Receptors (Basel, Switzerland)最新文献

The Role of Substance P and NK1 Receptors in Mild to Severe Traumatic Brain Injury: From CTE to ICP P物质和NK1受体在轻至重度颅脑外伤中的作用:从CTE到ICP

Receptors (Basel, Switzerland) Pub Date : 2023-11-11 DOI: 10.3390/receptors2040015

Robert Vink, Frances Corrigan

引用次数: 0

Regulation of Cholesterol Transporters by Nuclear Receptors 核受体对胆固醇转运蛋白的调控

Receptors (Basel, Switzerland) Pub Date : 2023-10-09 DOI: 10.3390/receptors2040014

Michinori Matsuo

{"title":"Regulation of Cholesterol Transporters by Nuclear Receptors","authors":"Michinori Matsuo","doi":"10.3390/receptors2040014","DOIUrl":"https://doi.org/10.3390/receptors2040014","url":null,"abstract":"Atherosclerosis is a pathological condition characterized by the accumulation of plaques in the arteries, leading to cardiovascular diseases. The deposition of cholesterol in peripheral cells increases the risk of atherosclerosis. Reverse cholesterol transport (RCT) is essential to reduce the risk of atherosclerosis because it removes excessive cholesterol from the peripheral tissues. ATP-binding cassette transporters such as ABCA1, ABCG1, ABCG5, and ABCG8 are involved in the efflux of cholesterol. The upregulation of these ABC transporters enhances RCT, thereby promoting the removal of excess cholesterol from the body. The expression and activity of ABC transporters are regulated by transcriptional and post-transcriptional mechanisms, as well as by post-translational modifications. In this review, the regulation of ABC transporters by nuclear receptors such as farnesoid X receptor, liver X receptor, retinoid X receptor, retinoic acid receptor, and peroxisome proliferator-activated receptors is discussed. Pharmacological and natural compounds serving as agonists for the nuclear receptors have been identified to elevate the mRNA levels of the transporters. Consequently, it is anticipated that these compounds will attenuate the development of atherosclerosis through stimulation of the ABC transporters, thereby enhancing RCT and fecal cholesterol excretion. Understanding these regulatory processes can aid in the development of therapeutic approaches to prevent atherosclerosis.","PeriodicalId":74651,"journal":{"name":"Receptors (Basel, Switzerland)","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135142109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expression of the Purinergic P2X7 Receptor in Murine MOPC315.BM Myeloma Cells 嘌呤能P2X7受体在小鼠MOPC315中的表达。骨髓瘤细胞

Receptors (Basel, Switzerland) Pub Date : 2023-09-07 DOI: 10.3390/receptors2030013

Eva Risborg Høyer, Melisa Demir, Lasse Kristoffer Bak, Niklas Rye Jørgensen, Ankita Agrawal

{"title":"Expression of the Purinergic P2X7 Receptor in Murine MOPC315.BM Myeloma Cells","authors":"Eva Risborg Høyer, Melisa Demir, Lasse Kristoffer Bak, Niklas Rye Jørgensen, Ankita Agrawal","doi":"10.3390/receptors2030013","DOIUrl":"https://doi.org/10.3390/receptors2030013","url":null,"abstract":"The adenosine-5’ triphosphate (ATP)-gated, ion channel, P2X receptor superfamily has seven members expressed by many cancer types. Subtype 7 (P2X7 receptor) is expressed consistently at levels higher than in comparatively healthy tissues. Moreover, transcript variant heterogeneity is associated with drug resistance. We have previously described the role of the P2X7 receptor in myeloma, a rare blood disease that uniquely presents with aggressive bone destruction. In this study, we used known agonists of the P2X7 receptor to induce calcium influx and YO-PRO-1 uptake in murine MOPC315.BM myeloma cells as readouts of P2X7 receptor-mediated channel activation and pore formation, respectively. Neither ATP- nor BzATP-induced calcium influx and YO-PRO-1 indicated an absence of the P2X7 receptor function on MOPC315.BM cells. TaqMan revealed low (Ct > 35) P2rx7 but high P2rx4 gene expression in MOPC315.BM; the latter was downregulated with BzATP treatment. The concomitant downregulation of CD39/Entpd1, Icam-1, and Nf-kb1 and the upregulation of Casp-1 genes regulated during purinergic signaling and with established roles in myeloma progression suggest P2RX4-mediated survival adaptation by cancer cells. Further studies are needed to characterize the P2RX4 pharmacology on MOPC315.BM since transcriptional regulation may be utilized by cancer cells to overcome the otherwise toxic effects of high extracellular ATP.","PeriodicalId":74651,"journal":{"name":"Receptors (Basel, Switzerland)","volume":"64 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77934839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Estrogen Receptor β Isoforms Regulate Chemotherapy Resistance and the Cancer Stem Cell Population in Prostate Cancer Cells 雌激素受体β亚型调节前列腺癌细胞化疗耐药和癌症干细胞群

Receptors (Basel, Switzerland) Pub Date : 2023-08-01 DOI: 10.3390/receptors2030012

Jessica H. Stevens, Ayesha Bano, Lamia Bensaoula, Anders M. Strom, J.-Å. Gustafsson

{"title":"Estrogen Receptor β Isoforms Regulate Chemotherapy Resistance and the Cancer Stem Cell Population in Prostate Cancer Cells","authors":"Jessica H. Stevens, Ayesha Bano, Lamia Bensaoula, Anders M. Strom, J.-Å. Gustafsson","doi":"10.3390/receptors2030012","DOIUrl":"https://doi.org/10.3390/receptors2030012","url":null,"abstract":"Estrogen receptor beta 1 (ERβ1) is a ligand-activated nuclear receptor, which has been shown to maintain tissue differentiation in the normal prostate, and regulate androgen response and increase expression of tumor suppressors in prostate cancer cell lines. There are three shorter isoforms of ERβ expressed in the human prostate, ERβ2, ERβ4, and ERβ5, which have already been implicated in chemotherapy resistance and disease progression, suggesting a possible oncogenic role. Their ligand-binding domain (LBD) is truncated, so they are unable to activate canonical ERβ1 signaling pathways; however, they were shown to participate in hypoxic signaling and to induce a gene expression signature associated with stemness and hypoxia. To elucidate the role of the truncated ERβ isoforms in prostate cancer, we created a knockout of all isoforms, as well as a truncation of the LBD, to remove the function of ERβ1. We showed that the removal of all isoforms leads to a decrease in the expression of cancer stem cell (CSC)-associated genes, decreased chemotherapy resistance, and a decrease in the CSC population, based on sphere formation ability and SORE6 (CSC reporter) activity, while removing the LBD function only had the opposite effect. Our results suggest a more aggressive phenotype in prostate cancer cell lines expressing ERβ variants.","PeriodicalId":74651,"journal":{"name":"Receptors (Basel, Switzerland)","volume":"69 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88956476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

From Antibodies to Crystals: Understanding the Structure of the Glucocorticoid Receptor and Related Proteins 从抗体到晶体:了解糖皮质激素受体和相关蛋白的结构

Receptors (Basel, Switzerland) Pub Date : 2023-07-03 DOI: 10.3390/receptors2030011

I. McEwan

引用次数: 0

Cycle Numbers of Cell Surface Recycling Receptors 细胞表面再循环受体的周期数

Receptors (Basel, Switzerland) Pub Date : 2023-06-06 DOI: 10.3390/receptors2020010

D. Steverding

引用次数: 0

Analysis of Cell–Cell Communication by Single-Nuclei RNA Sequencing Identifies AHR-Mediated Induction of NRG-ERBB Signaling 通过单核RNA测序分析细胞-细胞通讯鉴定ahr介导的NRG-ERBB信号传导

Receptors (Basel, Switzerland) Pub Date : 2023-05-11 DOI: 10.3390/receptors2020009

R. Nault, Giovan N. Cholico, T. Zacharewski

{"title":"Analysis of Cell–Cell Communication by Single-Nuclei RNA Sequencing Identifies AHR-Mediated Induction of NRG-ERBB Signaling","authors":"R. Nault, Giovan N. Cholico, T. Zacharewski","doi":"10.3390/receptors2020009","DOIUrl":"https://doi.org/10.3390/receptors2020009","url":null,"abstract":"Communication between cells is essential in maintaining homeostasis. The persistent disruption of cell–cell communication by environmental contaminants contributes to progressive disease and toxicity. In this study, single-nuclei RNA sequencing (snRNAseq) data was used to examine dose-dependent cell-specific changes in cell–cell communication associated with the development of liver pathologies following the persistent activation of the aryl hydrocarbon receptor (AHR) by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Published hepatic snRNAseq data from male mice gavaged with sesame-oil vehicle or TCDD every 4 days for 28 days was used to assess the AHR-mediated disruption of ligand–receptor interactions. Analysis identified that portal fibroblasts and liver sinusoidal endothelial cells contributed the most ligand–receptor pairs at doses < 0.3μg/kg TCDD. Doses ≥ 0.3 μg/kg TCDD increased the putative intercellular communication between hepatocytes and hepatic stellate cells. In control livers, interactions primarily consisted of protease-activated receptor (PAR) signaling. TCDD treatment increased the number of active signaling pathways. Within hepatocytes, neuregulin signaling was induced, activating the NRG1–ERBB4 ligand axis, consistent with AHR genomic enrichment at dioxin response elements in a published chromatin immunoprecipitation sequencing (ChIP-seq) dataset, which suggested a direct regulation. Collectively, the results suggest that the disruption of cell signaling may play a central role in TCDD-elicited liver pathologies.","PeriodicalId":74651,"journal":{"name":"Receptors (Basel, Switzerland)","volume":"82 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83745534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Molecular Characterization and Pharmacology of Melatonin Receptors in Animals 动物褪黑激素受体的分子表征和药理学研究

Receptors (Basel, Switzerland) Pub Date : 2023-04-14 DOI: 10.3390/receptors2020008

E. Cecon, J. Boutin, R. Jockers

引用次数: 1

Estrogen Receptor Knockout Mice and Their Effects on Fertility 雌激素受体敲除小鼠及其对生育能力的影响

Receptors (Basel, Switzerland) Pub Date : 2023-03-07 DOI: 10.3390/receptors2010007

I. Nalvarte, P. Antonson

引用次数: 1

Role of Hepatic Aryl Hydrocarbon Receptor in Non-Alcoholic Fatty Liver Disease. 肝芳香烃受体在非酒精性脂肪肝中的作用

Receptors (Basel, Switzerland) Pub Date : 2023-03-01 Epub Date: 2023-01-04 DOI: 10.3390/receptors2010001

Nikhil Y Patil, Jacob E Friedman, Aditya D Joshi

{"title":"Role of Hepatic Aryl Hydrocarbon Receptor in Non-Alcoholic Fatty Liver Disease.","authors":"Nikhil Y Patil, Jacob E Friedman, Aditya D Joshi","doi":"10.3390/receptors2010001","DOIUrl":"10.3390/receptors2010001","url":null,"abstract":"<p><p>Numerous nuclear receptors including farnesoid X receptor, liver X receptor, peroxisome proliferator-activated receptors, pregnane X receptor, hepatic nuclear factors have been extensively studied within the context of non-alcoholic fatty liver disease (NAFLD). Following the first description of the Aryl hydrocarbon Receptor (AhR) in the 1970s and decades of research which unveiled its role in toxicity and pathophysiological processes, the functional significance of AhR in NAFLD has not been completely decoded. Recently, multiple research groups have utilized a plethora of in vitro and in vivo models that mimic NAFLD pathology to investigate the functional significance of AhR in fatty liver disease. This review provides a comprehensive account of studies describing both the beneficial and possible detrimental role of AhR in NAFLD. A plausible reconciliation for the paradox indicating AhR as a 'double-edged sword' in NAFLD is discussed. Finally, understanding AhR ligands and their signaling in NAFLD will facilitate us to probe AhR as a potential drug target to design innovative therapeutics against NAFLD in the near future.</p>","PeriodicalId":74651,"journal":{"name":"Receptors (Basel, Switzerland)","volume":"2 1","pages":"1-15"},"PeriodicalIF":0.0,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10240927/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9623114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0