Allergologie Select最新文献_第4页

111 years of allergen-immunotherapy: A long and successful history of the only available disease-modifier in allergic diseases. 111年的过敏原免疫治疗:过敏性疾病中唯一可用的疾病调节剂的漫长而成功的历史。

Allergologie Select Pub Date : 2022-01-01 DOI: 10.5414/ALX02330E

Jan Gutermuth, Martine Grosber, Oliver Pfaar, Karl Christian Bergmann, Johannes Ring

{"title":"111 years of allergen-immunotherapy: A long and successful history of the only available disease-modifier in allergic diseases.","authors":"Jan Gutermuth, Martine Grosber, Oliver Pfaar, Karl Christian Bergmann, Johannes Ring","doi":"10.5414/ALX02330E","DOIUrl":"https://doi.org/10.5414/ALX02330E","url":null,"abstract":"The great milestones in medicine almost always have their precursors, which help the great event to break through. So it was with allergen-specific immunotherapy (AIT) and the great work of Noon and Freeman and their world-renowned publication in 1911. In this article, we want to outline AIT's long journey, from early attempts to achieve tolerance to allergens in the environment. Many very different methods were used; from homeopathy to the use of recombinant allergens. Initially, the allergen extracts were given only subcutaneously, but then also through other routes, such as nasal, rectal, intradermal, epicutaneous, in lymph nodes, or oral. It was the great merit of Bill Franklin, whom many of us still experienced as active participants in congresses, to point out that the effect of AIT must be documented not only by clinical observation but in a controlled form including placebo injections. AIT was thus transferred to evidence-based medicine, which we successfully apply today. We would like to express our gratitude to Bill Franklin himself and all others involved in the development of AIT with this summary of 111 years of immunotherapy.","PeriodicalId":7485,"journal":{"name":"Allergologie Select","volume":"6 ","pages":"248-258"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9707371/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10268088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Alpha-gal syndrome and delayed anaphylaxis after ingestion of red meat: A case report. α -半乳糖综合征和摄入红肉后的延迟过敏反应:一例报告。

Allergologie Select Pub Date : 2022-01-01 DOI: 10.5414/ALX02394E

Lea Caron, Valeria G R Ortolani, Eleonora Bono, Christian P Ratti, Enrico Iemoli

{"title":"Alpha-gal syndrome and delayed anaphylaxis after ingestion of red meat: A case report.","authors":"Lea Caron, Valeria G R Ortolani, Eleonora Bono, Christian P Ratti, Enrico Iemoli","doi":"10.5414/ALX02394E","DOIUrl":"https://doi.org/10.5414/ALX02394E","url":null,"abstract":"α-gal syndrome (AGS) is caused by the intake of products containing α-gal (galactose-α-1,3-galactose) like mammalian meat. Over the last decade, scientific literature about AGS has been increasing, but the true burden of cases is still unknown [1, 2]. In the USA (University of Virginia Allergy Clinic), the number of confirmed cases of AGS was 24 in 2009 [3] and increased to 34,000 in the entire USA by 2019 [4]. As shown in surveys, in Italy AGS is present throughout the country [5]. The literature suggests that a previous tick bite can cause AGS, but in our case it was not possible to demonstrate this association as the patient did not recall any tick bite, even in childhood. After eating red meat, a 56-year-old male patient had developed symptoms such as a generalized urticaria, diarrhea, and faintness, requiring admission to the Emergency Department. The diagnosis was verified using blood CAP-FEIA test and prick-to-prick test. After completing the diagnostic process, we provided the patient with emergency therapy, and auto-injectable adrenaline was prescribed. Despite the diagnosis, the patient ate red meat once again which resulted in severe urticaria 2 hours after the meal, requiring a second visit to the Emergency Room. Now the patient is under follow-up at our Department of Allergy and Clinical Immunology.","PeriodicalId":7485,"journal":{"name":"Allergologie Select","volume":"6 ","pages":"299-303"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9793718/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10800682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Digital health for allergen immunotherapy. 过敏原免疫治疗的数字健康。

Allergologie Select Pub Date : 2022-01-01 DOI: 10.5414/ALX02301E

Stephanie Dramburg, Paolo Maria Matricardi, Oliver Pfaar, Ludger Klimek

引用次数: 2

Cutaneous mastocytosis in childhood. 儿童皮肤肥大细胞增多症。

Allergologie Select Pub Date : 2022-01-01 DOI: 10.5414/ALX02304E

Katja Nemat, Susanne Abraham

{"title":"Cutaneous mastocytosis in childhood.","authors":"Katja Nemat, Susanne Abraham","doi":"10.5414/ALX02304E","DOIUrl":"https://doi.org/10.5414/ALX02304E","url":null,"abstract":"Mastocytoses are characterized by clonal proliferation of mast cells in various tissues. In childhood, cutaneous mastocytosis (CM) occurs almost exclusively. It is confined to the skin, and has a good prognosis. The most common form is the maculopapular cutaneous mastocytosis (MPCM), formerly called urticaria pigmentosa. A distinction is made between a monomorphic variant of MPCM with multiple small, roundish maculopapular skin lesions and the - more common - polymorphic variant with larger lesions of variable size. One quarter of CM diagnosed in childhood are mastocytomas, which often occur solitary or at multiple sites. The diffuse variant of CM (DCM), which affects 5% of children with CM, should be distinguished from these forms. Systemic mastocytoses (SM) with mast cell infiltrates in the bone marrow or other extracutaneous tissues, such as the gastrointestinal tract, occur predominantly in adults. The diagnosis of CM is usually made clinically: Manifestation in infancy, typical morphology and distribution, pathognomonic Darier sign. Basal serum tryptase is determined if DCM or systemic mastocytosis are to be diagnosed. Children with mastocytosis should be managed in a specialized outpatient clinic. For affected families, detailed information about the clinical picture including prognosis assessment is essential. Mast cell mediated symptoms are controlled by oral non-sedating antihistamines if needed.","PeriodicalId":7485,"journal":{"name":"Allergologie Select","volume":"6 ","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8750954/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9622843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Nonpharmacological measures to prevent allergic symptoms in pollen allergy: A critical review. 预防花粉过敏症状的非药物措施：重要综述。

Allergologie Select Pub Date : 2021-12-01 eCollection Date: 2021-01-01 DOI: 10.5414/ALX02294E

Karl-Christian Bergmann, Markus Berger, Ludger Klimek, Oliver Pfaar, Barbora Werchan, Matthias Werchan, Torsten Zuberbier

{"title":"Nonpharmacological measures to prevent allergic symptoms in pollen allergy: A critical review.","authors":"Karl-Christian Bergmann, Markus Berger, Ludger Klimek, Oliver Pfaar, Barbora Werchan, Matthias Werchan, Torsten Zuberbier","doi":"10.5414/ALX02294E","DOIUrl":"10.5414/ALX02294E","url":null,"abstract":"Allergic rhinoconjunctivitis (hay fever) is the most common chronic disease in all industrialized nations. Therapy consists essentially in the use of anti-allergic and anti-inflammatory drugs, which mostly show a good and quick effect. With allergen-specific immunotherapy, there is also a causal possibility of tolerance induction. There is currently a considerable undersupply, as those affected trivialize the symptoms and often have concerns about long-term drug therapy. There is also great interest in using non-medicinal measures to prevent and/or relieve allergic symptoms on the assumption that these are free from side effects. In this publication, we present non-drug methods for which clinical studies are available in the literature. The methods have varying degrees of effectiveness. An evidence-based comparative assessment between the methods is not possible. There are also hardly any studies in comparison to standard drug therapy. A large number of the interventions consist of allergen reduction, e.g., with air filters, or cleaning of the mucous membranes with nasal irrigation, etc., none of which should be seen as a substitute but as a supplement to drug therapy.","PeriodicalId":7485,"journal":{"name":"Allergologie Select","volume":"5 ","pages":"349-360"},"PeriodicalIF":0.0,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8638355/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39785692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The influence of air pollution on pollen allergy sufferers. 空气污染对花粉过敏患者的影响。

Allergologie Select Pub Date : 2021-12-01 eCollection Date: 2021-01-01 DOI: 10.5414/ALX02284E

Markus Berger, Maximilian Bastl, Johannes Bouchal, Lukas Dirr, Uwe Berger

引用次数: 9

Allergic contact dermatitis to rubber accelerators in protective gloves: Problems, challenges, and solutions for occupational skin protection. 防护手套中橡胶加速剂引起的过敏性接触性皮炎:职业性皮肤保护的问题、挑战和解决方案。

Allergologie Select Pub Date : 2021-10-22 eCollection Date: 2021-01-01 DOI: 10.5414/ALX02265E

Andreas Hansen, Richard Brans, Flora Sonsmann

{"title":"Allergic contact dermatitis to rubber accelerators in protective gloves: Problems, challenges, and solutions for occupational skin protection.","authors":"Andreas Hansen, Richard Brans, Flora Sonsmann","doi":"10.5414/ALX02265E","DOIUrl":"https://doi.org/10.5414/ALX02265E","url":null,"abstract":"Protective gloves are an elementary component of personal protective equipment in many occupations and are intended to protect the hands from various hazards (e.g., wetness, chemicals, mechanical forces, or thermal stress). This is particularly important when other occupational safety measures (e.g., technical-organizational measures) cannot be implemented or are insufficient. However, it is not uncommon for protective gloves themselves to become a problem, as some of their ingredients (e.g., rubber accelerators) can cause allergic reactions. Accelerators in rubber gloves include thiurams, dithiocarbamates, thiazoles, guanidines, and thioureas. If no alternative means of protection are available, this may even result in abandoning the profession. This article is about rubber accelerators, which are often contained in protective gloves made of different rubber materials (e.g., natural rubber (latex) and nitrile rubber) and may cause delayed-type allergies, as well as related challenges, problems, and solutions for occupational skin protection.","PeriodicalId":7485,"journal":{"name":"Allergologie Select","volume":"5 ","pages":"335-344"},"PeriodicalIF":0.0,"publicationDate":"2021-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8561832/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39693691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Allergologie Select Pub Date : 2021-10-05 eCollection Date: 2021-01-01 DOI: 10.5414/ALX02280E

Alexandra M Preisser, Dirk Koschel, Rolf Merget, Dennis Nowak, Monika Raulf, Jan Heidrich

引用次数: 2

Guideline on management of suspected adverse reactions to ingested histamine: Guideline of the German Society for Allergology and Clinical Immunology (DGAKI), the Society for Pediatric Allergology and Environmental Medicine (GPA), the Medical Association of German Allergologists (AeDA) as well as the Swiss Society for Allergology and Immunology (SGAI) and the Austrian Society for Allergology and Immunology (ÖGAI). 摄入组胺的疑似不良反应管理指南:德国过敏学和临床免疫学学会(DGAKI)、儿科过敏学和环境医学学会(GPA)、德国过敏学家医学协会(AeDA)、瑞士过敏学和免疫学学会(SGAI)和奥地利过敏学和免疫学学会(ÖGAI)指南。

Allergologie Select Pub Date : 2021-10-05 eCollection Date: 2021-01-01 DOI: 10.5414/ALX02269E

Imke Reese, Barbara Ballmer-Weber, Kirsten Beyer, Sabine Dölle-Bierke, Jörg Kleine-Tebbe, Ludger Klimek, Sonja Lämmel, Ute Lepp, Joachim Saloga, Christiane Schäfer, Zsolt Szepfalusi, Regina Treudler, Thomas Werfel, Torsten Zuberbier, Margitta Worm

{"title":"Guideline on management of suspected adverse reactions to ingested histamine: Guideline of the German Society for Allergology and Clinical Immunology (DGAKI), the Society for Pediatric Allergology and Environmental Medicine (GPA), the Medical Association of German Allergologists (AeDA) as well as the Swiss Society for Allergology and Immunology (SGAI) and the Austrian Society for Allergology and Immunology (ÖGAI).","authors":"Imke Reese, Barbara Ballmer-Weber, Kirsten Beyer, Sabine Dölle-Bierke, Jörg Kleine-Tebbe, Ludger Klimek, Sonja Lämmel, Ute Lepp, Joachim Saloga, Christiane Schäfer, Zsolt Szepfalusi, Regina Treudler, Thomas Werfel, Torsten Zuberbier, Margitta Worm","doi":"10.5414/ALX02269E","DOIUrl":"https://doi.org/10.5414/ALX02269E","url":null,"abstract":"Adverse reactions to food or food ingredients are more often perceived than objectively verifiable. However, reliable laboratory tests are often lacking. As a result, people with perceived adverse reactions to food often follow extensive elimination diets for years and unnecessarily restrict their diet, as in the case of the frequently suspected histamine intolerance. In this condition, laboratory parameters such as the determination of diamine oxidase in serum have been shown to be inconclusive. The lack of symptom reproducibility calls into question the clinical picture of adverse reactions to ingested histamine. In order to approach persons with perceived histamine intolerance and to support them in moving from blanket restrictions, which are often unnecessarily strict, to effective personalized therapeutic strategies, the present guideline of the Working Group on Food Allergy of the German Society of Allergology and Clinical Immunology (DGAKI) in cooperation with the Medical Association of German Allergists (AeDA), the Pediatric Allergology and Environmental Medicine (GPA) as well as the Swiss Society of Allergology and Immunology (SGAI) and the Austrian Society of Allergology and Immunology (ÖGAI) recommends a practicable diagnostic and therapeutic approach.","PeriodicalId":7485,"journal":{"name":"Allergologie Select","volume":"5 ","pages":"305-314"},"PeriodicalIF":0.0,"publicationDate":"2021-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8511827/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39522316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Janus kinase inhibitors for the therapy of atopic dermatitis. Janus激酶抑制剂治疗特应性皮炎。

Allergologie Select Pub Date : 2021-08-27 eCollection Date: 2021-01-01 DOI: 10.5414/ALX02272E

Stephan Traidl, Sina Freimooser, Thomas Werfel

引用次数: 33