基因组编辑工具修饰免疫细胞

IF 0.2 Q4 ALLERGY

Alergologia Polska - Polish Journal of Allergology Pub Date : 2021-01-01 DOI:10.5114/pja.2021.111800

E. Stoczyńska-Fidelus, P. Rieske

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引用次数: 0

摘要

一个特殊的角色。abSTract Techniques干燥为TALEN、CRISPR-CAS9或以类似于电子集成电路开发中使用的方式处理细胞及其成分，如蛋白质。PE由两个嵌合体组成，每个嵌合体由三个亚基组成。三种蛋白质组成一个嵌合体由于基因组编辑技术在合成生物学中发挥着重要作用，免疫系统细胞似乎也特别适合作为创造全新细胞类型的起点。所有这些都使CRISPR-CAS9或PE对免疫学家越来越感兴趣。本文讨论了这些技术的基础，并解释了他们不完美的原因。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Genome editing tools to modify immune cells

szczególną rolę. abSTracT Techniques such as TALEN, CRISPR-CAS9 or traktuje komórkę oraz jej elementy, np. białka, w sposób podobny do tego, którego używa się przy opracowywaniu układów scalonych w elektronice. PE polega na działaniu dwóch chimer, każdej złożonej z trzech podjednostek. Trzy elementy białkowe tworzą jedną chimerę (nikaza, odwrotna editing systems in therapy. Immune system cells also seem to be particularly suitable as starting points for the creation of completely new cell types thanks to synthetic biology, in which genome editing techniques play an important role. All this makes CRISPR-CAS9 or PE more and more interesting for immunologists. The article discusses the basics of these techniques and explains the reasons for their imperfections.

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来源期刊

Alergologia Polska - Polish Journal of Allergology ALLERGY-

自引率

50.00%

发文量

期刊介绍： Alergologia Polska - Polish Journal of Allergology is aimed mainly at allergologists, but also medical doctors working in related fields, such as otolaryngology, pulmonology, and dermatology. The main goal of the journal is to ensure rapid publication of important research papers and interesting case studies from the following areas: allergology, diagnostics, therapy of allergic diseases, in particular in the area of immunotherapy, rhinitis, asthma. The Editorial Board accepts for publication original papers, case studies and letters to the Editor. We also publish review articles (both commissioned and those agreed upon with the Editor-in-Chief), articles dealing with standards of medical practice, as well as special issues. The journal is published quarterly. We guarantee short review times (up to two weeks) and immediate publication on-line upon Editor acceptance.