Obstetrics and gynecology research最新文献

{"title":"Semicircular Canal Functions Throughout Pregnancy: Case series using Video Head Impulse Test (vHIT)","authors":"Melissa Castillo-Bustamante, María Nazareth Campo-Campo, Daniel Peña-Tobon, O. Briceño, Johanna M. Vanegas-Munera, Jorge Madrigal","doi":"10.26502/ogr0134","DOIUrl":"https://doi.org/10.26502/ogr0134","url":null,"abstract":"Pregnancy involves several anatomic and functional changes in several organs including the vestibular system. Symptoms such as unsteadiness, dizziness and vertigo are reported by pregnant patients. However, there is a lack of evidence about the vestibular functional and anatomic changes throughout the pregnancy. Some studies have detailed unilateral deficits, increased","PeriodicalId":74336,"journal":{"name":"Obstetrics and gynecology research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69352606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"“What you are asking is not what we are told to prepare’’: A communitybased study of Birth preparedness and complication readiness among postpartum women in a rural district, northern Tanzania","authors":"Minael G. Mjemmas, Edwin J. Shewiyo, Ester J. Diarz, Patricia Swai, Beatrice J. Leyaro, Sia E. Msuya.","doi":"10.26502/ogr0120","DOIUrl":"https://doi.org/10.26502/ogr0120","url":null,"abstract":"","PeriodicalId":74336,"journal":{"name":"Obstetrics and gynecology research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69352458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exosomal Lipid Biomarkers of Oligodendrocyte Pathology to Predict Scoliosis in Children with Cerebral Palsy.","authors":"Nune Darbinian, Emily C Sparks, Armine Darbinyan, Nana Merabova, Tamara Tatevosian-Geller, Katie Calaku, Sarah Bachman, Huaqing Zhao, Shohreh Amini, Laura Goetzl, Solomon P Samuel, Amer Samdani, Michael E Selzer","doi":"10.26502/ogr0127","DOIUrl":"10.26502/ogr0127","url":null,"abstract":"<p><strong>Introduction: </strong>Cerebral Palsy (CP), the most common cause of disability in children, is phenotypically heterogeneous. Approximately 20% of cases develop severe scoliosis. A pathological hallmark of CP is periventricular leukomalacia (PVL), which is due to dysmyelination, suggesting the possibility of a lipidomic abnormality. Risk factors for CP include perinatal hypoxia, prematurity, multiple gestation, ischemia, infection, and maternal alcohol consumption. There is evidence for low serum levels of omega-3 (ω-3) fatty acids in CP patients, and separately in idiopathic scoliosis. Many effects of free fatty acids (FFAs) are mediated via specific G protein-coupled free fatty acid receptors (FFARs), which play essential roles as nutritional and signaling molecules. FFAs, including ω-3, and their receptors are involved in the development and metabolism of oligodendrocytes (OLs), and are critical to myelination. Thus, the cases of CP that will develop severe scoliosis might be those in which there is a deficiency of ω-3, FFARs, or other lipidomic abnormality that is detectable early in the plasma. If so, we might be able to predict scoliosis and prevent it with dietary supplementation.</p><p><strong>Methods: </strong>Blood samples were collected from four groups of patients at the Philadelphia Shriners Children's Hospital (SCH-P): 1) patients with CP; 2) severe scoliosis (>40o); 3) CP plus scoliosis; and 4) non-impaired controls stratified by age (2-18 yrs), gender, and race/ethnicity, under an IRB-approved protocol. Serum proteins and RNA were purified, and OL-derived exosomes (OL-Es) isolated, using myelin basic protein (MBP) as a late OL marker. Protein was used for the detection of MBP and FFAR by enzyme-linked immunosorbent assays (ELISAs), and by flow cytometry. RNA was assayed by digital droplet polymerase chain reaction (ddPCR) for OL markers and FFAR expression.</p><p><strong>Results: </strong>FFAR and MBP proteins were downregulated in each of the three patient groups compared to controls, and this difference was greatest in both patients with CP plus scoliosis.</p><p><strong>Conclusion: </strong>Altogether, MBP and FFAR levels were reduced in OL-Es from both children with CP plus scoliosis. The lipid abnormalities specific to CP with scoliosis were concentrated in OLs. Our data might i) suggest therapeutic targets to reduce dysmyelination and scoliosis in CP, ii) predict which children are at risk for developing scoliosis, iii) lead to therapeutic trials of fatty acids for CP and other dysmyelinating neurological disorders.</p>","PeriodicalId":74336,"journal":{"name":"Obstetrics and gynecology research","volume":"6 2","pages":"160-170"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10399299/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9953806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Prospective Study on the Reliability of First-Trimester Ultrasound in Identifying the Gestational Sac Implantation Site","authors":"R. Svirsky, O. Moore, N. Smorgick, U. Rozovski, A. Zimerman, R. Maymon","doi":"10.26502/ogr0116","DOIUrl":"https://doi.org/10.26502/ogr0116","url":null,"abstract":"Objectives: Normal and abnormal implantation of the gestational sac may affect obstetrical outcomes. We sought to evaluate whether ultrasound can correctly identify the first-trimester gestational sac implantation wall compared to diagnostic hysteroscopy. Methods: Consecutive women diagnosed with first-trimester pregnancy loss who opted for surgical termination of pregnancy were prospectively recruited to the study. Pre-operatively, an ultrasound scan was performed to assess for the gestational sac implantation wall. Subsequently, the surgical procedure of diagnostic hysteroscopy combined with suction and curettage was performed. The sonographers were blinded to the hysteroscopy results. The gestational sac implantation wall was determined and compared between the two modalities. Results: Twenty-three women were included in the study. The median gestational age 9 (range: 6 to 13) weeks, and the median crown-rump length was 7 (range 6-9) mm. In one case, the implantation site was determined only by the U.S. In the remaining, the U.S. and hysteroscopy gestational sac location were identical (21/22, 95%). Thus, the correlation between the sonographic and hysteroscopy findings was 0.96. Conclusion: Ultrasound is a reliable method for the detection of the early gestational sac implantation site.","PeriodicalId":74336,"journal":{"name":"Obstetrics and gynecology research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69352058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal Blood Lipid Biomarkers of Oligodendrocyte Pathology to Predict Fetal Alcohol Spectrum Disorders.","authors":"Nune Darbinian, Emily C Sparks, Armine Darbinyan, Nana Merabova, Gabriel Tatevosian, Ekaterina Vadachkoria, Huaqing Zhao, Shohreh Amini, Laura Goetzl, Michael E Selzer","doi":"10.26502/ogr0122","DOIUrl":"10.26502/ogr0122","url":null,"abstract":"<p><strong>Introduction: </strong>Up to 9.9% of children have fetal alcohol spectrum disorders (FASD), the most frequent cause of intellectual disability in the US. FASD may involve abnormal brain development, including dysmyelination, suggesting abnormal development of oligodendrocytes (OLs), which make myelin and are rich in lipids. Indeed, low serum levels of omega-3 fatty acids (ω-3) have been reported in FASD. Free fatty acids bind to specific receptors (FFARs). We have isolated cell type-specific fetal brain-derived exosomes (FB-E) from maternal blood and sampled their contents to search for lipid-related biomarkers that predict FASD.</p><p><strong>Methods: </strong>Blood samples were collected from two groups of pregnant women: 1) those who consumed EtOH during pregnancy, and 2) non-EtOH using controls, under an IRB-approved protocol. Serum and OL-derived exosomes (OL-Es) were used to assay myelin basic protein (MBP) and FFAR by ELISA and droplet digital PCR (ddPCR), respectively.</p><p><strong>Results: </strong>FFAR and MBP proteins were downregulated in the EtOH group compared to controls, and this difference was greatest in OL-Es from maternal blood compared maternal serum.</p><p><strong>Conclusion: </strong>MBP and FFAR levels were reduced in OL-Es from EtOH-consuming pregnant women. The data suggest potential therapeutic targets to predict which children are at risk for developing FASD and reduce dysmyelination in developing.</p>","PeriodicalId":74336,"journal":{"name":"Obstetrics and gynecology research","volume":"1 1","pages":"127-138"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10732461/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69352490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parental Postnatal Depressive Symptoms in NICU are strongly related to Demographic factors and Maternal as well as Neonatal Perinatal Clinical Outcome","authors":"I. Ioannou, A. Giotsa","doi":"10.26502/ogr0133","DOIUrl":"https://doi.org/10.26502/ogr0133","url":null,"abstract":"Introduction: Giving birth to a preterm infant is undoubtedly a stressful event on parents’ psychological wellbeing. Aim: To determine the depression levels and define the related demographic and clinical factors. Material and Methods: A prospective, follow up–cohort study, in “Helena Venizelou” Maternity Hospital’s NICU (Athens, Greece), between December 2019 to December 2022, with the sample of sixty couples, whose infants’ birth weight (BW) was <1750g and gestational age (GA) <34weeks. Data were collected using the Edinburg Postnatal Depression Scale in 3rd–4th, in 20th– 25th day of life and at NICU discharge. Results: Mothers experienced higher levels of depression than fathers did, at all assessments (1st: p<0.001, 2nd: p<0.001, 3rd: p<0.001). Our data concluded that the rate of maternal depression in the 1st & 2nd assessment [Mean (SD):14.9(5.9) and Mean (SD):12.4(6.2), respectively] was significantly higher than the 3rd [Mean (SD):10.3 (5.9)]. Moreover, the rate of fathers’ depression in the 1st assessment [Mean (SD):10.3(5.8)] was higher compared to the 3rd [Mean (SD):6.4(5.2)]. Other factors that contributed to higher levels of depression were maternal health problems & receiving in vitro fertilisation treatment for mothers as well as Apgar score 5΄ for fathers. Maternal age, clinical course of pregnancy (primiparous & single pregnancies), neonatal BW & hospitalization duration as well as Apgar and CRIB II score were also found to correlate with levels of depression. Conclusion:","PeriodicalId":74336,"journal":{"name":"Obstetrics and gynecology research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69352580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Un Unbelievable Intradural Extramedullary Metastasis from a Uterine Leiomyosarcoma: The First Case and Review of Literature","authors":"Marinaccio M, Giannoccaro A, Marzullo A, D. A., Messina R, de Gennaro L, Cicinelli E, Mastronardi M","doi":"10.26502/ogr0123","DOIUrl":"https://doi.org/10.26502/ogr0123","url":null,"abstract":"","PeriodicalId":74336,"journal":{"name":"Obstetrics and gynecology research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69352504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Effects of Human Chorionic Gonadotropin and Recombinant Luteinizing Hormone Supplementation during the Late Follicular Phase","authors":"Le Duc Thang, MD, Hoang Bao Long, MD, MPH, Tham Chi Dung, Vu Thi Mai Anh","doi":"10.26502/ogr0124","DOIUrl":"https://doi.org/10.26502/ogr0124","url":null,"abstract":"","PeriodicalId":74336,"journal":{"name":"Obstetrics and gynecology research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69352509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Clinical Presentation and Management of Postpartum Haemorrhage: A Single Center Experience","authors":"ahan L, Jahan K, A. S, Akter S, Akter Y, J. N, Tribedi S, N. S, Sharmin P, Rahman Akms","doi":"10.26502/ogr0129","DOIUrl":"https://doi.org/10.26502/ogr0129","url":null,"abstract":"","PeriodicalId":74336,"journal":{"name":"Obstetrics and gynecology research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69352555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Insecurity on the Care of Pregnant Women in the Democratic Republic of the Congo: A Cross-Sectional Study","authors":"Michel Dikete Ekanga, P. Simon, Y. Coppieters","doi":"10.26502/ogr0130","DOIUrl":"https://doi.org/10.26502/ogr0130","url":null,"abstract":"","PeriodicalId":74336,"journal":{"name":"Obstetrics and gynecology research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69352562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}