001, resp.). No patient had a symptomatic urinary tract infection. There were 11 postoperative complications.</p><p><strong>Conclusions: </strong>Routine antibiotic prophylaxis appears to significantly decrease bacteriuria and pyuria in the immediate postoperative period; however, no difference was observed in symptomatic urinary tract infection or postoperative complications. Clinical Trial Registration Number NCT02593903.</p>","PeriodicalId":7490,"journal":{"name":"Advances in Urology","volume":"2018 ","pages":"7031906"},"PeriodicalIF":1.4,"publicationDate":"2018-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2018/7031906","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36114524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
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