AIDS patient care and STDs最新文献

{"title":"Aging and AIDS: A Need for Focus on Neurodegenerative Diseases and the Broad Benefits of Such Research.","authors":"Jeffrey Laurence","doi":"10.1177/10872914261448351","DOIUrl":"https://doi.org/10.1177/10872914261448351","url":null,"abstract":"","PeriodicalId":7476,"journal":{"name":"AIDS patient care and STDs","volume":" ","pages":"10872914261448351"},"PeriodicalIF":3.8,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147832468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient and Service Provider Perspectives of Barriers and Facilitators to HIV Care in North Carolina.","authors":"Meagan C Zarwell, Sebastian Marin-Cespedes, Jordyn McCrimmon, Marielle Indyg, Ian Dale, Eunice Okumu, Alicia Diggs, Jesse Strunk Elkins, Maria Esposito, Ujunwa Onyeama, Grace Galphin, Carol Golin, Matthew Zinck, Travis Barnes, Keenan Phillips, Patrick Robinson, Ann M Dennis","doi":"10.1177/10872914261448349","DOIUrl":"https://doi.org/10.1177/10872914261448349","url":null,"abstract":"<p><p>Barriers to initiating and maintaining HIV care continue to impede efforts to \"End the HIV Epidemic\" in the United States, particularly among members of Black sexual and gender minoritized (BSGM) groups in the US South. Evidence-informed social network-based interventions may improve engagement in HIV care services among BSGM; however, understanding and addressing context-specific barriers and facilitators to HIV service use are critical for intervention effectiveness. We explored barriers to HIV care engagement to inform the adaptation of a social network strategy to increase participation in HIV prevention and care services in Charlotte, NC. We interviewed BSGM with HIV who were in treatment, local health department officials, clinicians, and community-based organization leaders and held four focus groups (FGs) with HIV public health services staff. Transcripts were iteratively coded and analyzed thematically. We identified two themes across all FGs and in-depth interviews (IDIs). Two additional themes were identified specifically from IDIs with BSGM. Across data sources, participants described multi-level stigma, competing priorities, and logistical hurdles that impede BSGM engagement in HIV care. BSGM with HIV indicated that supportive social networks enhanced HIV treatment adherence and described how their personal agency and self-efficacy evolved after receiving an HIV diagnosis. Interventions to improve HIV care engagement among BSGM with HIV must address inequities, leverage social support networks, and enhance self-efficacy.</p>","PeriodicalId":7476,"journal":{"name":"AIDS patient care and STDs","volume":" ","pages":"10872914261448349"},"PeriodicalIF":3.8,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147832525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Approaches to HIV and STI Testing Among Heterosexually Active Women and Men in New York City.","authors":"Andrea Ávila, Étienne Meunier, Paul Kobrak","doi":"10.1177/10872914261439967","DOIUrl":"https://doi.org/10.1177/10872914261439967","url":null,"abstract":"<p><p>New York City surveillance data document substantial heterosexual transmission of HIV and other sexually transmitted infections (STIs). Existing research provides limited insight into how heterosexual adults approach and use HIV and STI testing, an intervention that can inform the need for treatment and reduce onward transmission. Through in-depth interviews with 50 heterosexually active women and men in New York City conducted in 2023 and 2024, we found that testing for HIV and STIs was widespread and integrated into broader health care routines. Our exploratory study identified three primary approaches that participants used as needed: <i>preemptive testing</i> (used before having sex with new partners or discontinuing condom use); <i>reactive testing</i> (following heightened risk perceptions); and <i>routine screening</i> (as part of ongoing sexual health maintenance). Our findings suggest that for many heterosexually active women and men HIV and STI testing is an accessible and acceptable practice, which public health can promote to reduce transmission.</p>","PeriodicalId":7476,"journal":{"name":"AIDS patient care and STDs","volume":" ","pages":"10872914261439967"},"PeriodicalIF":3.8,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147626694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interventions to Improve HIV Care and Treatment Outcomes Among People with HIV Who Have Substance Use Disorder or At-Risk Substance Use: A Narrative Review.","authors":"Hilary Goldhammer, Milo Dorfman, David R A Coelho, Ellis Jaewon Yeo, Demetrios Psihopaidas, Joseph Stango, Carol Dawson-Rose, Kenneth H Mayer, Alex S Keuroghlian","doi":"10.1177/10872914261435808","DOIUrl":"https://doi.org/10.1177/10872914261435808","url":null,"abstract":"<p><p>Substance use adversely affects engagement in HIV care, adherence to medication, and HIV viral suppression. This review assessed the scope of US interventions designed to promote positive outcomes along the HIV care continuum for people with HIV who have substance use disorder (SUD) or at-risk substance use. A literature search identified 27 interventions published in peer-reviewed articles found on PubMed and PsycINFO databases between January 1, 2019, and December 31, 2023. Common strategies to improve HIV care continuum outcomes included support for HIV medication adherence, motivational interviewing, medications to treat SUD, contingency management, cognitive-behavioral skills building, patient navigation, mindfulness practice, and low-barrier entry to care. Contingency management (offering financial or material incentives for attaining desired outcomes) alone or combined with other strategies was most consistently associated with positive HIV outcomes, but more research is needed to understand how these outcomes can be sustained. Few intervention studies addressed or measured linkage to care (12%) or retention in care (15%), despite a clear need to better engage this population. Further innovation is needed to improve HIV engagement and retention among people with SUD or at-risk substance use.</p>","PeriodicalId":7476,"journal":{"name":"AIDS patient care and STDs","volume":" ","pages":"10872914261435808"},"PeriodicalIF":3.8,"publicationDate":"2026-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147621583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinician Perspectives on Integrating Biomedical HIV Prevention with Gender-Affirming Care Delivered via Telehealth.","authors":"Caroline S O'Brien, Moira Kyweluk, Nadia Dowshen, Florence Momplaisir, Nancy Aitcheson","doi":"10.1177/10872914261430810","DOIUrl":"10.1177/10872914261430810","url":null,"abstract":"<p><p>Preexposure prophylaxis (PrEP) and postexposure prophylaxis (PEP) continue to be underutilized among transgender people despite elevated HIV incidence in this population. Many transgender individuals report that their gender-affirming care (GAC) is their highest health care priority, and an increasing number seek this care via telehealth. We sought to understand clinician perspectives and needs regarding integrating HIV PrEP and HIV PEP into GAC in a telehealth model. We conducted semi-structured interviews with clinicians who self-identified as providing gender-affirming care via telehealth. We used the transdisciplinary approach to evidence-based practice to inform our interview guide and codebook and used thematic analysis to analyze the resulting data. Among our 20 participants interviewed in December 2023 and January 2024, there was enthusiasm to offer trans patients biomedical HIV prevention within GAC. Participants were most comfortable managing oral PrEP. Identified barriers include lab work cadence and issues getting medication to patients (especially the drugs for HIV PEP). PrEP navigators, patient self-advocacy, and trusting patient-clinician relationships were identified as facilitators of co-location. A clinician's ability to offer a transgender patient both GAC and PrEP/HIV PEP in the same telehealth visit is a promising strategy to tackle the disproportionate incidence of HIV among trans people. Trusting clinical relationships facilitated by the provision of GAC can be utilized to more accurately assess HIV risk and more effectively offer PrEP and HIV PEP.</p>","PeriodicalId":7476,"journal":{"name":"AIDS patient care and STDs","volume":" ","pages":"153-160"},"PeriodicalIF":3.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147389216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perspectives on Long-Acting Injectable Treatment and Related Provider Communication Among Men with HIV in Australia and the US Who Have Sex with Men.","authors":"Kaosisochukwu C Onochie, Martin Holt, David A Kalwicz, Carla Treloar, Elena Cama, Anthony K J Smith, Loren Brener, Timothy R Broady, Benjamin R Bavinton, Sarah K Calabrese","doi":"10.1177/10872914261429683","DOIUrl":"10.1177/10872914261429683","url":null,"abstract":"<p><p>New HIV treatment modalities, including long-acting injectable antiretroviral therapy (LAI-ART), increase the range of options available to people with HIV (PWH). As new treatments become available, it is important to understand how PWH perceive these new options and the role of providers in informing patients about them. We explored the perspectives of gay, bisexual, and other men who have sex with men with HIV (MWH) on new HIV treatment modalities and provider communication about these modalities. Semi-structured interviews were conducted with a total of 18 MWH from the US (<i>n</i> = 9) and Australia (<i>n</i> = 9), who were recruited in partnership with two community organizations. Participants identified as gay, cisgender men aged 29-66 years (Median = 54). All reported taking oral ART and having an undetectable viral load. Two main themes were identified: (1) Long-acting injectables are not as simple as daily pills, and (2) Providers should inform patients about new HIV treatments. Most MWH perceived LAI-ART to be more complex compared with their current oral treatment regimen because of frequent clinic visits to receive injections, discomfort with needles, and concerns about missed doses and side effects. MWH believed providers should inform all patients about new treatments and were less likely to do so if they did not have a relationship with their patients, were not satisfied with patients' current treatment, or were limited on time. Standardizing patient education about new treatments and broadening information channels may enhance informed decision-making among PWH, including those most likely to benefit from new modalities.</p>","PeriodicalId":7476,"journal":{"name":"AIDS patient care and STDs","volume":" ","pages":"138-145"},"PeriodicalIF":3.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147389156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unmet HIV and STI Prevention Needs and Limited Linkage to Care Among Gay, Bisexual, and Other Men Who Have Sex with Men in Southern Spain: A Community-Based Intervention Study.","authors":"Anaïs Corma-Gómez, Marta Santos, Jésica Martín-Carmona, Jesús García, Abelardo Castro, Alejandro Bertó, Sara Gil-Cidoncha, Pilar Rincón, Margarita Pérez-García, Luis M Real, Juan A Pineda, Juan Macías","doi":"10.1177/10872914261429704","DOIUrl":"10.1177/10872914261429704","url":null,"abstract":"<p><p>To evaluate the proportion of gay, bisexual, and other men who have sex with men (GBMSM) with ongoing high-risk sexual practices not engaged in care, and to assess linkage to and retention in care following a community-based intervention. A two-phase study was conducted (January-June 2023) in a sex-on-premises venue in Spain. Community-based screening for HIV and hepatitis C virus (HCV) was offered, followed by a fast-track referral intervention. Individuals with reactive results were linked to specialized care. Individuals with negative results not engaged in care were referred to pre-exposure prophylaxis or sexually transmitted infections (STI) screening programs. Outcomes: (i) Primary: proportion of participants requiring care who were not engaged in routine sexual health services; (ii) Secondary: linkage to and retention in care at 6 months. Of 614 individuals invited, 405 (66%) participated. At baseline, 226 participants (56%) were not engaged in HIV or PrEP follow-up. One (0.3%) previously undiagnosed HIV infection was identified. One (0.2%) HCV infection was detected. Among 165 HIV-negative GBMSM residing in Andalusia who were not engaged in care, 148 (89.7%) were either not linked to sexual health services or not retained in PrEP care, including 63 (42.6%) who fulfilled PrEP criteria. In conclusion, a substantial proportion of GBMSM with ongoing high-risk sexual practices were not engaged in sexual health services. While few HIV and HCV infections were identified, linkage to and retention in PrEP and STI prevention services were limited, with losses before or shortly after first contact, underscoring persistent gaps in the prevention cascade among GBMSM.</p>","PeriodicalId":7476,"journal":{"name":"AIDS patient care and STDs","volume":" ","pages":"146-152"},"PeriodicalIF":3.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147389219","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global Perspectives on Pre-Exposure Prophylaxis: A Systematic Review and Meta-Analysis of Health Care Providers' Awareness, Willingness, and Barriers.","authors":"Tesfaye Engdaw Habtie, Sefineh Fenta Feleke, Getachew Mekonnen Chanie, Melesse Abiye Munie, Yabibal Asfaw Derso, Molalign Aligaz Adisu","doi":"10.1177/10872914261424544","DOIUrl":"10.1177/10872914261424544","url":null,"abstract":"<p><p>This systematic review and meta-analysis aimed to assess health care providers' awareness, willingness, and key barriers in implementing HIV pre-exposure prophylaxis (PrEP). The review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, and the protocol was registered in International Prospective Register of Systematic Reviews (PROSPERO) (registration number: CRD42024620671). A comprehensive search was conducted across major databases, and the eligible studies published between May 2014 and November 2024 were selected based on predefined inclusion and exclusion criteria. Participants were primarily health care providers involved in the adult PrEP care, with some studies also including providers caring for adolescents. A total of 23 cross-sectional studies comprising 6977 participants from various regions were included. The pooled awareness rate of health care providers regarding HIV PrEP was 89% (95% confidence interval [CI]: 85-93%), while their willingness to prescribe PrEP was 70% (95% CI: 65-75%). Providers with experience in caring for at least one HIV-positive patient (odds ratio [OR] = 1.35, 95% CI: 1.02-1.68) and those with greater knowledge (OR = 1.60, 95% CI: 1.06-2.14) demonstrated higher odds of prescribing PrEP. Despite the high level of awareness, the pooled willingness to prescribe PrEP was suboptimal, indicating limited adoption. The findings identify a small but critical group of less-aware providers who represent a key target for awareness and training initiatives. Barriers to PrEP implementation were identified at individual, community, and structural levels, including limited training, concerns about toxicity and resistance, discomfort with sexual health discussions, and low acceptance among both providers and patients. Targeted interventions addressing these barriers are essential to enhance PrEP uptake and optimize HIV prevention efforts globally.</p>","PeriodicalId":7476,"journal":{"name":"AIDS patient care and STDs","volume":" ","pages":"127-137"},"PeriodicalIF":3.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147315869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is Cognitive Care the Next Blind Spot in HIV Clinical Practice? Exploring the Facilitators and Barriers to Integrating Cognitive Care into Routine HIV Care in Malaysia: A Mixed Method Study.","authors":"Kejal Hasmukharay, Ho Ming Hui, Nazlin A Mahyudin, Anisa Salleh, Anjanna Kukreja, Pui Li Wong, Chong Meng Li, Eleanor J Ong, Tan Xin Woen, Syaza Hisham, Ashutosh Kumar Verma, Kathryn L Lovero, Jeremy Ross, Reena Rajasuriar","doi":"10.1177/10872914261423775","DOIUrl":"10.1177/10872914261423775","url":null,"abstract":"<p><p>In the antiretroviral therapy era, as people living with HIV (PWH) age, the decline of HIV-associated dementia has been accompanied by a growing burden of earlier Alzheimer-type pathology and other milder, heterogeneous cognitive impairments, underscoring the need for proactive detection and multidisciplinary management within routine HIV care. Yet, cognitive care remains largely absent, particularly in low- and middle-income countries (LMIC). We evaluated readiness to integrate a multidomain cognitive-rehabilitation program into tertiary HIV clinic in Malaysia and identified implementation determinants. We used a sequential mixed-methods design. An online Knowledge-Attitude-Practice survey was distributed to all infectious-disease physicians nationwide (<i>N</i> = 94). Qualitative data were generated through focus-group discussions with health care providers (HCPs) and in-depth interviews with PWH aged >40 years. Transcripts were analyzed thematically using the Consolidated Framework for Implementation Research (CFIR 2.0). Forty-nine physicians responded (52.4% response), median age was 44 years (inter-quartile range (IQR) 38-51), and 71.4% were female. While 71-82% demonstrated satisfactory knowledge and attitudes toward cognitive health, 88% reported poor practice; only 20.5% routinely screened older PWH. Thirty-three HCPs from multidisciplinary backgrounds participated in five focus groups, alongside 19 in-depth interviews with PWH. Three interlinked domains emerged: (1) knowledge-practice gap related to uncertainty around screening tools, referral pathways, and evidence applicability; (2) systemic barriers including time constraints, high caseloads, lack of guidelines, and workforce limitations; and (3) stigma affecting acceptability. Facilitators included strong patient motivation for brain health, allied health upskilling, physician-initiated referrals, and dedicated care coordination. Integration of multidisciplinary cognitive rehabilitation is hindered by modifiable structural deficits in knowledge translation, workforce organization, and guideline support. HIV-adapted screening algorithms, formalized referral processes, and task-shared coordinator roles could enable earlier cognitive interventions for older adults living with HIV in Malaysia and similar LMIC settings.</p>","PeriodicalId":7476,"journal":{"name":"AIDS patient care and STDs","volume":" ","pages":"161-173"},"PeriodicalIF":3.8,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147315893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lenacapavir-Containing Antiretroviral Therapy in the OPERA Cohort: Patterns of Use and Treatment Outcomes.","authors":"Karam Mounzer, Laurence Brunet, Ricky K Hsu, Philip C Lackey, Michael G Sension, Michael B Wohlfeiler, Keith Dunn, Jennifer S Fusco, Gregory P Fusco","doi":"10.1177/10872914261437163","DOIUrl":"https://doi.org/10.1177/10872914261437163","url":null,"abstract":"<p><p>Lenacapavir (LEN), a twice-yearly injectable long-acting capsid inhibitor used in combination with an optimized background regimen, is indicated for heavily treatment-experienced adults with multi-drug-resistant HIV-1 infection. From the US Observational Pharmaco-Epidemiology Research & Analysis (OPERA) cohort, 116 adults with HIV with ≥1 set of LEN injections were included [baseline viral load (VL) <200 copies/mL = 74; ≥200 copies/mL = 42]. Many (56%) simplified their regimen at LEN initiation and/or later, and 31% maintained all the antiretrovirals (ARVs) from their prior regimen throughout LEN use. Among those with a baseline VL <200 copies/mL, the cumulative probability (Kaplan-Meier) of maintaining suppression to <200 copies/mL was 92% [95% confidence interval (CI): 80, 96]. Among those with a baseline VL ≥200 copies/mL, the cumulative probability of achieving suppression was 73% (95% CI: 59, 86). Among 78 individuals who received ≥2 sets of LEN injections, 82% received all sets of injections on time or early (≤28 weeks after the prior set) and 18% received ≥1 set late (>28 weeks after the prior set). The median delay was 11 days past the injection window (interquartile range: 4, 118). At study end, 91% remained on a LEN-containing regimen. In this cohort representative of routine clinical care in the United States, factors other than virologic control may be driving the decision to start LEN (e.g., safety, tolerability, resistance, simplification). Most people experienced favorable virologic outcomes and good adherence to LEN, which may serve as an effective option for those who could benefit from a long-acting injectable agent from a novel ARV class.</p>","PeriodicalId":7476,"journal":{"name":"AIDS patient care and STDs","volume":" ","pages":"10872914261437163"},"PeriodicalIF":3.8,"publicationDate":"2026-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147571841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}