Open access journal of contraception最新文献

{"title":"A Tale as Old as Time: Contraception Concerns in the 21st Century.","authors":"Rachel Margaret Bottomley-Wise, Amie Woodward, Adenike Okanlawon, Amanda J Mason-Jones","doi":"10.2147/OAJC.S581526","DOIUrl":"https://doi.org/10.2147/OAJC.S581526","url":null,"abstract":"<p><p>Historical inconsistencies in contraception research have led to concerns about side effects regarding hormonal contraception. Today, concerns about the hormonal contraceptive pill are still ongoing. The side effects from hormonal contraception and prevailing socioeconomic barriers to effective contraception have heralded in the use of Mobile Health (mHealth) applications as birth control methods. These applications are set to become ubiquitous with the proliferation of wearable devices that monitor biodata. Access to modern contraceptives depends on who you are and where you live and often has cost-implications. The use of \"mHealth\" applications has been rising in recent years and are marketed as having maximal reward for minimal cost and perhaps could alleviate some of these concerns. While mHealth applications are flexible, accessible, and low cost, this paper suggests that we exercise caution so as not to repeat past mistakes. We provide a critical review of the history of research into contraception. We may have come far, but we still have a long way to go for equitable access to contraceptive healthcare.</p>","PeriodicalId":74348,"journal":{"name":"Open access journal of contraception","volume":"17 ","pages":"581526"},"PeriodicalIF":2.2,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13070127/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147679182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experiences of Contraceptive Use and Contraceptive Counseling Among German Psychology Students: A Cross-Sectional Online Survey.","authors":"Johanna Seiwert, Anja Lindig","doi":"10.2147/OAJC.S560274","DOIUrl":"https://doi.org/10.2147/OAJC.S560274","url":null,"abstract":"<p><strong>Purpose: </strong>In recent years, hormonal contraceptive use has declined in Germany, yet little is known about the contraceptive needs and preferences of its population. This study addresses this gap by (1) identifying attitudes, subjective knowledge, and information needs of psychology students regarding contraceptive methods, (2) evaluating person-centeredness (PC) and shared decision-making (SDM) in contraceptive counseling, and (3) comparing users of hormonal and non-hormonal methods regarding attitudes, knowledge, and age.</p><p><strong>Patients and methods: </strong>We conducted a cross-sectional study applying an online survey among psychology students in Germany, who were biologically capable of becoming pregnant. PC in counseling was assessed using the Person-Centered Contraceptive Counseling Scale (PCCC), while SDM was measured using the CollaboRATE questionnaire and Control Preference Scale. Attitudes, knowledge, and information needs were evaluated through adapted or self-developed items. We translated and adapted the PCCC using a team translation protocol (TRAPD).</p><p><strong>Results: </strong>Of 126 participants, 82.6% used at least one contraceptive method, mainly condoms (43.8%) and the combined pill (19.8%). Most participants were satisfied with their currently used method and do not want to change their current method. Hormonal users were younger (M=22.84) than non-hormonal users (M=25.40). Attitudes toward hormonal contraception were generally negative. Participants reported good or basic knowledge of 9 out of 15 methods; non-hormonal users knew more methods than hormonal users. Gynecologists (36.7%) were the most frequent information source. About 35.7% had received contraceptive counseling in the previous year but reported low satisfaction with the information provided. Overall, PC and SDM were only partially implemented in contraceptive counseling.</p><p><strong>Conclusion: </strong>Findings highlight the need for more person-centered counseling to support informed decisions. The results can inform interventions aimed at improving contraceptive knowledge among users and enhancing PC and SDM practices among gynecologists.</p>","PeriodicalId":74348,"journal":{"name":"Open access journal of contraception","volume":"17 ","pages":"560274"},"PeriodicalIF":2.2,"publicationDate":"2026-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13005624/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147500868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Dermatologic and Neuropsychological Side Effects of Oral Contraceptives, 2016-2020.","authors":"Joseph Visingardi, Paul J Feustel, Rachel Flink-Bochacki, Cassandra Denefrio","doi":"10.2147/OAJC.S556852","DOIUrl":"https://doi.org/10.2147/OAJC.S556852","url":null,"abstract":"<p><strong>Purpose: </strong>Many patients seek a contraceptive medication that lessens symptom burden of comorbid conditions. To date, there have been limited studies investigating how oral contraceptives compare in rates of skin and mood-related side effects. The goal of this study was to compare rates of dermatological and neuropsychological side effects with various oral contraceptive formulations.</p><p><strong>Patients and methods: </strong>We utilized FDA Adverse Event Reporting System (FAERS) and Medical Expenditure Panel Survey (MEPS) data to compare rates of reported subjective side effects for oral contraception pills from 2016 to 2020, including acne, migraine, anxiety, and depression. Ethinyl estradiol/Norethindrone was used as the reference pill, as it is the oldest and the most prescribed combination oral contraceptive.</p><p><strong>Results: </strong>Pills with drospirenone had higher rates of acne, migraine, depression, and anxiety. Acne was also greater with levonorgestrel and norgestimate pills, and anxiety was greater with levonorgestrel combination pills and norethindrone alone.</p><p><strong>Conclusion: </strong>Oral contraceptive formulation may affect dermatologic and neuropsychological symptoms. Multiple progestins may impact rates of acne and anxiety, with fewer effects on depression and migraine headaches. This knowledge may allow for the personalization of medication selection based on the patients' other co-morbid conditions.</p>","PeriodicalId":74348,"journal":{"name":"Open access journal of contraception","volume":"17 ","pages":"556852"},"PeriodicalIF":2.2,"publicationDate":"2026-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12927727/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147286487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum: Pathophysiological Consequences Associated with Hormonal Contraceptives Use in Sub-Saharan Africa: A Scoping Review [Corrigendum].","authors":"","doi":"10.2147/OAJC.S589709","DOIUrl":"https://doi.org/10.2147/OAJC.S589709","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.2147/OAJC.S563680.].</p>","PeriodicalId":74348,"journal":{"name":"Open access journal of contraception","volume":"16 ","pages":"229-230"},"PeriodicalIF":2.2,"publicationDate":"2025-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12731204/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145835596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Calcium Channels and Modulators as Potential Therapeutic Targets for Contraceptives and Male Fertility: A Scoping Review.","authors":"Marie Francoise Twambaze, Ismail Abiola Adebayo, Saidi Odoma, Abdullateef Isiaka Alagbonsi","doi":"10.2147/OAJC.S572080","DOIUrl":"10.2147/OAJC.S572080","url":null,"abstract":"<p><strong>Background: </strong>Calcium channels are critical regulators of spermatogenesis and sperm functions, orchestrating processes like motility, capacitation, and fertilization. Their dysfunction is linked to male infertility, contributing to approximately 50% of infertility cases globally. This scoping review synthesizes evidence on the role of calcium channels in male fertility, focusing on their physiological mechanisms and implications for reproductive health.</p><p><strong>Methods: </strong>Following the PRISMA-ScR checklist and Arksey and O'Malley's framework, a search of PubMed, Scopus, and Web of Science identified 978 records from January 2000 to July 2025. After screening, 142 peer-reviewed studies on mammalian models were included. Data were extracted on channel types, study designs, and outcomes, categorized by the physiological functions of sperm.</p><p><strong>Results: </strong>The review identified five channel-mediated regulators of sperm calcium, including CatSper, voltage-dependent calcium channels (VDCCs), TRP channels, inositol triphosphate (IP₃) and ryanodine receptors (IP3Rs & RyRs), and calcium-sensing receptor (CaSR), as key players in sperm motility, capacitation, and fertilization. About 19 non-channel mediators of sperm calcium were also reported.</p><p><strong>Conclusion: </strong>Calcium channels are pivotal to male fertility and contraceptives, offering diagnostic and therapeutic potential. Future research should focus on multi-channel interactions, human-based studies, and environmental impacts to enhance fertility treatments and develop non-hormonal contraceptives.</p>","PeriodicalId":74348,"journal":{"name":"Open access journal of contraception","volume":"16 ","pages":"199-228"},"PeriodicalIF":2.2,"publicationDate":"2025-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12724208/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145829211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ethinylestradiol Transfer into Breast Milk of Women Using Low-Dose Combined Hormonal Contraception Is Negligible.","authors":"Lior Segev, Avigail Ben Zimra, Gideon A Weitzman, Naamah Bloch, Itay Pitussi, Tatiana Alkhazov, Natalya M Kogan, David Peleg, Abraham O Samson, Inbar Ben Shachar","doi":"10.2147/OAJC.S555399","DOIUrl":"10.2147/OAJC.S555399","url":null,"abstract":"<p><strong>Introduction: </strong>Few studies have examined the transfer of Ethinylestradiol (EE) into breastmilk in women using Combined Hormonal Contraception (CHC). Most studies are decades old, from when EE doses (≈50 μg) were higher than today (≤35 μg).</p><p><strong>Methods: </strong>Here, we asses EE levels in milk from breastfeeding women on CHC with low-dose EE (15-35 µg/day EE) using mass spectrometry (MS). Our study included 14 breastfeeding women: 6 using oral CHC (15, 20, or 30 µg/day EE), 7 using a vaginal ring (15 µg/day EE), and 1 using a transdermal patch (35 µg/day EE). A control group of 8 breastfeeding women not using hormonal contraceptives was also included. All participants completed a background questionnaire and provided 5mL of breast-milk. Samples were lyophilized and extracted with methyl tert-butyl ether (MTBE) for Liquid Chromatography-Mass Spectrometry (LC-MS) analysis. EE levels were assessed using high-resolution LC-MS, with a limit of quantification (LOQ) of 3.5 ng/mL.</p><p><strong>Results: </strong>No measurable peak of the compound was found in any of the CHC users. To confirm that EE was not lost during sample preparation, pure EE was added to control breast milk and successfully detected.</p><p><strong>Conclusion: </strong>These findings suggest that EE transfer into breastmilk is less than 3.5 ng/mL, and therefore negligible compared to endogenous estradiol. This first LC-MS-based study provides novel evidence supporting the lactation safety of modern low-dose CHC, though larger studies with lower detection limits are needed for confirmation.</p>","PeriodicalId":74348,"journal":{"name":"Open access journal of contraception","volume":"16 ","pages":"189-197"},"PeriodicalIF":2.2,"publicationDate":"2025-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12702262/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145764753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathophysiological Consequences Associated with Hormonal Contraceptives Use in Sub-Saharan Africa: A Scoping Review.","authors":"Marie Gorette Kampire, Jean Claude Hakizimana, Joseph Mucumbitsi, Abdullateef Isiaka Alagbonsi","doi":"10.2147/OAJC.S563680","DOIUrl":"10.2147/OAJC.S563680","url":null,"abstract":"<p><strong>Background: </strong>Although the safety profile of hormonal contraceptives (HCs) in African populations is still unclear, their use is growing in Sub-Saharan Africa (SSA) to lower unwanted pregnancies. Hematological, cardiometabolic, endocrine, immunological, and psychological consequences are among the reported negative outcomes. This scoping review summarizes the most recent data on the pathophysiological consequences associated with the use of HCs in SSA.</p><p><strong>Methods: </strong>A comprehensive search via PubMed, African Journal Online, Wiley Online Library, and Google Scholar, following PRISMA-ScR guidelines, identified studies published between 2000 and 2025 on adverse outcomes of HCs in SSA. Eligible studies involved laboratory analysis, cross-sectional surveys, cohort studies, and randomized controlled trials and were conducted in English. Data were charted by country, design, contraceptive type, and adverse outcomes.</p><p><strong>Results: </strong>Fifty-one eligible studies from SSA were analyzed, revealing diverse pathophysiological consequences. Hematological effects were reported in 7 studies, showing a higher hematological profile and reduced anemia risk among users of HCs. Cardiometabolic impacts were noted in 17 studies, with dyslipidemia (40-60% prevalence), hypertension, and weight gain (1-3 kg/m² BMI increase) linked to depot medroxyprogesterone acetate (DMPA) and combined oral contraceptives (COCs). Endocrine effects were observed in 3 studies, while 12 studies showed vulnerability of HCs users to sexually transmitted and other forms of infections. Immune dysregulation and microbiota changes were reported in 5 studies. A study each reported varying consequences, including anthropometry, bone density, sexual dysfunction and depression, bleeding irregularities, electrocardiogram, spermatotoxicity, and biochemical changes.</p><p><strong>Conclusion: </strong>Use of HCs in SSA is linked to a variety of diseases in the immunological, metabolic, endocrine, hematologic, and psychological domains. To inform safe contraceptive usage and reproductive health policy in SSA, these findings highlight the necessity of integrated contraceptive counseling, clinical monitoring for comorbidities, and additional region-specific research.</p>","PeriodicalId":74348,"journal":{"name":"Open access journal of contraception","volume":"16 ","pages":"171-187"},"PeriodicalIF":2.2,"publicationDate":"2025-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12625715/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145558539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding Contraceptive Preferences Across Generations: Insights from Indonesian Millennials and Zillennials.","authors":"Syahmida Syahbuddin Arsyad, Laili Rahayuwati, Rahmadewi, Septi Nurhayati, Arga Nugraha, Darojad Nurjono Agung Nugroho, Oktriyanto, Mugia Bayu Rahardja, Yanu Endar Prasetyo, Yanti Astrelina Purba, Ruth Meilianna, Indra Murty Surbakti, Wahyu Utomo, Vira Amelia","doi":"10.2147/OAJC.S555967","DOIUrl":"10.2147/OAJC.S555967","url":null,"abstract":"<p><strong>Purpose: </strong>To find out the differences in the use of contraceptive methods in millennials and zillennials.</p><p><strong>Methods: </strong>This study employed a cross-sectional comparative design using secondary data from the National Socio-Economic Survey 2012 and 2022. A total of 31,345 women (2012) and 23,942 women (2022) were included. Generations were defined as follows: Millennials (born 1981-1996) and Zillennials (born 1997-2012). Descriptive statistics, chi-square and multinomial logistic regression were used to assess differences in contraceptive use between the two generations.</p><p><strong>Results: </strong>Age, residence, education, household expenditure, age at first marriage, number of living children, and internet access were significantly associated with contraceptive preferences. Among Millennials, education and internet access were most associated with SARC use. Among Zillennials, education and fewer living children were most associated with SARC use. Regarding traditional methods, among Millennials, age group and internet access were most associated with use, and among Zillennials, residence and education were most associated with traditional method use.</p><p><strong>Conclusion: </strong>Strengthening communication, information dissemination, and education tailored to the characteristics of the generation is essential to address their specific needs and preferences.</p>","PeriodicalId":74348,"journal":{"name":"Open access journal of contraception","volume":"16 ","pages":"159-170"},"PeriodicalIF":2.2,"publicationDate":"2025-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12584799/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145454172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drivers of Uptake of Immediate Postpartum Modern Contraceptives by Postpartum Women in Lira City, Northern Uganda: A Qualitative Inquiry.","authors":"Emmanuel Ekung, Samson Udho, Felister Apili, Emmanuel Madira, Beth Namukwana, Vicky Caroline Achayo, Patricia Akello, Anna Grace Auma, James Okello","doi":"10.2147/OAJC.S543288","DOIUrl":"10.2147/OAJC.S543288","url":null,"abstract":"<p><strong>Introduction: </strong>Immediate postpartum modern contraceptive uptake among postpartum women gives over 95% assurance of contraception and reduced chances of short interval pregnancies resulting in improved maternal and child health outcomes. The drivers of its uptake among women are vital in designing interventions aimed at improving and scaling up its uptake. The study therefore explored the drivers of uptake of immediate postpartum modern contraceptives by postpartum women in Lira City, northern Uganda.</p><p><strong>Methods: </strong>A descriptive qualitative approach was used. A face-to-face key informant interview was used to collect data from 15 key informants (healthcare providers) working in the department of Obstetrics and Gynecology of Lira Regional Referral Hospital. Data were analyzed using Atlas.Ti and thematic analysis was done. The approach enabled an in-depth understanding of the phenomenon from service providers.</p><p><strong>Results: </strong>The barriers to uptake of immediate postpartum modern contraceptives were health system constraints like commodity unavailability, lack of staff training, and inadequate staffing, knowledge and skills gaps of providers. Limited knowledge, religious and cultural beliefs, male partners objection, inadequate access to information, peer influence and fear of side effects were key barriers from recipients of care. The major facilitators include availability of commodities, improved staffing level, staff training, and timely education and counselling.</p><p><strong>Conclusion: </strong>This study highlights that the uptake of immediate postpartum modern contraceptives is hindered by both health system and client-related barriers. Presence of trained staff, availability of contraceptive commodities, improved staffing levels, and timely counselling and education were identified as key facilitators. Addressing both health system and individual barriers through strengthening health systems, targeted provider training, male involvement, and enhanced community education may improve the uptake of immediate postpartum modern contraceptives.</p>","PeriodicalId":74348,"journal":{"name":"Open access journal of contraception","volume":"16 ","pages":"147-157"},"PeriodicalIF":2.2,"publicationDate":"2025-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12570992/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145411208","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding Problematic Bleeding When Using Contraception: Guidance for Clinicians.","authors":"Marta Barretta, Giovanni Grandi","doi":"10.2147/OAJC.S431368","DOIUrl":"10.2147/OAJC.S431368","url":null,"abstract":"<p><p>Abnormal uterine bleeding (AUB) is a common side effect of hormonal contraceptive (HC) use and represents a significant cause of treatment discontinuation. Two main types of bleeding are recognized: withdrawal bleeding, which occurs during the hormone-free interval following a sudden drop in hormone levels, and breakthrough bleeding (BTB), defined as unscheduled bleeding during active hormone administration. Combined oral contraceptives (COCs) may induce BTB due to hormonal fluctuations or insufficient endometrial stabilization, while progestin-only contraception (POC) is commonly associated with abnormal bleeding due to endometrial changes induced by continuous progestin exposure. A structured and clinically oriented framework for the management of AUB in the context of HC is presented, highlighting the importance of appropriate counseling. Some strategies to improve adherence have been proposed, recognizing non-compliance as a major contributor to unscheduled bleeding. Contraceptive choice is addressed as an individualized process, involving adjustments to hormone type and dosage based on woman-specific needs. The aim is to provide clinicians with a clear and structured tool to address a highly prevalent yet often overlooked issue, still marked by significant uncertainty and inconsistency in the current literature.</p>","PeriodicalId":74348,"journal":{"name":"Open access journal of contraception","volume":"16 ","pages":"131-145"},"PeriodicalIF":2.2,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12535263/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145330964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}