Kristal S Potter, Jessica Beal-Stahl, Megan Luaces, Kevin Chin, Anam F Ismail, Courtney Guerra
{"title":"Unlocking Performance: Pharmacogenomic Insights for Athletes.","authors":"Kristal S Potter, Jessica Beal-Stahl, Megan Luaces, Kevin Chin, Anam F Ismail, Courtney Guerra","doi":"10.1055/a-2957-1103","DOIUrl":"10.1055/a-2957-1103","url":null,"abstract":"<p><p>Pharmacogenomics is the study of how genetic differences influence drug responses, offering a safer and more effective prescribing model. While pharmacogenomics is well-established in specialties such as oncology and psychiatry, its application in sports medicine remains limited. Athletes frequently use medications such as nonsteroidal anti-inflammatory drugs, opioids, and selective serotonin reuptake inhibitors, and these medications have well-documented gene-drug interactions. This review explores pharmacogenomics considerations for these commonly used substances in athletic populations, emphasizing how genetic variability in drug-metabolizing enzymes, including CYP2C9, CYP2D6, and CYP2C19, can impact medication efficacy and side effect risks. We summarize current evidence, highlight clinical guidelines, and outline how pharmacogenomics-guided prescribing could improve athlete care. By integrating pharmacogenomics into sports medicine, clinicians can tailor medication strategies to each athlete's genetic profile, supporting both health and performance. Broader adoption will require increased clinician education, interdisciplinary collaboration, and research specific to athletic populations, but pharmacogenomics offers a promising tool for advancing individualized, precision-based athlete healthcare.</p>","PeriodicalId":74857,"journal":{"name":"Sports medicine international open","volume":"10 ","pages":"a29571103"},"PeriodicalIF":0.0,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13643732/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149139867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tess Treinen Swake, Christopher M Juneau, Jason Tuori, Gabriel J Haberly
{"title":"Novel Isometric Testing of Frontal Plane Hip Strength in Collegiate Cross-Country Runners.","authors":"Tess Treinen Swake, Christopher M Juneau, Jason Tuori, Gabriel J Haberly","doi":"10.1055/a-2940-7121","DOIUrl":"10.1055/a-2940-7121","url":null,"abstract":"<p><p>In this cross-sectional study, we aimed to describe preseason hip abduction and adduction strength in Division III cross-country athletes using an externally fixated inline tension dynamometer to report sex-stratified normalized torque values (Nm/kg) and adduction:abduction ratios. Maximal isometric hip abduction and adduction peak forces were measured during a single session and normalized to body mass and moment arm length. Participants included 35 male runners (18.9±0.90 y) and 26 female runners (19.0±1.1 y). Normalized hip torque (Nm/kg) (right/left) for men was: abduction (1.82±0.38/1.84±0.36), adduction (1.98±0.43/1.70±0.41), and adduction:abduction ratio (1.10±0.18/0.92±0.12). Normalized hip torque (Nm/kg) (right/left) for women was: abduction (1.45±0.25/1.43±0.27), adduction (1.40±0.22/1.34±0.28), and adduction:abduction ratio (0.98±0.14/0.95±0.15). By accounting for joint moment arm length and body mass while minimizing measurement variability through rigid external fixation, this study establishes sex-stratified normative isometric hip strength reference profiles in healthy collegiate distance runners to support baseline strength profiling and standardized clinical screening.</p>","PeriodicalId":74857,"journal":{"name":"Sports medicine international open","volume":"10 ","pages":"a29407121"},"PeriodicalIF":0.0,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13559690/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148932056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lauren B L Jutlah, Kailey A Stevens, Ashley Meelu, Jeremy N Cohen, Jennifer Murphy, Joe P Warne, Jason S Au
{"title":"Work-to-rest ratios in repeated sprint assessments: A replication study.","authors":"Lauren B L Jutlah, Kailey A Stevens, Ashley Meelu, Jeremy N Cohen, Jennifer Murphy, Joe P Warne, Jason S Au","doi":"10.1055/a-2940-7047","DOIUrl":"10.1055/a-2940-7047","url":null,"abstract":"<p><p>Replication projects provide supplementary evidence to reinforce the veracity of novel claims. The Sports Science Replication Centre conducted an international effort to assess the replicability of sports and exercise science research; our research group was assigned to replicate the study by La Monica et al (2016) who reported that larger work-to-rest ratios during repeated cycle sprinting elicited greater oxygen consumption during the rest periods. Participants ( <i>n</i> = 21 men, 23 ± 3 y) completed a familiarization and three experimental visits of 10 maximal 6-second cycle sprints against a resistance of 7.5% body weight separated by one of the three active rest intervals: 24 seconds (1:4 work-to-rest ratio), 18 seconds (1:3), or 12 seconds (1:2). Both V̇O <sub>2work</sub> and V̇O <sub>2rest</sub> were higher during the 12-second rest interval compared to the 18-second and 24-second rest intervals ( <i>p</i> < 0.01). Changes in V̇O <sub>2rest</sub> were similar to the original study, although our observed effect size was lower (partial <i>η</i> <sup>2</sup> = 0.41 compared to the original partial <i>η</i> <sup>2</sup> = 0.75), consistent with typical replication studies. We observed differences in V̇O <sub>2work</sub> unlike the original study which found no differences between work-to-rest conditions. This replication attempt was partially successful in corroborating previous findings, supporting that larger work-to-rest ratios lead to decreased sprint performance and larger V̇O <sub>2</sub> demands, with more conservative effect sizes.</p>","PeriodicalId":74857,"journal":{"name":"Sports medicine international open","volume":"10 ","pages":"a29407047"},"PeriodicalIF":0.0,"publicationDate":"2026-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13551447/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148914680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Prevalence of Hip Skeletal Deformity in Japanese Male Collegiate Long-Distance Runners.","authors":"Ryota Yamamoto, Toshiharu Tsutsui, Suguru Torii","doi":"10.1055/a-2898-7378","DOIUrl":"10.1055/a-2898-7378","url":null,"abstract":"<p><p>This study aimed to examine whether hip deformity has already developed in Japanese male freshman collegiate long-distance runners and to investigate the association with their sports history.A total of 57 elite freshman collegiate long-distance runners participated. We collected sports history data during adolescence using a questionnaire, and hip images were measured using dual-energy X-ray absorptiometry. Cam morphology was defined based on visual scores of the anterior head-neck junction, classified as follows: (i) normal, (ii) flattening, and (iii) prominence. Pincer morphology was defined as a bony prominence or osteophyte-like protrusion at the acetabular rim.Cam morphology based on visual scores was found in 78 of 114 hips (68.4%; 40 right and 38 left). Pincer morphology based on visual scores was found in 73 of 114 hips (64.0%; 39 right and 34 left). There was no significant association between hip deformity and sports participation history ( <i>p</i> >0.58). In an additional exploratory non-athletic cohort, a similarly high prevalence of cam and pincer morphology was observed (cam: 14 of 18 hips [77.8%]; pincer: 13 of 18 hips [72.2%]). These may indicate that factors beyond participation in multidirectional sports, including internal factors, could contribute to hip morphology.</p>","PeriodicalId":74857,"journal":{"name":"Sports medicine international open","volume":"10 ","pages":"a28987378"},"PeriodicalIF":0.0,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13551460/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148914576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lotte van Dam, Rieneke Terink, Inge van den Akker-Scheek, Johannes Zwerver
{"title":"Monitoring Patellar Tendon Stiffness in Relation to Load, Function and Pain.","authors":"Lotte van Dam, Rieneke Terink, Inge van den Akker-Scheek, Johannes Zwerver","doi":"10.1055/a-2930-7880","DOIUrl":"10.1055/a-2930-7880","url":null,"abstract":"<p><p>Monitoring patellar tendon stiffness may provide new insights into tendon adaptation due to loads and pathology. This 12-week prospective observational pilot study aimed to determine the feasibility of monitoring patellar tendon stiffness in relation to training load, pain, and function in male talent volleyball players. Feasibility outcomes included willingness to participate and retention rate, measurement completeness, and adverse events. Willingness to participate and retention rate were 100% in the included 15 volleyball players. Measurement completeness was below the pre-defined success criteria: 72% for stiffness before training and 66% after training; 52% for internal load and 38% for external load; 71% for experienced pain measurements; and 68% for questionnaire completion. This feasibility study indicates that there are several challenges in obtaining a complete data set when monitoring talented volleyball players. Communication between researcher-coach-athlete, feedback on collected data, and education on the importance of maintaining (tendon) health can be considered important factors to overcome these challenges.</p>","PeriodicalId":74857,"journal":{"name":"Sports medicine international open","volume":"10 ","pages":"a29307880"},"PeriodicalIF":0.0,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13551455/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148914510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Roberto C M Leite, Rhaí A Arriel, Rodney Paixão, Leandro Sant'Ana, Moacir Marocolo
{"title":"Beyond the <i>p</i> -value: Pitfalls in Reporting and Applying Statistical Tests in Sports Science.","authors":"Roberto C M Leite, Rhaí A Arriel, Rodney Paixão, Leandro Sant'Ana, Moacir Marocolo","doi":"10.1055/a-2917-0363","DOIUrl":"10.1055/a-2917-0363","url":null,"abstract":"<p><p>Statistical inference underpins the credibility of sports science research, yet concerns remain regarding the rigor of statistical reporting and analysis. This study assessed the adequacy of statistical practices in sports science research according to established methodological guidelines. A total of 167 original studies published in 2020 across 15 sports science journals indexed in the Journal Citation Reports (Q1-Q3) were systematically reviewed. Up to 50 studies per journal were randomly selected, and data regarding study characteristics and statistical methods were extracted. Statistical adequacy was classified according to predefined criteria involving reporting omissions and/or statistical misapplications. Overall, 87.4% of studies presented at least one inadequacy. The most frequent reporting omissions involved failure to report assumptions such as normality, homogeneity of variances, and sphericity when required. Common statistical misapplications included the use of inappropriate dependent variables and incorrect treatment of independent observations as dependent measures. Deficiencies were identified across all journal quartiles, with no association between adequacy and journal ranking ( <i>p</i> =0.586). These findings raise concerns regarding validity, reproducibility, and practical interpretation in sports science research, reinforcing the need for greater statistical literacy, stricter reporting standards, and improved peer review practices.</p>","PeriodicalId":74857,"journal":{"name":"Sports medicine international open","volume":"10 ","pages":"a29170363"},"PeriodicalIF":0.0,"publicationDate":"2026-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13463360/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148727287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anna Maria Wissmann, Mohamed El Houssaini, Mathew W Hill, Thomas Muehlbauer
{"title":"Effects of balance training distribution on balance performance in adolescents.","authors":"Anna Maria Wissmann, Mohamed El Houssaini, Mathew W Hill, Thomas Muehlbauer","doi":"10.1055/a-2898-7328","DOIUrl":"10.1055/a-2898-7328","url":null,"abstract":"<p><p>It is firmly established that balance training leads to significant improvements in postural control in youth. However, little is known about how differences in balance training distribution (i.e., how total training volume is scheduled: duration×frequency), despite the equal total training volume, affect training-induced adaptations. This study was aimed at determining the effect of balance training distribution on balance performance. Twenty-five adolescents (15.8±0.6 y) were randomly assigned to either a 4-week balance training-3×/wk group (massed practice: 4 weeks of balance training for three sessions/wk) or a 6-week balance training-2×/wk group (distributed practice: 6 weeks of BT for two sessions/wk) group. Balance assessments included the timed One-Legged Stance test and the Y Balance Test Lower-Quarter. Significant pretest to post-test improvements were detected for all parameters of the One-Legged Stance test and Y Balance Test Lower-Quarter, irrespective of balance training distribution. Additionally, a group×test interaction ( <i>p</i> =0.041 and <i>η</i> <sub>p</sub> <sup>2</sup> =0.17) was detected for the posterolateral reach distance in favor of the massed practice group. These findings highlight that most outcomes improved regardless of balance training distribution, and only one outcome showed a benefit for the combination of shorter balance training duration with higher balance training frequency (i.e., massed practice) than vice versa (i.e., distributed practice).</p>","PeriodicalId":74857,"journal":{"name":"Sports medicine international open","volume":"10 ","pages":"a28987328"},"PeriodicalIF":0.0,"publicationDate":"2026-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13463927/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148724033","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ryan W Paul, Ryan Park, Francis J Sirch, Joelle Nyugen, Meghan E Bishop, Kevin B Freedman
{"title":"Injuries in Professional Roundnet (Spikeball) Athletes.","authors":"Ryan W Paul, Ryan Park, Francis J Sirch, Joelle Nyugen, Meghan E Bishop, Kevin B Freedman","doi":"10.1055/a-2891-5869","DOIUrl":"10.1055/a-2891-5869","url":null,"abstract":"<p><p>This study aimed to evaluate training workload and injury history in specifically professional roundnet athletes. An anonymous survey regarding players' injuries specific to roundnet was created with input from two premier roundnet athletes and two orthopedic surgeons. The 56 Spikeball Tour Series professional roundnet athletes from the 2023 season were contacted after the 2023 season to complete an anonymous injury history survey. Overall, 49 (88%) of the 56 professional roundnet athletes from the 2023 season were included in the study. Professional roundnet athletes had been competing in roundnet for a mean of 4 years and train 9.5 months per year. Players reported 82 roundnet injuries comprised of 43 (52%) upper extremity injuries, 24 (29%) lower extremity injuries, and 15 (18%) axial injuries. No reported injuries required surgical treatment. Upper extremity, lower extremity, and axial injuries had an average time to return to sport (RTS) of 1.8 months, 2.8 months, and 2.2 months missed, respectively. In conclusion, the upper extremity is the most commonly injured region in professional roundnet athletes, accounting for about half of roundnet injuries. Professional roundnet athletes most frequently experience significant acute injuries of the elbow and ankle, and significant chronic injuries of the shoulder and lower back.</p>","PeriodicalId":74857,"journal":{"name":"Sports medicine international open","volume":"10 ","pages":"a28915869"},"PeriodicalIF":0.0,"publicationDate":"2026-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13460297/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148714848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Katherine Frances Maguire, Margaret Wydotis, Jason Jaggers, Pete Quesada, Jennifer Daily, Yvette Cabrera-Rojas, John Francis Caruso
{"title":"Palm Cooling's Heart Rate and Thermal Impact on Exercise in Multiple Sclerosis Patients.","authors":"Katherine Frances Maguire, Margaret Wydotis, Jason Jaggers, Pete Quesada, Jennifer Daily, Yvette Cabrera-Rojas, John Francis Caruso","doi":"10.1055/a-2877-8927","DOIUrl":"10.1055/a-2877-8927","url":null,"abstract":"<p><p>Heat strain in multiple sclerosis patients during exercise limits their benefits from this treatment. One prior study examined this topic but did not measure thermal outcomes and constitutes a knowledge gap. The current pilot study assessed palm cooling for its impact on heart rates and thermal measures. Using a randomized within-subjects design, nine multiple sclerosis patients performed two 25-minute cycle ergometry workouts against 65 and 45% of their Astrand-Rhyming-based workloads. Heart rates, thermal flux, palm and tympanic temperatures were examined using two-way analyses of variance with repeated measures per independent variable. To control the family-wise error rate, a Bonferroni correction was applied at a lower α level of 0.0024. Paired <i>t</i> -tests identified sources of significant inter-treatment and -time differences. Palm temperature, thermal flux, and heart rate had significant two-way interactions. Palm temperature ( <i>η</i> <sup>2</sup> <sub><i>p</i></sub> =0.39) and heart rate ( <i>η</i> <sup>2</sup> <sub><i>p</i></sub> =0.22) results were significantly higher for the no palm cooling treatment at multiple times during and after workouts. Yet, thermal flux ( <i>η</i> <sup>2</sup> <sub><i>p</i></sub> =0.39) was significantly higher due to palm cooling at multiple times during and after workouts. Higher thermal flux from palm cooling may have evoked lower heart rates. Palm cooling may represent a practical strategy to mitigate exercise-induced heat strain in individuals with multiple sclerosis.</p>","PeriodicalId":74857,"journal":{"name":"Sports medicine international open","volume":"10 ","pages":"a28778927"},"PeriodicalIF":0.0,"publicationDate":"2026-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13295162/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148347663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jason Liu, Mina Ghali, Matthew Aceto, Vraj Amin, Samuel Hovland, Franz Jones
{"title":"Bodyweight and Weightlifting Exercise Injury Burden: National Analysis from 2014 to 2023.","authors":"Jason Liu, Mina Ghali, Matthew Aceto, Vraj Amin, Samuel Hovland, Franz Jones","doi":"10.1055/a-2866-5672","DOIUrl":"10.1055/a-2866-5672","url":null,"abstract":"<p><p>Bodyweight exercises and weightlifting are foundational to strength training, yet their relative public health burdens remain poorly defined in large, nationally representative samples. We analyzed data from the National Electronic Injury Surveillance System from 2014 to 2023. A standardized keyword screening protocol was utilized to identify cases of weightlifting and bodyweight injuries treated in US emergency departments. Variance estimation was performed using Taylor series linearization to account for the complex, stratified sampling design and generate nationally representative estimates. Over the 10-year study period, national estimates of 546,655 weightlifting-related injuries and 108,001 bodyweight-related injuries were identified. Weightlifting injuries primarily involved the trunk (70.1%) and phalanges (13.7%). Bodyweight injuries were significantly associated with upper and lower extremity trauma (20.7%) and joint dislocations (8.7%). After adjusting for age and sex in a cluster-robust multivariable model, exercise modality was not a significant predictor of inpatient hospitalization (adjusted odds ratio: 0.91; 95% confidence interval: 0.60-1.38; <i>p</i> =0.666). While weightlifting poses a higher absolute volume burden, there is no significant difference in hospitalization odds when adjusting for age and sex. Prevention should focus on a suitable technique for heavy lifts and safe joint positioning for dynamic bodyweight movements, with increased diagnostic precaution and safety monitoring recommended for older participants.</p>","PeriodicalId":74857,"journal":{"name":"Sports medicine international open","volume":"10 ","pages":"a28665672"},"PeriodicalIF":0.0,"publicationDate":"2026-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13295158/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148347629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}