AIDS patient care and STDs最新文献_第3页

Pre-Exposure Prophylaxis for the Prevention of HIV-1: An Assessment of Oral Pre-Exposure Prophylaxis Usage Patterns, First Evidence of HIV-1, and HIV-1 Risk Factors in the United States. 预防 HIV-1 的暴露前预防疗法：美国口服暴露前预防疗法使用模式、HIV-1 初诊证据和 HIV-1 风险因素评估》（Pre-Exposure Prophylaxis for the Prevention of HIV-1）。

IF 3.4 2区医学

AIDS patient care and STDs Pub Date : 2024-11-01 Epub Date: 2024-11-07 DOI: 10.1089/apc.2024.0158

Alan Oglesby, Guillaume Germain, Aimee A Metzner, François Laliberté, Sean D MacKnight, Annalise Hilts, Heidi Swygard, Mei S Duh

{"title":"Pre-Exposure Prophylaxis for the Prevention of HIV-1: An Assessment of Oral Pre-Exposure Prophylaxis Usage Patterns, First Evidence of HIV-1, and HIV-1 Risk Factors in the United States.","authors":"Alan Oglesby, Guillaume Germain, Aimee A Metzner, François Laliberté, Sean D MacKnight, Annalise Hilts, Heidi Swygard, Mei S Duh","doi":"10.1089/apc.2024.0158","DOIUrl":"10.1089/apc.2024.0158","url":null,"abstract":"In clinical trials, once-daily oral tenofovir-based pre-exposure prophylaxis (PrEP) significantly reduced HIV-1 acquisition risk; however, this was highly dependent on medication adherence and persistence. We report clinical characteristics, PrEP usage patterns, first evidence of HIV-1, and associated risk factors among adults with commercial insurance using oral PrEP in the United States using health plan claims from the IQVIA PharMetrics® Plus database between January 1, 2015, and March 31, 2020, from individuals who newly initiated emtricitabine/tenofovir disoproxil fumarate (FTC/TDF) or FTC/tenofovir alafenamide (TAF) for daily PrEP. Overall, 25,419 individuals were included (FTC/TDF, n = 24,232; FTC/TAF, n = 1187), with generally similar characteristics reported during the 6-month baseline period across cohorts. Mean follow-up length was 504 and 77 days for FTC/TDF and FTC/TAF, respectively, corresponding with the 2019 approval of FTC/TAF for PrEP. Similarly, mean PrEP use duration was 354 and 68 days for FTC/TDF and FTC/TAF, respectively. PrEP breaks (>90-day gap) were observed in 11.1% of individuals using FTC/TDF, with a mean break duration of 249 days; 20.0% of individuals using FTC/TDF and 7.3% using FTC/TAF had ≥1 sexually transmitted infection diagnosis during follow-up. From 6 to 12 months of follow-up, mean FTC/TDF proportion of days covered (PDC; 0.74 vs. 0.67) and persistence (70.2% vs. 57.4%) decreased; real-world PDC and persistence were lower than reported in globally conducted clinical trials. First evidence of HIV-1 was infrequent among individuals using FTC/TDF (0.6%), though 60.3% had PrEP on hand when HIV-1 definition was met; high-risk sexual behavior, syphilis, and gonorrhea were the most important risk factors.","PeriodicalId":7476,"journal":{"name":"AIDS patient care and STDs","volume":" ","pages":"495-506"},"PeriodicalIF":3.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142589792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Knowledge, Attitudes, and Perspectives of Women Who Have Migrated from Sub-Saharan Africa to France Toward HIV Pre-Exposure Prophylaxis in a Family Planning Center. 从撒哈拉以南非洲移居法国的妇女对计划生育中心艾滋病暴露前预防的认识、态度和观点。

IF 3.4 2区医学

AIDS patient care and STDs Pub Date : 2024-11-01 DOI: 10.1089/apc.2024.0190

Geoffroy Liegeon, Samantha A Devlin, Victoria Manda, Julie Castaneda, Catherine Marsh, Jessica P Ridgway, Amy K Johnson

{"title":"Knowledge, Attitudes, and Perspectives of Women Who Have Migrated from Sub-Saharan Africa to France Toward HIV Pre-Exposure Prophylaxis in a Family Planning Center.","authors":"Geoffroy Liegeon, Samantha A Devlin, Victoria Manda, Julie Castaneda, Catherine Marsh, Jessica P Ridgway, Amy K Johnson","doi":"10.1089/apc.2024.0190","DOIUrl":"https://doi.org/10.1089/apc.2024.0190","url":null,"abstract":"Women who have migrated from sub-Saharan Africa (SSA) are underrepresented among HIV pre-exposure prophylaxis (PrEP) users in France (∼2%), yet they account for around 20% of new HIV infections annually. We conducted focus groups to explore the knowledge, attitudes, and perspectives of these women toward PrEP in a French family planning center (FPC). Focus groups occurred from November 2023 to February 2024 within the Lariboisière Hospital FPC in Paris. The social ecological model informed the discussion guide, which explored women's PrEP experiences and determinants for uptake on various levels. Five focus groups were conducted (N = 19). The median age of participants was 29 [interquartile range (IQR) 28-37]. Eight African countries were represented. The average time in France since migration was 3 (IQR 1-6) years. The majority of women had never heard of PrEP but expressed strong interest in learning more about it. Women underscored the difficulty of negotiating HIV prevention tools with their partners, risks from transactional sex, and barriers to PrEP use such as adherence challenges to daily pills and misconceptions about HIV transmission. There was strong interest in long-acting injectable PrEP. Women reported high trust in FPC providers and viewed the FPC as an ideal location to access PrEP. Conspiracy theories, cultural beliefs, and anticipated stigma were also identified as barriers to PrEP uptake. Most women advocated for disseminating PrEP information to their peers using diverse community outreach strategies. Despite a strong interest, increasing PrEP uptake in women from SSA will remain challenging without multi-faceted and adapted implementation strategies.","PeriodicalId":7476,"journal":{"name":"AIDS patient care and STDs","volume":"38 11","pages":"507-516"},"PeriodicalIF":3.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142680568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factors Associated with HIV Viral Suppression in People Followed in an Outpatient Clinic in Angola During and After the COVID-19 Pandemic. 在 COVID-19 大流行期间和之后，安哥拉一家门诊诊所随访的艾滋病毒病毒抑制者的相关因素。

IF 3.4 2区医学

AIDS patient care and STDs Pub Date : 2024-10-01 Epub Date: 2024-10-04 DOI: 10.1089/apc.2024.0175

Andrea Calcagno, Costanza Pizzi, Barbara Pocongo, Niccolò Ronzoni, Francesca Alladio, Ngiambudulu M Francisco, Alberto Kalume, Giovanni Di Perri, Federico Gobbi

引用次数: 0

Co-Creation of Patient-Centered Metrics for Long-Term Well-Being Involving People with HIV and HIV Care Providers. 共同创建以患者为中心的长期福祉衡量标准，让艾滋病毒感染者和艾滋病毒护理提供者参与其中。

IF 3.4 2区医学

AIDS patient care and STDs Pub Date : 2024-10-01 Epub Date: 2024-10-04 DOI: 10.1089/apc.2024.0156

Trenton M White, Anne-Sophie Gresle, Joaquim Roqueta, Carolyn Pine, Jeffrey V Lazarus

{"title":"Co-Creation of Patient-Centered Metrics for Long-Term Well-Being Involving People with HIV and HIV Care Providers.","authors":"Trenton M White, Anne-Sophie Gresle, Joaquim Roqueta, Carolyn Pine, Jeffrey V Lazarus","doi":"10.1089/apc.2024.0156","DOIUrl":"10.1089/apc.2024.0156","url":null,"abstract":"Achieving viral suppression alone does not fully resolve the multifaceted health challenges faced by people with HIV (PWH), such as early aging, multimorbidity, and low health-related quality of life. This co-creation pilot study to investigate patient-centered metrics for long-term well-being involved the development of a knowledge, attitudes, and practices survey through focus groups and its implementation among HIV care providers in Barcelona, Spain, in 2024. A collaborative approach of involving PWH from the community was essential in ensuring the relevance of the identified issues. The results underscored the importance of monitoring comorbidities such as mental health issues, cardiovascular diseases, and neurological disorders, alongside the use of patient-reported outcome measures (PROMs) and patient-reported experience measures (PREMs). The findings highlighted several barriers to implementing PROMs, including time constraints, patient health literacy, and technical issues. Overall, the study emphasizes the need for health systems in Barcelona, Spain, to integrate PROMs and PREMs into routine HIV care to enhance patient-centered care and address the comprehensive well-being of PWH.","PeriodicalId":7476,"journal":{"name":"AIDS patient care and STDs","volume":" ","pages":"487-492"},"PeriodicalIF":3.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142370740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sexual Health of Young Adults Living with Perinatally Acquired HIV in Paris, France: A Qualitative Study. 法国巴黎围产期感染艾滋病毒的年轻成年人的性健康：定性研究。

IF 3.4 2区医学

AIDS patient care and STDs Pub Date : 2024-10-01 Epub Date: 2024-08-21 DOI: 10.1089/apc.2024.0124

Nour Ibrahim, Jean-Paul Viard, Maude Ludot-Grégoire, Jonathan Lachal, Agnès Dumas, Patricia Brazille, Damien Lechat, Sophie Bridou, Domitille Molinari, Christine Hassler, Alexandra Rouquette

{"title":"Sexual Health of Young Adults Living with Perinatally Acquired HIV in Paris, France: A Qualitative Study.","authors":"Nour Ibrahim, Jean-Paul Viard, Maude Ludot-Grégoire, Jonathan Lachal, Agnès Dumas, Patricia Brazille, Damien Lechat, Sophie Bridou, Domitille Molinari, Christine Hassler, Alexandra Rouquette","doi":"10.1089/apc.2024.0124","DOIUrl":"10.1089/apc.2024.0124","url":null,"abstract":"We aimed to explore the sexual health of young adults with perinatally acquired human immunodeficiency virus (PHIV). Eighteen to 25 years old PHIV participants were recruited in two tertiary care units in Paris. Sexually transmitted HIV was an exclusion criterion. Individual interviews were conducted. Transcripts were analyzed using a semio-pragmatic phenomenological method. Twenty-five participants were interviewed from March 2022 to September 2022. Some of them renounced being in any romantic relationship. Those who disclosed their HIV status to their romantic partner reported that dating was more complex and those who did not disclose reported that keeping HIV a secret was a significant mental burden. Young men tended to disclose their HIV status to their romantic partner whereas young women did not consider doing so before marriage. Many participants had to educate themselves about sexuality, through school or websites. Identified interlocutors for sexuality varied across participants. All participants were aware of U = U (Undetectable = Untransmittable) slogan. Despite that, participants remained worried about transmitting HIV to their sexual partners. That hindered their sexual satisfaction. In addition, they neglected the risk of unwanted pregnancies or sexually transmitted diseases (STDs). In our study, knowing the U = U slogan did not provide reassurance to PHIV participants regarding the risk of onward HIV transmission. Further, they showed very little concern for protecting themselves from their partner's STD.","PeriodicalId":7476,"journal":{"name":"AIDS patient care and STDs","volume":" ","pages":"477-486"},"PeriodicalIF":3.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142008088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A6 HIV Subtype in a Pharmacist-Directed Cabotegravir/Rilpivirine Screening Protocol. 药剂师指导的卡博特拉韦/利匹韦林筛查方案中的 A6 HIV 亚型。

IF 3.4 2区医学

AIDS patient care and STDs Pub Date : 2024-10-01 Epub Date: 2024-08-22 DOI: 10.1089/apc.2024.0160

Patricia P Fulco, Suzanne Lavoie

引用次数: 0

Perceived Versus Actual Costs of HIV Pre-Exposure Prophylaxis Among Gay, Bisexual, and Other Men Who Have Sex with Men in the United States. 美国男同性恋、双性恋及其他男男性行为者对 HIV 暴露前预防的认知成本与实际成本。

IF 4.9 2区医学

AIDS patient care and STDs Pub Date : 2024-09-18 DOI: 10.1089/apc.2024.0145

Rahel Dawit,Zachary Predmore,Julia Raifman,Philip A Chan,Lorraine T Dean

{"title":"Perceived Versus Actual Costs of HIV Pre-Exposure Prophylaxis Among Gay, Bisexual, and Other Men Who Have Sex with Men in the United States.","authors":"Rahel Dawit,Zachary Predmore,Julia Raifman,Philip A Chan,Lorraine T Dean","doi":"10.1089/apc.2024.0145","DOIUrl":"https://doi.org/10.1089/apc.2024.0145","url":null,"abstract":"Gay, bisexual, and other men who have sex with men (GBMSM) account for the highest proportion of HIV diagnoses in the United States, with daily pre-exposure prophylaxis (PrEP) significantly reducing transmission risk. Since 2021, the Affordable Care Act rules have required PrEP and accompanying care visits to be free for most Americans; nevertheless, insurers have found ways to circumvent no-cost PrEP and some employers are receiving exemptions from including it in their formularies. Despite this, perceived costs and indirect expenses still hinder PrEP adoption. This study examines the differences between perceived and actual costs among GBMSM who have and have not used PrEP. We conducted a one-time online survey with 692 adults from six New England states between May 2020 and October 2021. Participants who had never used PrEP estimated its cost, while those with prior PrEP experience reported their actual expenses. Bivariate analysis and multi-variable logistic regression were used to assess the data. Results showed a 60% difference between perceived ($48) and actual ($30) median monthly costs. Higher perceived costs among nonusers were linked to race and income, while high actual costs for prior users were associated with insurance type, income, wealth, race, and self-rated consumer credit. This significant disparity in PrEP cost perceptions highlights the need for targeted outreach and messaging to improve PrEP uptake among at-risk populations who have not yet accessed it.","PeriodicalId":7476,"journal":{"name":"AIDS patient care and STDs","volume":"18 1","pages":""},"PeriodicalIF":4.9,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142248531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intimate Partner Violence and HIV Pre-Exposure Prophylaxis Care Engagement Among Sexual Minority Men: A Systematic Review. 少数性取向男性中的亲密伴侣暴力与 HIV 暴露前预防护理参与度：系统回顾。

IF 3.4 2区医学

AIDS patient care and STDs Pub Date : 2024-09-01 Epub Date: 2024-07-24 DOI: 10.1089/apc.2024.0115

Chenglin Hong

{"title":"Intimate Partner Violence and HIV Pre-Exposure Prophylaxis Care Engagement Among Sexual Minority Men: A Systematic Review.","authors":"Chenglin Hong","doi":"10.1089/apc.2024.0115","DOIUrl":"10.1089/apc.2024.0115","url":null,"abstract":"Sexual minority men (SMM) who experience intimate partner violence (IPV) may also be at increased risk for HIV; however, little is known about the relationship between these experiences and the utilization of pre-exposure prophylaxis (PrEP) for HIV prevention. This systematic review aimed to synthesize available literature to examine the complex interplay between IPV experiences and engagement in the PrEP care continuum among SMM. A comprehensive search following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines in Embase, PubMed, PsycINFO, Web of Science, Medline, and CINAHL identified only 13 relevant articles, most of which were conducted in the United States (n = 9) and only two in low- and middle-income countries (LMICs). Nearly all studies (n = 12, 92.3%) were quantitative in design and used cross-sectional data. The findings of this review identified critical gaps in measuring IPV and PrEP outcomes and revealed mixed findings regarding the complex interplay between IPV and PrEP care engagement in the context of syndemics experienced by SMM. The results highlight the critical need for future research to understand the impact of IPV on PrEP uptake and adherence and its underlying mechanisms. This includes investigating the effects of different types of IPV (e.g., emotional, physical, sexual) on PrEP utilization and how these experiences influence PrEP preferences, such as daily PrEP versus on-demand PrEP or long-acting injectable PrEP. The implications of this review call for comprehensive public health policies and integrated health care practices that provide tailored interventions for IPV screening in PrEP care settings to deliver IPV services and promote engagement in the PrEP care continuum among SMM, as well as further investigation in LMICs.","PeriodicalId":7476,"journal":{"name":"AIDS patient care and STDs","volume":" ","pages":"438-452"},"PeriodicalIF":3.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141756582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Knowledge and Attitudes About HIV Pre-Exposure Prophylaxis Among Sexually Active Black and Latina Cisgender Women: Findings from the 2017 and 2018 New York City Sexual Health Survey. 性生活活跃的黑人和拉丁裔双性恋女性对 HIV 暴露前预防措施的了解和态度：2017年和2018年纽约市性健康调查的结果。

IF 3.4 2区医学

AIDS patient care and STDs Pub Date : 2024-09-01 Epub Date: 2024-09-04 DOI: 10.1089/apc.2024.0142

Devon M Price, Marné Garretson, Xiang Cai, Fardina Miah, Kathleen Scanlin, Oni Blackstock, Zoe Edelstein

{"title":"Knowledge and Attitudes About HIV Pre-Exposure Prophylaxis Among Sexually Active Black and Latina Cisgender Women: Findings from the 2017 and 2018 New York City Sexual Health Survey.","authors":"Devon M Price, Marné Garretson, Xiang Cai, Fardina Miah, Kathleen Scanlin, Oni Blackstock, Zoe Edelstein","doi":"10.1089/apc.2024.0142","DOIUrl":"10.1089/apc.2024.0142","url":null,"abstract":"Pre-exposure prophylaxis (PrEP) is a highly effective tool to prevent HIV, yet it is underutilized among women. The current study aims to evaluate the awareness, attitudes, and perceptions of PrEP among a large survey sample of Black and Latina women in New York City (NYC). Interviewer-administered surveys were conducted in high HIV incidence neighborhoods in NYC among Black, Latina, and Afro-Latina women who reported recent sex with a man in 2017 (n = 398) and 2018 (n = 405). About 40% of participants were aware of PrEP, whereas 30.4% indicated interest in using it. The top reason for not utilizing it was low HIV risk perception. However, most participants supported the idea that using PrEP meant asserting control over their health (94.1%). Primary care providers and obstetricians/gynecologists were participants' preferred sources for PrEP (91.6%). Across survey cycles, compared to non-Black Latina participants, Black participants had significantly higher PrEP awareness (44.4% vs. 29.1%). PrEP awareness was also significantly higher among survey participants in 2018 (45.2%) than in 2017 (34.3%). Less than half of the participants were aware of PrEP, but those who were aware expressed largely positive attitudes toward the medication. Our findings may inform future PrEP implementation strategies to optimize awareness and access to PrEP among women disproportionately affected by HIV, like focusing on personal empowerment instead of risk-based messaging and training women's sexual health care providers in PrEP provision.","PeriodicalId":7476,"journal":{"name":"AIDS patient care and STDs","volume":" ","pages":"428-437"},"PeriodicalIF":3.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142124539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reported Side Effects and Adherence of Daily HIV Pre-Exposure Prophylaxis Users in Ontario, Canada: An Analysis of the Ontario Pre-Exposure Prophylaxis Cohort Study. 加拿大安大略省每日使用艾滋病暴露前预防疗法者报告的副作用和坚持使用情况：安大略省暴露前预防队列研究分析》（Ontario Pre-Exposure Prophylaxis Cohort Study）。

IF 3.4 2区医学

AIDS patient care and STDs Pub Date : 2024-09-01 DOI: 10.1089/apc.2024.0144

Monica Rudd, Matthew McGarrity, Ryan Lisk, Paul MacPherson, David Knox, Kevin Woodward, Jeff Reinhart, John MacLeod, Isaac I Bogoch, Deanna Clatworthy, Mia J Biondi, Sean Sullivan, Alan Li, Garfield Durrant, Andrew Schonbe, Fanta Ongoiba, Ann N Burchell, Darrell H S Tan

{"title":"Reported Side Effects and Adherence of Daily HIV Pre-Exposure Prophylaxis Users in Ontario, Canada: An Analysis of the Ontario Pre-Exposure Prophylaxis Cohort Study.","authors":"Monica Rudd, Matthew McGarrity, Ryan Lisk, Paul MacPherson, David Knox, Kevin Woodward, Jeff Reinhart, John MacLeod, Isaac I Bogoch, Deanna Clatworthy, Mia J Biondi, Sean Sullivan, Alan Li, Garfield Durrant, Andrew Schonbe, Fanta Ongoiba, Ann N Burchell, Darrell H S Tan","doi":"10.1089/apc.2024.0144","DOIUrl":"https://doi.org/10.1089/apc.2024.0144","url":null,"abstract":"Side effects are a common concern of current and potential HIV pre-exposure prophylaxis (PrEP) users, potentially leading to missed doses. We examined the relationship between reported side effects and adherence in the Ontario PrEP Cohort Study (ON-PrEP). In total, 600 predominantly gay (87.3%), White (65.8%), and male (95.0%) participants completed questionnaires assessing the presence and severity of five side effect categories (nausea, diarrhea, headache, abdominal pain, and \"other\") as well as their adherence to daily PrEP (any missed doses in the previous 4 days). In total, 175 participants (29%) ever reported experiencing side effects: most commonly diarrhea (7.5% of study visits), and most were of mild severity. Lower incomes (p = 0.01), identifying as bisexual (p = 0.04), and baseline concern about side effects (p < 0.001) were associated with ever reporting side effects. The odds of reporting any side effects decreased by a factor of 0.44 (95% confidence interval 0.25-0.80) with each additional year of PrEP use, however 1 in 10 participants still reported side effects after 1 year of use. The odds of reporting optimal adherence were 0.48 (0.28-0.83) times lower for participants reporting any side effects, 0.67 (0.51-0.89) times lower per additional side effect category reported, and 0.78 (0.65-0.97) times lower per incremental increase in side effect severity ratings. We found some evidence of interaction between side effect measures and duration of PrEP use, suggesting that these relationships were stronger for participants taking PrEP for longer. Clinicians should make efforts to ascertain patients' experience of side effects and consider risk counseling and alternative PrEP regimens to promote adherence.","PeriodicalId":7476,"journal":{"name":"AIDS patient care and STDs","volume":"38 9","pages":"382-392"},"PeriodicalIF":3.4,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142278951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0