Ophthalmology and eye diseases最新文献_第4页

Dorzolamide chlorhydrate versus acetazolamide in the management of chronic macular edema in patients with retinitis pigmentosa: description of three case reports. 氯水合多唑胺与乙酰唑胺治疗色素性视网膜炎患者慢性黄斑水肿:三个病例报告的描述。

Ophthalmology and eye diseases Pub Date : 2014-05-27 eCollection Date: 2014-01-01 DOI: 10.4137/OED.S13617

Elena Pacella, Loredana Arrico, Valentina Santamaria, Paolo Turchetti, Maria Rosaria Carbotti, Giuseppe La Torre, Fernanda Pacella

{"title":"Dorzolamide chlorhydrate versus acetazolamide in the management of chronic macular edema in patients with retinitis pigmentosa: description of three case reports.","authors":"Elena Pacella, Loredana Arrico, Valentina Santamaria, Paolo Turchetti, Maria Rosaria Carbotti, Giuseppe La Torre, Fernanda Pacella","doi":"10.4137/OED.S13617","DOIUrl":"https://doi.org/10.4137/OED.S13617","url":null,"abstract":"Aims: To assess the efficacy of topical dorzolamide for treating cystoid macular edema in patients with retinitis pigmentosa and minimize the secondary effects of maintenance therapy in patients with retinitis pigmentosa (RP) who present with chronic microcystic macular edema.Methods: To replace acetazolamide systemic treatment, with a topical treatment using 2% dorzolamide in three patients. The methods performed were OCT scan with a Spectralis HRA-OCT, for the measurement of macular thickness and morphology; best corrected visual acuity was assessed using Early Treatment Diabetic Retinopathy Study (ETDRS), was assessed slit-lamp biomicroscopy, ocular tonometry, fundus biomiocrosopy, and color fundus photography. This therapeutic protocol has been applied and described in three patients.Results: In all three tested patients, following the administration of dorzolamide in eye drop, we observed a remarkable decrease in macular edema, almost comparable to that obtained with acetazolamide per os.Conclusion: The study confirms the anti-edematogenic effect of topical dorzolamide in RP with recurring macular cysts, as this can have a favorable response with topical dorzolamide. In all the three examined patients, the instillation of topical dorzolamide caused a remarkable reduction in their macular edema, as highlighted on OCT.","PeriodicalId":74362,"journal":{"name":"Ophthalmology and eye diseases","volume":"6 ","pages":"21-6"},"PeriodicalIF":0.0,"publicationDate":"2014-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4137/OED.S13617","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32427983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Evaluating the potentiating effect of amethocaine on tropicamide-induced mydriasis in darkly pigmented irides, using infrared pupillometry. 用红外瞳孔测量法评价阿莫西卡因对热带酰胺诱导的黑色素虹膜丝虫病的增强作用。

Ophthalmology and eye diseases Pub Date : 2014-04-08 eCollection Date: 2014-01-01 DOI: 10.4137/OED.S13991

Olufunmilola A Ogun, Jeffrey W Oliver, Adeyinka O Ashaye, Benedictus Gk Ajayi

{"title":"Evaluating the potentiating effect of amethocaine on tropicamide-induced mydriasis in darkly pigmented irides, using infrared pupillometry.","authors":"Olufunmilola A Ogun, Jeffrey W Oliver, Adeyinka O Ashaye, Benedictus Gk Ajayi","doi":"10.4137/OED.S13991","DOIUrl":"https://doi.org/10.4137/OED.S13991","url":null,"abstract":"Purpose: To determine whether prior instillation of amethocaine would increase the rate and magnitude of tropicamide-induced pupillary dilatation in darkly pigmented irides.Method: A total of 50 healthy Africans aged 18-40 years, with darkly pigmented irides, received a drop of amethocaine in one eye and a drop of placebo in the contralateral eye, followed by two drops of tropicamide in both eyes. Serial pupil diameters were measured using a monocular infrared video pupillometer. Rate of pupillary dilatation was compared in both eyes. Survival statistics were calculated for the time taken to reach a clinically effective dilatation, clinically effective diameter (CED) of 6.0 mm.Results: Mean difference in pupil diameters between amethocaine- and placebo-treated eyes was 0.30 ± 0.09 mm (P < 0.002). In all, 62% of amethocaine-treated eyes and only 46% of placebo-treated eyes reached the CED.Conclusion: We observed a small but statistically significant potentiating effect of a drop of amethocaine on tropicamide-induced dilatation within 20 minutes.","PeriodicalId":74362,"journal":{"name":"Ophthalmology and eye diseases","volume":"6 ","pages":"13-9"},"PeriodicalIF":0.0,"publicationDate":"2014-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4137/OED.S13991","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32326737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Ocular surface cytotoxicity and safety evaluation of tafluprost, a recently developed anti-glaucoma prostaglandin analog. 最近开发的抗青光眼前列腺素类似物他氟前列素的眼表细胞毒性和安全性评价。

Ophthalmology and eye diseases Pub Date : 2014-02-13 eCollection Date: 2014-01-01 DOI: 10.4137/OED.S12445

Yoshimi Niwano, Atsuo Iwasawa, Masahiko Ayaki

{"title":"Ocular surface cytotoxicity and safety evaluation of tafluprost, a recently developed anti-glaucoma prostaglandin analog.","authors":"Yoshimi Niwano, Atsuo Iwasawa, Masahiko Ayaki","doi":"10.4137/OED.S12445","DOIUrl":"https://doi.org/10.4137/OED.S12445","url":null,"abstract":"In vitro cytotoxicity of tafluprost, which is the most recently developed anti-glaucoma prostaglandin (PG) analog, in ocular surface cells is addressed in comparison with other PG analogs. Irrespective of cell lines and models, the cytotoxicity of anti-glaucoma PG eyedrops was primarily related to the concentration of benzalkonium chloride (BAK) contained in the eyedrops as a preservative. Accordingly, preservative-free tafluprost was apparently less cytotoxic than BAK-preserved PG analogs. Furthermore, our study for cytotoxicity assays on ocular cells, conducted by comprehensive investigations covering a variety of concentrations and treatment times, which is termed the cell viability score (CVS) system, demonstrated that 0.001% BAK-preserved tafluprost was not cytotoxic, and suggested that tafluprost may even reduce the cytotoxic effect of BAK. It has been reported that adverse reactions associated with tafluprost in healthy human volunteers and patients with glaucoma include conjunctival hyperemia, eyelid pigmentation, eyelash bristles, and deepening of upper eyelid sulcus. Nonetheless, most clinical studies have demonstrated that not only preservative-free tafluprost but also BAK-preserved tafluprost is well tolerated and safe in patients with glaucoma and ocular hypertension. ","PeriodicalId":74362,"journal":{"name":"Ophthalmology and eye diseases","volume":"6 ","pages":"5-12"},"PeriodicalIF":0.0,"publicationDate":"2014-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4137/OED.S12445","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"32143340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Cohort study of intracameral moxifloxacin in postoperative endophthalmitis prophylaxis. 莫西沙星在术后预防眼内炎中的队列研究。

Ophthalmology and eye diseases Pub Date : 2014-01-16 eCollection Date: 2014-01-01 DOI: 10.4137/OED.S13102

Virgilio Galvis, Alejandro Tello, Mary Alejandra Sánchez, Paul Anthony Camacho

引用次数: 33

Aphakia correction by injection of foldable intra ocular lens in the anterior chamber. 前房可折叠人工晶状体注射矫正无晶状体。

Ophthalmology and eye diseases Pub Date : 2013-12-01 eCollection Date: 2013-01-01 DOI: 10.4137/OED.S12672

Kagmeni Giles, Moukouri Ernest, Domngang Christelle, Nguefack-Tsague Georges, Cheuteu Raoul, Ebana Mvogo Come, Peter Wiedemann

{"title":"Aphakia correction by injection of foldable intra ocular lens in the anterior chamber.","authors":"Kagmeni Giles, Moukouri Ernest, Domngang Christelle, Nguefack-Tsague Georges, Cheuteu Raoul, Ebana Mvogo Come, Peter Wiedemann","doi":"10.4137/OED.S12672","DOIUrl":"https://doi.org/10.4137/OED.S12672","url":null,"abstract":"We assessed the outcomes of the use of anterior chamber foldable lens for unilateral aphakia correction at the University Teaching Hospital of Yaounde. In this retrospective, non-comparative, consecutive case series study, we reviewed the records of patients who underwent an operation for aphakia correction by the means of injection of an angular supported foldable lens between January 2009 and December 2011 in the University Teaching Hospital Yaounde. Student's paired t-test was carried out to compare pre-operative and post-operative visual acuity (VA) and intraocular pressure (IOP). P-values less than 0.05 were considered statistically significant. Twenty-one patients were included in the study; twelve were male (57.1%) and nine were female (42.9%). The mean age was 55.38 ± 17.67 years (range 9-75 years). The mean follow-up duration was 5.95 ± 3.14 months (range 2-12 months). The mean log-MAR visual acuity was 1.26 ± 0.46 pre-operatively and 0.78 ± 0.57 post-operatively (P = 0.003). The change in intraocular pressure was not statistically significant. Complications included intraocular hypertension (over 21 mmHg) in 3 patients (14.3%) and macular edema, pupillar ovalization, and retinal detachment in one patient each. The results indicate that injection of an angular support foldable lens in the anterior chamber is a useful technique for the correction of aphakia in eyes without capsular support. More extended follow-up, however, and a larger series of patients are needed to ascertain the effectiveness and safety of this procedure. ","PeriodicalId":74362,"journal":{"name":"Ophthalmology and eye diseases","volume":"5 ","pages":"17-22"},"PeriodicalIF":0.0,"publicationDate":"2013-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4137/OED.S12672","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31943642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Effect of Bevacizumab Injection before Vitrectomy on Intravitreal Hemorrhage in Pseudophakic Patients with Proliferative Diabetic Retinopathy. 玻璃体切除术前注射贝伐单抗对假性白内障合并增殖性糖尿病视网膜病变玻璃体内出血的影响。

Ophthalmology and eye diseases Pub Date : 2013-07-15 Print Date: 2013-01-01 DOI: 10.4137/OED.S12352

Mehmet Demir, Ersin Oba, Efe Can, Orhan Kara, Sonmez Cinar

{"title":"Effect of Bevacizumab Injection before Vitrectomy on Intravitreal Hemorrhage in Pseudophakic Patients with Proliferative Diabetic Retinopathy.","authors":"Mehmet Demir, Ersin Oba, Efe Can, Orhan Kara, Sonmez Cinar","doi":"10.4137/OED.S12352","DOIUrl":"https://doi.org/10.4137/OED.S12352","url":null,"abstract":"We evaluated the effect of intravitreal bevacizumab (IVB) injection before pars plana vitrectomy (PPV) on intravitreal hemorrhage (VH) during and after vitrectomy for postoperative the first day and the first month in pseudophakic patients with proliferative diabetic retinopathy (PDR). This retrospective study was performed on 44 eyes of 44 patients who underwent vitrectomy for PDR. Patients were divided into PPV (n = 22 eyes) and PPV + IVB (n = 22 eyes) groups. Injection of bevacizumab (1.25 mg/0.05 mL) was performed 3 days before vitrectomy. Outcomes of visual acuity as well as intraoperative and postoperative VH were compared between the two groups. One month after surgery, visual acuity improved in PPV and PPV + IVB groups (P = 0.005, P = 0.006), respectively. There was no difference between the two groups in best corrected visual acuity at baseline and after vitrectomy (P = 0.71). Intraoperative bleeding into the vitreous was recorded in 14 (63.6%) cases in the PPV group and in 7 (31.8%) cases in the PPV + IVB group. The first month, intravitreal hemorrhage was recorded in six patients in the PPV group and in two patients in the PPV + IVB group (P = 0.03). The mean pre-postoperative central macular thickness was similar in both groups. Intravitreal injection of IVB before vitrectomy decreased the rate of VH at the time of surgery and at the first postoperative month in patients with PDR. ","PeriodicalId":74362,"journal":{"name":"Ophthalmology and eye diseases","volume":"5 ","pages":"11-5"},"PeriodicalIF":0.0,"publicationDate":"2013-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4137/OED.S12352","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31641271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Voclosporin as a treatment for noninfectious uveitis. 氯菌素治疗非感染性葡萄膜炎。

Ophthalmology and eye diseases Pub Date : 2013-05-05 Print Date: 2013-01-01 DOI: 10.4137/OED.S7995

Clyde Schultz

引用次数: 14

Peters' anomaly. 彼得斯的异常。

Ophthalmology and eye diseases Pub Date : 2013-02-13 Print Date: 2013-01-01 DOI: 10.4137/OED.S11142

Robert W Sault, Jeffrey Sheridan

引用次数: 1

Systemic reduction of interleukin-4 or interleukin-10 fails to reduce the frequency or severity of experimental cytomegalovirus retinitis in mice with retrovirus-induced immunosuppression. 在逆转录病毒诱导的免疫抑制小鼠中，全身减少白细胞介素-4或白细胞介素-10不能降低实验性巨细胞病毒视网膜炎的频率或严重程度。

Ophthalmology and eye diseases Pub Date : 2012-09-25 Print Date: 2012-01-01 DOI: 10.4137/OED.S10294

Emily L Blalock, Hsin Chien, Richard D Dix

引用次数: 12

Paracentesis as surgical intervention in traumatic hyphaema: opinions and practices of nigerian ophthalmologists. 作为外伤性垂体出血的外科干预:尼日利亚眼科医生的意见和实践。

Ophthalmology and eye diseases Pub Date : 2012-08-30 Print Date: 2012-01-01 DOI: 10.4137/OED.S9411

Okosa Michael Chuka, Onyekwe Lawrence Obizoba

{"title":"Paracentesis as surgical intervention in traumatic hyphaema: opinions and practices of nigerian ophthalmologists.","authors":"Okosa Michael Chuka, Onyekwe Lawrence Obizoba","doi":"10.4137/OED.S9411","DOIUrl":"https://doi.org/10.4137/OED.S9411","url":null,"abstract":"Introduction: Various aspects of management of traumatic hyphaema are enmeshed in controversy. Surgery is done to prevent complications: optic atrophy and corneal blood staining occurring if a high risk exists of either or both occurring. Circumstances considered high risk do not enjoy universal consensus.Objectives: To determine what Nigerian ophthalmologists consider absolute indications for surgical intervention by means of anterior chamber paracentesis and hyphaema washout in closed globe traumatic hyphaema, evaluate these absolute indications, and attempt to evolve a guideline for surgical intervention based on areas of consensus and disagreement.Method: A semi-structured, pre-tested questionnaire with responses analyzed with SPSS 11 software.Result: Near universal agreement on indication exist on early corneal blood staining and sickle cell haemoglobinopathy. Differing views concern blackball, volume and duration of hyphaema and secondary hypertension-associated hyphaema. However, it appears surgery is embarked on earlier than other practitioners elsewhere may consider necessary.Conclusion: Risk level for non-surgical management against risk and benefit of surgery should be evaluated for each individual before surgery.","PeriodicalId":74362,"journal":{"name":"Ophthalmology and eye diseases","volume":"4 ","pages":"71-8"},"PeriodicalIF":0.0,"publicationDate":"2012-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4137/OED.S9411","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31504834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3