PHAGE (New Rochelle, N.Y.)最新文献_第8页

Pathways to Phage Therapy Enlightenment, or Why I Have Become a Scientific Curmudgeon. 噬菌体疗法启蒙之路，或我为何成为科学怪人》。

PHAGE (New Rochelle, N.Y.) Pub Date : 2022-06-01 Epub Date: 2022-06-16 DOI: 10.1089/phage.2022.0012

Stephen T Abedon

引用次数: 0

Data to Power Precision Phage Therapy: A Look at the Phage Directory-Phage Australia Partnership. 为精准噬菌体治疗提供动力的数据:噬菌体目录-噬菌体澳大利亚合作伙伴关系的展望。

PHAGE (New Rochelle, N.Y.) Pub Date : 2022-06-01 DOI: 10.1089/phage.2022.29030.jcs

Jessica C Sacher, Jan Zheng, Ruby C Y Lin

引用次数: 1

inPhocus: Once Upon a Time …. inPhocus：Once Upon a Time ....

PHAGE (New Rochelle, N.Y.) Pub Date : 2022-06-01 Epub Date: 2022-06-16 DOI: 10.1089/phage.2022.0017

Peder Worning

引用次数: 0

Using Phages to Reduce Salmonella Prevalence in Chicken Meat: A Systematic Review. 利用噬菌体降低鸡肉中沙门氏菌流行率的系统综述。

PHAGE (New Rochelle, N.Y.) Pub Date : 2022-03-01 DOI: 10.1089/phage.2021.0017

Malak Almutairi, Mohammed Imam, Nouf Alammari, Radwan Hafiz, Faizal Patel, Sulaiman Alajel

{"title":"Using Phages to Reduce Salmonella Prevalence in Chicken Meat: A Systematic Review.","authors":"Malak Almutairi, Mohammed Imam, Nouf Alammari, Radwan Hafiz, Faizal Patel, Sulaiman Alajel","doi":"10.1089/phage.2021.0017","DOIUrl":"https://doi.org/10.1089/phage.2021.0017","url":null,"abstract":"Salmonellosis is an infection that significantly impacts chicken and humans who consume it; it is a burden on public health and a contributor to commercial losses in the chicken industry worldwide. To tackle chicken meat-related bacterial infections, significant quantities of antibiotics alongside several infection prevention measures are used worldwide. However, chemical additives, such as organic acids, and chlorine-based interventions all have different limitations. These include feed refusal due to a change of taste, and incompatibility between organic acids and other inoculated preservative agents such as antimicrobial agents. Phages are host-specific viruses that interact with bacteria in a specific manner. Therefore, they possess unique biological and therapeutic features that can be used to reduce bacterial contamination, leading to improved food safety and quality. This systematic review examines the current evidence regarding the effectiveness of various phages on Salmonella colonization in chicken meat. This review summarizes findings from 17 studies that were conducted in vitro with similar experimental conditions (temperature and incubation parameters) to test the efficacy of isolated and commercially available phages on chicken raw meat samples. The current evidence suggests that most of the in vitro studies that used phages as a biocontrol to eradicate Salmonella contamination in chicken meat were successful. This indicates that phages constitute a promising solution worldwide for tackling foodborne bacteria, including Salmonella.","PeriodicalId":74428,"journal":{"name":"PHAGE (New Rochelle, N.Y.)","volume":"3 1","pages":"15-27"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9041517/pdf/phage.2021.0017.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10814644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Isolation and Characterization of Lytic Bacteriophages Targeting Diverse Enterobacter spp. Clinical Isolates. 多种肠杆菌噬菌体的分离与鉴定。临床分离物。

PHAGE (New Rochelle, N.Y.) Pub Date : 2022-03-01 DOI: 10.1089/phage.2021.0011

Amanda G Finney, Jalyne M Perry, Daniel R Evans, Kevin J Westbrook, Christi L McElheny, Alina Iovleva, Yohei Doi, Ryan K Shields, Daria Van Tyne

{"title":"Isolation and Characterization of Lytic Bacteriophages Targeting Diverse Enterobacter spp. Clinical Isolates.","authors":"Amanda G Finney, Jalyne M Perry, Daniel R Evans, Kevin J Westbrook, Christi L McElheny, Alina Iovleva, Yohei Doi, Ryan K Shields, Daria Van Tyne","doi":"10.1089/phage.2021.0011","DOIUrl":"https://doi.org/10.1089/phage.2021.0011","url":null,"abstract":"Background: Enterobacter spp. are opportunistic pathogens that cause nosocomial infections. Bacteriophages could be used to treat antibiotic-resistant Enterobacter infections. Materials and Methods: We used 10 genetically diverse clinical Enterobacter spp. isolates to identify lytic bacteriophages in hospital and municipal wastewater. Comparative genomics was performed on host bacterial isolates and isolated phages. Activity of each phage against all 10 host isolates was determined. We also tested phage activity against paired isolates from two patients who developed ceftazidime-avibactam resistance. Results: Bacteria belonged to three Enterobacter species and Klebsiella aerogenes. We isolated 12 bacteriophages, most of which belonged to the Myoviridae and Autographiviridae families. Most phages were able to lyse multiple bacterial isolates, and many lysed isolates of different species. Ceftazidime-avibactam-resistant isolates were still phage susceptible, and one isolate showed increased susceptibility compared with the parent isolate. Conclusion: The phages we isolated expand the diversity of Enterobacter-targeting phages, and could be useful for treating antibiotic-resistant Enterobacter infections.","PeriodicalId":74428,"journal":{"name":"PHAGE (New Rochelle, N.Y.)","volume":"3 1","pages":"50-58"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b3/90/phage.2021.0011.PMC9041515.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10159252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

inPhocus: Current State and Challenges of Phage Research in Singapore. 新加坡噬菌体研究的现状和挑战。

PHAGE (New Rochelle, N.Y.) Pub Date : 2022-03-01 DOI: 10.1089/phage.2022.29028.nkv

Navin Kumar Verma, Si Jia Tan, John Chen, Hanrong Chen, Muhammad Hafiz Ismail, Scott A Rice, Pablo Bifani, Sukumar Hariharan, Vivek Daniel Paul, Bharathi Sriram, Linh Chi Dam, Chia Ching Chan, Peiying Ho, Boon Chong Goh, Shimin Jasmine Chung, Kenneth Choon Meng Goh, Shu Hua Thong, Andrea Lay-Hoon Kwa, Adam Ostrowski, Thet Tun Aung, Halimah Razali, Shermaine W Y Low, Mani Shankar Bhattacharyya, Hemant K Gautam, Rajamani Lakshminarayanan, Thomas Sicheritz-Pontén, Martha R J Clokie, Wilfried Moreira, Maurice Adrianus Monique van Steensel

{"title":"inPhocus: Current State and Challenges of Phage Research in Singapore.","authors":"Navin Kumar Verma, Si Jia Tan, John Chen, Hanrong Chen, Muhammad Hafiz Ismail, Scott A Rice, Pablo Bifani, Sukumar Hariharan, Vivek Daniel Paul, Bharathi Sriram, Linh Chi Dam, Chia Ching Chan, Peiying Ho, Boon Chong Goh, Shimin Jasmine Chung, Kenneth Choon Meng Goh, Shu Hua Thong, Andrea Lay-Hoon Kwa, Adam Ostrowski, Thet Tun Aung, Halimah Razali, Shermaine W Y Low, Mani Shankar Bhattacharyya, Hemant K Gautam, Rajamani Lakshminarayanan, Thomas Sicheritz-Pontén, Martha R J Clokie, Wilfried Moreira, Maurice Adrianus Monique van Steensel","doi":"10.1089/phage.2022.29028.nkv","DOIUrl":"https://doi.org/10.1089/phage.2022.29028.nkv","url":null,"abstract":"Bacteriophages and phage-derived proteins are a promising class of antibacterial agents that experience a growing worldwide interest. To map ongoing phage research in Singapore and neighboring countries, Lee Kong Chian School of Medicine, Nanyang Technological University Singapore (NTU) and Yong Loo Lin School of Medicine, National University of Singapore (NUS) recently co-organized a virtual symposium on Bacteriophage and Bacteriophage-Derived Technologies, which was attended by more than 80 participants. Topics were discussed relating to phage life cycles, diversity, the roles of phages in biofilms and the human gut microbiome, engineered phage lysins to combat polymicrobial infections in wounds, and the challenges and prospects of clinical phage therapy. This perspective summarizes major points discussed during the symposium and new perceptions that emerged after the panel discussion.","PeriodicalId":74428,"journal":{"name":"PHAGE (New Rochelle, N.Y.)","volume":"3 1","pages":"6-11"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9436264/pdf/phage.2022.29028.nkv.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10820874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Evolution of Phage - Phage Cartoon by Ellie Jameson. 《噬菌体的进化——噬菌体卡通》艾丽·詹姆森著。

PHAGE (New Rochelle, N.Y.) Pub Date : 2022-03-01 DOI: 10.1089/phage.2022.29029.car

引用次数: 0

A March Mashup. 三月混搭。

PHAGE (New Rochelle, N.Y.) Pub Date : 2022-03-01 DOI: 10.1089/phage.2022.29027.edi

Martha R J Clokie

引用次数: 0

In Vitro Evolution of Specific Phages Infecting the Fish Pathogen Flavobacterium psychrophilum. 感染鱼类致病菌嗜冷黄杆菌特异性噬菌体的体外进化。

PHAGE (New Rochelle, N.Y.) Pub Date : 2022-03-01 DOI: 10.1089/phage.2022.0006

Daniel Castillo, Alexander Ravndal Højsting, Andrea Roosvall, Giorgos Smyrlis, Johanna Jørgensen, Mathias Middelboe

{"title":"In Vitro Evolution of Specific Phages Infecting the Fish Pathogen Flavobacterium psychrophilum.","authors":"Daniel Castillo, Alexander Ravndal Højsting, Andrea Roosvall, Giorgos Smyrlis, Johanna Jørgensen, Mathias Middelboe","doi":"10.1089/phage.2022.0006","DOIUrl":"https://doi.org/10.1089/phage.2022.0006","url":null,"abstract":"Background: Flavobacterium psychrophilum is the causative agent of the bacterial cold-water disease and rainbow trout fry syndrome. Owing to the issues associated with increasing use of antibiotics to control the diseases, phage therapy has been proposed as an alternative method to control Flavobacterium infection within the industry.Materials and methods: We explored two simple and fast in vitro strategies for the isolation of evolved F. psychrophilum phages, using three well-characterized phages FpV4, FpV9, and FPSV-S20.Results: During in vitro serial transfer experiments, 12 evolved phages were selected 72-96 h after phage exposure in the first or second week. Phenotype analysis showed improvement of host range and efficiency of plating and adsorption constants. Comparative genomic analysis of the evolved phages identified 13 independent point mutations causing amino acid changes mostly in hypothetical proteins.Conclusions: These results confirmed the reliability and effectivity of two strategies to isolate evolved F. psychrophilum phages, which may be used to expand phage-host range and target phage-resistant pathogens in phage therapy applications against Flavobacterium infections.","PeriodicalId":74428,"journal":{"name":"PHAGE (New Rochelle, N.Y.)","volume":"3 1","pages":"28-37"},"PeriodicalIF":0.0,"publicationDate":"2022-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10071593/pdf/phage.2022.0006.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9325091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Call for Special Issue Papers: Phage/Host Combat: Phage Strategies for Taking Over the Host and Host Strategies for Defense: Deadline for Manuscript Submission: July 1, 2022. 特刊论文征集:噬菌体/宿主战斗:接管宿主的噬菌体策略和防御宿主策略:手稿提交截止日期:2022年7月1日。

PHAGE (New Rochelle, N.Y.) Pub Date : 2022-03-01 DOI: 10.1089/phage.2022.29026.cfp

Deborah M Hinton, Paul E Turner

引用次数: 0