AIDS patient care and STDs最新文献

Pre-Exposure Prophylaxis for the Prevention of HIV-1: An Assessment of Oral Pre-Exposure Prophylaxis Usage Patterns, First Evidence of HIV-1, and HIV-1 Risk Factors in the United States. 预防 HIV-1 的暴露前预防疗法：美国口服暴露前预防疗法使用模式、HIV-1 初诊证据和 HIV-1 风险因素评估》（Pre-Exposure Prophylaxis for the Prevention of HIV-1）。

IF 3.4 2区医学

AIDS patient care and STDs Pub Date : 2024-11-07 DOI: 10.1089/apc.2024.0158

Alan Oglesby, Guillaume Germain, Aimee A Metzner, François Laliberté, Sean D MacKnight, Annalise Hilts, Heidi Swygard, Mei S Duh

{"title":"Pre-Exposure Prophylaxis for the Prevention of HIV-1: An Assessment of Oral Pre-Exposure Prophylaxis Usage Patterns, First Evidence of HIV-1, and HIV-1 Risk Factors in the United States.","authors":"Alan Oglesby, Guillaume Germain, Aimee A Metzner, François Laliberté, Sean D MacKnight, Annalise Hilts, Heidi Swygard, Mei S Duh","doi":"10.1089/apc.2024.0158","DOIUrl":"10.1089/apc.2024.0158","url":null,"abstract":"In clinical trials, once-daily oral tenofovir-based pre-exposure prophylaxis (PrEP) significantly reduced HIV-1 acquisition risk; however, this was highly dependent on medication adherence and persistence. We report clinical characteristics, PrEP usage patterns, first evidence of HIV-1, and associated risk factors among adults with commercial insurance using oral PrEP in the United States using health plan claims from the IQVIA PharMetrics® Plus database between January 1, 2015, and March 31, 2020, from individuals who newly initiated emtricitabine/tenofovir disoproxil fumarate (FTC/TDF) or FTC/tenofovir alafenamide (TAF) for daily PrEP. Overall, 25,419 individuals were included (FTC/TDF, n = 24,232; FTC/TAF, n = 1187), with generally similar characteristics reported during the 6-month baseline period across cohorts. Mean follow-up length was 504 and 77 days for FTC/TDF and FTC/TAF, respectively, corresponding with the 2019 approval of FTC/TAF for PrEP. Similarly, mean PrEP use duration was 354 and 68 days for FTC/TDF and FTC/TAF, respectively. PrEP breaks (>90-day gap) were observed in 11.1% of individuals using FTC/TDF, with a mean break duration of 249 days; 20.0% of individuals using FTC/TDF and 7.3% using FTC/TAF had ≥1 sexually transmitted infection diagnosis during follow-up. From 6 to 12 months of follow-up, mean FTC/TDF proportion of days covered (PDC; 0.74 vs. 0.67) and persistence (70.2% vs. 57.4%) decreased; real-world PDC and persistence were lower than reported in globally conducted clinical trials. First evidence of HIV-1 was infrequent among individuals using FTC/TDF (0.6%), though 60.3% had PrEP on hand when HIV-1 definition was met; high-risk sexual behavior, syphilis, and gonorrhea were the most important risk factors.","PeriodicalId":7476,"journal":{"name":"AIDS patient care and STDs","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142589792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence, Monitoring, Treatment, and Control of Type 2 Diabetes by Race and Sexual Orientation Among Males with HIV. 按种族和性取向分列的男性 HIV 感染者中 2 型糖尿病的患病率、监测、治疗和控制情况。

IF 3.4 2区医学

AIDS patient care and STDs Pub Date : 2024-10-28 DOI: 10.1089/apc.2024.0193

Jiali Guo, Samuel C O Opara, Sophia A Hussen, Jithin Sam Varghese

引用次数: 0

Acceptability and Feasibility of Implementing a Home-Based HIV Pre-Exposure Prophylaxis Program in an Urban Clinic. 在城市诊所实施家庭艾滋病暴露前预防计划的可接受性和可行性。

IF 3.4 2区医学

AIDS patient care and STDs Pub Date : 2024-10-25 DOI: 10.1089/apc.2024.0159

Tiffany Yuh, Linden Lalley-Chareczko, Dante' Zanders, Harlan Shaw, Terrence Spencer, Dana Serafin, Helen Koenig, Florence Momplaisir

{"title":"Acceptability and Feasibility of Implementing a Home-Based HIV Pre-Exposure Prophylaxis Program in an Urban Clinic.","authors":"Tiffany Yuh, Linden Lalley-Chareczko, Dante' Zanders, Harlan Shaw, Terrence Spencer, Dana Serafin, Helen Koenig, Florence Momplaisir","doi":"10.1089/apc.2024.0159","DOIUrl":"https://doi.org/10.1089/apc.2024.0159","url":null,"abstract":"Personal and structural barriers to HIV pre-exposure prophylaxis (PrEP) care result in its underutilization and premature discontinuation. A home-based PrEP program comprised of telemedicine visits and/or self-administered lab testing may address some of these barriers. Our objective was to assess the acceptability and feasibility of a home-based PrEP program among stakeholders at an urban HIV and primary care clinic. We used the consolidated framework for implementation research to evaluate determinants of successful implementation of the program. We surveyed and interviewed PrEP patients and their health care team. In a baseline survey of PrEP users (n = 112) administered between May 2021 and August 2022, 65% expressed interest in switching to the home-based PrEP program. Seventeen patients over the course of follow-up through December 2023 started home-based PrEP, including 12 patients who completed both a telemedicine visit and a self-administered lab kit, and 5 patients who completed only a telemedicine visit. Of these, over 80% had positive feedback on the telemedicine visits. Survey results demonstrated excellent acceptability and feasibility of the lab kits. Patients indicated in interviews that the home-based PrEP program provided the strong advantage of convenience. Despite mixed feelings from PrEP providers on telemedicine visits (n = 5), most felt that the program made PrEP care delivery easier for patients and would encourage their patients to use the program if it were a good fit. Barriers to program success included shipping delays and staff turnover during program implementation. In conclusion, uptake of the home-based program was low but program participants expressed high acceptability.","PeriodicalId":7476,"journal":{"name":"AIDS patient care and STDs","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142492836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Pilot Randomized Control Trial of the Motivational Interviewing to Increase PrEP Uptake Intervention Among Black Women in the United States. 在美国黑人妇女中开展动机访谈以提高 PrEP 使用率干预的试点随机对照试验。

IF 3.4 2区医学

AIDS patient care and STDs Pub Date : 2024-10-17 DOI: 10.1089/apc.2024.0189

Sannisha K Dale, Victoria Petrulla, Ian A Wright

{"title":"A Pilot Randomized Control Trial of the Motivational Interviewing to Increase PrEP Uptake Intervention Among Black Women in the United States.","authors":"Sannisha K Dale, Victoria Petrulla, Ian A Wright","doi":"10.1089/apc.2024.0189","DOIUrl":"https://doi.org/10.1089/apc.2024.0189","url":null,"abstract":"Despite the disproportional impact of HIV, Black individuals are benefiting the least from pre-exposure prophylaxis (PrEP). Motivational interviewing (MI) for PrEP uptake (MI-PrEP) is a two-session culturally tailored intervention incorporating MI strategies to improve PrEP motivation and uptake among cisgender Black women. A pilot randomized control trial was conducted in the Southeastern United States, and 41 women were randomized to MI-PrEP (session 1 with PrEP psychoeducation and MI and session 2 with MI and light case management) or enhanced treatment as usual (ETAU; two sessions of PrEP psychoeducation [videos explaining PrEP]). Women completed one follow-up assessment (1 month after visit 2). Measures captured primary (motivation [via contemplation and readiness ruler] and PrEP uptake via medical records) and secondary outcomes (e.g., PrEP knowledge, barriers to PrEP, and speaking to a provider about PrEP). Difference-in-differences analyses comparing MI-PrEP with ETAU as well as t-tests for within-group changes over time were conducted. Women who completed MI-PrEP (90.5% retained) compared with ETAU (100% retained) had a significantly higher likelihood of speaking to a provider about PrEP (OR = 4.42e7, CI [8.55e6, 2.29e8], DiD = 17.60, se = 0.84, p < 0.001). Within the MI-PrEP group, women had significant increases in PrEP prescription, knowledge, and motivation/contemplation, and significant decreases in financial resources as a PrEP barrier and medical mistrust (MMT). ETAU had within-group increases in PrEP prescription and speaking to a provider, no changes in motivation and MMT, and increases in specific barriers to care (e.g., transportation). MI-PrEP shows promise, and a large-scale study may be beneficial to further assess efficacy and examine implementation.","PeriodicalId":7476,"journal":{"name":"AIDS patient care and STDs","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142455848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identifying Motivators, Facilitators, and Barriers to Engagement and Retention in Anal Cancer Screening Among Men and Women with HIV in One Ryan White HIV/AIDS Clinic. 确定瑞安-怀特艾滋病毒/艾滋病诊所中感染艾滋病毒的男性和女性参与和坚持肛门癌筛查的动机、促进因素和障碍。

IF 3.4 2区医学

AIDS patient care and STDs Pub Date : 2024-10-14 DOI: 10.1089/apc.2024.0171

Maria C Geba, Divya Kalluri, Emma M Mitchell, Tabor Flickinger, Ben Cardenas, Rebecca Dillingham, Tania A Thomas

{"title":"Identifying Motivators, Facilitators, and Barriers to Engagement and Retention in Anal Cancer Screening Among Men and Women with HIV in One Ryan White HIV/AIDS Clinic.","authors":"Maria C Geba, Divya Kalluri, Emma M Mitchell, Tabor Flickinger, Ben Cardenas, Rebecca Dillingham, Tania A Thomas","doi":"10.1089/apc.2024.0171","DOIUrl":"https://doi.org/10.1089/apc.2024.0171","url":null,"abstract":"Anal squamous cell carcinoma disproportionally affects people with HIV (PWH); however, engagement in anal cancer screening is low in many settings. This study was conducted to assess knowledge and perceptions of anal cancer screening to identify factors in the engagement and retention in prevention services among PWH. Semistructured interviews were conducted among adult PWH eligible for anal cancer screening in our Ryan White HIV/AIDS Program clinic. Descriptive statistics were tabulated; thematic analyses were performed to identify emerging motivators, facilitators, and barriers. Among 26 PWH, 9 had not been screened, 8 had undergone Papanicolaou (Pap) testing alone, and 9 had undergone anoscopy. The median age of the cohort was 55.2 years; 54% identified as men who have sex with men, and 54% identified as Black. In the unscreened cohort, participants were motivated by investing in their health and positive attitudes toward cancer prevention however were deterred by a lack of referral and low awareness about screening. Among those who had Pap testing, trust in healthcare providers and abnormal testing results were motivators to engagement, whereas lack of perceived risk of anal cancer and worry about pain of an anoscopy were prominent barriers. Among those who had anoscopy, perceived risk, positive experience with the procedure, and use of anxiolytics prior to anoscopy were motivators, whereas anxiety around a new cancer diagnosis and negative experience with anoscopy were barriers. Clinics seeking to build or strengthen their anal cancer screening programs can address the barriers described in this study to promote access to anal cancer screening among PWH.","PeriodicalId":7476,"journal":{"name":"AIDS patient care and STDs","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142455849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factors Associated with HIV Viral Suppression in People Followed in an Outpatient Clinic in Angola During and After the COVID-19 Pandemic. 在 COVID-19 大流行期间和之后，安哥拉一家门诊诊所随访的艾滋病毒病毒抑制者的相关因素。

IF 3.4 2区医学

AIDS patient care and STDs Pub Date : 2024-10-01 Epub Date: 2024-10-04 DOI: 10.1089/apc.2024.0175

Andrea Calcagno, Costanza Pizzi, Barbara Pocongo, Niccolò Ronzoni, Francesca Alladio, Ngiambudulu M Francisco, Alberto Kalume, Giovanni Di Perri, Federico Gobbi

引用次数: 0

Co-Creation of Patient-Centered Metrics for Long-Term Well-Being Involving People with HIV and HIV Care Providers. 共同创建以患者为中心的长期福祉衡量标准，让艾滋病毒感染者和艾滋病毒护理提供者参与其中。

IF 3.4 2区医学

AIDS patient care and STDs Pub Date : 2024-10-01 Epub Date: 2024-10-04 DOI: 10.1089/apc.2024.0156

Trenton M White, Anne-Sophie Gresle, Joaquim Roqueta, Carolyn Pine, Jeffrey V Lazarus

{"title":"Co-Creation of Patient-Centered Metrics for Long-Term Well-Being Involving People with HIV and HIV Care Providers.","authors":"Trenton M White, Anne-Sophie Gresle, Joaquim Roqueta, Carolyn Pine, Jeffrey V Lazarus","doi":"10.1089/apc.2024.0156","DOIUrl":"10.1089/apc.2024.0156","url":null,"abstract":"Achieving viral suppression alone does not fully resolve the multifaceted health challenges faced by people with HIV (PWH), such as early aging, multimorbidity, and low health-related quality of life. This co-creation pilot study to investigate patient-centered metrics for long-term well-being involved the development of a knowledge, attitudes, and practices survey through focus groups and its implementation among HIV care providers in Barcelona, Spain, in 2024. A collaborative approach of involving PWH from the community was essential in ensuring the relevance of the identified issues. The results underscored the importance of monitoring comorbidities such as mental health issues, cardiovascular diseases, and neurological disorders, alongside the use of patient-reported outcome measures (PROMs) and patient-reported experience measures (PREMs). The findings highlighted several barriers to implementing PROMs, including time constraints, patient health literacy, and technical issues. Overall, the study emphasizes the need for health systems in Barcelona, Spain, to integrate PROMs and PREMs into routine HIV care to enhance patient-centered care and address the comprehensive well-being of PWH.","PeriodicalId":7476,"journal":{"name":"AIDS patient care and STDs","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142370740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sexual Health of Young Adults Living with Perinatally Acquired HIV in Paris, France: A Qualitative Study. 法国巴黎围产期感染艾滋病毒的年轻成年人的性健康：定性研究。

IF 3.4 2区医学

AIDS patient care and STDs Pub Date : 2024-10-01 Epub Date: 2024-08-21 DOI: 10.1089/apc.2024.0124

Nour Ibrahim, Jean-Paul Viard, Maude Ludot-Grégoire, Jonathan Lachal, Agnès Dumas, Patricia Brazille, Damien Lechat, Sophie Bridou, Domitille Molinari, Christine Hassler, Alexandra Rouquette

{"title":"Sexual Health of Young Adults Living with Perinatally Acquired HIV in Paris, France: A Qualitative Study.","authors":"Nour Ibrahim, Jean-Paul Viard, Maude Ludot-Grégoire, Jonathan Lachal, Agnès Dumas, Patricia Brazille, Damien Lechat, Sophie Bridou, Domitille Molinari, Christine Hassler, Alexandra Rouquette","doi":"10.1089/apc.2024.0124","DOIUrl":"10.1089/apc.2024.0124","url":null,"abstract":"We aimed to explore the sexual health of young adults with perinatally acquired human immunodeficiency virus (PHIV). Eighteen to 25 years old PHIV participants were recruited in two tertiary care units in Paris. Sexually transmitted HIV was an exclusion criterion. Individual interviews were conducted. Transcripts were analyzed using a semio-pragmatic phenomenological method. Twenty-five participants were interviewed from March 2022 to September 2022. Some of them renounced being in any romantic relationship. Those who disclosed their HIV status to their romantic partner reported that dating was more complex and those who did not disclose reported that keeping HIV a secret was a significant mental burden. Young men tended to disclose their HIV status to their romantic partner whereas young women did not consider doing so before marriage. Many participants had to educate themselves about sexuality, through school or websites. Identified interlocutors for sexuality varied across participants. All participants were aware of U = U (Undetectable = Untransmittable) slogan. Despite that, participants remained worried about transmitting HIV to their sexual partners. That hindered their sexual satisfaction. In addition, they neglected the risk of unwanted pregnancies or sexually transmitted diseases (STDs). In our study, knowing the U = U slogan did not provide reassurance to PHIV participants regarding the risk of onward HIV transmission. Further, they showed very little concern for protecting themselves from their partner's STD.","PeriodicalId":7476,"journal":{"name":"AIDS patient care and STDs","volume":null,"pages":null},"PeriodicalIF":3.4,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142008088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A6 HIV Subtype in a Pharmacist-Directed Cabotegravir/Rilpivirine Screening Protocol. 药剂师指导的卡博特拉韦/利匹韦林筛查方案中的 A6 HIV 亚型。

IF 3.4 2区医学

AIDS patient care and STDs Pub Date : 2024-10-01 Epub Date: 2024-08-22 DOI: 10.1089/apc.2024.0160

Patricia P Fulco, Suzanne Lavoie

引用次数: 0

Perceived Versus Actual Costs of HIV Pre-Exposure Prophylaxis Among Gay, Bisexual, and Other Men Who Have Sex with Men in the United States. 美国男同性恋、双性恋及其他男男性行为者对 HIV 暴露前预防的认知成本与实际成本。

IF 4.9 2区医学

AIDS patient care and STDs Pub Date : 2024-09-18 DOI: 10.1089/apc.2024.0145

Rahel Dawit,Zachary Predmore,Julia Raifman,Philip A Chan,Lorraine T Dean

{"title":"Perceived Versus Actual Costs of HIV Pre-Exposure Prophylaxis Among Gay, Bisexual, and Other Men Who Have Sex with Men in the United States.","authors":"Rahel Dawit,Zachary Predmore,Julia Raifman,Philip A Chan,Lorraine T Dean","doi":"10.1089/apc.2024.0145","DOIUrl":"https://doi.org/10.1089/apc.2024.0145","url":null,"abstract":"Gay, bisexual, and other men who have sex with men (GBMSM) account for the highest proportion of HIV diagnoses in the United States, with daily pre-exposure prophylaxis (PrEP) significantly reducing transmission risk. Since 2021, the Affordable Care Act rules have required PrEP and accompanying care visits to be free for most Americans; nevertheless, insurers have found ways to circumvent no-cost PrEP and some employers are receiving exemptions from including it in their formularies. Despite this, perceived costs and indirect expenses still hinder PrEP adoption. This study examines the differences between perceived and actual costs among GBMSM who have and have not used PrEP. We conducted a one-time online survey with 692 adults from six New England states between May 2020 and October 2021. Participants who had never used PrEP estimated its cost, while those with prior PrEP experience reported their actual expenses. Bivariate analysis and multi-variable logistic regression were used to assess the data. Results showed a 60% difference between perceived ($48) and actual ($30) median monthly costs. Higher perceived costs among nonusers were linked to race and income, while high actual costs for prior users were associated with insurance type, income, wealth, race, and self-rated consumer credit. This significant disparity in PrEP cost perceptions highlights the need for targeted outreach and messaging to improve PrEP uptake among at-risk populations who have not yet accessed it.","PeriodicalId":7476,"journal":{"name":"AIDS patient care and STDs","volume":null,"pages":null},"PeriodicalIF":4.9,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142248531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0