Recent patents on DNA & gene sequences最新文献_第8页

Tumor necrosis factor inhibitors from poxviruses with an emphasis on tanapoxvirus-2L protein. 痘病毒的肿瘤坏死因子抑制剂，重点是痘病毒- 2l蛋白。

Recent patents on DNA & gene sequences Pub Date : 2011-08-01 DOI: 10.2174/187221511796392033

David Jeng, Masmudur M Rahman, Grant McFadden, Karim Essani

{"title":"Tumor necrosis factor inhibitors from poxviruses with an emphasis on tanapoxvirus-2L protein.","authors":"David Jeng, Masmudur M Rahman, Grant McFadden, Karim Essani","doi":"10.2174/187221511796392033","DOIUrl":"https://doi.org/10.2174/187221511796392033","url":null,"abstract":"Viruses have evolved strategies to counteract host defenses. Some tactics employ viral proteins to neutralize host immune effector proteins such as cytokines, chemokines and their receptors, which help coordinate the host responses against the virus. Tumor necrosis factor (TNF) is one of the crucial pro-inflammatory/anti-viral cytokines involved in inflammatory and autoimmune diseases. Poxvirus anti-immune proteins represent some of the most complex and efficient mechanisms of regulating TNF and its pathological effects. These proteins have considerable potential for treating TNF-related diseases. Here we discuss two major classes of poxvirus-TNF inhibitors focusing on the tanapoxvirus (TPV)-2L protein, previously called TPV-gp38. TPV-2L has been shown to interact and biologically neutralize human (h)TNF, and has been indirectly associated with the inhibition of other cytokines (hIFN-γ, hIL-2 and hIL-5). The TPV-2L protein alone has been expressed, purified and shown to bind with high affinity to hTNF, but lacked binding to the other cytokines. Further studies identified sequential binding of hβ2-microglobulin and hα2-macroglobulin to TPV-2L. The ability of a single viral protein to form multi-protein complexes suggests that TPV might also possess other novel strategies of evading the immune system. Reviewed here are patented poxvirus TNF-binding proteins and their genes to evaluate their potential therapeutic value.","PeriodicalId":74646,"journal":{"name":"Recent patents on DNA & gene sequences","volume":"5 2","pages":"97-103"},"PeriodicalIF":0.0,"publicationDate":"2011-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/187221511796392033","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29846528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Recent advances and novel applications in microbial diversity estimation based on DNA analysis methods. 基于DNA分析方法的微生物多样性估算研究进展及新应用。

Recent patents on DNA & gene sequences Pub Date : 2011-08-01 DOI: 10.2174/187221511796392088

J A Narváez-Zapata, M A Reyes-López

引用次数: 0

Recent patents on biclustering algorithms for gene expression data analysis. 基因表达数据分析的双聚类算法的最新专利。

Recent patents on DNA & gene sequences Pub Date : 2011-08-01 DOI: 10.2174/187221511796392097

Alan Wee-Chung Liew, Ngai-Fong Law, Hong Yan

{"title":"Recent patents on biclustering algorithms for gene expression data analysis.","authors":"Alan Wee-Chung Liew, Ngai-Fong Law, Hong Yan","doi":"10.2174/187221511796392097","DOIUrl":"https://doi.org/10.2174/187221511796392097","url":null,"abstract":"In DNA microarray experiments, discovering groups of genes that share similar transcriptional characteristics is instrumental in functional annotation, tissue classification and motif identification. However, in many situations a subset of genes only exhibits a consistent pattern over a subset of conditions. Although used extensively in gene expression data analysis, conventional clustering algorithms that consider the entire row or column in an expression matrix can therefore fail to detect useful patterns in the data. Recently, biclustering has been proposed as a powerful computational tool to detect subsets of genes that exhibit consistent pattern over subsets of conditions. In this article, we review several recent patents in bicluster analysis, and in particular, highlight a recent patent from our group about a novel geometric-based biclustering method that handles the class of bicluster patterns with linear coherent variation across the row and/or column dimension. This class of bicluster patterns is of particular importance since it subsumes all constant, additive, and multiplicative bicluster patterns normally used in gene expression data analysis.","PeriodicalId":74646,"journal":{"name":"Recent patents on DNA & gene sequences","volume":"5 2","pages":"117-25"},"PeriodicalIF":0.0,"publicationDate":"2011-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/187221511796392097","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29846530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

DNA vaccines: a mini review. DNA疫苗:一个小回顾。

Recent patents on DNA & gene sequences Pub Date : 2011-08-01 DOI: 10.2174/187221511796392114

Ratul Saha, Sarah Killian, Robert S Donofrio

引用次数: 17

Human DNA extraction methods: patents and applications. 人类DNA提取方法:专利及应用。

Recent patents on DNA & gene sequences Pub Date : 2011-04-01 DOI: 10.2174/187221511794839264

Francesco M Carpi, Fabio Di Pietro, Silvia Vincenzetti, Fiorenzo Mignini, Valerio Napolioni

引用次数: 49

Different proposed applications of bacteriorhodopsin. 细菌视紫红质的不同应用。

Recent patents on DNA & gene sequences Pub Date : 2011-04-01 DOI: 10.2174/187221511794839273

Seema Trivedi, Om Prakash Choudhary, Jitendra Gharu

引用次数: 17

Significance of P2X7 receptor variants to human health and disease. P2X7受体变异对人类健康和疾病的意义

Recent patents on DNA & gene sequences Pub Date : 2011-04-01 DOI: 10.2174/187221511794839219

Ronald Sluyter, Leanne Stokes

{"title":"Significance of P2X7 receptor variants to human health and disease.","authors":"Ronald Sluyter, Leanne Stokes","doi":"10.2174/187221511794839219","DOIUrl":"https://doi.org/10.2174/187221511794839219","url":null,"abstract":"The human P2X7 receptor is a trimeric ligand-gated cation channel coded by the P2XR7 gene located at chromosome position 12q24. P2X7 is expressed in a wide variety of normal and disease-associated cell types. Activation of this receptor by extracellular adenosine 5'-triphosphate results in numerous downstream events including the release of pro-inflammatory mediators, cell proliferation or death, and killing of intracellular pathogens. As a result, P2X7 plays important roles in inflammation, immunity, bone homeostasis, neurological function and neoplasia. The P2XR7 gene encodes a P2X7 subunit 595 amino acids in length, however splice isoforms that can alter receptor expression and function, and modify the signaling properties downstream of receptor activation also exist. Moreover, the relative amount of P2X7 function varies between human individuals due to numerous single nucleotide polymorphisms resulting in either loss- or gain-of-function. Combinations of these polymorphisms give rise to various haplotypes that can also modify P2X7 function. Collectively, P2X7, and its splice and polymorphic variants are attracting considerable interest in relation to human health and disease, including the development and publication of a number of patents.","PeriodicalId":74646,"journal":{"name":"Recent patents on DNA & gene sequences","volume":"5 1","pages":"41-54"},"PeriodicalIF":0.0,"publicationDate":"2011-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/187221511794839219","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29656363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 139

Recent patents in cationic lipid carriers for delivery of nucleic acids. 核酸输送用阳离子脂质载体的最新专利。

Recent patents on DNA & gene sequences Pub Date : 2011-04-01 DOI: 10.2174/187221511794839255

Rumiana Koynova, Boris Tenchov

{"title":"Recent patents in cationic lipid carriers for delivery of nucleic acids.","authors":"Rumiana Koynova, Boris Tenchov","doi":"10.2174/187221511794839255","DOIUrl":"https://doi.org/10.2174/187221511794839255","url":null,"abstract":"Gene therapy is a medical technique intended for treatment of disorders caused by defective, missing, or overexpressing genes. Efficient delivery vectors are necessary in order to transport genetic material to the target cells. Such vectors include viral and non-viral carriers. Viral vectors transfect cells efficiently, however risks associated with their use have limited their clinical applications. Nonviral delivery systems are safer, easier to prepare, more versatile and cost effective. However, their transfection efficiency still falls behind that of the viral vectors. Considerable research into nonviral gene delivery has been conducted in the last two decades on synthetic soft materials such as cationic lipids, polymers, surfactants, and dendrimers as prospective nucleotide carriers for gene delivery. So far, cationic lipids are the most widely used constituents of nonviral gene carriers, with multiple strategies employed to improve their in vitro and in vivo transfection. Efforts in synthesizing new cationic lipids were not fully successful in closing the gap between the efficiency of the viral vectors and that of binary cationic lipid/DNA complexes. Current efforts for improving lipofection efficiency are focused on the development of multicomponent carriers including cationic lipids as key constituents. This review summarizes the recent patents on new cationic lipids as well as on multicomponent formulations enhancing their efficiency as nucleotide carriers.","PeriodicalId":74646,"journal":{"name":"Recent patents on DNA & gene sequences","volume":"5 1","pages":"8-27"},"PeriodicalIF":0.0,"publicationDate":"2011-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/187221511794839255","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29643865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 34

Recent patents concerning targeted therapy of apoptosis resistance in pancreatic cancer. 胰腺癌细胞凋亡耐药靶向治疗新专利。

Recent patents on DNA & gene sequences Pub Date : 2011-04-01 DOI: 10.2174/187221511794839237

Kristin Werner, Felix Rückert, Hans-Detlev Saeger, Robert Grützmann, Christian Pilarsky

{"title":"Recent patents concerning targeted therapy of apoptosis resistance in pancreatic cancer.","authors":"Kristin Werner, Felix Rückert, Hans-Detlev Saeger, Robert Grützmann, Christian Pilarsky","doi":"10.2174/187221511794839237","DOIUrl":"https://doi.org/10.2174/187221511794839237","url":null,"abstract":"Pancreatic cancer is one of the most malignant forms of cancer. Due to numerous defects of the apoptosis machinery this tumor shows a high resistance towards conventional oncological therapies. On the level of the extrinsic pathway, signal transduction is flawed by over-expression of decoy receptors but also by a dysfunctional death inducing signaling complex (DISC). The mitochondrial pathway, normally stimulated by cell stress and toxic agents is impeded by over-expression of anti-apoptotic members of the Bcl 2 protein family and the so-called inhibitor of apoptosis proteins (IAPs). To overcome the dysfunction of the apoptosis pathway, new therapeutics focus on molecular targets within the apoptosis pathway. Recently, many new treatment modalities have been reported like recombinant ligands of the cell death receptors or inhibitors of anti-apoptotic Bcl-2 members. Furthermore, various substances for the direct activation of the caspase cascade were patented and the over-expression of IAPs could be treated by binding inhibitors or using RNA interference techniques. The present review aims at giving an overview on these new treatment modalities.","PeriodicalId":74646,"journal":{"name":"Recent patents on DNA & gene sequences","volume":"5 1","pages":"28-34"},"PeriodicalIF":0.0,"publicationDate":"2011-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.2174/187221511794839237","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"29566202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

The diagnostic and therapeutic importance of human growth hormone isoforms. 人类生长激素异构体的诊断和治疗意义。

Recent patents on DNA & gene sequences Pub Date : 2011-04-01 DOI: 10.2174/187221511794839228

Marina María de Jesús Romero-Prado, Noa Beatriz Martín-Cófreces

引用次数: 1