AIDS patient care and STDs最新文献

{"title":"<i>Letter:</i> Contraception and Relevant Health Outcomes Among Adolescent Girls and Young Women with HIV: A Cohort Study of Urban Youth in the United States.","authors":"Emily Alpin, Justin Unternaher, Tierra Williams, Olivia Munger, Hanifa Mohiuddin, Katarina Y Manzi, Natella Rakhmanina","doi":"10.1177/10872914261480937","DOIUrl":"10.1177/10872914261480937","url":null,"abstract":"","PeriodicalId":7476,"journal":{"name":"AIDS patient care and STDs","volume":" ","pages":"423-425"},"PeriodicalIF":4.4,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148811672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postpartum Virologic Failure Among Women with HIV Suppressed at Delivery in Spain: Incidence, Timing, and Associated Factors.","authors":"Rebeca Izquierdo, Marta Rava, Victoria Hernando, Inés Suárez-García, Félix Gutiérrez, Antonio Rivero, Roberto Güerri-Fernández, Rafael Rubio, Juan García-Arriaza, Manuel Gutiérrez-Cuadra, Laura Pérez-Martínez, Rosario Palacios, María José Galindo, Inmaculada Jarrín","doi":"10.1177/10872914261486529","DOIUrl":"10.1177/10872914261486529","url":null,"abstract":"<p><p>The postpartum period remains a vulnerable phase for maintaining virologic suppression among women with HIV (WWH); however, evidence on postpartum virologic failure (VF) among women virologically suppressed at delivery is limited. We analyzed data from the CoRIS cohort including WWH aged 18-50 years who had a live birth while receiving antiretroviral therapy (ART) and were virologically suppressed at delivery between 2004 and 2024. The primary outcome was time to VF within 12 months postpartum, defined as two consecutive HIV RNA measurements >50 copies/mL or a single measurement >1000 copies/mL. Secondary outcomes included virologic non-suppression (VnS) and CD4⁺ cell count changes at 12 months postpartum. Kaplan-Meier and Cox models were used to assess time to VF and generalized estimating equations (logistic and linear model) to evaluate VnS and CD4⁺ changes, accounting for repeated deliveries. The analysis included 422 deliveries among 337 women. The cumulative incidence of VF was 15.7% (95% CI: 12.1-19.1) at 12 months postpartum. VF risk was lower in more recent calendar periods. At 12 months postpartum, 18.0% of deliveries showed VnS. Earlier calendar periods, younger maternal age, and protease inhibitor-based ART regimens were associated with higher odds of non-suppression. Mean CD4⁺ cell counts increased by 88.5 cells/µL overall, with greater improvements in more recent years. Postpartum ART discontinuation decreased markedly over time, alongside increasing treatment stability. Maintaining virologic suppression postpartum remains challenging despite advances in ART. Targeted postpartum strategies are needed to ensure durable virologic control.</p>","PeriodicalId":7476,"journal":{"name":"AIDS patient care and STDs","volume":" ","pages":"431-445"},"PeriodicalIF":4.4,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148966026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health Care Stigma and HIV/Sexually Transmitted Infection Prevention Service Uptake Among Cisgender Men and Gender-Diverse Individuals Who Have Sex with Men in Five Asian Countries: Implications for Differentiated Service Delivery.","authors":"Takeshi Miwa, Benjamin R Bavinton, Adam Bourne, Sin How Lim, Thomas E Guadamuz, Martin Holt, Carol Strong","doi":"10.1177/10872914261475842","DOIUrl":"10.1177/10872914261475842","url":null,"abstract":"<p><p>Health care stigma remains a key barrier to HIV and sexually transmitted infection (STI) prevention, yet its effects may differ across health care systems. We examined associations between health care stigma and HIV/STI prevention service uptake across five Asian countries. A cross-sectional online survey was conducted in early 2020 among cisgender men and gender-diverse individuals who have sex with men in Japan, Malaysia, Indonesia, Thailand, and Vietnam. Outcomes were HIV testing and STI testing in the past 12 months, and pre-exposure prophylaxis (PrEP) initiation. Anticipated stigma was defined as health care avoidance due to fear of disclosing same-sex behavior: enacted stigma as experiences of poor treatment or provider ridicule related to same-sex behavior. Country-specific adjusted odds ratios (aORs) were estimated using pooled logistic regression models with country-stigma interaction terms. Among 10,274 participants who were HIV negative or had never been tested (median age 31 years; interquartile range 25-41), anticipated stigma was consistently associated with lower odds of HIV and STI testing across all five countries. Associations for enacted stigma varied by country. In Japan, enacted stigma was positively associated with STI testing [aOR = 1.74; 95% confidence interval (CI): 1.25-2.41], HIV testing (aOR = 1.66; 95% CI: 1.19-2.30), and PrEP initiation (aOR = 1.99; 95% CI: 1.20-3.29). In Thailand, enacted stigma was negatively associated with STI testing (aOR = 0.63; 95% CI: 0.44-0.88), HIV testing (aOR =0.54; 95% CI: 0.38-0.77), and PrEP initiation (aOR = 0.55; 95% CI: 0.33-0.90). In settings with more differentiated and community-based options, individuals engaged in prevention services may encounter less stigmatizing care. Expanding differentiated service delivery alongside stigma-reduction interventions may strengthen HIV and STI prevention across the Asia-Pacific region.</p>","PeriodicalId":7476,"journal":{"name":"AIDS patient care and STDs","volume":" ","pages":"446-455"},"PeriodicalIF":4.4,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148696900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"I Just Need Guidance Through This Maze I'm Going Through\": Addressing Unmet Basic and Mental Health Needs to Facilitate Engagement in HIV Prevention Services in the Context of Stimulant Use.","authors":"Jacklyn D Foley, Kenneth H Mayer, Surabhi Iyer, Julia Scheinbach, Abigail W Batchelder","doi":"10.1177/10872914261478191","DOIUrl":"10.1177/10872914261478191","url":null,"abstract":"<p><p>There is a global syndemic of HIV, mental health challenges, substance use, and structural barriers. Critical to local HIV prevention efforts is understanding this syndemic in the context of rising stimulant use to inform intervention development. Adhering to the EPIS model, we conducted 32 in-depth individual qualitative interviews with people who use stimulants and have unmet structural needs to (1) identify barriers/facilitators of HIV prevention and (2) get feedback on evidence-based intervention content (e.g., emotion- and problem-focused coping skills) to address identified barriers. Thematic content analysis was applied. The sample had a mean age of 48 years (standard deviation = 10.8), with 46.9% identifying as men, 62.5% as White, and 50.0% as having ≤high school diploma/GED (general educational development). Multi-level barriers/facilitators of HIV prevention included knowledge, motivation (individual), provider relationships (interpersonal), access, and cost (institutional/structural). Skills to cope with psychosocial distress and problem-solve barriers to getting social services were perceived to be helpful. A psycho-behavioral intervention would best be implemented as part of syndemic-focused programming that also includes contingency management for HIV prevention behaviors and stimulant use, social activities not centered on drug use, and case management. This study advances HIV prevention by informing psycho-behavioral intervention development that is person-centered and focused on sustainable implementation.</p>","PeriodicalId":7476,"journal":{"name":"AIDS patient care and STDs","volume":" ","pages":"456-465"},"PeriodicalIF":4.4,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13618760/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148786885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tolerability and Virologic Outcomes after Transition from Long-Acting Injectable ART to Oral ART.","authors":"Marianna Giurco, Lucia Taramasso, Elena Ricci, Nicola Squillace, Sergio Ferrara, Andrea Parisini, Giancarlo Orofino, Barbara Menzaghi, Filippo Lagi, Eleonora Sarchi, Paolo Bonfanti, Antonio Di Biagio","doi":"10.1177/10872914261487462","DOIUrl":"10.1177/10872914261487462","url":null,"abstract":"<p><p>The tolerability of oral antiretroviral therapy (ART) administered after discontinuation of long-acting injectable (LAI) cabotegravir (CAB) + rilpivirine (RPV), during the period of residual injectables persistence, has not been described. Limited data are available on the oral ART regimens used after all-cause LAI discontinuations and on their effectiveness. This analysis was conducted in Surveillance Cohort Long-Term Toxicity of Antiretrovirals, an active, multicenter, prospective, observational pharmacovigilance cohort that monitors antiretroviral safety and development of adverse reactions. In the cohort, 75/682 people living with HIV (PWH) discontinued LAI, the majority due to adverse events (AEs). No worsening or new AEs were observed after initiation of oral ART, even among PWH who discontinued CAB + RPV due to systemic symptoms. All patients were switched to a single-tablet regimen, with 34.7% receiving a non-nucleoside reverse transcriptase inhibitor (NNRTI)-containing regimen. Among individuals who discontinued LAI for reasons other than virologic failure (VF), all those previously on NNRTI-and/or integrase inhibitor (INSTI)-based oral ART resumed regimens containing the same drug classes. After discontinuation due to VF, a protease inhibitor-based regimen was newly introduced in 4/10 PWH. Within 6 months, HIV-RNA was ≤50 copies/mL in 96.0% and ≤200 copies/mL in 98.7% of participants. The overlap between the residual CAB + RPV and the oral therapy was well tolerated; most individuals restarted their previous oral regimen, and virological suppression remained high 6 months after resuming oral ART.</p>","PeriodicalId":7476,"journal":{"name":"AIDS patient care and STDs","volume":" ","pages":"426-430"},"PeriodicalIF":4.4,"publicationDate":"2026-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148954770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Letter:</i> Improving HIV Care Continuum Assessment During Hospitalization.","authors":"Patrick Ryscavage, Jerrell Smith, Walker Weinstein, Scott Hale, Natalie Spicyn","doi":"10.1177/10872914261502264","DOIUrl":"https://doi.org/10.1177/10872914261502264","url":null,"abstract":"","PeriodicalId":7476,"journal":{"name":"AIDS patient care and STDs","volume":" ","pages":"10872914261502264"},"PeriodicalIF":4.4,"publicationDate":"2026-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149260487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Provider Perspectives on the Delivery of Long-Acting PrEP for HIV Prevention to Men Who Have Sex with Men and Who Use Methamphetamine\".","authors":"","doi":"10.1177/10872914261495527","DOIUrl":"10.1177/10872914261495527","url":null,"abstract":"","PeriodicalId":7476,"journal":{"name":"AIDS patient care and STDs","volume":" ","pages":"10872914261495527"},"PeriodicalIF":4.4,"publicationDate":"2026-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149236593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delivering Long-Acting Injectable Cabotegravir PrEP to People Experiencing Homelessness and People Who Use Drugs.","authors":"Nicky J Mehtani, Stephen J Matzat, Anoushka Rustagi, Hannah Stowe, Sarah Strieff, Derek Sportsman, Morgan M Philbin, Monica Gandhi, Mallory O Johnson","doi":"10.1177/10872914261494329","DOIUrl":"https://doi.org/10.1177/10872914261494329","url":null,"abstract":"<p><p>Long-acting injectable cabotegravir (CAB-LA) may be particularly advantageous for preventing HIV among people experiencing homelessness (PEH) and people who use drugs (PWUD), populations at high HIV risk with poor oral pre-exposure prophylaxis (PrEP) outcomes. In a retrospective study using the RE-AIM framework to organize programmatic outcomes, we evaluated real-world implementation of CAB-LA at the Maria X. Martinez Health Resource Center, a status-neutral, fully drop-in municipal clinic in San Francisco, CA, serving >4000 patients annually for diverse health needs. We included all patients prescribed CAB-LA between October 2022 and December 2025. Outcomes included reach, adoption, implementation (injection timeliness, delivery setting, guideline-concordant HIV monitoring), maintenance (retention), and exploratory effectiveness (HIV acquisitions relative to active coverage). Nineteen providers prescribed CAB-LA to 68 patients (63% experiencing homelessness; 56% with stimulant use disorder, 34% opioid use disorder, 51% psychotic-spectrum illness); 52 (76%) received ≥1 injection. Of 304 injections, 42% occurred outside the clinic, including in shelters, on the street, and in jail or inpatient settings; 76% of follow-up injections were on time. HIV testing concordant with the Centers for Disease Control and Prevention guidelines (antigen/antibody plus RNA) accompanied 37% of injections. Twelve-month retention was 49%. Two patients acquired HIV, both during gaps in CAB-LA coverage. Sustaining coverage required intensive outreach, population tracking, insurance reenrollment, and financial incentives. Findings suggest that CAB-LA can be delivered in a fully drop-in clinic serving PEH and PWUD, while highlighting the resource-intensive support required to maintain coverage. Adapting delivery models, laboratory monitoring protocols, and financing to the realities of structurally vulnerable populations is essential to extend the benefits of long-acting PrEP.</p>","PeriodicalId":7476,"journal":{"name":"AIDS patient care and STDs","volume":" ","pages":"10872914261494329"},"PeriodicalIF":4.4,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149126503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ComPrEmetidos: A Multidisciplinary Consensus to Transform HIV Prevention in Spain.","authors":"Inmaculada Jarrín, Nuria Fernandez, Jorge Garrido, Luis López, Rosa Polo","doi":"10.1177/10872914261472566","DOIUrl":"10.1177/10872914261472566","url":null,"abstract":"<p><p>Despite progress in antiretroviral therapy and prevention, HIV remains a major public health challenge in Spain. Pre-exposure prophylaxis (PrEP) is a proven and effective prevention strategy, but challenges in access, equity, adherence and persistence limit its population impact. Our aim was to identify current barriers to PrEP adoption in Spain and develop actionable solutions. We conducted a structured consensus process (September 2024-May 2025) with 19 experts from fields including infectious diseases/HIV care, sexual health/sexually transmitted infection services, primary care, emergency medicine, nursing, pediatrics, hospital pharmacy, public health, epidemiology/biostatistics, and community-based organizations. It included semi-structured interviews, multidisciplinary small-group sessions, and two plenary workshops. Complementary descriptive surveys of healthcare professionals (HCPs) and NGO/community health centers (<i>n</i> = 150) and current/potential/past PrEP users (<i>n</i> = 95) provided contextual data. Consensus statements were developed using a facilitator-led approach based on nominal group techniques, with community representatives contributing lived-experience insights. The panel identified key challenges, including fragmented access (hospital-centered), capacity constraints, restrictive eligibility criteria, knowledge gaps, adherence and persistence issues, and limitations in information systems. To address these, a focused decalogue was developed to promote decentralization, equity, person-centered care and preparedness for transformative innovation in PrEP. The ComPrEmetidos consensus offers an operational roadmap to move Spain from policy availability to program performance and more effectively reduce new HIV infections in Spain. Priorities include decentralization, improving the training and knowledge of HCPs and the general public, rapid linkage to PrEP, and the incorporation of innovation, especially for those for whom oral PrEP is not sufficient.</p>","PeriodicalId":7476,"journal":{"name":"AIDS patient care and STDs","volume":" ","pages":"391-400"},"PeriodicalIF":4.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148672793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Provider Perspectives on the Delivery of Long-Acting PrEP for HIV Prevention to Men Who Have Sex with Men and Who Use Methamphetamine.","authors":"Vanessa M McMahan, Emily Pope, Xochitl Luna Marti, Albert Y Liu, Phillip O Coffin","doi":"10.1177/10872914261474992","DOIUrl":"10.1177/10872914261474992","url":null,"abstract":"<p><p>Methamphetamine use is associated with HIV risk behaviors, seroconversion, and suboptimal daily, oral PrEP adherence among men who have sex with men (MSM). Long-acting pre-exposure prophylaxis (PrEP) formulations, such as bimonthly cabotegravir (CAB) and biannual lenacapavir (LEN) injections, may be particularly effective for HIV prevention in this population. We conducted interviews with 17 individuals in the western US who provided a service in the past month to an HIV-negative man who has sex with men and uses methamphetamine. Interviews were audio recorded and transcribed. Interviews inquired about barriers to each step of the PrEP cascade and strategies to overcome them. Transcriptions were coded by at least two analysts and reconciled. Interviews revealed several barriers to long-acting PrEP engagement among MSM who use methamphetamine across the cascade, most notably homelessness, which included competing priorities and inconsistent phone access. Despite the identification of housing instability as a barrier to long-acting PrEP engagement, it was also cited as a reason why long-acting PrEP may be particularly promising for MSM who use methamphetamine. Anticipated stigma was also identified as a primary barrier to long-acting PrEP engagement. Provider-level barriers were described, including overburdened clinics, limited hours, requisite staffing expertise, and billing restrictions. Strategies to increase long-acting PrEP provision among this population who could benefit from PrEP included reducing provider-side barriers and integrating long-acting PrEP with other appealing services (e.g., syringe services programs), extended hours, mobile delivery, and contingency management.</p>","PeriodicalId":7476,"journal":{"name":"AIDS patient care and STDs","volume":" ","pages":"408-416"},"PeriodicalIF":4.4,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13641754/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148672870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}