Advances in Skin & Wound Care最新文献

{"title":"Efficacy of Reactive Oxygen Species-Enriched Dressings Compared With Antimicrobial Silver-Based Dressings in Chronic Colonized Wounds: A Randomized Clinical Trial.","authors":"Sara Sandroni, Jacopo Fiorini, Maddalena De Maria, Stefania Fabrizi, Elisa Marinelli, Rita Mencherini, Vianella Agostinelli, Alessandro Sili","doi":"10.1097/ASW.0000000000000481","DOIUrl":"10.1097/ASW.0000000000000481","url":null,"abstract":"<p><strong>Objective: </strong>Chronic wounds have increased due to the aging population and concomitant comorbidities. The wounds in this study persisted more than 4 weeks and were mostly colonized, requiring a local treatment with antimicrobial dressings, such as anti-adherent silver ones. However, silver dressings can have negative effects and limited long-term success, necessitating alternative solutions. Reactive oxygen dressings are natural dressings based on the stimulation of reactive oxygen species that promote wound healing. This study sought to evaluate the efficacy of an oxygen-enriched oleic matrix dressing compared with an antimicrobial silver dressing.</p><p><strong>Methods: </strong>A comparative efficacy randomized, controlled, parallel-arm, double-blind clinical trial was conducted. Eighty-one adult patients with colonized chronic wounds were recruited and randomly allocated (2:1 ratio) to the experimental group (reactive oxygen dressing) or the control group (silver dressing). Primary outcomes included wound area and characteristics (edges, depth, tissue, and exudate presence). Secondary outcomes included colonization status and patient-reported pain. Data were analyzed using inferential statistics.</p><p><strong>Results: </strong>The findings showed improvements in the reactive oxygen-dressing group compared with the silver dressing group. Wound area reduced by 60.9% in the experimental group versus 38.7% in the control group. Colonization rates also dropped significantly, with 40.7% in the experimental group achieving culture negativity versus 9.9% in the control group. Both groups experienced reductions in pain, but the reactive oxygen-dressing group achieved a greater overall mean reduction.</p><p><strong>Conclusions: </strong>These findings underscore reactive oxygen dressings as an effective and natural alternative to silver dressings, promoting faster healing, reducing pain, and colonization within a month. Further studies on cost efficacy are recommended.</p>","PeriodicalId":7489,"journal":{"name":"Advances in Skin & Wound Care","volume":" ","pages":"378-384"},"PeriodicalIF":1.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148161390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting Risk Factors of Pressure Injury for Perioperative Patients Through Machine Learning With SHapley Additive exPlanations Based on Hospital Information System.","authors":"Guirong Shi, Xin Xu, Peipei Zhang, Ping Huang, Qingyuan Gong, Ping Liu, Liping Jiang","doi":"10.1097/ASW.0000000000000495","DOIUrl":"10.1097/ASW.0000000000000495","url":null,"abstract":"<p><strong>Objective: </strong>Perioperative pressure injuries (PIs) are a common complication of surgical hospitalization that can lead to serious health problems, compromise wound healing, and cause infections. This study aimed to predict the early risk of PI in perioperative patients by developing an interpretable machine-learning model.</p><p><strong>Methods: </strong>Clinical data of perioperative surgical inpatients in a tertiary hospital in Shanghai from 2017 to 2023 were retrospectively analyzed, covering a total of 14,416 patients for screening. Feature variables were selected using the XGBoost model. Seven machine-learning (ML) models were employed to predict these variables. To evaluate the performance of these prediction models, various metrics such as accuracy, recall, and area under the curve were employed. In addition, a 10-fold cross-validation method was implemented to ensure the generalizability of the models. Furthermore, this study incorporated SHapley Additive exPlanations (SHAP) values to visualize and elucidate the significance of each factor involved. This study was reported using the TRIPOD checklist.</p><p><strong>Results: </strong>In the 7 ML models developed, both the Random Forest model and the XGBoost model exhibited exceptional performance. In addition, the study incorporated the SHAP framework to enhance the interpretability of these models. The importance of SHAP variables in the model from high to low were operation duration, age, serum albumin, body mass index, body temperature, and anesthesia grade.</p><p><strong>Conclusions: </strong>The ML model developed in this study demonstrated strong performance in predicting perioperative PIs. Furthermore, the SHAP method offered valuable insights for interpreting the ML model.</p>","PeriodicalId":7489,"journal":{"name":"Advances in Skin & Wound Care","volume":" ","pages":"371-377"},"PeriodicalIF":1.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148306816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New Data: Deep Tissue Pressure Injury and Trombley-Brennan Terminal Tissue Injury at End of Life.","authors":"R Gary Sibbald, Hiske Smart, Elizabeth A Ayello","doi":"10.1097/ASW.0000000000000502","DOIUrl":"10.1097/ASW.0000000000000502","url":null,"abstract":"","PeriodicalId":7489,"journal":{"name":"Advances in Skin & Wound Care","volume":"39 7","pages":"340"},"PeriodicalIF":1.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148535047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Defining Trombley-Brennan Terminal Tissue Injury With Long-Wave Infrared Thermography.","authors":"Mary R Brennan, Lily Thomas, Deanna Vargo, Meredith Akerman","doi":"10.1097/ASW.0000000000000493","DOIUrl":"10.1097/ASW.0000000000000493","url":null,"abstract":"<p><strong>Objective: </strong>To determine whether long-wave infrared thermography (LWIT) can identify a unique thermal signature for Trombley-Brennan terminal tissue injury (TB-TTI) and to distinguish its thermal characteristics from deep tissue pressure injury (DTPI).</p><p><strong>Methods: </strong>A prospective observational study was conducted in a 10-bed palliative care unit of a quaternary hospital. Patients aged 18 or older, newly presenting with skin changes consistent with DTPI or TB-TTI and without preexisting PIs, were eligible. Infrared thermographic imaging was performed using the LWIT to capture thermal and visual images of affected and adjacent skin. Temperatures and wound dimensions were analyzed.</p><p><strong>Results: </strong>After adjusting for age and gender, significant differences were found between DTPI and TB-TTI in mean (-2.07 vs. -0.21, P <.0001), maximum (-1.77 vs. 0.52, P =.0434), and minimum (-1.85 vs. -0.22, P =.0049) discolored tissue temperatures. TB-TTI wounds had a significantly higher percentage of area within ±1 °C of normal skin temperature (89.16% vs. 54.94%, P =.0011) compared with the adjacent tissue. No significant differences were observed in wound size or perimeter.</p><p><strong>Conclusions: </strong>LWIT successfully identified a distinct thermal profile for TB-TTI, differentiating it from DTPI. These findings support the use of LWIT as a noninvasive, objective tool for accurate identification of TB-TTI, particularly in patients with dark skin tones. The technique has the potential to improve prognostication, reduce misclassification, and guide care for end-of-life patients.</p>","PeriodicalId":7489,"journal":{"name":"Advances in Skin & Wound Care","volume":" ","pages":"361-367"},"PeriodicalIF":1.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148257024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Retrospective Analysis of Deep Tissue Pressure Injury Prevalence and Incidence Using a Large-scale Wound Care Database in Long-term Care Settings Across North America.","authors":"Robert D J Fraser, Heba Tallah Mohammed, Matthew Wynn, Rishabh Gupta, Dhanesh Ramachandram, Sharjeel Mustafa, Lucas Goldstone, Celeste Pols, Jose Rameriz-GarciaLuna, Kevin Woo, Joshua Moralejo, Joyce Black, Amy Cassata","doi":"10.1097/ASW.0000000000000488","DOIUrl":"10.1097/ASW.0000000000000488","url":null,"abstract":"<p><strong>Objective: </strong>Deep tissue pressure injuries (DTPIs) are a severe form of pressure injuries (PIs) that originate in deeper skin layers and are associated with high morbidity and health care costs, particularly in the elderly population in long-term care. The Centers for Medicare and Medicaid Services have prioritized DTPI prevention as a quality measure for skilled nursing facilities (SNFs). Early detection through regular skin inspection and risk assessment is critical. Digital wound care solutions (DWCS) support standardized wound evaluation through images and documentation. This study used DWCS data set from more than 2 million residents and 100,000 DTPIs to explore prevalence and incidence in SNFs (2019-2023).</p><p><strong>Methods: </strong>A retrospective study was conducted to extract DTPI cases from 3,920,280 wound assessments of 937,363 residents across SNFs. DTPI prevalence was subcategorized by age and sex. Chi-squared tests and post hoc Bonferroni correction assessed associations between residents' characteristics and DTPI distribution. The data set included 204,706 unique DTPI wounds from 120,689 residents across 4053 SNFs using DWCS.</p><p><strong>Results: </strong>Annual DTPI prevalence ranged from 5.17% in 2019 to 7.16% in 2021, and then stabilized at 6.2% in 2022-2023. Older patients (81 to 90 y) and females exhibited higher DTPI rates. Incidence rose from 4.94 per 100,000 in 2019 to 6.76 in 2021, followed by a decline in 2022 and a slight rebound to 6.11 in 2023.</p><p><strong>Conclusions: </strong>The rise in DTPI incidence during 2020-2021 may reflect health care strain from the COVID-19 pandemic, whereas stabilization in 2022-2023 suggests improvements in prevention. DWCS are valuable tools for monitoring and advancing DTPI research.</p>","PeriodicalId":7489,"journal":{"name":"Advances in Skin & Wound Care","volume":" ","pages":"350-360"},"PeriodicalIF":1.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13372364/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148306716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to \"Comparing Square Excision and Transposition Flap Versus Modified Limberg Flap in Sacrococcygeal Pilonidal Sinus Disease Surgery: A New Technique With Fewer Wound Issues\".","authors":"Jiayi Chen","doi":"10.1097/ASW.0000000000000496","DOIUrl":"10.1097/ASW.0000000000000496","url":null,"abstract":"","PeriodicalId":7489,"journal":{"name":"Advances in Skin & Wound Care","volume":"39 7","pages":"E311"},"PeriodicalIF":1.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148535031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postoperative Inflammatory Complications Do Not Increase the Risk of Subsequent Primary Skin Cancer.","authors":"Madelyn Schmidt, Travis S Dowdle, Richard F Wagner","doi":"10.1097/ASW.0000000000000499","DOIUrl":"10.1097/ASW.0000000000000499","url":null,"abstract":"<p><strong>Objective: </strong>Although there is an established risk for subsequent nonmelanoma skin cancer (NMSC) development at sites unrelated to the initial cancer, it is unknown whether postoperative inflammatory complications (IC) augment this risk after Mohs micrographic surgery (MMS) or excisions. This study aims to evaluate the 3-year risk of NMSC in patients with post-surgical IC.</p><p><strong>Methods: </strong>Using the TriNetX Research Network, patients were identified focusing on patients who experienced IC within 1 month of MMS or excision for basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and squamous cell carcinoma in situ (SCCIS). The calculated hazard ratios (HRs) and absolute risk differences (ARDs) were compared with the previously reported 3-year risks of subsequent NMSC (44% for BCC and 18% for SCC/SCCIS).</p><p><strong>Results: </strong>The hazard ratio for SCC/SCCIS in patients with postoperative IC was statistically significant (HR: 1.08, 95% CI: [1.04, 1.12]; ARD: 2.43%, 95% CI: [1.23, 3.65]) but did not exceed the 18% 3-year risk benchmark and was not considered clinically significant. Inflammatory complications were protective against BCC development (HR: 0.93, 95% CI: [0.90, 0.97]; ARD: -1.68%, 95% CI: [-2.87, -0.51]).</p><p><strong>Conclusions: </strong>These findings suggest postoperative ICs do not increase the 3-year risk of NMSC development.</p>","PeriodicalId":7489,"journal":{"name":"Advances in Skin & Wound Care","volume":" ","pages":"368-370"},"PeriodicalIF":1.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148300712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond the Skin: Risk Factors of Pressure Injury Development in Premature Infants.","authors":"Ann Marie Nie","doi":"10.1097/ASW.0000000000000484","DOIUrl":"10.1097/ASW.0000000000000484","url":null,"abstract":"<p><strong>Objective: </strong>Premature infants are understudied in relation to pressure injury (PI) development. Prevention of PIs relies on understanding PI risk factors. Research was conducted to determine PI risk factors for premature infants aged 24 to 37 weeks' gestation.</p><p><strong>Methods: </strong>A retrospective, observational, correlational study was conducted that included 799 PIs that developed in hospitalized pediatric patients between April 2017 and February 2020. This study included 108 premature infants who developed 130 PIs. Adult and pediatric PI risk factors were utilized for a stepwise multivariate logistic regression model.</p><p><strong>Results: </strong>Analysis revealed that 30 (23%) full-thickness and 100 (77%) partial-thickness PIs were present. Nine (7%) immobility-related PIs and 121 (93%) medical device-related PIs (MDRPI) were noted. Two logistic regression models were performed: full-thickness versus partial-thickness and immobility-related PI versus MDRPIs. The results of the full-thickness versus partial-thickness PIs analysis noted that generalized edema was statistically significant (P = .033; 95% CI, 1.793 to 10.097). The analysis for immobility-related PI versus MDRPI noted significance for low hemoglobin (P = .006; 95% CI, 2.346 to 167.585) and generalized edema (P < .001; 95% CI, 3.542 to 68.320). Length of stay (LOS) was significant for the development of MDRPI: LOS [F = 3.183; t = -.2.669 (df = 128); P = .009; mean difference, -.390; SE, .146; 95% CI, -0.679 to 0.101].</p><p><strong>Conclusions: </strong>Pressure injury risk factors for premature infants differ from adult risk factors. Prevention measures should be tailored to risk factors while understanding that 93% of PIs in premature infants are medical device-related. Pressure injury prevention measures should focus on medical devices.</p><p><strong>General purpose: </strong>To understand risk factors of pressure injury (PI) development in premature infants.</p><p><strong>Target audience: </strong>This continuing education activity is intended for physicians, physician assistants, nurse practitioners, and registered nurses with an interest in skin and wound care.</p><p><strong>Learning objectives/outcomes: </strong>After participating in this educational activity, the participant will: Evaluate limitations and evidence gaps in the current literature on PI risk factors and prevention strategies in premature infants.Analyze the research methods and study findings used to identify risk factors associated with the development of PIs in premature infants.Apply study findings related to PI incidence and associated risk factors to inform PI prevention strategies in premature infants.</p>","PeriodicalId":7489,"journal":{"name":"Advances in Skin & Wound Care","volume":"39 7","pages":"343-349"},"PeriodicalIF":1.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148534934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Continuous Z-Plasty Technique for Linear Scar Repair on the Face: A Retrospective Analysis.","authors":"Zhiliang Zhang, Zhihong Fan, Xiaoyun Ren","doi":"10.1097/ASW.0000000000000485","DOIUrl":"10.1097/ASW.0000000000000485","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to evaluate the efficacy and safety of the continuous Z-plasty technique for repairing facial linear scars and to assess patient satisfaction.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on patients with facial linear scars who underwent continuous Z-plasty at the authors' institution from January 2020 to December 2022. Inclusion criteria were patients with facial linear scars, excluding those with other complex facial injuries. Surgical details, preoperative and postoperative Vancouver Scar Scale scores, scar width, and patient satisfaction survey results were collected and analyzed.</p><p><strong>Results: </strong>This study included 21 patients (9 males, 12 females) with a mean age of 36.7 years. The frontal area was the most common location. Hypertrophic scars were present in 4 cases, superficial atrophic in 8, and normal in 9. The median time since scar formation was 14 months. Vancouver Scar Scale scores decreased from a median of 8 preoperatively to 3 postoperatively, with scar widths reducing from 4.5 to 1.5 mm. Follow-up at a median of 18 months showed no recurrence or complications, with significant aesthetic improvement. Comparative photos before and after surgery clearly demonstrated an improvement in scar appearance.</p><p><strong>Conclusions: </strong>Continuous Z-plasty has proven to be both an effective and safe approach for improving the appearance of facial linear scars. It not only enhances aesthetic outcomes but also boosts patient satisfaction. Future research should focus on evaluating its long-term results and comparing its effectiveness with other treatment options.</p>","PeriodicalId":7489,"journal":{"name":"Advances in Skin & Wound Care","volume":" ","pages":"385-391"},"PeriodicalIF":1.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13372363/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148248774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond the Skin: Risk Factors of Pressure Injury Development in Premature Infants.","authors":"","doi":"10.1097/ASW.0000000000000508","DOIUrl":"10.1097/ASW.0000000000000508","url":null,"abstract":"","PeriodicalId":7489,"journal":{"name":"Advances in Skin & Wound Care","volume":"39 7","pages":"E312"},"PeriodicalIF":1.5,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148535049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}