Neuronal signaling最新文献_第7页

Extracellular microRNAs as messengers in the central and peripheral nervous system. 细胞外微rna在中枢和外周神经系统中的信使作用。

Neuronal signaling Pub Date : 2017-11-02 eCollection Date: 2017-12-01 DOI: 10.1042/NS20170112

Hannah Scott

引用次数: 13

SUMOylation and calcium signalling: potential roles in the brain and beyond. sumo酰化和钙信号传导:在大脑内外的潜在作用。

Neuronal signaling Pub Date : 2017-07-19 eCollection Date: 2017-08-01 DOI: 10.1042/NS20160010

Leticia Coelho-Silva, Gary J Stephens, Helena Cimarosti

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引用次数: 7

Stochastic, structural and functional factors influencing AMPA and NMDA synaptic response variability: a review. 影响AMPA和NMDA突触反应变异性的随机、结构和功能因素综述。

Neuronal signaling Pub Date : 2017-06-14 eCollection Date: 2017-08-01 DOI: 10.1042/NS20160051

Vito Di Maio, Francesco Ventriglia, Silvia Santillo

引用次数: 7

Conventional protein kinase C in the brain: 40 years later. 脑中的常规蛋白激酶C: 40年后。

Neuronal signaling Pub Date : 2017-04-10 eCollection Date: 2017-04-01 DOI: 10.1042/NS20160005

Julia A Callender, Alexandra C Newton

引用次数: 56

Targeting bone morphogenetic protein signalling in midbrain dopaminergic neurons as a therapeutic approach in Parkinson's disease. 靶向中脑多巴胺能神经元骨形态发生蛋白信号作为帕金森病的治疗方法。

Neuronal signaling Pub Date : 2017-03-31 eCollection Date: 2017-04-01 DOI: 10.1042/NS20170027

Gerard W O'Keeffe, Shane V Hegarty, Aideen M Sullivan

{"title":"Targeting bone morphogenetic protein signalling in midbrain dopaminergic neurons as a therapeutic approach in Parkinson's disease.","authors":"Gerard W O'Keeffe, Shane V Hegarty, Aideen M Sullivan","doi":"10.1042/NS20170027","DOIUrl":"https://doi.org/10.1042/NS20170027","url":null,"abstract":"Parkinson's disease (PD) is the second most common neurodegenerative disease, characterized by the degeneration of midbrain dopaminergic (mDA) neurons and their axons, and aggregation of α-synuclein, which leads to motor and late-stage cognitive impairments. As the motor symptoms of PD are caused by the degeneration of a specific population of mDA neurons, PD lends itself to neurotrophic factor therapy. The goal of this therapy is to apply a neurotrophic factor that can slow down, halt or even reverse the progressive degeneration of mDA neurons. While the best known neurotrophic factors are members of the glial cell line-derived neurotrophic factor (GDNF) family, their lack of clinical efficacy to date means that it is important to continue to study other neurotrophic factors. Bone morphogenetic proteins (BMPs) are naturally secreted proteins that play critical roles during nervous system development and in the adult brain. In this review, we provide an overview of the BMP ligands, BMP receptors (BMPRs) and their intracellular signalling effectors, the Smad proteins. We review the available evidence that BMP-Smad signalling pathways play an endogenous role in mDA neuronal survival in vivo, before outlining how exogenous application of BMPs exerts potent effects on mDA neuron survival and axon growth in vitro and in vivo. We discuss the molecular mechanisms that mediate these effects, before highlighting the potential of targeting the downstream effectors of BMP-Smad signalling as a novel neuroprotective approach to slow or stop the degeneration of mDA neurons in PD.","PeriodicalId":74287,"journal":{"name":"Neuronal signaling","volume":"1 2","pages":"NS20170027"},"PeriodicalIF":0.0,"publicationDate":"2017-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1042/NS20170027","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38203074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

AMPK: keeping the (power)house in order? AMPK：让（电力）房子井然有序？

Neuronal signaling Pub Date : 2017-03-24 eCollection Date: 2017-04-01 DOI: 10.1042/NS20160020

Claire Thornton

引用次数: 0

Retrograde apoptotic signaling by the p75 neurotrophin receptor. p75神经营养因子受体的逆行凋亡信号。

Neuronal signaling Pub Date : 2017-02-24 eCollection Date: 2017-02-01 DOI: 10.1042/NS20160007

Amrita Pathak, Bruce D Carter

引用次数: 8

Trafficking of neuronal calcium channels. 神经元钙通道的运输。

Neuronal signaling Pub Date : 2017-02-20 eCollection Date: 2017-02-01 DOI: 10.1042/NS20160003

Norbert Weiss, Gerald W Zamponi

引用次数: 22

Neuronal Signaling: an introduction. 神经元信号:导论。

Neuronal signaling Pub Date : 2016-10-18 eCollection Date: 2017-02-01 DOI: 10.1042/NS20160025

Aideen M Sullivan

引用次数: 0