PET在免疫疾病的表征和治疗方法的发展。

Oxford open immunology Pub Date : 2025-05-24 eCollection Date: 2025-01-01 DOI:10.1093/oxfimm/iqaf005
Natasha Patel, Mats Bergstrom, Philip S Murphy, Juliana Maynard
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引用次数: 0

摘要

免疫系统是一个由细胞、组织和器官组成的复杂网络,它保护身体免受有害病原体的侵害。免疫系统的表征对于理解病理生理学基础上的复杂相互作用和为现代药物开发提供治疗靶向性的见解是必不可少的。组织和外周取样报告了重要的生物标志物,但可能不能充分取样复杂的、异质性的全身性疾病。影像学已广泛应用于免疫疾病的研究,主要依赖于疾病表现的结构测量(例如类风湿关节炎关节间隙狭窄的x线)。这些测量是药物作用的下游,无法深入了解免疫系统的复杂性。分子成像,特别是通过正电子发射断层扫描,有可能在全身水平上绘制免疫系统,提供非侵入性的定量读数。迄今为止,PET在临床和用于研究免疫过程的药物开发目的方面的应用受到限制,在神经科学和肿瘤学方面的应用滞后。新兴的技术发展可能会为免疫系统监测创造新的机会:(i)正在开发一套广泛的临床探针来研究免疫细胞和相关过程,(ii)全身PET的出现能够在降低辐射剂量负担的情况下从所有组织捕获高灵敏度测量。本文探讨了PET在免疫药物开发中的潜在应用、技术进步以及如何克服采用障碍。未来的免疫工具集可能需要一种综合的方法,使用组织和外周读数结合免疫特异性成像。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
PET in the characterization of immune diseases and development of therapeutics.

The immune system is a complex network of cells, tissues and organs that protects the body against harmful pathogens. Characterization of the immune system is essential for understanding the complex interactions underlying pathophysiology and providing insights to enable therapeutic targeting for modern drug development. Tissue and peripheral sampling report on important biomarkers, but may not adequately sample complex, heterogeneous systemic diseases. Imaging has been extensively used in the study of immune diseases, largely relying upon structural measurements of disease manifestation (e.g. X-ray for joint space narrowing in rheumatoid arthritis). These measurements are downstream from drug action, offering no insight into the intricacies of the immune system. Molecular imaging, particularly through Positron Emission Tomography has the potential to map the immune system at the whole-body level, providing non-invasive, quantitative readouts. Adoption of PET clinically and for drug development purposes for studying immune processes has been limited to date, lagging use in neuroscience and oncology. Emerging technical developments are likely to create new opportunities for immune system monitoring: (i) A broad set of clinical probes to study immune cells and associated processes are in development, (ii) The advent of TotalBody PET able to capture high-sensitivity measurements from all tissues with reduced radiation dose burden. This review explores the potential applications of PET for immune drug development, the technology advancements and suggests how adoption barriers can be overcome. The immune toolset of the future will likely demand an integrated approach, using tissue and peripheral readouts combined with immune-specific imaging.

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CiteScore
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