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Alergologia Polska - Polish Journal of Allergology最新文献

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Asthma, chronic obstructive pulmonary disease (COPD) and asthma-COPD overlap syndrome and the risk of severe COVID-19 哮喘、慢性阻塞性肺疾病(COPD)和哮喘-COPD重叠综合征以及严重COVID-19的风险
IF 0.2
Alergologia Polska - Polish Journal of Allergology Pub Date : 2021-01-01 DOI: 10.5114/PJA.2021.104655
Klaudia Waszczykowska, Marta Węgierska, Roxana Drygała, R. Pawliczak
{"title":"Asthma, chronic obstructive pulmonary disease (COPD) and asthma-COPD overlap syndrome and the risk of severe COVID-19","authors":"Klaudia Waszczykowska, Marta Węgierska, Roxana Drygała, R. Pawliczak","doi":"10.5114/PJA.2021.104655","DOIUrl":"https://doi.org/10.5114/PJA.2021.104655","url":null,"abstract":"Asthma, chronic obstructive pulmonary disease (COPD) and asthma-COPD overlap syndrome (ACOS) significantly affect the patient's respiratory system, which requires individualised treatment and professional control During the SARS-CoV-2 pandemic, all respiratory diseases were taken into consideration as risk factors for severe COVID-19 ACE2 and TMPRSS2 genes, which are crucial for SARS-CoV-2 to enter the host cell, have different expression in the occurrence of asthma or COPD Also, comparing the severity and mortality of patients with coexistence of asthma or COPD and COVID-19, only COPD patients had worse outcomes of COVID-19, and their mortality was significantly higher Although ACOS is also a potential risk factor for hospitalisation and mortality in COVID-19 patients, the condition still requires further studies This overview presents the current state of knowledge on the relationship between the diseases mentioned above and COVID-19","PeriodicalId":7469,"journal":{"name":"Alergologia Polska - Polish Journal of Allergology","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70478643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The gluten enteropathy in East Slovakia 东斯洛伐克的麸质肠病
IF 0.2
Alergologia Polska - Polish Journal of Allergology Pub Date : 2021-01-01 DOI: 10.5114/pja.2021.106683
Gabriela Harvanová, S. Duranková, A. Csanády
{"title":"The gluten enteropathy in East Slovakia","authors":"Gabriela Harvanová, S. Duranková, A. Csanády","doi":"10.5114/pja.2021.106683","DOIUrl":"https://doi.org/10.5114/pja.2021.106683","url":null,"abstract":"Celiac disease is characterized as an autoimune disorder, and the trigger is gluten delivered into the body in a meal. The main purpose of the study was the issues about gluten enteropaty in East Slovakia, based on special scientific and foreign literature which was avaliable, also there are characteristics about digestion, celiac disease and gluten, critical factors and also premiss beginners of celiac disease. The research, which is discussed at the end of the thesis, was conducted in East Slovakia, namely in the gastroenterologic ambulance in the Humenné town. The above-mentioned research brought us information about the current position of celiac disease between different ages in the Humenné region. Our main aim was to find out whether there is any significant correlation between the age and risk of involvement of celiac disease.","PeriodicalId":7469,"journal":{"name":"Alergologia Polska - Polish Journal of Allergology","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70479023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Safety of biological treatment of severe asthma during the COVID-19 pandemic COVID-19大流行期间重症哮喘生物治疗的安全性
IF 0.2
Alergologia Polska - Polish Journal of Allergology Pub Date : 2021-01-01 DOI: 10.5114/pja.2021.109381
Dorota Nawarycz, R. Pawliczak
{"title":"Safety of biological treatment of severe asthma during the COVID-19 pandemic","authors":"Dorota Nawarycz, R. Pawliczak","doi":"10.5114/pja.2021.109381","DOIUrl":"https://doi.org/10.5114/pja.2021.109381","url":null,"abstract":"COVID-19 is an infectious disease that rapidly spread around the world and therefore is a challenge for treating chronic diseases, such as severe asthma. According to the guidelines of various health organizations, biological treatment in patients with severe asthma should be continued. The aim of this study was to evaluate the information we have gathered so far about safety of biological treatment of severe asthma during the COVID-19 pandemic. We analyzed data involving omalizumab, reslizumab, mepolizumab, benralizumab and dupilumab coming from case studies, surveys, single-center and multicenter studies, and review articles as well. The study focuses on risks of asthmatic patients' deterioration during COVID-19 and the severity of the infection itself. As a result, we learned that there is no strong evidence for asthma exacerbations in patients infected with COVID-19 while on their biological treatment course. Biological therapy can be safely used in patients with severe asthma, as long as all the precautions and the individual evaluation are provided.","PeriodicalId":7469,"journal":{"name":"Alergologia Polska - Polish Journal of Allergology","volume":"8 1","pages":"134-138"},"PeriodicalIF":0.2,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70479231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immunotherapy – the causes of sub-optimal efficacy in inhaled allergies 免疫疗法-吸入性过敏的次优疗效的原因
IF 0.2
Alergologia Polska - Polish Journal of Allergology Pub Date : 2021-01-01 DOI: 10.5114/PJA.2021.104618
M. Nittner-Marszalska
{"title":"Immunotherapy – the causes of sub-optimal efficacy in inhaled allergies","authors":"M. Nittner-Marszalska","doi":"10.5114/PJA.2021.104618","DOIUrl":"https://doi.org/10.5114/PJA.2021.104618","url":null,"abstract":"Allergen immunotherapy (AIT) has proven efficacy in IgE-dependent respiratory diseases. When AIT is con-ducted continnuosly for 3 years, it confers long-term clinical benefits after cessation of treatment. While multiple studies confirm high efficacy of AIT, there are some patients who do not respond to this therapy (“non-responders”) or find its results non-satisfactory (“poor-responders”). What factors may be responsible for lack of a therapeutic success of AIT or the therapy’s not fully optimal result? How to predict AIT treatment failures? Can biomarkers facilitate the prediction? How to identify patients who may turn out to be treatment failures? The article sets forth causes of AIT failures: wrong diagnosis of the underlying allergic disease, selection of a clinically non-important allergen for AIT, lack of sensibilization to the major allergen and badly performed AIT. In regard to AIT success of failure, additionally addressed is the issue of heterogeneity of molecular profiles and the sensibilization to clinically important molecules like Der p 23.","PeriodicalId":7469,"journal":{"name":"Alergologia Polska - Polish Journal of Allergology","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70478899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CAR-T therapy in oncology and other fields of medicine CAR-T疗法在肿瘤学和其他医学领域的应用
IF 0.2
Alergologia Polska - Polish Journal of Allergology Pub Date : 2021-01-01 DOI: 10.5114/pja.2021.106685
Amelia Kierasińska, Damian Ciunowicz, Marta Węgierska, E. Stoczyńska-Fidelus, P. Rieske
{"title":"CAR-T therapy in oncology and other fields of medicine","authors":"Amelia Kierasińska, Damian Ciunowicz, Marta Węgierska, E. Stoczyńska-Fidelus, P. Rieske","doi":"10.5114/pja.2021.106685","DOIUrl":"https://doi.org/10.5114/pja.2021.106685","url":null,"abstract":"Recently, there has been a breakthrough in immunotherapy. The development of the advanced therapy medicinal product (ATMP) is a striking example of that. Chimeric antigen receptors T cell therapy (CAR-T therapy) is the result of cooperation between biotechnologists, oncologists and immunologists. This article deals with the issues related to the development of CAR-T technology. The basics of CAR-T design and the mechanism of this therapy action are discussed. Its successes were indicated mainly in the treatment of patients with leukemias and lymphomas. EGFRvIII as an exemplary target for the therapy of solid tumors is described. However, it was pointed out what difficulties the therapy against mutated variant of epidermal growth factor receptor EGFRvIII-positive cells encounters. The growing importance of PSMA and GD2 as targets for CAR-T was also pointed out. New trends in this technology, such as the next generations of CAR-T and development of CAR-M, were noticed. Finally, the potential of CAR-T treatment in non-cancerous diseases, such as cardiac diseases, allergies or infectious diseases, including COVID-19, was characterized.","PeriodicalId":7469,"journal":{"name":"Alergologia Polska - Polish Journal of Allergology","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70478754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
17th International Academy of Dermatology and Allergology (17ADA), Gdynia 2021 第17届国际皮肤病学和过敏症学会(17ADA)， Gdynia 2021
IF 0.2
Alergologia Polska - Polish Journal of Allergology Pub Date : 2021-01-01 DOI: 10.5114/PJA.2021.104657
E. Grubska-Suchanek, R. Nowicki
{"title":"17th International Academy of Dermatology and Allergology (17ADA), Gdynia 2021","authors":"E. Grubska-Suchanek, R. Nowicki","doi":"10.5114/PJA.2021.104657","DOIUrl":"https://doi.org/10.5114/PJA.2021.104657","url":null,"abstract":"","PeriodicalId":7469,"journal":{"name":"Alergologia Polska - Polish Journal of Allergology","volume":"8 1","pages":"48-54"},"PeriodicalIF":0.2,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70478871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Do parents of children with allergic diseases need psychological support? 过敏性疾病患儿的父母需要心理支持吗?
IF 0.2
Alergologia Polska - Polish Journal of Allergology Pub Date : 2021-01-01 DOI: 10.5114/PJA.2021.106689
E. U. Severcan, Nilgun Erdonmez Karslioglu, I. Bostanci
{"title":"Do parents of children with allergic diseases need psychological support?","authors":"E. U. Severcan, Nilgun Erdonmez Karslioglu, I. Bostanci","doi":"10.5114/PJA.2021.106689","DOIUrl":"https://doi.org/10.5114/PJA.2021.106689","url":null,"abstract":"","PeriodicalId":7469,"journal":{"name":"Alergologia Polska - Polish Journal of Allergology","volume":"8 1","pages":"55-58"},"PeriodicalIF":0.2,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70479209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genome editing tools to modify immune cells 基因组编辑工具修饰免疫细胞
IF 0.2
Alergologia Polska - Polish Journal of Allergology Pub Date : 2021-01-01 DOI: 10.5114/pja.2021.111800
E. Stoczyńska-Fidelus, P. Rieske
{"title":"Genome editing tools to modify immune cells","authors":"E. Stoczyńska-Fidelus, P. Rieske","doi":"10.5114/pja.2021.111800","DOIUrl":"https://doi.org/10.5114/pja.2021.111800","url":null,"abstract":"szczególną rolę. abSTracT Techniques such as TALEN, CRISPR-CAS9 or traktuje komórkę oraz jej elementy, np. białka, w sposób podobny do tego, którego używa się przy opracowywaniu układów scalonych w elektronice. PE polega na działaniu dwóch chimer, każdej złożonej z trzech podjednostek. Trzy elementy białkowe tworzą jedną chimerę (nikaza, odwrotna editing systems in therapy. Immune system cells also seem to be particularly suitable as starting points for the creation of completely new cell types thanks to synthetic biology, in which genome editing techniques play an important role. All this makes CRISPR-CAS9 or PE more and more interesting for immunologists. The article discusses the basics of these techniques and explains the reasons for their imperfections.","PeriodicalId":7469,"journal":{"name":"Alergologia Polska - Polish Journal of Allergology","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70480102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hereditary angioedema type III – case report 遗传性血管性水肿III型1例报告
IF 0.2
Alergologia Polska - Polish Journal of Allergology Pub Date : 2021-01-01 DOI: 10.5114/PJA.2021.104656
Katarzyna Waligóra-Dziwak, M. Woźniak, D. Jenerowicz, Z. Adamski, M. Czarnecka-Operacz
{"title":"Hereditary angioedema type III – case report","authors":"Katarzyna Waligóra-Dziwak, M. Woźniak, D. Jenerowicz, Z. Adamski, M. Czarnecka-Operacz","doi":"10.5114/PJA.2021.104656","DOIUrl":"https://doi.org/10.5114/PJA.2021.104656","url":null,"abstract":"Hereditary angioedema (HAE) is a genetically determined disease characterized by recurrent episodes of subcu-taneous or submucosal tissue oedema. Failure to respond to the classical treatment of angioedema with antihista-mines, glucocorticosteroids as well as adrenaline is highly characteristic for HAE. Three main types of HAE have been described: type I – associated with hereditary reduction of C1 esterase inhibitor plasma concentration, type II – associated with its dysfunction and type III with both C1 inhibitor concentration and activity being within the normal range. We present a case report of a 16-year-old female patient with chronic spontaneous angioedema with normal activity and concentration of C1 inhibitor as well as an updated review of the current knowledge concerning pathophysiology, clinical genetic HAE type","PeriodicalId":7469,"journal":{"name":"Alergologia Polska - Polish Journal of Allergology","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70478724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Importance of aerobiological monitoring to determine artemisia and ambrosia hypersensitivity 生物监测对青蒿和凤仙花超敏反应的重要性
IF 0.2
Alergologia Polska - Polish Journal of Allergology Pub Date : 2021-01-01 DOI: 10.5114/pja.2021.106688
M. M. Cicekliyurt, M. Akkaya
{"title":"Importance of aerobiological monitoring to determine artemisia and ambrosia hypersensitivity","authors":"M. M. Cicekliyurt, M. Akkaya","doi":"10.5114/pja.2021.106688","DOIUrl":"https://doi.org/10.5114/pja.2021.106688","url":null,"abstract":"Introduction: Allergic sensitization to aeroallergen (atmospheric pollen and fungal spores) is the most common seasonal allergy trigger. The main reason for that study is unexpected skin prick test results obtained in our dermatology department. For that reason, we would like to check whether the consequences depend on cross-reactivity or aeroallergen invasion. Aim: The purpose of the present study is to determine the pollen types, including the amount and concentration of the native and invasive pollen in the Çanakkale Region during the spring and summer periods. The main reason for that study is unexpected skin prick test results obtained in our dermatology department. For that reason, we would like to check whether the consequences depend on cross-reactivity or aeroallergen invasion. Material and methods: The pollen monitoring station was placed in the Çanakkale Central Public Park. The sampling was performed by a Durham trap based on the gravimetric method. The slide was replaced with a new one every week and evaluated by 10× ocular and 40× apochromatic lenses. Results: The primary pollen producers were the following arboreal plants: Pinus sp. (65.0%), Quercus sp. (9.37%), Platanus sp. (4.29%), Moraceae (3.87%), Oleaceae (2.71%). The pollen distribution of herbaceous plants and bushes were determined as Poaceae (4.34%), Chenopodiaceae (1.99%), Plantago sp. (1.97%) and Xanthium sp. (1.35%). In addition to our current knowledge, Ambrosia pollens’ first record was found with a ratio of 0.22% in the Çanakkale atmosphere. These invasive plants have most probably entered the atmosphere with long-distance transport. Conclusions: Aerobiological monitoring is essential to determine allergen variety and concentrations to find a cure against pollinosis. The health professionals should apply a skin prick test against a significant allergen, i.e. Ambrosia pollens even if there is no previous report in the region. The authors also advised clinicians to be aware of pollen invasion to ensure that patients do not have false-negative results.","PeriodicalId":7469,"journal":{"name":"Alergologia Polska - Polish Journal of Allergology","volume":"1 1","pages":""},"PeriodicalIF":0.2,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70479528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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