Prilozi (Makedonska akademija na naukite i umetnostite. Oddelenie za medicinski nauki)最新文献

{"title":"Origin of the Right Vertebral Artery Examined with CTA.","authors":"Ace Dodevski, Julija Zhivadinovik, Anamarija Paunkoska, Jovana Kordoska, Vjolca Aliji, Goran Pavlovski","doi":"10.2478/prilozi-2025-0030","DOIUrl":"https://doi.org/10.2478/prilozi-2025-0030","url":null,"abstract":"<p><p><b>Background</b>: The vertebral artery arises from the first part of the subclavian artery and provides posterior brain circulation. The abnormal origin of the vertebral arteries is an uncommon finding. The aim of this study was to examine the origin of the right vertebral artery and to discuss its clinical implications. <b>Materials and methods</b>: We examined radiographs of 203 patients who had CT angiography undertaken for a variety of clinical reasons, performed as part of their medical treatment at the University Clinic for Radiology in Skopje, R. N. Macedonia. <b>Results</b>: The study population included 203 patients, 108 male and 95 female, age range from 19-82, mean age 59.6 years. In 202 patients (99.5%) the right vertebral artery originated from the right subclavian artery. In one patient (0.49%) we found atypical right vertebral artery arising from the right common carotid artery in combination with the origin of the right subclavian artery from the aortic arch. <b>Conclusions</b>: The knowledge of the potential vertebral artery origin variants is important for clinicians for safe performance of diagnostic and interventional procedures in radiology and for surgeons during planning and accomplishing surgical interventions.</p>","PeriodicalId":74492,"journal":{"name":"Prilozi (Makedonska akademija na naukite i umetnostite. Oddelenie za medicinski nauki)","volume":"46 3","pages":"129-134"},"PeriodicalIF":0.0,"publicationDate":"2025-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145710449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Well-Being Among Anesthesia Providers: Results from a National Survey.","authors":"Biljana Kuzmanovska, Aleksandra Gavrilovska Brzanov, Igor Kuzmanovski, Nikola Brzanov, Marija Jovanovski Srceva","doi":"10.2478/prilozi-2025-0026","DOIUrl":"https://doi.org/10.2478/prilozi-2025-0026","url":null,"abstract":"<p><p><b>Introduction</b>:Anesthesiology is a demanding medical specialty that requires intense focus, long working hours, and frequent exposure to high-stress situations. These factors often lead to significant occupational stress. Supporting the well-being of anesthesiologists is essential for maintaining patient safety and a stable healthcare workforce. <b>Methods</b>: We conducted a survey among anesthesiology residents and specialists in North Macedonia. Standardized tools were used, including the Safety Attitudes Questionnaire (SAQ), WHO-5 Well-Being Index, and custom questions related to workplace culture, mental health, and teamwork. Data were collected anonymously via Google Forms and analyzed with SPSS v29.0, focusing on work conditions, psychological well-being, and burnout levels. <b>Results</b>: A total of 100 participants participated-60% residents and 40% specialists. Residents reported significantly higher stress and burnout, along with lower perceived support from institutions and weaker team dynamics (p < 0.05). Specialists noted better job satisfaction and stronger organizational backing (p < 0.05). Both groups highlighted a lack of mental health support and weak safety culture, particularly in under-resourced settings; however, these differences were not statistically significant (p > 0.05). Overall, resource limitations were widely recognized as key contributors to workplace challenges in middle-income countries (p < 0.05). <b>Conclusion</b>: Anesthesiology residents face higher levels of stress and lower job satisfaction compared to specialists, with resource constraints worsening these disparities. To address these issues, targeted interventions are needed, including mental health support services, mentoring programs, stress management training, and policies that promote a positive work environment and psychological safety.</p>","PeriodicalId":74492,"journal":{"name":"Prilozi (Makedonska akademija na naukite i umetnostite. Oddelenie za medicinski nauki)","volume":"46 3","pages":"93-104"},"PeriodicalIF":0.0,"publicationDate":"2025-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145710419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When Words Fail: Investigating Alexithymia And Coping Strategies In Adolescent Mental Health.","authors":"Haris Sulejmani, Nada Pop-Jordanova","doi":"10.2478/prilozi-2025-0019","DOIUrl":"https://doi.org/10.2478/prilozi-2025-0019","url":null,"abstract":"<p><p><b>Introduction</b>: Alexithymia, defined by difficulty identifying and verbalizing emotions, has emerged as a significant factor influencing emotional regulation and coping behaviors in youth. Adolescents with high levels of alexithymia may be at greater risk of psychological distress due to maladaptive coping mechanisms and reduced social support engagement. <b>Materials and Methods</b>: This cross-sectional study was conducted among 141 high school students aged 15-18 in Skopje, North Macedonia. Participants completed validated instruments including the Toronto Alexithymia Scale (TAS-20) and the Adolescent Coping Orientation for Problem Experiences (COPE-A). Statistical analyses included descriptive statistics, Pearson correlations, to examine associations between alexithymia and coping strategies. <b>Results</b>: The mean TAS-20 score suggested a high prevalence of alexithymic traits in the sample. Approximately 44% of adolescents in the sample scored above the clinical threshold for alexithymia (TAS-20 > 61), highlighting the prevalence of emotional processing difficulties in this population. Significant correlations were found between higher alexithymia and maladaptive emotion regulation strategies such as self-blame, rumination, and catastrophizing. Conversely, positive coping strategies like positive reappraisal and acceptance were negatively correlated with alexithymia levels. Participants with high alexithymia reported a greater tendency to engage in maladaptive coping behaviors. <b>Discussion</b>: Findings underscore alexithymia as a trait associated with emotion dysregulation and diminished coping flexibility in adolescents. The results highlight the interplay between poor emotional awareness and a tendency to adopt dysfunctional cognitive responses to stress, which may exacerbate vulnerability to psychological problems. <b>Conclusion</b>: Early identification of alexithymic traits and the promotion of emotional literacy and adaptive coping in adolescence are crucial. Preventive school-based programs focusing on emotional skill development and peer support may buffer the impact of alexithymia and enhance youth mental health outcomes.</p>","PeriodicalId":74492,"journal":{"name":"Prilozi (Makedonska akademija na naukite i umetnostite. Oddelenie za medicinski nauki)","volume":"46 3","pages":"15-26"},"PeriodicalIF":0.0,"publicationDate":"2025-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145710435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Music Changes Brain Functioning and Development.","authors":"Nada Pop-Jordanova","doi":"10.2478/prilozi-2025-0018","DOIUrl":"https://doi.org/10.2478/prilozi-2025-0018","url":null,"abstract":"<p><p>It is well documented that music is a basic and ubiquitous socio-cultural domain in humans. Across human cultures music was a source of affective and pleasurable experience, moving people both physically and emotionally. Researches confirmed that music shapes brain structure and brain function as well. The neuroscience of music suggests that neural oscillations synchronize with musical stimuli. Fundamental dynamical principles based on known neural mechanisms can explain the basic aspects of music perception and performance, as summarized in \"neural resonance theory\". Music is an integral part of every human society. Music can bring pleasure, calm anxiety, soothe sorrow, inspire and/or stimulate movement, and promote social connections. Musical experiences may also have the remarkable ability to enhance brain and cognitive development, improve function and well-being, optimize the quality of life, and possibly ameliorate the symptoms of a broad range of diseases and disorders. This article summarizes some effects of music on brain functioning and development.</p>","PeriodicalId":74492,"journal":{"name":"Prilozi (Makedonska akademija na naukite i umetnostite. Oddelenie za medicinski nauki)","volume":"46 3","pages":"5-14"},"PeriodicalIF":0.0,"publicationDate":"2025-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145710420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Total Soluble Solids Content and Viscosity of Commercially Available Mouthwashes.","authors":"Kushtrim Dakaj, Marija Andonovska, Vlatko Kokolanski, Marija Glavas-Dodov, Dushko Shalabalija, Kiro Ivanovski, Maja Dimitrovska, Teodora Tasevska, Julijana Nikolovska, Spiro Spasovski, Bojan Poposki, Maja Milosevic Markovic","doi":"10.2478/prilozi-2025-0025","DOIUrl":"https://doi.org/10.2478/prilozi-2025-0025","url":null,"abstract":"<p><p><b>Aim of the study</b>: To evaluate the total soluble solid content (TSSC) and viscosity of commercially available mouthwashes available on the market in Macedonia. <b>Material and methods</b>: A market analysis was conducted from January to October 2024. Products meeting defined inclusion criteria were analyzed using refractometry (Atago® Rx-5000i, 37°C) to determine TSSC (°Brix), and a modular compact rheometer (MCR 92, Anton Paar) to assess viscosity (mPa·s) under constant shear rate conditions. Each measurement was performed in triplicate. <b>Results</b>: TSSC values ranged from 0 to 38.84 °Brix, with a mean of 11.17±5.95 °Brix. Viscosity varied between 0.81 and 74.39 mPa·s, averaging 2.86±8.69 mPa·s. Outliers included products exceeding 35.99 °Brix or 3.03 mPa·s. A strong positive correlation was found between TSSC and viscosity (ρ = 0.722, p < 0.001), suggesting increased viscosity with higher solid content. <b>Conclusion</b>: The wide variability in TSSC and viscosity reflects the complexity of mouthwash formulations and their potential impact on oral health. The strong correlation between these parameters highlights the need to assess them together in both product development and clinical guidance. Further in vivo research is essential to determine their clinical relevance and support evidence-based recommendations for safe use.</p>","PeriodicalId":74492,"journal":{"name":"Prilozi (Makedonska akademija na naukite i umetnostite. Oddelenie za medicinski nauki)","volume":"46 3","pages":"83-92"},"PeriodicalIF":0.0,"publicationDate":"2025-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145710443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiology Approach to Invasive Breast Lobular Carcinoma - Initial Experience.","authors":"Sandra Dejanova Panev, Biljana Bozinovska, Biljana Prgova Veljanovska, Natasa Prvulovic Bunovic, Maja Jakimovska Dimitrovska","doi":"10.2478/prilozi-2025-0031","DOIUrl":"https://doi.org/10.2478/prilozi-2025-0031","url":null,"abstract":"<p><p>It is well known that invasive lobular carcinoma (ILC) accounts for approximately 5-15 % of invasive breast cancers that remain one of the most common malignancies among women globally. ILC is distinguished from the more common invasive ductal carcinoma (IDC) by characteristics histopathology features. The aim of the study was to emphasize the need of more specified diagnostic imaging approach in order to detect breast ILC, based on our institution experience. We describe a number of 17 female cases (58±7 years) who presented: breast fullness/asymmetry - 11 patients (64.7 %), pain - 2 patients (11.7 %), and the rest 4 patients (23.5 %) were asymptomatic. Diagnostic modalities used in this study were: 2D Mammography, Ultrasound, Digital Breast Tomosynthesis (DBT), and core biopsy in guidance by Ultrasound. On 2D Mammography, visible mass was found in 8 patients (47 %), and architectural distortion was found in 4 patients (23.5 %). On DBT additional 5 patients were examined from the total number of patients, and additional lesions were found such as occult lesions and additional architectural distortion. Using DBT, occult lesion was found in 3 patients (17.6 %) and architectural distortion was found in 2 patients (11.7%). Due to these inconclusive findings, DBT was carried out to improve visualization especially in those with more glandular tissue. The occult lesions were seen in 3 patients, which showed as false negative on 2D, as well as an architectural distortion in 2 patients, additionally seen on DBT. This multimodality approach, including DBT, holds promise for more reliable detection of occult lesions and distortions especially in denser breast, and for better clinical outcomes in patients with ILC, respectively.</p>","PeriodicalId":74492,"journal":{"name":"Prilozi (Makedonska akademija na naukite i umetnostite. Oddelenie za medicinski nauki)","volume":"46 3","pages":"135-142"},"PeriodicalIF":0.0,"publicationDate":"2025-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145710445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of the Level of Middle Colic Artery Ligation Influence on Survival in Right-Sided Colon Cancer.","authors":"Cemal Ulusoy, Mehmet Güray Duman, Andrej Nikolovski","doi":"10.2478/prilozi-2025-0012","DOIUrl":"https://doi.org/10.2478/prilozi-2025-0012","url":null,"abstract":"<p><p><b>Aim</b>: This study aims to investigate whether the addition of ligation of the Middle Colic Artery in its origin to Complete Mesocolic Excision (CME) with Central Vascular Ligation (CVL) affects overall survival and lymph node retrieval. <b>Method</b>: Patients with right-sided colon cancer who underwent curative right or extended right hemicolectomy with CME and CVL were included. In cases with tumors located in the distal part of the ascending colon and the hepatic flexure, the middle colic artery was ligated in its origin. For the cecal and proximal localization of the tumor, the point of ligation was decided on the surgeons' decision. <b>Results</b>: A total number of 169 patients were operated. In 78 patients the tumor was localized in the caecum, in 70 patients in the ascending colon, and 21 in the hepatic flexure. In 59 patients, the middle colic artery was ligated in its origin. Different artery ligation sites according to tumor localization subgroup presented with statistical significance (P = 0.004). The mean number of harvested lymph nodes between the groups was presented with a difference (33.4 vs. 28.5; P = 0.037). Survival rates for cecal, ascending, and hepatic flexure cancer were as follows: 61.5%, 67.1%, and 85.7%, respectively (P = 0.22). The survival rate for all patients was 66.9% (69.5% for patients with middle colic artery ligation and 65.5% for the right branch of middle colic artery ligation, P = 0.42). <b>Conclusion</b>: Ligation of the middle colic artery in its origin did not improve overall survival. However, it resulted in a significantly higher number of harvested lymph nodes.</p>","PeriodicalId":74492,"journal":{"name":"Prilozi (Makedonska akademija na naukite i umetnostite. Oddelenie za medicinski nauki)","volume":"46 2","pages":"39-48"},"PeriodicalIF":0.0,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144568191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lymphocyte Subsets Changes in Children with Acute Lymphoblastic Leukemia during Chemotherapy.","authors":"Arijeta Hasani, Aleksandar Petlickovski, Irina Panovska, Teodora Brnjarcevska, Nevenka Ridova, Svetlana Kocheva","doi":"10.2478/prilozi-2025-0013","DOIUrl":"https://doi.org/10.2478/prilozi-2025-0013","url":null,"abstract":"<p><p><b>Background</b>: Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy, with chemotherapy significantly impacting immune cell populations. This study evaluates changes in lymphocyte subsets in children with ALL during treatment. <b>Methods</b>: A retrospective-prospective study analyzed 17 pediatric patients (aged 2-12 years) treated at the University Clinic for Children's Disease- Skopje following the BFM ALL-IC 2002 protocol. Lymphocyte subsets (CD3, CD4, CD19, CD45) were assessed before chemotherapy, after induction, and after reinduction using flow cytometry. <b>Results</b>: Children with ALL exhibited reduced cellular immunity at the end of therapy. Lymphocyte depletion was observed in all patients following the induction phase. A statistically significant difference in CD19+ cell values across the three time points was confirmed (p=0.017). Post-hoc analysis revealed significantly lower CD19+ cell values after induction compared to baseline (1.22 vs. 15.3, p=0.008) and significantly lower values at the end of therapy compared to pre-therapy levels (2.5 vs. 15.3, p=0.021). <b>Conclusion</b>: Intensive chemotherapy induces profound immunosuppression in pediatric ALL patients, primarily affecting B cells. These findings highlight the necessity for immune function assessment and consideration of supportive immunotherapy.</p>","PeriodicalId":74492,"journal":{"name":"Prilozi (Makedonska akademija na naukite i umetnostite. Oddelenie za medicinski nauki)","volume":"46 2","pages":"49-56"},"PeriodicalIF":0.0,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144568197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Various Cases of Venous Thrombembolism.","authors":"Ivica Bojovski, Emilija Lazarova Trajkovska, Dimitar Galachev, Simona Jovchevska, Ivona Bogevska Naumovska, Tomislav Konjanovski, Elif Vrajnko, Vegim Zhaku, Ile Kuzmanoski, Miroslav Boskovski, Irena Bede, Bekim Pocesta, Marijan Bosevski, Enes Shehu, Robert Nikolovski, Natasha Skrcheska, Mario Jovanoski, Valentina Andova, Irena Mitevska","doi":"10.2478/prilozi-2025-0009","DOIUrl":"10.2478/prilozi-2025-0009","url":null,"abstract":"<p><p>Venous thromboembolism (VTE) with its two forms: deep vein thrombosis (DVT) and pulmonary embolism (PE) occurs due to interacting genetic and environmental risk factors. The strongest risk factors are major surgery, major trauma and malignancies. Over the last decade many new risk factors for venous thrombosis have been identified. Even risk factors, clinical signs, symptoms and diagnostic methods of venous thromboembolism (VTE) are well known, there are still uncommon scenarios for this disease. This paper includes eight case reports of venous thromboembolism with different etiologies. Ongoing studies in this field are focused on improving diagnostic strategies for suspected venous thrombosis, comparing different direct oral anticoagulants (DOACs), developing safer anticoagulants, and further individualizing approaches for the prevention and management of VTE.</p>","PeriodicalId":74492,"journal":{"name":"Prilozi (Makedonska akademija na naukite i umetnostite. Oddelenie za medicinski nauki)","volume":"46 2","pages":"15-21"},"PeriodicalIF":0.0,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144568200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cystatin C Versus Urea and Creatinine in Early Detection of Acute Kidney Injury after Laparoscopic Prostatectomy.","authors":"Natka Petrova Chemerski, Aleksandra Gavrilovska-Brzanov, Aleksandra Panovska Petrusheva, Bashkim Shabani, Andrijan Kartalov, Biljana Kuzmanovska, Marija Jovanovski Srceva, Jasmina Pluncevic Glogoroska","doi":"10.2478/prilozi-2025-0014","DOIUrl":"https://doi.org/10.2478/prilozi-2025-0014","url":null,"abstract":"<p><p><b>Introduction</b>: Acute kidney injury (AKI) is a potentially serious complication subsequent to laparoscopic radical prostatectomy (LRP). Serum creatinine, the prevailing standard biomarker, has demonstrated inadequacy for the early identification of AKI due to its delayed elevation in the initial stages. There is a necessity for innovative biomarkers that facilitate early detection and prompt intervention, hence enhancing patient outcomes. <b>Objectives</b>: To assess and compare the values of biochemical markers of renal function (serum urea, creatinine, and cystatin C) in the preoperative and postoperative periods in patients undergoing LRP. <b>Materials and Methods</b>: This prospective, comparative study included 30 patients who underwent LRP. The investigated serum parameters-urea, creatinine, and cystatin C-were assessed at three time points: preoperatively (T1), immediately after LRP (T2), and 12 hours after the start of LRP (T3). <b>Results</b>: All patients exhibited normal preoperative biochemical indicators of renal function. Postoperatively, AKI was identified in three patients. Out of a total of 30 patients who underwent LRP, only three patients (10%) met the criteria for AKI diagnosis. One patient (3%) developed AKI based on increased serum creatinine levels, while three patients (6%), including the one who met the creatinine-based criteria, were diagnosed with AKI based on elevated serum cystatin C levels. Serum cystatin C levels were significantly elevated in patients with AKI at T2 and remained elevated at T3 in comparison to T1. <b>Conclusion</b>: The results indicate that serum cystatin C has greater sensitivity for identifying AKI than serum urea and creatinine in the initial 12 hours post- LRP.</p>","PeriodicalId":74492,"journal":{"name":"Prilozi (Makedonska akademija na naukite i umetnostite. Oddelenie za medicinski nauki)","volume":"46 2","pages":"57-65"},"PeriodicalIF":0.0,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144568193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}