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Precision cancer medicine最新文献

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Analytical Phase: Principles for Immunohistochemistry (IHC) 分析阶段:免疫组织化学原理(IHC)
Precision cancer medicine Pub Date : 2021-01-01 DOI: 10.1007/978-3-030-84087-7_9
B. Jasani, R. Huss, C. Taylor
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引用次数: 0
Role of Pathologist in Precision Molecular and Digital Image Analyses 病理学家在精确分子和数字图像分析中的作用
Precision cancer medicine Pub Date : 2021-01-01 DOI: 10.1007/978-3-030-84087-7_17
B. Jasani, R. Huss, C. Taylor
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引用次数: 0
Lung cancer in women 女性肺癌
Precision cancer medicine Pub Date : 2021-01-01 DOI: 10.21037/pcm-22-32
E. Baldini
{"title":"Lung cancer in women","authors":"E. Baldini","doi":"10.21037/pcm-22-32","DOIUrl":"https://doi.org/10.21037/pcm-22-32","url":null,"abstract":"","PeriodicalId":74487,"journal":{"name":"Precision cancer medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44171323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
KRAS G12V mutation as an acquired resistance mechanism after treatment with dabrafenib and trametinib in non-small cell lung cancer harbouring the BRAF V600E mutation: a case report KRAS G12V突变作为携带BRAF V600E突变的癌症用达非尼和曲美替尼治疗后获得性耐药性机制的一例报告
Precision cancer medicine Pub Date : 2021-01-01 DOI: 10.21037/pcm-21-55
H. Oi, K. Yoh, S. Matsumoto, H. Izumi, Y. Shibata, T. Sakai, K. Nosaki, Y. Zenke, K. Goto
{"title":"KRAS G12V mutation as an acquired resistance mechanism after treatment with dabrafenib and trametinib in non-small cell lung cancer harbouring the BRAF V600E mutation: a case report","authors":"H. Oi, K. Yoh, S. Matsumoto, H. Izumi, Y. Shibata, T. Sakai, K. Nosaki, Y. Zenke, K. Goto","doi":"10.21037/pcm-21-55","DOIUrl":"https://doi.org/10.21037/pcm-21-55","url":null,"abstract":"","PeriodicalId":74487,"journal":{"name":"Precision cancer medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43750034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Oncogene-addicted non-small-cell lung cancer in women: a narrative review of the importance of gender-related differences in treatment outcome 女性癌基因成瘾的非小细胞肺癌:性别差异在治疗结果中的重要性的叙述性回顾
Precision cancer medicine Pub Date : 2021-01-01 DOI: 10.21037/pcm-21-31
C. Tibaldi, I. Stasi, E. Baldini
{"title":"Oncogene-addicted non-small-cell lung cancer in women: a narrative review of the importance of gender-related differences in treatment outcome","authors":"C. Tibaldi, I. Stasi, E. Baldini","doi":"10.21037/pcm-21-31","DOIUrl":"https://doi.org/10.21037/pcm-21-31","url":null,"abstract":"","PeriodicalId":74487,"journal":{"name":"Precision cancer medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43290769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Squeezed into defection?—nuclear displacement by steatosis activates yes-associated protein (YAP) linked to oncogenic pathways in hepatocytes 被迫叛逃--脂肪变性引起的细胞核移位激活与肝细胞致癌途径相关的yes相关蛋白
Precision cancer medicine Pub Date : 2021-01-01 DOI: 10.21037/pcm-21-21
G. Baffy
{"title":"Squeezed into defection?—nuclear displacement by steatosis activates yes-associated protein (YAP) linked to oncogenic pathways in hepatocytes","authors":"G. Baffy","doi":"10.21037/pcm-21-21","DOIUrl":"https://doi.org/10.21037/pcm-21-21","url":null,"abstract":"","PeriodicalId":74487,"journal":{"name":"Precision cancer medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41426535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Utility of intraparenchymal blood patch testing following CT- guided lung biopsy CT引导下肺活检后肺实质内血斑试验的应用
Precision cancer medicine Pub Date : 2021-01-01 DOI: 10.21037/pcm-22-62
K. Syed, B. Benn, J. Kurman
{"title":"Utility of intraparenchymal blood patch testing following CT- guided lung biopsy","authors":"K. Syed, B. Benn, J. Kurman","doi":"10.21037/pcm-22-62","DOIUrl":"https://doi.org/10.21037/pcm-22-62","url":null,"abstract":"","PeriodicalId":74487,"journal":{"name":"Precision cancer medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41726540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Wielding a double-edged sword in head and neck cancers—diagnosis, risk factors and mitigation strategies of radiation-induced head and neck sarcomas: a narrative review 在头颈部癌症中挥舞双刃剑——辐射诱发的头颈部肉瘤的诊断、危险因素和缓解策略:一项叙述性综述
Precision cancer medicine Pub Date : 2021-01-01 DOI: 10.21037/pcm-21-30
T. Chan, Venkatesh Alagappan, B. Vellayappan
{"title":"Wielding a double-edged sword in head and neck cancers—diagnosis, risk factors and mitigation strategies of radiation-induced head and neck sarcomas: a narrative review","authors":"T. Chan, Venkatesh Alagappan, B. Vellayappan","doi":"10.21037/pcm-21-30","DOIUrl":"https://doi.org/10.21037/pcm-21-30","url":null,"abstract":"National University Cancer Institute, Singapore, Singapore; Novi High School, Novi, MI, USA Contributions: (I) Conception and design: TY Chan, B Vellayappan; (II) Administrative support: All authors; (III) Provision of study materials or patients: TY Chan, B Vellayappan; (IV) Collection and assembly of data: TY Chan, B Vellayappan; (V) Data analysis and interpretation: TY Chan, B Vellayappan; (VI) Manuscript writing: All authors; (VII) Final approval of manuscript: All authors. Correspondence to: Balamurugan Vellayappan. 1E Kent Ridge Road, Level 7 Tower Block, Singapore 119228, Singapore. Email: bala_vellayappan@nuhs.edu.sg.","PeriodicalId":74487,"journal":{"name":"Precision cancer medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47713245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of cancer incidence and mortality between China and the United States 中美两国癌症发病率和死亡率比较
Precision cancer medicine Pub Date : 2021-01-01 DOI: 10.21037/pcm-21-25
Zezhou Wang, Changming Zhou, Xiaoshuang Feng, M. Mo, Jie Shen, Ying Zheng
{"title":"Comparison of cancer incidence and mortality between China and the United States","authors":"Zezhou Wang, Changming Zhou, Xiaoshuang Feng, M. Mo, Jie Shen, Ying Zheng","doi":"10.21037/pcm-21-25","DOIUrl":"https://doi.org/10.21037/pcm-21-25","url":null,"abstract":"","PeriodicalId":74487,"journal":{"name":"Precision cancer medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43560316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Partial hippocampal sparing whole brain radiotherapy in a patient with bilateral malignant melanoma metastases to the hippocampus: a case report 保留海马部分全脑放射治疗双侧恶性黑色素瘤海马转移1例
Precision cancer medicine Pub Date : 2021-01-01 DOI: 10.21037/pcm-21-23
M. McKay, H. Zadeh, Carolyn Sanderson, Thomas A McKay, Aaron Chindewere
{"title":"Partial hippocampal sparing whole brain radiotherapy in a patient with bilateral malignant melanoma metastases to the hippocampus: a case report","authors":"M. McKay, H. Zadeh, Carolyn Sanderson, Thomas A McKay, Aaron Chindewere","doi":"10.21037/pcm-21-23","DOIUrl":"https://doi.org/10.21037/pcm-21-23","url":null,"abstract":": Whole brain radiotherapy (WBRT) has been used for some decades in the treatment of metastatic cancer to the brain. It modestly improves overall survival of brain metastasis patients and in some randomised studies has been shown to prevent neurological deterioration and distant in-brain failure rates. WBRT can however, be associated with adverse quality-of-life and neurocognitive defects. Since the hippocampus has a major role in short term memory and cognitive function, hippocampal-avoidance WBRT (HA-WBRT) has become a more prevalent WBRT technique in recent years. It does not seem to be associated with increased hippocampal failures in magnetic resonance imaging-screened patients. We present the case of a 64-year-old male with metastatic malignant melanoma to the brain, who had multiple brain metastases including bilateral hippocampal metastases. We treated him with partial HA-WBRT, namely, by including in the high dose volume the hippocampal-associated metastases along with the rest of the brain, avoiding high dose to the remainder of the normal hippocampi, in an attempt to maximise his neurocognitive function. For the right hippocampal avoidance structure, the D100% was 10 Gy, maximum 18.4 Gy, while for the left hippocampal avoidance structure, the D100% was 8.45 Gy, maximum 18.1 Gy. The planning target volume (PTV) received 28.9 Gy, with <2% receiving >31 Gy. We prioritised minimising hot spots in the PTV because of the patient’s previous stereotactic radiosurgery (SRS) treatment (adjacent to the brainstem).","PeriodicalId":74487,"journal":{"name":"Precision cancer medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42240652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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