Springer seminars in immunopathology最新文献_第10页

Modulation of antitumor responses by dendritic cells. 树突状细胞抗肿瘤反应的调控。

Springer seminars in immunopathology Pub Date : 2005-01-01 DOI: 10.1007/s00281-004-0175-1

Johannes Vieweg, Andrew Jackson

{"title":"Modulation of antitumor responses by dendritic cells.","authors":"Johannes Vieweg, Andrew Jackson","doi":"10.1007/s00281-004-0175-1","DOIUrl":"https://doi.org/10.1007/s00281-004-0175-1","url":null,"abstract":"The discovery that dendritic cells (DC) play a key role in regulating antitumor immunity has prompted considerable efforts in developing DC-based cancer vaccines for use in clinical oncology. Early translational trials using antigen-loaded DC have established clear evidence of vaccine safety, and demonstrated bioactivity by stimulating immunological and even clinical responses in selected subjects. Despite these encouraging results, the vaccine-induced immune responses achieved to date are not yet sufficient to attain a robust and durable therapeutic effect in the cancer patient. Therefore, further improvements are required to enhance vaccine potency and optimize the potential for clinical success. This article presents a set of emerging concepts that, together, form a framework for a multi-pronged approach that will further enhance the efficacy of DC-based vaccination by either directly improving DC-mediated T cell activation or by inhibiting mechanisms that suppress the induction of an effective antitumor response. The clinical translation of these concepts will result in new opportunities to successfully modulate immune responses in clinical settings.","PeriodicalId":74860,"journal":{"name":"Springer seminars in immunopathology","volume":" ","pages":"329-41"},"PeriodicalIF":0.0,"publicationDate":"2005-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s00281-004-0175-1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25039303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 26

Factors and signals that govern the migration of dendritic cells via lymphatics: recent advances. 控制树突状细胞通过淋巴管迁移的因素和信号:最新进展。

Springer seminars in immunopathology Pub Date : 2005-01-01 DOI: 10.1007/s00281-004-0168-0

Gwendalyn J Randolph, Guzman Sanchez-Schmitz, Veronique Angeli

{"title":"Factors and signals that govern the migration of dendritic cells via lymphatics: recent advances.","authors":"Gwendalyn J Randolph, Guzman Sanchez-Schmitz, Veronique Angeli","doi":"10.1007/s00281-004-0168-0","DOIUrl":"https://doi.org/10.1007/s00281-004-0168-0","url":null,"abstract":"Dendritic cell (DC) migration from peripheral organs to lymph nodes plays a key role in initiating immune responses, whether migratory DCs bring antigen in tow to lymph nodes or position themselves to capture antigen that drains into the lymph node. CCR7 prominently controls DC migration into afferent lymphatic vessels and the positioning of DCs within the lymph node. Expression of CCR7 is not sufficient for function, as its function is positively regulated by a variety of other extracellular triggers. At least one of these triggers, synthesis and secretion of PGE(2), is brought on by the activation of p38 MAP kinase. The MAP kinase pathway has been well studied in DCs and exhibits a complex regulatory role in which the activation of different MAP kinase members leads to biologically distinct outcomes that are dependent upon stage of differentiation at the time of activation as well as the duration of signaling. Almost all of our knowledge of how DCs mature and ultimately mobilize to lymph nodes comes from studies in which DC migration is probed in the context of immune activation and priming. A reasonable body of evidence has gathered to suggest that many molecular events important for DC migration in this context do not affect accumulation of DCs in lymph nodes in the steady state, but mediators that interface with the signaling adaptor DAP-12 may play key roles in the steady state. It may thus become possible to devise approaches to modulate DC mobilization in the context of inflammation without affecting the traffic of DCs during more quiescent conditions. Considering the finely tuned regulation of DC maturation, migration, and cytokine production, with the realization that these phenotypes can be mutually exclusive, manipulation of DC migration in the clinic will be a challenging, albeit feasible, task.","PeriodicalId":74860,"journal":{"name":"Springer seminars in immunopathology","volume":"26 3","pages":"273-87"},"PeriodicalIF":0.0,"publicationDate":"2005-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s00281-004-0168-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24659441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 147

Natural endogenous adjuvants. 天然内源性佐剂。

Springer seminars in immunopathology Pub Date : 2005-01-01 Epub Date: 2004-10-14 DOI: 10.1007/s00281-004-0173-3

Kenneth L Rock, Arron Hearn, Chun-Jen Chen, Yan Shi

{"title":"Natural endogenous adjuvants.","authors":"Kenneth L Rock, Arron Hearn, Chun-Jen Chen, Yan Shi","doi":"10.1007/s00281-004-0173-3","DOIUrl":"https://doi.org/10.1007/s00281-004-0173-3","url":null,"abstract":"It has long been known that immunization with a protein by itself is often not sufficient to stimulate immunity, and may instead induce tolerance. To elicit productive immune responses exogenous adjuvants need to be co-injected with an antigen. One important class of adjuvants are the unique (non-mammalian) components of microbes. It is now believed that an adjuvant is required for immunity because the immune system evolved to respond to dangerous situations such as infections, and the presence of an adjuvant is the mechanism used to identify these situations. However, there are some circumstances where immune responses are generated in the apparent absence of any microbial or other exogenous adjuvant. Such situations include immune responses to transplants, tumors, autoimmunity and possibly certain viral infections. It has been postulated that in these situations the danger signals come from endogenous adjuvants that are released from dying cells. There is abundant evidence that dead cells are immunogenic, and recently it has been shown that cells contain endogenous adjuvant activities that are released after death. Some actual and putative endogenous adjuvants, such as monosodium urate and heat shock proteins, have been identified and there are others whose identities are not yet known. The potential biological roles of this class of adjuvants are discussed.","PeriodicalId":74860,"journal":{"name":"Springer seminars in immunopathology","volume":" ","pages":"231-46"},"PeriodicalIF":0.0,"publicationDate":"2005-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s00281-004-0173-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24869313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 163

Plasmacytoid dendritic cell precursors/type I interferon-producing cells sense viral infection by Toll-like receptor (TLR) 7 and TLR9. 浆细胞样树突状细胞前体/ I型干扰素产生细胞通过toll样受体(TLR) 7和TLR9感知病毒感染。

Springer seminars in immunopathology Pub Date : 2005-01-01 Epub Date: 2004-11-13 DOI: 10.1007/s00281-004-0180-4

Tomoki Ito, Yui-Hsi Wang, Yong-Jun Liu

引用次数: 217

Pathways for antigen cross presentation. 抗原交叉递呈途径。

Springer seminars in immunopathology Pub Date : 2005-01-01 Epub Date: 2004-12-03 DOI: 10.1007/s00281-004-0176-0

Pierre Guermonprez, Sebastian Amigorena

{"title":"Pathways for antigen cross presentation.","authors":"Pierre Guermonprez, Sebastian Amigorena","doi":"10.1007/s00281-004-0176-0","DOIUrl":"https://doi.org/10.1007/s00281-004-0176-0","url":null,"abstract":"Dendritic cells (DCs) have the unique ability to capture cellular tissue antigens, and to present them on MHC class I molecules to antigen-specific CD8(+) T lymphocytes after migration to the draining lymph nodes. This process, called \"cross presentation\" can lead either to the tolerization or activation of antigen-specific CD8(+) T cells. Antigen capture is believed to occur by phagocytosis of antigen-bearing dead cells. Recent studies suggest that the antigen transferred from the phagocytosed cell to the DC during cross presentation is a proteasome substrate, rather than a proteasomal degradation product. In most cases, the formation of the peptide-MHC class I complexes in DCs requires the export of protein antigens from phagosomes to the cytosol, where they undergo proteasomal degradation. The resulting peptides are then translocated by TAP to the lumen of a cross presentation-loading compartment, for association to MHC class I under the control of chaperones and oxido-reductases. This loading compartment may be either the endoplasmic reticulum (ER) or a mix phagosome-ER compartment. MHC class I egress from the loading compartment to cell surface remains to be analyzed.","PeriodicalId":74860,"journal":{"name":"Springer seminars in immunopathology","volume":" ","pages":"257-71"},"PeriodicalIF":0.0,"publicationDate":"2005-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s00281-004-0176-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24856522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 107

HIV-1 and the hijacking of dendritic cells: a tug of war. HIV-1和劫持树突状细胞:一场拉锯战。

Springer seminars in immunopathology Pub Date : 2005-01-01 DOI: 10.1007/s00281-004-0178-y

Marie Larsson

引用次数: 35

Dendritic cell-mediated T cell polarization. 树突细胞介导的T细胞极化。

Springer seminars in immunopathology Pub Date : 2005-01-01 Epub Date: 2004-10-14 DOI: 10.1007/s00281-004-0167-1

Esther C de Jong, Hermelijn H Smits, Martien L Kapsenberg

引用次数: 394

Modulation of the immune system by synthetic polynucleotides 合成多核苷酸对免疫系统的调节

Springer seminars in immunopathology Pub Date : 2005-01-01 DOI: 10.1007/BF01891666

A. G. Johnson

引用次数: 2

Lysophosphatidylcholine (lysolecithin) and its synthetic analogues. Immunemodulating and other biologic effects 溶血磷脂酰胆碱及其合成类似物。免疫调节和其他生物效应

Springer seminars in immunopathology Pub Date : 2005-01-01 DOI: 10.1007/BF01891668

P. G. Munder, M. Modolell, R. Andreesen, H. Weltzien, O. Westphal

引用次数: 28

Induction of antigen cross-presentation by Toll-like receptors. toll样受体诱导抗原交叉递呈。

Springer seminars in immunopathology Pub Date : 2005-01-01 Epub Date: 2004-10-14 DOI: 10.1007/s00281-004-0174-2

Sandip K Datta, Eyal Raz

引用次数: 40