OBM neurobiology最新文献_第9页

Human Attention Assessment Using A Machine Learning Approach with GAN-based Data Augmentation Technique Trained Using a Custom Dataset 使用自定义数据集训练的基于gan的数据增强技术的机器学习方法的人类注意力评估

OBM neurobiology Pub Date : 2022-09-30 DOI: 10.21926/obm.neurobiol.2203139

Christian Napoli, Samuele Russo, L. Iocchi, Nicolo’ Brandizzi, Simone Tedeschi, Sveva Pepe

引用次数: 5

Computerized Assessment of Cognitive Development in Neurotypical and Neurodivergent Children 神经典型和神经发散儿童认知发展的计算机评估

OBM neurobiology Pub Date : 2022-09-28 DOI: 10.21926/obm.neurobiol.2203137

Igor Val Danilov, Araksia Svajyan, S. Mihailova

引用次数: 5

Neuroprotective (Antioxidant, Antiamyloidogenic, and Antiexcitatory) Effects of TrévoTM against Cadmium Chloride Neurotoxicity in Adult Male Wistar Rats trimao对成年雄性Wistar大鼠氯化镉神经毒性的神经保护(抗氧化、抗淀粉样变性和抗兴奋)作用

OBM neurobiology Pub Date : 2022-09-26 DOI: 10.21926/obm.neurobiol.2203135

O. Ilesanmi, U. Okotie, E. Adeogun, Aleneme Chinenye, Rosephine Enadeghe

{"title":"Neuroprotective (Antioxidant, Antiamyloidogenic, and Antiexcitatory) Effects of TrévoTM against Cadmium Chloride Neurotoxicity in Adult Male Wistar Rats","authors":"O. Ilesanmi, U. Okotie, E. Adeogun, Aleneme Chinenye, Rosephine Enadeghe","doi":"10.21926/obm.neurobiol.2203135","DOIUrl":"https://doi.org/10.21926/obm.neurobiol.2203135","url":null,"abstract":"Cadmium (Cd) is a heavy metal that is deleterious to brain development as it increases brain aging. Trévo is a multi-herbal supplement that provides various health benefits, including boosting the immune system and detoxification. In this study, we investigated the neuroprotective effects of Trévo against the neurotoxic effects of cadmium chloride (CdCl2). Thirty male Wistar rats were equally divided into three groups: Group I (normal control), Group II (administered CdCl2), and Group III (administered Trévo and CdCl2), and were used in the experiments. Animals were pretreated with 2 mL/kg of Trévo for five days and injected with Cd intraperitoneally 3 h later. Cd significantly increased the production of malondialdehyde (MDA), amyloidogenesis, activation of caspase 3 and 9, and the production of p53 and glutamate. It also inhibited the activity of Na+/K+ ATPase, glutamate dehydrogenase, catalase, superoxide dismutase, and glutathione-S-transferase. The administration of Trévo revealed its antioxidant, anti-amyloidogenic, anti-excitotoxicity, and anticholinesterase properties as it prevented the biochemical changes induced by Cd toxicity in the brain of male Wistar rats. Our results supported the reported health benefits of Trévo as a good dietary supplement in preventing the toxic effects of poisonous substances, such as cadmium.","PeriodicalId":74334,"journal":{"name":"OBM neurobiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46060012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Interview with Dr. Francisco J. Barrantes 采访弗朗西斯科·j·巴兰特斯博士

OBM neurobiology Pub Date : 2022-09-26 DOI: 10.21926/obm.neurobiol.2203136

Obm Neurobiology Editorial Office

引用次数: 0

Modeling of Information Processing in Biomorphic Neuroprocessor 生物形态神经处理器的信息处理建模

OBM neurobiology Pub Date : 2022-09-22 DOI: 10.21926/obm.neurobiol.2203134

S. Udovichenko, A. Gubin, A. Bobylev, A. Ebrahim, A. Busygin, A. Pisarev

引用次数: 0

Targeting Neuroplasticity for the Management of Pain and Agitation in Alzheimer’s Disease via Bergamot Nanotherapy 通过佛手柑纳米疗法靶向神经可塑性治疗阿尔茨海默病的疼痛和激动

OBM neurobiology Pub Date : 2022-07-05 DOI: 10.21926/obm.neurobiol.2203133

D. Scuteri, P. Tonin, M. Corasaniti, G. Bagetta

{"title":"Targeting Neuroplasticity for the Management of Pain and Agitation in Alzheimer’s Disease via Bergamot Nanotherapy","authors":"D. Scuteri, P. Tonin, M. Corasaniti, G. Bagetta","doi":"10.21926/obm.neurobiol.2203133","DOIUrl":"https://doi.org/10.21926/obm.neurobiol.2203133","url":null,"abstract":"Alzheimer’s disease (AD) accounts for 50–70% of cases of dementia worldwide and is a social burden to the affected population. Although several pathogenetic hypotheses have been proposed, evidence favoring the role of aberrant neuroplasticity in the development of the neuropsychiatric symptoms associated with dementia is increasing. Specifically, agitation is resistant to treatment and affects the quality of life, also because of the lack of safe and effective treatment for AD. Alterations in pain processing due to plastic modifications occur during aging and neurodegeneration. Up to 80% of AD patients have chronic pain due to age-related comorbidities that are misdiagnosed and remain unattended due to a lack of self-reporting because of communication hindrance, which also contributes to the development of agitation. Here, we reported a strategy to target altered neuroplasticity for treating pain and agitation by applying bergamot essential oil with evidence for in-vivo analgesic effects on neuropathic and inflammatory pain preclinical models. Bergamot was engineered in a nanotechnology delivery system, NanoBEO, which provides the opportunity to investigate its efficacy in the NCT04321889 randomized, double-blind, placebo-controlled clinical trial BRAINAID. This trial can provide a rational basis for safe and effective treatment to alleviate agitation and pain, thus improving the quality of life of people suffering from AD.","PeriodicalId":74334,"journal":{"name":"OBM neurobiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44586850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Migraine in Adolescents: Comparison of Attack Frequency During School and Vacation Periods 青少年偏头痛：学校和假期发作频率的比较

OBM neurobiology Pub Date : 2022-05-18 DOI: 10.21926/obm.neurobiol.2203131

Johannes Drescher, C. Gaul, P. Kropp, Yannic Siebenhaar, Dirk Reinel, Jörg Scheidt

引用次数: 0

Assessment of Loneliness During the Pandemic: Comparing Various Short Forms of the UCLA Loneliness Scale in South Africa Using Classical Test Theory and Mokken Analysis 流行病期间孤独感的评估：使用经典测试理论和Mokken分析比较南非加州大学洛杉矶分校孤独感量表的各种简短形式

OBM neurobiology Pub Date : 2022-05-01 DOI: 10.21926/obm.neurobiol.2203132

T. Pretorius, A. Padmanabhanunni

{"title":"Assessment of Loneliness During the Pandemic: Comparing Various Short Forms of the UCLA Loneliness Scale in South Africa Using Classical Test Theory and Mokken Analysis","authors":"T. Pretorius, A. Padmanabhanunni","doi":"10.21926/obm.neurobiol.2203132","DOIUrl":"https://doi.org/10.21926/obm.neurobiol.2203132","url":null,"abstract":"An important mental health concern arising from the COVID-19 pandemic was the loneliness resulting from the lockdown measures taken by many countries due to the outbreak. Thus, loneliness needs to be studied in detail for intervention purposes. The UCLA Loneliness Scale is the most widely used measure of loneliness. However, the 20-item measure has some drawbacks, including questionnaire fatigue, especially when used with other measures, and a lack of accurate responses to all items. In this study, we evaluated two short forms of the UCLA Loneliness Scale used in other studies (UCLA-10 and UCLA-8), as well as a five-item version developed in this study, through the classical test theory and Mokken analysis with two different sample groups (teachers, N = 337; students, N = 355). The results of the Mokken analysis and the confirmatory factor analysis showed that the UCLA-10 and UCLA-5 were unidimensional and exhibited reliability and convergent validity. In contrast, the UCLA-8 was multidimensional and violated several assumptions of monotonicity and invariant item-ordering, although it showed satisfactory reliability and concurrent validity. All three versions of the scale correlated significantly with other indices of psychological well-being regarding concurrent validity, and the correlation coefficients were comparable to the coefficients of the 20-item version with the same variables. All three versions of the loneliness scale also demonstrated satisfactory convergent and discriminant validity. The results indicated that the UCLA-10 and UCLA-5 can be used as reliable and valid measures when the use of the long version of the UCLA Loneliness Scale is unsuitable.","PeriodicalId":74334,"journal":{"name":"OBM neurobiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42921493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Generalized Resistance Resources in the Time of COVID-19: The Role of Sense of Coherence and Resilience in the Relationship between COVID-19 Fear and Loneliness among Schoolteachers 新冠肺炎时期的广义抵抗资源：一致感和韧性在教师新冠肺炎恐惧与孤独关系中的作用

OBM neurobiology Pub Date : 2022-04-30 DOI: 10.21926/obm.neurobiol.2203130

A. Padmanabhanunni, S. Isaacs, T. Pretorius, B. Faroa

{"title":"Generalized Resistance Resources in the Time of COVID-19: The Role of Sense of Coherence and Resilience in the Relationship between COVID-19 Fear and Loneliness among Schoolteachers","authors":"A. Padmanabhanunni, S. Isaacs, T. Pretorius, B. Faroa","doi":"10.21926/obm.neurobiol.2203130","DOIUrl":"https://doi.org/10.21926/obm.neurobiol.2203130","url":null,"abstract":"Fear has been the most common emotional response to the COVID-19 pandemic, and excessive fear is associated with various indices of psychological distress, particularly loneliness. Although most people have experienced pandemic-related fear and distress, certain groups who are on the front of service provision have experienced the pandemic in distinct ways, owing to its impact on the nature of their work. Schoolteachers represent one such group; therefore, it is imperative to identify resources that can safeguard against negative mental-health outcomes in schoolteachers. The current study investigated the potential protective role of sense of coherence (SOC) and resilience in the relationship between COVID-19 fear and loneliness. The participants were South African schoolteachers (N = 355); the participants completed the Fear of COVID-19 Scale, the University of California Loneliness Scale, the Connor-Davidson Resilience Scale-10, and the Sense of Coherence Scale-13. The results indicated that SOC and resilience had significant direct effects on loneliness, thereby suggesting their health-sustaining role. SOC and resilience also fully mediated the relationship between COVID-19 fear and loneliness. Therefore, although the provision of material resources is important, it is equally necessary to enhance people’s ability to comprehend, give meaning to, and manage the challenges associated with the pandemic. A salutogenic approach to mental health promotion in the workplace may be beneficial for enhancing SOC and resilience among schoolteachers.","PeriodicalId":74334,"journal":{"name":"OBM neurobiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48735906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

An Interview with Dr. Roy G. Beran Roy G. Beran博士访谈

OBM neurobiology Pub Date : 2022-04-02 DOI: 10.21926/obm.neurobiol.2202118

引用次数: 0