Springer seminars in immunopathology最新文献_第4页

Molecular pathogenesis of SLE. SLE的分子发病机制。

Springer seminars in immunopathology Pub Date : 2006-10-01 DOI: 10.1007/s00281-006-0032-5

Toshikazu Shirai, Sachiko Hirose

引用次数: 19

TCRzeta mRNA splice variant forms observed in the peripheral blood T cells from systemic lupus erythematosus patients. 在系统性红斑狼疮患者外周血T细胞中观察到TCRzeta mRNA剪接变异形式。

Springer seminars in immunopathology Pub Date : 2006-10-01 Epub Date: 2006-09-05 DOI: 10.1007/s00281-006-0035-2

Kensei Tsuzaka, Kyoko Nozaki, Chika Kumazawa, Kiyono Shiraishi, Yumiko Setoyama, Keiko Yoshimoto, Tohru Abe, Tsutomus Takeuchi

{"title":"TCRzeta mRNA splice variant forms observed in the peripheral blood T cells from systemic lupus erythematosus patients.","authors":"Kensei Tsuzaka, Kyoko Nozaki, Chika Kumazawa, Kiyono Shiraishi, Yumiko Setoyama, Keiko Yoshimoto, Tohru Abe, Tsutomus Takeuchi","doi":"10.1007/s00281-006-0035-2","DOIUrl":"https://doi.org/10.1007/s00281-006-0035-2","url":null,"abstract":"Systemic lupus erythematosus (SLE) is a systemic autoimmune disease of unknown etiology. Tyrosine phosphorylation and protein expression of the T-cell receptor zeta chain (zeta) have been reported to be significantly decreased in SLE T cells. In addition, zeta mRNA with alternatively spliced 3' untranslated region (zetamRNA/as-3'UTR) is detected predominantly in SLE T cells, and aberrant zeta mRNA accompanied by the mutations in the open reading frame including zeta mRNA lacking exon7 (zetamRNA/exon7-) is observed in SLE T cells. These zeta mRNA splice variant forms exhibit a reduction in the expression of TCR/CD3 complex and zeta protein on their cell surface due to the instability of zeta mRNA splice variant forms as well as the reduction in interleukin (IL)-2 production after stimulating with anti-CD3 antibody. Data from cDNA microarray showed that 36 genes encoding cytokines and chemokines, including IL-2, IL-15, IL-18, and TGF-beta2, were down-regulated in the MA5.8 cells transfected with the zeta mRNA splice variant forms. Another 16 genes were up-regulated and included genes associated with membranous proteins and cell damage granules, including the genes encoding poliovirus-receptor-related 2, syndecan-1, and granzyme A.","PeriodicalId":74860,"journal":{"name":"Springer seminars in immunopathology","volume":"28 2","pages":"185-93"},"PeriodicalIF":0.0,"publicationDate":"2006-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s00281-006-0035-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26295182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Current topics in human SLE genetics. 人类SLE遗传学的当前主题。

Springer seminars in immunopathology Pub Date : 2006-10-01 Epub Date: 2006-08-29 DOI: 10.1007/s00281-006-0031-6

Maida Wong, Betty P Tsao

引用次数: 75

Regulatory T cells and innate immune regulation in tumor immunity 调节性T细胞与肿瘤免疫中的先天免疫调节

Springer seminars in immunopathology Pub Date : 2006-09-01 DOI: 10.1007/s00281-006-0044-1

R.-F. Wang

引用次数: 59

Regulatory T cells in pregnancy. 妊娠期的调节性T细胞。

Springer seminars in immunopathology Pub Date : 2006-08-01 Epub Date: 2006-07-13 DOI: 10.1007/s00281-006-0023-6

Ana Claudia Zenclussen

引用次数: 104

The role of virus-induced regulatory T cells in immunopathology. 病毒诱导的调节性 T 细胞在免疫病理学中的作用。

Springer seminars in immunopathology Pub Date : 2006-08-01 Epub Date: 2006-07-14 DOI: 10.1007/s00281-006-0019-2

Shelly J Robertson, Kim J Hasenkrug

{"title":"The role of virus-induced regulatory T cells in immunopathology.","authors":"Shelly J Robertson, Kim J Hasenkrug","doi":"10.1007/s00281-006-0019-2","DOIUrl":"10.1007/s00281-006-0019-2","url":null,"abstract":"In recent years, regulatory T cells have received increased attention for their role in immune responses to microbial infections. The list of microbial pathogens associated with regulatory T cell responses is growing rapidly and includes bacteria, viruses, parasites, and fungi. As the biology of regulatory T cells is revealed, we are discovering that their induction during infection is a normal aspect of immunity, necessary to limit collateral damage from inflammatory responses and aggressive immunological effectors. Thus, these cells play a critical role in maintaining the delicate balance between preventing immunopathology and allowing the immune response to clear infections. While generally successful, there are notable exceptions where regulatory T cell-mediated suppression appears to be responsible for allowing certain viruses to establish and maintain a persistent state. In this review, we will discuss our current understanding of what virus-induced regulatory T cells are, how they are induced, and what mechanisms they use to suppress immunity. The complex role of Tregs in regulating immunity to viral infections, and the consequences their activity has on disease is illustrated by a review of specific viral infections including hepatitis C virus and human immunodeficiency virus.","PeriodicalId":74860,"journal":{"name":"Springer seminars in immunopathology","volume":"28 1","pages":"51-62"},"PeriodicalIF":0.0,"publicationDate":"2006-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7079961/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26144698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Regulatory T cells and innate immune regulation in tumor immunity. 调节性T细胞与肿瘤免疫中的先天免疫调节。

Springer seminars in immunopathology Pub Date : 2006-08-01 Epub Date: 2006-07-13 DOI: 10.1007/s00281-006-0022-7

Rong-Fu Wang

{"title":"Regulatory T cells and innate immune regulation in tumor immunity.","authors":"Rong-Fu Wang","doi":"10.1007/s00281-006-0022-7","DOIUrl":"https://doi.org/10.1007/s00281-006-0022-7","url":null,"abstract":"Innate and adaptive immunity play important roles in immunosurveillance and tumor destruction. However, increasing evidence suggests that tumor-infiltrating immune cells may have a dual function: inhibiting or promoting tumor growth and progression. Although regulatory T (Treg) cells induce immune tolerance by suppressing host immune responses against self- or nonself-antigens, thus playing critical roles in preventing autoimmune diseases, they might inhibit antitumor immunity and promote tumor growth. Recent studies demonstrate that elevated proportions of Treg cells are present in various types of cancers and suppress antitumor immunity. Furthermore, tumor-specific Treg cells can inhibit immune responses only when they are exposed to antigens presented by tumor cells. Therefore, Treg cells at tumor sites have detrimental effects on immunotherapy directed to cancer. This review will discuss recent progress in innate immunity, Treg cells, and their regulation through Toll-like receptor (TLR) signaling. It was generally thought that TLR-mediated recognition of specific structures of invading pathogens initiate innate and adaptive immune responses through dendritic cells. New evidence suggests that TLR signaling may directly regulate the suppressive function of Treg cells. Linking TLR signaling to the functional control of Treg cells opens intriguing opportunities to manipulate TLR signaling to control both innate and adaptive immunity against cancer.","PeriodicalId":74860,"journal":{"name":"Springer seminars in immunopathology","volume":"28 1","pages":"17-23"},"PeriodicalIF":0.0,"publicationDate":"2006-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s00281-006-0022-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26142696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Regulatory T cells in experimental autoimmune disease. 实验性自身免疫性疾病中的调节性T细胞

Springer seminars in immunopathology Pub Date : 2006-08-01 Epub Date: 2006-07-13 DOI: 10.1007/s00281-006-0021-8

Elisabeth Suri-Payer, Benedikt Fritzsching

{"title":"Regulatory T cells in experimental autoimmune disease.","authors":"Elisabeth Suri-Payer, Benedikt Fritzsching","doi":"10.1007/s00281-006-0021-8","DOIUrl":"https://doi.org/10.1007/s00281-006-0021-8","url":null,"abstract":"During the past 10 years, CD4(+)CD25(+)Foxp3(+) regulatory T cells (Treg) have been extensively studied for their function in autoimmune disease. This review summarizes the evidence for a role of Treg in suppression of innate and adaptive immune responses in experimental models of autoimmunity including arthritis, colitis, diabetes, autoimmune encephalomyelitis, lupus, gastritis, oophoritis, prostatitis, and thyroiditis. Antigen-specific activation of Treg, but antigen-independent suppressive function, emerges as a common paradigm derived from several disease models. Treg suppress conventional T cells (Tcon) by direct cell contact in vitro. However, downmodulation of dendritic cell function and secretion of inhibitory cytokines such as IL-10 and TGF-beta might underlie Treg function in vivo. The final outcome of autoimmunity vs tolerance depends on the balance between stimulatory signals (Toll-like receptor engagement, costimulation, and antigen dose) and inhibitory signals from Treg. Whereas most experimental settings analyze the capacity of Treg to prevent onset of autoimmune disease, more recent efforts indicate successful treatment of ongoing disease. Thus, Treg are on the verge of moving from experimental animal models into clinical applications in humans.","PeriodicalId":74860,"journal":{"name":"Springer seminars in immunopathology","volume":"28 1","pages":"3-16"},"PeriodicalIF":0.0,"publicationDate":"2006-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s00281-006-0021-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26142697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 85

Regulatory T cells in microbial infection. 微生物感染中的调节性T细胞。

Springer seminars in immunopathology Pub Date : 2006-08-01 Epub Date: 2006-07-28 DOI: 10.1007/s00281-006-0024-5

Jocelyne Demengeot, Santiago Zelenay, Maria Francisca Moraes-Fontes, Iris Caramalho, António Coutinho

{"title":"Regulatory T cells in microbial infection.","authors":"Jocelyne Demengeot, Santiago Zelenay, Maria Francisca Moraes-Fontes, Iris Caramalho, António Coutinho","doi":"10.1007/s00281-006-0024-5","DOIUrl":"https://doi.org/10.1007/s00281-006-0024-5","url":null,"abstract":"Natural T regulatory cells (NatTReg) limit immunopathology and protective immune responses induced upon microbial infection. In addition, infection increases the number and activity of NatTReg. These findings need to be conciliated with the process of 'self-nonself' discrimination based on the function of NatTReg committed intrathymically and positively selected (and activated) on thymic epithelial cells. A review of the available evidence comforts the assumptions that, in physiological conditions, NatTReg engaged in the immune responses to microbial infections are drawn from the autoreactive repertoire even if some may appear to be microbe specific. This contention also provides a suitable explanation for the 'hygiene hypothesis': infections re-enforce the physiological mechanisms of natural dominant tolerance, through the expansion of naturally occurring regulatory T cells. Accumulating evidence demonstrates that pro-inflammatory ligands of Toll-like receptors expressed by NatTReg, both of microbial (e.g., lipopolysaccharide, flagellin, peptidoglycans) and endogenous (e.g., stress proteins and degradation products of the extracellular matrix) origin, may play a critical role in their activation and expansion. As NatTReg vigorously respond to IL-2/IL-15 locally produced by ongoing effector responses, this whole set of mechanisms provides for a robust feedback process that limits tissue damage and accounts for an 'organism-centered' quality control of immune responses. Detailed knowledge on these molecular and cellular bases should open novel opportunities for intervention in a variety of critical conditions, such as autoimmunity, allergy, chronic infections, and cancer, for which we currently lack effective therapies.","PeriodicalId":74860,"journal":{"name":"Springer seminars in immunopathology","volume":"28 1","pages":"41-50"},"PeriodicalIF":0.0,"publicationDate":"2006-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s00281-006-0024-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26171054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 51

Regulatory T cells in graft-versus-host disease. 移植物抗宿主病中的调节性T细胞。

Springer seminars in immunopathology Pub Date : 2006-08-01 Epub Date: 2006-06-29 DOI: 10.1007/s00281-006-0020-9

Benoît L Salomon, Muriel Sudres, José L Cohen

引用次数: 13