Oxford open immunology最新文献

{"title":"Correction to: Scientific communication and vaccine hesitation: an analysis of the editorial line of a great Brazilian newspaper.","authors":"","doi":"10.1093/oxfimm/iqag006","DOIUrl":"10.1093/oxfimm/iqag006","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1093/oxfimm/iqaf012.].</p>","PeriodicalId":74384,"journal":{"name":"Oxford open immunology","volume":"7 1","pages":"iqag006"},"PeriodicalIF":0.0,"publicationDate":"2026-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13019307/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147576931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence age is bimodal for myalgic encephalomyelitis/chronic fatigue syndrome, with higher severity burden for early onset disease.","authors":"Simon J McGrath, Charles B Hillier, Joshua J Dibble, Trude Schei, Arild Angelsen, Audrey A Ryback","doi":"10.1093/oxfimm/iqag007","DOIUrl":"https://doi.org/10.1093/oxfimm/iqag007","url":null,"abstract":"<p><p>Myalgic Encephalomyelitis, or Chronic Fatigue Syndrome (ME/CFS), is a disease of uncertain origin. Studies of Norwegian health records have suggested that ME/CFS incidence across age groups is bimodal-a characteristic that could provide insight into the aetiology of the disease. Here, we analysed survey data from over 9000 respondents with ME/CFS from 10 European countries, and observe an early onset peak with a mean of 16.0 years old (standard deviation [SD]: 4.3) and a late onset peak at 36.6 years old (SD: 10.5). Statistical support for multimodal onset age was evident in 7 of the 10 countries examined. Infection as a trigger for ME/CFS was 10 percentage points higher among early compared to late onset disease (<i>p</i> = 2.1 × 10^-13). Early onset ME/CFS was associated with greater odds of being severely or very severely affected (OR = 2.15, 95% CI [1.84-2.51], <i>p</i> < 2 × 10^-16). Those with first degree relatives with ME/CFS had greater odds of early than late onset ME/CFS (OR = 1.43, 95% CI [1.25-1.63], <i>p</i> = 4.4 × 10^-07). We further validated our findings in a UK dataset where we replicated bimodal onset age and observed significantly greater odds of glandular fever/infectious mononucleosis as a trigger in early onset cases (OR = 2.32, 95% CI [1.99-2.71], <i>p</i> = 2.4 × 10^-24). Our findings suggest that incidence of ME/CFS peaks in adolescence and in early middle-age and that early onset ME/CFS is more common in those with affected relatives, more often triggered by infection, and associated with more severe disease.</p>","PeriodicalId":74384,"journal":{"name":"Oxford open immunology","volume":"7 1","pages":"iqag007"},"PeriodicalIF":0.0,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13070794/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147693929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: <i>In-vitro</i> assessment of cutaneous immune responses to <i>aedes</i> mosquito salivary gland extract and dengue virus in Cambodian individuals.","authors":"","doi":"10.1093/oxfimm/iqag004","DOIUrl":"https://doi.org/10.1093/oxfimm/iqag004","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1093/oxfimm/iqae003.].</p>","PeriodicalId":74384,"journal":{"name":"Oxford open immunology","volume":"7 1","pages":"iqag004"},"PeriodicalIF":0.0,"publicationDate":"2026-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12989206/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147470172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ImmUQBench: a benchmark on uncertainty quantification of protein immunogenicity prediction.","authors":"Alif Bin Abdul Qayyum, Amir Hossein Rahmati, Xiaoning Qian, Byung-Jun Yoon","doi":"10.1093/oxfimm/iqag003","DOIUrl":"10.1093/oxfimm/iqag003","url":null,"abstract":"<p><p>Discovering antigen proteins, capable of eliciting desired immune responses, is of paramount importance in developing immunogenic therapeutics for combating various diseases, particularly autoimmune disorders, infectious diseases, as well as cancers. Despite recent advances in artificial intelligence (AI) and machine learning (ML), accurate and generalizable immunogenicity prediction remains challenging due to limited labeled data and model over-simplifications. Uncertainty quantification (UQ) approaches are commonly used to address the aforementioned challenges when applying AI/ML methods with limited training data, aiming to reduce the risk of catastrophic errors. This study aims to systematically evaluate the performance of UQ methods for antigen immunogenicity prediction and to establish a benchmark for assessing model reliability in data-scarce setting. We here present <i>ImmUQBench</i>, a comprehensive benchmark that compares several well-known UQ methods for antigen immunogenicity prediction tasks. The benchmark assesses models in terms of predictive accuracy, calibration, and robustness under both in and out of distribution settings, providing standardized evaluation framework. Our evaluation reveals that different UQ strategies exhibit varying capabilities in capturing predictive uncertainty and maintaining robustness. This work yields critical insights into the performance and reliability of various UQ methods when applied to immunogenicity data, helping to identify which methods offer the most trustworthy predictions. <i>ImmUQBench</i> provides a unified platform for assessing UQ approaches in immunogenicity prediction, facilitating the development of more trustworthy AI/ML models for therapeutic antigen design. By offering insights into the strengths and limitations of existing UQ methods, our work facilitates more effective and reliable immunogenic therapeutic discovery.</p>","PeriodicalId":74384,"journal":{"name":"Oxford open immunology","volume":"7 1","pages":"iqag003"},"PeriodicalIF":0.0,"publicationDate":"2026-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12996882/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147488740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scientific communication and vaccine hesitation: an analysis of the editorial line of a great Brazilian newspaper.","authors":"Heslley Machado Silva","doi":"10.1093/oxfimm/iqaf012","DOIUrl":"10.1093/oxfimm/iqaf012","url":null,"abstract":"<p><p>The text critically examines the anti-vaccine editorial line adopted by \"Gazeta do Povo\", one of Brazil's leading newspapers, and its possible repercussions on vaccine hesitancy in the country. By analyzing headlines published over the course of a year, a trend of misinformation and sensationalism was found, addressing supposed or insignificant risks in relation to COVID-19 vaccines. A structured qualitative document analysis was conducted, based on the systematic retrieval of all vaccine-related headlines published by the newspaper between December 2022 and December 2023. Headlines were collected using predefined search terms relevant to COVID-19 vaccination and assessed according to their scientific accuracy and potential to induce vaccine hesitancy, following WHO and CDC communication guidelines. The analysis highlights how such news, often contradictory to scientific knowledge, can negatively influence the decision-making of citizens concerned about their health and that of their children. The article also highlights the responsibility of the press in disseminating reliable information, as well as the need for effective reactions to the anti-vaccine movement and scientific denialism in Brazil and globally.</p>","PeriodicalId":74384,"journal":{"name":"Oxford open immunology","volume":"7 1","pages":"iqaf012"},"PeriodicalIF":0.0,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12956047/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147357981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the role of gelsolin and high-density lipoproteins in autoimmune diseases: spotlight on rheumatoid arthritis and systemic lupus erythematosus.","authors":"Julián Pérez-Ocampo, Juan C Hernandez","doi":"10.1093/oxfimm/iqag002","DOIUrl":"https://doi.org/10.1093/oxfimm/iqag002","url":null,"abstract":"<p><p>Rheumatological systemic autoimmune diseases constitute a significant health problem globally due to their chronicity, potentially permanent incapacity and higher mortality rates. Rheumatoid arthritis and systemic lupus erythematosus are among the most common of these diseases. Although there is a substantial body of research on these autoimmune diseases, there is still a need to identify better biomarkers of disease activity and progression. In this context, gelsolin and high-density lipoproteins arise as novel biomarkers from the perspective of immunomodulation and their role in the immunopathology of autoimmune diseases. Gelsolin is an actin cytoskeleton remodeling protein involved in immune regulatory mechanisms related to inflammation. High-density lipoproteins are plasmatic cargo molecules involved in reverse lipid transport, whereas their study in autoimmunity has focused on their value as cardiovascular risk predictors. However, new functions of these proteins related to immune and inflammation regulation have also been described recently. Therefore, this review aims to provide insight into the role of these biomolecules and their implications in the immunopathology and immunomodulation of autoimmune diseases from the perspective of rheumatoid arthritis and systemic lupus erythematosus.</p>","PeriodicalId":74384,"journal":{"name":"Oxford open immunology","volume":"7 1","pages":"iqag002"},"PeriodicalIF":0.0,"publicationDate":"2026-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12910385/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146222465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic potential of TAM receptors in autoimmune diseases: insights from original studies.","authors":"Sheu Ibrahim Adedayo, Taiye Abdullahi Gegele, Kehinde Ahmad Adeshina, Baliqis Adejoke Olukade, Ridwanullah Abiodun Abubakar, Adullateef Abdulsalam, Toheeb Oladejo Olalekan, Mohamed Mustaf Ahmed, Kasimu Ghandi Ibrahim","doi":"10.1093/oxfimm/iqag001","DOIUrl":"10.1093/oxfimm/iqag001","url":null,"abstract":"<p><p>TAM receptors, composed of Tyro3, Axl, and Mertk, belong to the receptor tyrosine kinase family and are activated by binding of their cognate ligands, Gas6 and Pros1. These receptor-ligand interactions mediate critical physiological processes, including the maintenance of immunological equilibrium, thrombocyte aggregation and subsequent thrombus development, apoptotic cellular debris clearance, homeostatic regulation of endothelial and vascular smooth muscle cells, and erythrocyte production. Perturbations in TAM signaling cascades have been shown to compromise the clearance of apoptotic cells, leading to persistent inflammatory responses that can contribute to the development of various autoimmune pathologies, including multiple sclerosis, rheumatoid arthritis, Sjögren's syndrome, and systemic lupus erythematosus. We retrieved and reviewed only the primary studies addressing the roles of TAM receptors and their ligands in selected autoimmune diseases from Google Scholar, Scopus, Web of Science, and PubMed. The critical roles of TAM receptors in immune homeostasis and apoptotic cell clearance are well established. However, findings from several primary studies discussed in this review further emphasized that the loss of TAM receptor function in these processes significantly contributes to the pathogenesis and progression of autoimmune diseases. Herein, we highlight the role of TAM receptors in several autoimmune diseases, suggesting that TAM receptors are potential biomarkers for monitoring disease prognosis and therapeutic targets to improve patient outcomes.</p>","PeriodicalId":74384,"journal":{"name":"Oxford open immunology","volume":"7 1","pages":"iqag001"},"PeriodicalIF":0.0,"publicationDate":"2026-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12860480/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146108960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantifications of CD4+ T-Lymphocytes levels in adult sickle cell patients: Examining immunological vulnerability and Vaso-Occlusive crises in a low-resource setting, northwestern Nigeria.","authors":"Abubakar Babangida Usman, Abubakar Hassan Gulma, Kabir Magaji Hamid, Adamu Muhammad Ibrahim, Shuaibu Saidu Musa, Jomar L Aban, Jerico Bautista Ogaya, Kristine Joy Gacutno, Angelica Joyce Gacutno-Evardone, Carina Joane V Barroso, Pearl Irish V De Paz, Mohamed Mustaf Ahmed, Sani Muhammed, Don Eliseo Lucero-Prisno","doi":"10.1093/oxfimm/iqaf013","DOIUrl":"https://doi.org/10.1093/oxfimm/iqaf013","url":null,"abstract":"<p><strong>Introduction: </strong>Sickle Cell Disease (SCD) is a chronic genetic disorder that impairs red blood cell function and contributes to recurrent complications, particularly vaso-occlusive crises.</p><p><strong>Aim: </strong>This study evaluates the level of CD4 + T-lymphocyte counts in adult SCD patients in Northwestern Nigeria, assessing their association with clinical states, and epidemiological factors, to better understand immunological vulnerability.</p><p><strong>Methods: </strong>A descriptive cross-sectional study was conducted at Specialist Hospital Sokoto, 45 adult SCD patients were recruited and stratified by clinical status (steady state versus crisis). CD4 + counts were measured via flow cytometry, and data were analyzed for relationships with haemoglobin levels, gender, and age.</p><p><strong>Results: </strong>Patients in vaso-occlusive crisis observed reduction in CD4 counts compared to those in steady state. However, haemoglobin levels did not show a statistically significant difference between the crisis state (9.43 ± 1.98 g/dL) and steady state (10.08 ± 1.60 g/dL; <i>P </i>= 0.231). Gender-based analysis indicated no significant difference in CD4 + counts (<i>P </i>= 0.403) ++ or haemoglobin levels (<i>P </i>= 0.542) between male and female patients. Age-related analysis showed the highest mean CD4 + count among the 31-40-year age group (1151.80 ± 626.06 cells/µL) and the lowest in patients aged 40 years and above (601.00 ± 0.00 cells/µL). Correlation analysis demonstrated weak and non-significant relationships between CD4 + counts and haemoglobin levels (<i>r </i>= -0.095, <i>P </i>= 0.530), gender (<i>r </i>= -0.126, <i>P </i>= 0.403), and age (<i>r </i>= 0.193, <i>P </i>= 0.198).</p><p><strong>Conclusion: </strong>These findings highlight significant reduced CD4 levels in SCD patients during crises, underscoring the need for regular immunological monitoring.</p>","PeriodicalId":74384,"journal":{"name":"Oxford open immunology","volume":"7 1","pages":"iqaf013"},"PeriodicalIF":0.0,"publicationDate":"2026-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12920040/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147273182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative analysis of malignant pleural effusion and peripheral blood reveals unique T cell signatures associated with survival in mesothelioma patients.","authors":"Nicola Principe, Kofi L P Stevens, Amber-Lee Phung, Melanie McCoy, Joel Kidman, Ali Ismail, Alistair M Cook, Abha Chopra, Mark Watson, Bruce W Robinson, Jenette Creaney, Y C Gary Lee, Jason Waithman, W Joost Lesterhuis, Richard A Lake, Anna K Nowak, Jonathan Chee, Alison M McDonnell","doi":"10.1093/oxfimm/iqaf008","DOIUrl":"10.1093/oxfimm/iqaf008","url":null,"abstract":"<p><p>The success of cancer immunotherapies has highlighted the importance of monitoring the anti-tumour T cell response. Patients with mesothelioma frequently present with a malignant pleural effusion (MPE) that is commonly drained regularly to alleviate symptoms. As MPE contains tumour cells, T cells and cytokines, it provides a unique opportunity to sample immune events at the tumour site. However, there is minimal information on how MPE T cells are distinct from those in the blood, and whether T cell phenotypes unique to each compartment correlate with survival. We characterised T cell populations of matched MPE and blood from 31 mesothelioma patients using flow cytometry and bulk T cell receptor beta (TCRβ) sequencing. MPE CD8⁺ and CD4⁺ T cells displayed increased expression of PD-1, TIGIT, LAG-3 and TIM-3 compared to blood, with co-expression of inhibitory receptors greatest on MPE CD8⁺ T cells with a tissue resident memory T cell phenotype (CD69⁺CD103⁺). CD8⁺ TCRβ repertoires displayed clonal overlap between MPE and blood, suggesting that a majority of T cells traffic between these compartments. Finally, we show that high expression of PD-1 on circulating CD4⁺ T cells is an independent prognostic factor for poor survival in this patient group. This work suggests that MPE T cell phenotypes differ from those in circulation, with blood-based T cell subsets more sensitive predictors of outcome in this study.</p>","PeriodicalId":74384,"journal":{"name":"Oxford open immunology","volume":"7 1","pages":"iqaf008"},"PeriodicalIF":0.0,"publicationDate":"2025-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12823008/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146032001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Capturing the full spectrum of T cell responses with spectral flow cytometry.","authors":"Anna Olofsson, Annika C Karlsson","doi":"10.1093/oxfimm/iqaf011","DOIUrl":"10.1093/oxfimm/iqaf011","url":null,"abstract":"<p><p>Over a decade has passed since the first commercial spectral flow cytometry (SFC) instrument was introduced. Unlike conventional flow cytometers, SFC utilizes an array of detectors to capture the full emission spectrum of fluorochromes, from which composite signatures are deconvoluted using an unmixing algorithm. This allows fluorochromes with overlapping peaks to be used within the same panel, enabling panels with up to 50 parameters. As its availability increases, more immunologists are looking to incorporate SFC into their experiments. One area of research benefiting from the larger SFC panels is the characterization of rare cells, including antigen-specific T cells identified directly ex vivo using either antigen stimulation or major histocompatibility complex-peptide multimers. In this brief review, we outline some practical considerations when combining ex-vivo T cell stimulation with SFC, drawing on our transition from conventional to SFC. Key aspects include designing the experiment and panel for stimulated cells, acquiring high-quality reference controls, strategies to manage autofluorescence and an overview of the data analysis, including both manual and computational approaches.</p>","PeriodicalId":74384,"journal":{"name":"Oxford open immunology","volume":"7 1","pages":"iqaf011"},"PeriodicalIF":0.0,"publicationDate":"2025-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12823006/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146032077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}