Palliative medicine reports最新文献

{"title":"Association of Timely Goals of Care Discussions with Hospitalizations Due to Infections in Nursing Homes.","authors":"Jung A Kang, Andrew W Dick, Laurent G Glance, Lara Dhingra, Patricia W Stone","doi":"10.1177/26892820251410099","DOIUrl":"10.1177/26892820251410099","url":null,"abstract":"<p><strong>Background: </strong>Hospitalizations from infections are common among nursing home (NH) residents and can lead to burdensome treatments that may not align with residents' preferences for care. Although goals of care discussions can ensure that residents' wishes are honored, little is known about the impact of timely discussions on residents' infection outcomes.</p><p><strong>Objectives: </strong>To determine the association between timely goals of care (TGOC) discussions and infection-related hospitalizations among NH residents.</p><p><strong>Design: </strong>Retrospective cross-sectional analysis.</p><p><strong>Setting/subjects: </strong>The sample consisted of 892 NHs who participated in a 2018 national survey in the United States that included a TGOC index.</p><p><strong>Measurements: </strong>A facility-level TGOC index (scored 0-18) was categorized into two levels (0-5, 6-18). Hospitalizations from infections were identified using CMS claims data. Multivariable logistic regression was used to examine the association between infection-related hospitalization and TGOC intensity.</p><p><strong>Results: </strong>A total of 867 NHs with 988,502 resident observations were analyzed. The mean TGOC index was 13.6 (SD = 5.1); about 10% fell in the lower TGOC category (0-5). Residents were, on average, 82 (SD = 9) years old; mostly female (63.9%), and White (84.6%). In fully adjusted models, residents in facilities with higher TGOC engagement (scores 6-18) had lower odds of infection-related hospitalization compared to those in facilities with lower engagement (scores 0-5) (AOR 0.84, 95% CI: 0.72-0.99, <i>p</i> < 0.05). Sensitivity analyses using the original four-level TGOC index produced consistent results.</p><p><strong>Conclusions: </strong>TGOC discussions are associated with reduced infection-related hospitalizations in NHs. Future research should examine how facility policies and staff training shape TGOC implementation.</p>","PeriodicalId":74394,"journal":{"name":"Palliative medicine reports","volume":"7 ","pages":"26892820251410099"},"PeriodicalIF":1.3,"publicationDate":"2026-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13439547/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148681452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Palliative Management of Malignant Esophago-Tracheobronchial Fistula Using Covered Self-Expandable Metallic Stents: A Single-Center Case Series.","authors":"Keisuke Eguchi, Takahiro Nakajima, Takeshi Terashima","doi":"10.1177/26892820261428670","DOIUrl":"10.1177/26892820261428670","url":null,"abstract":"<p><strong>Background: </strong>Malignant esophago-tracheobronchial fistula (ETBF) is a devastating complication of thoracic malignancies, especially advanced esophageal cancer. Covered self-expandable metallic stents (CSMSs) have emerged as a minimally invasive palliative option.</p><p><strong>Methods: </strong>Between May 2015 and June 2021, seven patients with malignant ETBF (five men and two women; mean age 63 ± 5.8 years) underwent CSMS placement at our institution. Primary diseases included five esophageal cancers and two metastatic mediastinal carcinomas. Clinical characteristics, technical success, complications, and outcomes were retrospectively reviewed.</p><p><strong>Results: </strong>No intraoperative mortality occurred. All patients experienced improvement in dysphagia and/or airway aspiration, allowing resumption of oral intake, which was maintained for a median of 62 days (range, 10-124 days). Median post-stenting survival was 104 days (range, 14-250 days).</p><p><strong>Conclusion: </strong>CSMS placement is a safe and effective palliative treatment for malignant ETBF, preventing aspiration pneumonia and restoring oral intake, thereby supporting home-based care.</p>","PeriodicalId":74394,"journal":{"name":"Palliative medicine reports","volume":"7 ","pages":"26892820261428670"},"PeriodicalIF":1.3,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13422747/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148655231","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unfinished Business and Experiences of Bereaved Families of Patients with Cancer: A Cross-Sectional Survey.","authors":"Masanori Mori, Tatsuya Morita, Kengo Imai, Toshihiro Yamauchi, Satoru Miwa, Soichiro Okamoto, Satoshi Inoue, Sayuri Itoga, Kaori Fukuta, Naosuke Yokomichi, Yumi Sakuma, Koichi Sugiyama, Keiko Tamura, Akemi Shirado Naito, Hiroyuki Otani, Mitsunori Miyashita","doi":"10.1177/26892820261428901","DOIUrl":"10.1177/26892820261428901","url":null,"abstract":"<p><strong>Background: </strong>Unfinished business (UB) is common among bereaved families of patients with advanced cancer and is associated with poor psychological outcomes, but remains underexplored.</p><p><strong>Objectives: </strong>To examine the prevalence, psychological impact, care-related factors, and families' experiences associated with UB using multidimensional assessments.</p><p><strong>Design: </strong>A cross-sectional survey was conducted.</p><p><strong>Setting/subjects: </strong>Bereaved family members of patients with cancer at a Japanese inpatient hospice.</p><p><strong>Measurements: </strong>UB was assessed using a one-item scale, the Unfinished Business in Bereavement Scale-Short (UBBS), and the Unfinished Business Scale-Family (UBS-F). Depression and complicated grief were measured using the Patient Health Questionnaire-2 (PHQ-2) and the Brief Grief Questionnaire (BGQ), respectively. Analyses included <i>t</i> tests, chi-square tests, and multivariate logistic regression.</p><p><strong>Results: </strong>Of 455 bereaved families, 319 (70%) participated. UB was reported by 53.9% (95% confidence interval [CI] = 48.4-59.4%) on the one-item scale and by 34.5-40.8% and 27.9-65.5% using UBBS and UBS-F, respectively. Using the one-item UB scale, families with UB had significantly higher respective depression (PHQ-2 = 1.73 vs. 1.13; <i>p</i> = 0.002) and grief (BGQ = 4.53 vs. 3.06; <i>p</i> < 0.001) scores. UB was more likely among families of younger patients (OR = 0.73 per 10-year increase), spouses (OR = 3.81), children (OR = 4.24), those less prepared for death (OR = 3.69-6.31), and those who felt clinicians were unconcerned about the family's wishes (OR = 1.91). Many (71.8%) expressed a wish to do something for the patient but were preoccupied with daily responsibilities.</p><p><strong>Conclusions: </strong>UB is prevalent and associated with psychological distress among bereaved families of patients with cancer. Interventions promoting preparedness and supporting patients and families to realize wishes may reduce UB and improve bereavement outcomes.</p>","PeriodicalId":74394,"journal":{"name":"Palliative medicine reports","volume":"7 ","pages":"26892820261428901"},"PeriodicalIF":1.3,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13554666/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148922135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dilated Gallbladder Causing Right Iliac Fossa Pain in a Patient with Advanced Pancreatic Cancer: A Diagnostic and Symptom Management Challenge at End of Life.","authors":"Sumayyah Omar Bintalib","doi":"10.1177/26892820261424786","DOIUrl":"10.1177/26892820261424786","url":null,"abstract":"<p><strong>Introduction: </strong>Gallbladder distension secondary to malignant biliary obstruction is an under-recognized cause of abdominal pain in advanced pancreatic cancer and may present atypically outside the right upper quadrant. Pain assessment can be further complicated in older adults with cognitive impairment and superimposed delirium.</p><p><strong>Case presentation: </strong>We present an 83-year-old female with locally advanced pancreatic adenocarcinoma and baseline cognitive impairment, admitted to an acute tertiary hospital with painless jaundice. She subsequently developed persistent right iliac fossa pain that was poorly responsive to escalating opioid therapy despite empirical treatment for urinary tract infection and constipation. The inpatient palliative care team was consulted to assist with symptom control. Delirium on a background of cognitive impairment complicated pain assessment. Imaging performed to clarify the cause of escalating pain revealed a grossly dilated gallbladder extending into the mid abdomen, likely due to malignant biliary obstruction. Following multidisciplinary discussions and conversations with family regarding goals of care, invasive interventions were deferred. Pain control improved with opioid titration and the addition of antispasmodic therapy. The patient later developed sepsis and died during the admission.</p><p><strong>Discussion: </strong>This case highlights key learning points for palliative care practice. Atypical and opioid-refractory pain should prompt reconsideration of pain etiology rather than reflexive opioid escalation. Cognitive impairment and delirium necessitate iterative, multimodal assessment, while caregiver concerns regarding opioid use require proactive engagement. Opioids alone may be insufficient for colicky biliary pain, underscoring the importance of mechanism-based adjuvant strategies. When aligned with goals of care, judicious use of imaging at the end of life can clarify pain etiology and guide proportionate, comfort-focused management.</p><p><strong>Conclusion: </strong>In advanced cancer, particularly in patients with cognitive impairment and delirium, careful assessment of pain mechanisms, caregiver engagement, and proportionate investigations are essential to optimize comfort and support individualized end-of-life care.</p>","PeriodicalId":74394,"journal":{"name":"Palliative medicine reports","volume":"7 ","pages":"26892820261424786"},"PeriodicalIF":1.3,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13554681/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148922072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing Inclusive Care: Embedding Health Equity in Palliative Care Fellowship Training.","authors":"Sudha Natarajan, Alexis Drutchas, Carine Davila, Kyle Kozelka, Perla Macip Rodriguez, Alexandra Manyak, Kathleen Doyle, Jane deLima Thomas","doi":"10.1177/26892820251408397","DOIUrl":"10.1177/26892820251408397","url":null,"abstract":"<p><strong>Background: </strong>Providing quality palliative care requires an understanding of the causes of structural inequities that lead to disparities in health outcomes for minoritized patients.</p><p><strong>Methods: </strong>The Harvard Interprofessional Palliative Care Fellowship program (Boston, MA) is a year-long fellowship comprised of physicians, nurse practitioners, a social worker, and a pharmacist training in either adult or pediatric palliative care. A novel health equity curriculum, consisting of a day-long retreat, incorporation of health equity content into existing core didactics and quarterly health equity didactic sessions, was developed and integrated into the existing educational structure of the fellowship. The content included topics such as understanding implicit bias, structural inequities and trauma-informed care. The fellows' perceptions of the curriculum were evaluated using qualitative analysis and retrospective pre-post survey methodology.</p><p><strong>Results: </strong>Sixteen fellows completed the health equity retreat evaluation and 18 fellows completed the end-of-year evaluation. The data demonstrated an increase in percentage of fellows reporting: ability to identify how structural racism affects the health of palliative care patients (44.4% to 94.4%) and comfort speaking up about racism and/or microaggressions (38.9% to 94.4%). Importantly, 88.9% of fellows reported that the learning environment felt safe and conducive to self-reflection and sharing.</p><p><strong>Conclusion: </strong>This novel health equity curriculum was effective in imparting health equity-related knowledge and skills in a safe learning environment.</p>","PeriodicalId":74394,"journal":{"name":"Palliative medicine reports","volume":"7 ","pages":"26892820251408397"},"PeriodicalIF":1.3,"publicationDate":"2026-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13439543/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148681479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative-Qualitative Discordance in Measuring Distress Among Intensive Care Unit Family Caregivers: A Mixed-Methods Study.","authors":"Blair Wendlandt, Scott Vasher, Timothy Gee, Bradley Gaynes, Shannon Carson, Laura Hanson, Mark Toles","doi":"10.1177/26892820251408605","DOIUrl":"10.1177/26892820251408605","url":null,"abstract":"<p><strong>Background: </strong>The Impact of Events Scale-Revised (IES-R) is widely used in outcomes research involving family caregivers in the intensive care unit (ICU), but whether IES-R scores align with caregivers' perceptions of their own distress is not known.</p><p><strong>Methods: </strong>We performed a secondary mixed-methods analysis, comparing 6-month IES-R scores and self-described wellness or distress outcomes in a semi-structured interview to categorize caregivers as experiencing quantitative-qualitative concordance or discordance and describing caregivers' specific symptoms.</p><p><strong>Results: </strong>The frequency of quantitative-qualitative discordance was 4/18 (22%), and all cases involved a low IES-R score (suggesting quantitative wellness) and qualitative distress. These caregivers described physical and financial stress rather than psychological symptoms.</p><p><strong>Conclusion: </strong>One in four ICU family caregivers identified qualitative distress that was not captured by the IES-R. While the IES-R performed well in identifying caregivers with intense psychological symptoms, additional outcome measures are needed to identify caregivers experiencing physical or financial distress.</p>","PeriodicalId":74394,"journal":{"name":"Palliative medicine reports","volume":"7 ","pages":"26892820251408605"},"PeriodicalIF":1.3,"publicationDate":"2026-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13458331/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148715044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Qualitative Study of the Initial Diagnosis and Treatment Experience of Black Patients with Newly Diagnosed Acute Myeloid Leukemia.","authors":"Allison O Taylor, Laura J Fish, Kris W Herring, Jordan Infield, Kimberly S Johnson, Thomas W LeBlanc","doi":"10.1177/26892820251403847","DOIUrl":"10.1177/26892820251403847","url":null,"abstract":"<p><strong>Purpose: </strong>Black patients with acute myeloid leukemia (AML) experience disparate outcomes, and factors such as structural racism and differential treatment access have been implicated. We sought to understand the experience of Black patients with newly diagnosed AML to gain insight into their unique experience.</p><p><strong>Methods: </strong>We interviewed Black patients ≥18 years of age with newly diagnosed AML (diagnosed from 7/1/2021 to 7/31/2022) over Zoom. Interviews were conducted by the same interviewer, with concordance in race between the interviewer and interviewees. A rapid qualitative content analysis was employed.</p><p><strong>Results: </strong>Ten patients were interviewed, with a median age of 63.5 years (range, 36-82 years). Six were male, married, and treated with a hypomethylating agent. Seven patients had secondary AML. Themes were broadly categorized under (1) the diagnosis and treatment experience, (2) challenges that arose, and (3) coping strategies. Unique findings included the experience of bias during the initial diagnosis period (but not during treatment decision-making discussions), and the overwhelming role of faith/religion/spirituality in coping. Other notable themes included trust, shock and urgent decision making, diverse support systems, physical limitations, the psychological impact, and financial constraints.</p><p><strong>Conclusions: </strong>Interviewed Black patients with newly diagnosed AML reported bias in the initial diagnosis period, possibly racially motivated, but did not feel this was at play in treatment discussions. The importance of faith/religion/spirituality in coping was also highlighted. Interventions focused on implicit bias training and supporting spiritual needs are critical to improve the experience of Black patients with AML and provide equitable care to all patients with AML.</p>","PeriodicalId":74394,"journal":{"name":"Palliative medicine reports","volume":"7 ","pages":"26892820251403847"},"PeriodicalIF":1.3,"publicationDate":"2026-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13539012/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148889693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Candidiasis as a Potential Marker of Imminent Mortality in Palliative Care: A Retrospective Observational Study.","authors":"Andreia Mandim, Licinia Araújo, Susete Freitas","doi":"10.1177/26892820251374977","DOIUrl":"https://doi.org/10.1177/26892820251374977","url":null,"abstract":"<p><strong>Background: </strong>Predicting short-term mortality in patients receiving palliative care can help tailor interventions, manage expectations, and improve end-of-life planning. This study explores whether candidiasis, particularly in patients on corticosteroids, is associated with increased 30-day mortality.</p><p><strong>Methods: </strong>We conducted a retrospective study of patients admitted to a specialized palliative care unit in 2022. Data collected included demographics, candidiasis diagnosis (oral/esophageal), corticosteroid use, and mortality. Patients with candidemia were excluded. Of 59 deaths in the unit, 35 had complete records and met inclusion criteria.</p><p><strong>Results: </strong>Of the 35 patients analyzed, 71.4% were female; the median age was 61. Ten patients developed candidiasis, all with advanced cancer and functional decline. Among candidiasis cases, 30-day mortality was 60% versus 0% in those without. Median time from candidiasis diagnosis to death was 19 days. Among corticosteroid users, candidiasis was associated with significantly higher short-term mortality.</p><p><strong>Conclusions: </strong>Candidiasis in patients receiving palliative care-particularly those on corticosteroids-may indicate imminent death. These findings suggest its potential as a simple prognostic marker in resource-limited settings, meriting further prospective validation.</p>","PeriodicalId":74394,"journal":{"name":"Palliative medicine reports","volume":"7 ","pages":"26892820251374977"},"PeriodicalIF":1.3,"publicationDate":"2026-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13443232/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148686933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Depression and Coping Strategies Among Palliative Care Patients in a Tertiary Hospital in Karachi, Pakistan.","authors":"Hina Ali, Ismat Jabeen, Nawazish Zehra","doi":"10.1177/26892820251394288","DOIUrl":"10.1177/26892820251394288","url":null,"abstract":"<p><strong>Background: </strong>Depression is a common yet under-recognized condition among palliative care patients, often affecting their psychological well-being and quality of life. Coping strategies used by these patients may influence their mental health outcomes and overall adaptation to illness.</p><p><strong>Objective: </strong>To assess the presence of depression and identify coping strategies among palliative care patients attending a tertiary teaching hospital in Karachi, Pakistan.</p><p><strong>Setting/subjects: </strong>This cross-sectional study was conducted at Aga Khan University Hospital, Karachi, Pakistan, over six months (June to December 2023). A total of 81 adult patients receiving palliative care for at least one month were enrolled in the study. Depression was assessed using the Patient Health Questionnaire-9, while coping strategies were evaluated using the Brief COPE Inventory. Descriptive and inferential statistics were applied using SPSS v. 21.</p><p><strong>Results: </strong>Depression was present in majority of participants, with 30% showing minimal, 18% mild, 19% moderate, 22% moderately severe, and 11% severe symptoms. The coping styles used were problem-focused (2.65 ± 0.65), emotion-focused (2.18 ± 0.32), and avoidant coping (1.74 ± 0.34). Female participants were more likely to employ emotion-focused coping compared to male participants (<i>p</i> = 0.012). A weak inverse correlation was observed between education level and depression severity (<i>r</i> = -0.213, <i>p</i> = 0.056).</p><p><strong>Conclusion: </strong>Depression is highly prevalent among palliative care patients in this context. Most patients adopt adaptive coping strategies, particularly emotional support and religious coping. These findings highlight the need for integrated psychological care as a routine component of palliative treatment.</p>","PeriodicalId":74394,"journal":{"name":"Palliative medicine reports","volume":"6 1","pages":"574-582"},"PeriodicalIF":1.3,"publicationDate":"2025-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12670687/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145672492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender Differences in Patients with Advanced Heart Failure: A Secondary Data Analysis of the ENABLE CHF-PC Randomized Clinical Trial.","authors":"Lindsay Aaron-Wade, Rachel Wells, Andres Azuero, Shena Gazaway, J Nicholas Odom, Marie Bakitas, Deborah Ejem","doi":"10.1177/26892820251396380","DOIUrl":"10.1177/26892820251396380","url":null,"abstract":"<p><strong>Background: </strong>Women appear to be underrepresented in heart failure and palliative care research. Given this underrepresentation, their unique characteristics, needs, and outcomes require further investigation.</p><p><strong>Methods: </strong>A secondary analysis of baseline data of the Educate, Nurture, Advise, Before Life Ends Comprehensive Heartcare for Patients and Caregivers study, a randomized clinical trial of Deep South patients ≥50 years of age with advanced HF. Differences in sociodemographics and measures of quality of life and mood between female and male patients were examined using bivariate tests and effect-size measures.</p><p><strong>Results: </strong>Statistically significant gender differences were observed with females reporting poorer quality of life-The Kansas City Cardiomyopathy Measure (49.55 ± 20.04 vs. 55.37 ± 21.52, <i>d</i> = 0.28, p-adj = 0.01), Patient-Reported Outcome Measurement Information System (PROMIS) Global Mental Health (44 ± 8.02 vs. 46.53 ± 9.01, <i>d</i> = 0.30, p-adj = 0.007), and PROMIS Global Physical Health (37.37 ± 7.65 vs. 39.2 ± 8.20, <i>d</i> = 0.23, p-adj = 0.034) and Hospital Anxiety and Depression Scale anxiety (6.9 ± 4.38 vs. 4.72 ± 3.89, <i>d</i> = 0.53, p-adj = 0.003) compared with men at baseline.</p><p><strong>Conclusion: </strong>Further investigation of gender differences is necessary to improve outcomes and inform the refinement of PC-HF interventions for females.</p>","PeriodicalId":74394,"journal":{"name":"Palliative medicine reports","volume":"6 1","pages":"595-600"},"PeriodicalIF":1.3,"publicationDate":"2025-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12670693/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145672682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}