Obstetrics and gynecology research最新文献

Sex-Specific Dysregulation of Placental Lipid Metabolism in Preeclampsia. 子痫前期胎盘脂质代谢的性别特异性失调

Obstetrics and gynecology research Pub Date : 2024-01-01 Epub Date: 2024-07-23 DOI: 10.26502/ogr0159

Jay S Mishra, Hanjie Zhao, Jing Zheng, Sathish Kumar

{"title":"Sex-Specific Dysregulation of Placental Lipid Metabolism in Preeclampsia.","authors":"Jay S Mishra, Hanjie Zhao, Jing Zheng, Sathish Kumar","doi":"10.26502/ogr0159","DOIUrl":"10.26502/ogr0159","url":null,"abstract":"Background: Preeclampsia (PE) is a hypertensive disorder of pregnancy associated with adverse maternal and fetal outcomes. While placental dysfunction is implicated in PE pathogenesis, the impact of PE on placental lipid metabolism and its potential sexual dimorphism remains poorly understood.Methods: We conducted a comprehensive analysis of term placentas from PE and normotensive pregnancies with male and female fetuses. Lipid profiles were quantified using mass spectrometry, and mRNA expression of genes involved in fatty acid oxidation, esterification, and transport was assessed using qPCR.Results: Placentas from PE pregnancies exhibited elevated lipid levels, with male placentas showing a more pronounced increase in triacylglycerols, cholesteryl esters, and free cholesterol compared to female placentas. Gene expression analysis revealed sexually dimorphic alterations, with male PE placentas exhibiting upregulation of genes involved in fatty acid uptake, oxidation, and esterification, while female PE placentas showed a more complex response with both upregulation and downregulation of certain genes. Notably, peroxisomal fatty acid oxidation was upregulated in male PE placentas but suppressed in female PE placentas.Conclusions: Our findings reveal sexually dimorphic alterations in placental lipid metabolism in PE, suggesting that male placentas may be more vulnerable to lipotoxicity. These insights may have implications for understanding the pathogenesis of PE and developing sex-specific interventions to improve maternal and fetal outcomes.","PeriodicalId":74336,"journal":{"name":"Obstetrics and gynecology research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11315440/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141918275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polyclonal Anti-D Antibodies Significantly Reduce the Rate of Miscarriages in Rh(D) positive Women with Recurrent Pregnancy loss. 多克隆抗-D抗体显著降低Rh(D)阳性复发性流产妇女的流产率。

Obstetrics and gynecology research Pub Date : 2023-03-15 DOI: 10.26502/ogr0119

Frauke Ringel, Falk Lewandofski, Holger Kiesewetter, Jalid Sehouli, Berthold Hoppe, Alina Kiesewetter, Reinhard Hannen, Christian Friedrich Stoll, Sylvia Maas, Abdulgabar Salama

{"title":"Polyclonal Anti-D Antibodies Significantly Reduce the Rate of Miscarriages in Rh(D) positive Women with Recurrent Pregnancy loss.","authors":"Frauke Ringel, Falk Lewandofski, Holger Kiesewetter, Jalid Sehouli, Berthold Hoppe, Alina Kiesewetter, Reinhard Hannen, Christian Friedrich Stoll, Sylvia Maas, Abdulgabar Salama","doi":"10.26502/ogr0119","DOIUrl":"https://doi.org/10.26502/ogr0119","url":null,"abstract":"Background: Macrophages play a key role in all environmental conditions surrounding pregnancy. Coating of autologous red blood cells (RBCs) with polyclonal antibodies to Rh(D) antigen may result in an immunomodulation and improved outcome in Rh(D) positive women with recurrent pregnancy loss (RPL).Methods: A total of 60 Rh(D) positive women (age 23 to 45 years) with a history of RPL and ineffective treatment with low molecular weight heparin (LMWH) and/or aspirin were included in this retrospective study. In addition to this treatment, Anti-D (300 μg) was given subcutaneously to each woman either prior to pregnancy and/or two times within 12 weeks of gestation.Results: Treatment with Anti-D in non-responders to heparin/aspirin resulted in successful pregnancies in 67% of all cases. The remaining women had only aborts (23%) or did not become pregnant (10%). None of the treated women has developed anemia due to this treatment or any other significant adverse reaction. The rate of successful pregnancies does not appear to be influenced by the administration of: Anti-D prior to pregnancy, age, thrombophilia or previous alive births.Conclusion: The improved outcome following the administration of Anti-D in women with RPL might be explained by immune modulations induced by different immune reactions including polarization of decidual macrophages. The results obtained in this study clearly indicate that Anti-D is safe and highly effective in treatment of Rh(D) positive women with RPL. However, further studies are required to support our results and to find out the optimal dose and timing of Anti-D administration.","PeriodicalId":74336,"journal":{"name":"Obstetrics and gynecology research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10167743/pdf/nihms-1890894.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9522110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic and management dilemmas in secondary abdominal pregnancy: A case report and literature review of 314 cases from 1930-2021 继发性腹部妊娠的诊断和治疗困境:1930-2021年314例病例报告和文献回顾

Obstetrics and gynecology research Pub Date : 2023-01-01 DOI: 10.26502/ogr0111

Nehal Machado, A. Vasudeva, Sunanda Bharatnur, S. Kanchan

引用次数: 1

Widest Uterine Grip Width Measurement Clinically to Predict the Success of the Vaginal Hysterectomy of a Very Large Fibroid Uterus 子宫最宽握柄宽度测量临床预测阴道子宫切除术成功的巨大肌瘤子宫

Obstetrics and gynecology research Pub Date : 2023-01-01 DOI: 10.26502/ogr0121

Ramkrishna Purohit, J. Sharma, Devajani Meher

引用次数: 0

A Literature Review Comparing Combined Oral Contraceptive Pill use and Mirena during Perimenopause 比较围绝经期联合口服避孕药和月乐的文献综述

Obstetrics and gynecology research Pub Date : 2023-01-01 DOI: 10.26502/ogr0132

Rafia Jeddy, Ahmed S. Keshta, Kamel Ikbariah, Mohamed S. Keshta

引用次数: 0

Predictive Factors of Early Pregnancy Loss During In Vitro Fertilization/ Intracytoplasmic Sperm Injection (Ivf/Icsi): Retrospective Study on 1806 Embryo Transfers 体外受精/胞浆内单精子注射(Ivf/Icsi)早期妊娠丢失的预测因素:1806例胚胎移植的回顾性研究

Obstetrics and gynecology research Pub Date : 2023-01-01 DOI: 10.26502/ogr0137

Karine Morcel, P. Merviel, P. James, S. Bouée, Mathilde Le Guillou, D. Pertuisel, J. Chabaud, S. Roche, Aurore Perrin, H. Drapier, D. Beauvillard

{"title":"Predictive Factors of Early Pregnancy Loss During In Vitro Fertilization/ Intracytoplasmic Sperm Injection (Ivf/Icsi): Retrospective Study on 1806 Embryo Transfers","authors":"Karine Morcel, P. Merviel, P. James, S. Bouée, Mathilde Le Guillou, D. Pertuisel, J. Chabaud, S. Roche, Aurore Perrin, H. Drapier, D. Beauvillard","doi":"10.26502/ogr0137","DOIUrl":"https://doi.org/10.26502/ogr0137","url":null,"abstract":"Early pregnancy loss (EPL) is a spontaneous miscarriage of a clinical pregnancy during the �rst trimester. Several factors of EPL have been studied but results were discordant. We performed a retrospective study in our ART center, comparing baseline data and IVF/ICSI outcomes between cycles with EPL, ongoing pregnancy and without pregnancy. Ectopic pregnancies and biochemical pregnancies (without visualization of a gestational sac on ultrasound) were excluded. The aim of this study is to compare these different cycles, and analyze the risk factors for EPL. We included 2555 IVF/ICSI cycles leading to 2193 oocyte pick-ups and 1806 embryo transfers. Several characteristics (women’s age, infertility diagnosis and duration, estradiol level on the day of hCG-trigger, endometrial thickness, day of embryo transfer) appeared to be risk factors of EPL in univariate analysis. Only women’s age has a signi�cant (p < 0.001) in�uence in multivariate analysis on the rate of EPL, with an OR: 1.71 if the woman’s age ≥ 35 years old (reference < 35 y.o = 1), 2.96 if ≥ 38 y.o and 5.31 if ≥ 40 y.o. In this study, we observed an increase in EPL rate by 4.15% per year in women over 35 years of age.","PeriodicalId":74336,"journal":{"name":"Obstetrics and gynecology research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69352611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between Probable Generalized Anxiety Disorder with The Planning or Acceptance of The Pregnancy From The Beginning in Women Undergoing Prenatal Care 可能的广泛性焦虑障碍与产前护理妇女从一开始就计划或接受怀孕之间的关系

Obstetrics and gynecology research Pub Date : 2023-01-01 DOI: 10.26502/ogr0115

Monterrosa-Castro A, F. J, Romero-Martínez G, Romero-Martínez S

引用次数: 0

Knowledge of Pregnant Women in Rural Mozambique on Routine Practices to Prevent and Treat Common Conditions at the Antenatal Care Clinic 莫桑比克农村孕妇对产前保健诊所预防和治疗常见疾病的常规做法的了解

Obstetrics and gynecology research Pub Date : 2023-01-01 DOI: 10.26502/ogr0117

T. Nhampossa, K. Munguambe, Célia Chaúque, Mariza Chivangue, Maura Mazuze, Anete Mendes, L. García-Otero, R. González, Esperança Sevene, C. Menéndez, N. Torres

引用次数: 0

Hysteroscopic Imaging of Health Endometrium in Premenopausal Breast Cancer Patients Taking Anti-estrogen Therapies 接受抗雌激素治疗的绝经前乳腺癌患者健康子宫内膜的宫腔镜成像

Obstetrics and gynecology research Pub Date : 2023-01-01 DOI: 10.26502/ogr0131

G. Garuti, P. Sagrada, M. Mirra, Serena Migliaccio, A. Finco, M. Soligo

引用次数: 0

Effect of cervical pessary on pregnancy outcome in patients with twin pregnancies: a systematic review and meta-analysis 双胎妊娠患者宫颈托垫对妊娠结局的影响:一项系统回顾和荟萃分析

Obstetrics and gynecology research Pub Date : 2023-01-01 DOI: 10.26502/ogr0110

Wang Yue, Wu jiaxing, Malin Di, S. Xin, Lin Lin, Wang Bo, Huang Mingli

引用次数: 0