Nature cardiovascular research最新文献_第9页

Tirzepatide improves cardiorenal health in obese individuals with HFpEF 替扎帕肽可改善肥胖型高频心衰患者的心肾健康。

IF 9.4

Nature cardiovascular research Pub Date : 2025-01-03 DOI: 10.1038/s44161-024-00601-1

Andrea Tavosanis

引用次数: 0

Cardiac conduction system regeneration prevents arrhythmias after myocardial infarction 心脏传导系统再生可预防心肌梗死后的心律失常。

IF 9.4

Nature cardiovascular research Pub Date : 2025-01-03 DOI: 10.1038/s44161-024-00586-x

Judy R. Sayers, Hector Martinez-Navarro, Xin Sun, Carla de Villiers, Sarah Sigal, Michael Weinberger, Claudio Cortes Rodriguez, Leto Luana Riebel, Lucas Arantes Berg, Julia Camps, Neil Herring, Blanca Rodriguez, Tatjana Sauka-Spengler, Paul R. Riley

{"title":"Cardiac conduction system regeneration prevents arrhythmias after myocardial infarction","authors":"Judy R. Sayers, Hector Martinez-Navarro, Xin Sun, Carla de Villiers, Sarah Sigal, Michael Weinberger, Claudio Cortes Rodriguez, Leto Luana Riebel, Lucas Arantes Berg, Julia Camps, Neil Herring, Blanca Rodriguez, Tatjana Sauka-Spengler, Paul R. Riley","doi":"10.1038/s44161-024-00586-x","DOIUrl":"10.1038/s44161-024-00586-x","url":null,"abstract":"Arrhythmias are a hallmark of myocardial infarction (MI) and increase patient mortality. How insult to the cardiac conduction system causes arrhythmias following MI is poorly understood. Here, we demonstrate conduction system restoration during neonatal mouse heart regeneration versus pathological remodeling at non-regenerative stages. Tissue-cleared whole-organ imaging identified disorganized bundling of conduction fibers after MI and global His–Purkinje disruption. Single-cell RNA sequencing (scRNA-seq) revealed specific molecular changes to regenerate the conduction network versus aberrant electrical alterations during fibrotic repair. This manifested functionally as a transition from normal rhythm to pathological conduction delay beyond the regenerative window. Modeling in the infarcted human heart implicated the non-regenerative phenotype as causative for heart block, as observed in patients. These findings elucidate the mechanisms underpinning conduction system regeneration and reveal how MI-induced damage elicits clinical arrhythmogenesis. Sayers et al. reveal that heart regeneration during the neonatal period in mice extends to conduction system restoration after insult, highlighting the difference between this process and pathological remodeling in the adult heart.","PeriodicalId":74245,"journal":{"name":"Nature cardiovascular research","volume":"4 2","pages":"163-179"},"PeriodicalIF":9.4,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44161-024-00586-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142928842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Direct specification of lymphatic endothelium from mesenchymal progenitors 淋巴内皮从间充质祖细胞直接分化。

IF 9.4

Nature cardiovascular research Pub Date : 2025-01-02 DOI: 10.1038/s44161-024-00570-5

Irina-Elena Lupu, David E. Grainger, Nils Kirschnick, Sarah Weischer, Erica Zhao, Ines Martinez-Corral, Hans Schoofs, Marie Vanhollebeke, Grace Jones, Jonathan Godwin, Aden Forrow, Ines Lahmann, Paul R. Riley, Thomas Zobel, Kari Alitalo, Taija Mäkinen, Friedemann Kiefer, Oliver A. Stone

{"title":"Direct specification of lymphatic endothelium from mesenchymal progenitors","authors":"Irina-Elena Lupu, David E. Grainger, Nils Kirschnick, Sarah Weischer, Erica Zhao, Ines Martinez-Corral, Hans Schoofs, Marie Vanhollebeke, Grace Jones, Jonathan Godwin, Aden Forrow, Ines Lahmann, Paul R. Riley, Thomas Zobel, Kari Alitalo, Taija Mäkinen, Friedemann Kiefer, Oliver A. Stone","doi":"10.1038/s44161-024-00570-5","DOIUrl":"10.1038/s44161-024-00570-5","url":null,"abstract":"During embryogenesis, endothelial cells (ECs) are generally described to arise from a common pool of progenitors termed angioblasts, which diversify through iterative steps of differentiation to form functionally distinct subtypes of ECs. A key example is the formation of lymphatic ECs (LECs), which are thought to arise largely through transdifferentiation from venous endothelium. Opposing this model, here we show that the initial expansion of mammalian LECs is primarily driven by the in situ differentiation of mesenchymal progenitors and does not require transition through an intermediate venous state. Single-cell genomics and lineage-tracing experiments revealed a population of paraxial mesoderm-derived Etv2+Prox1+ progenitors that directly give rise to LECs. Morphometric analyses of early LEC proliferation and migration, and mutants that disrupt lymphatic development supported these findings. Collectively, this work establishes a cellular blueprint for LEC specification and indicates that discrete pools of mesenchymal progenitors can give rise to specialized subtypes of ECs. Lupu, Grainger, Kirschnick et al. show that, contrary to prevailing belief, the initial specification of mammalian lymphatic endothelial cells primarily occurs from previously unidentified mesenchymal angioblasts rather than from venous endothelium.","PeriodicalId":74245,"journal":{"name":"Nature cardiovascular research","volume":"4 1","pages":"45-63"},"PeriodicalIF":9.4,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44161-024-00570-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142924177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cross-species comparison reveals that Hmga1 reduces H3K27me3 levels to promote cardiomyocyte proliferation and cardiac regeneration 跨物种比较表明，Hmga1降低H3K27me3水平，促进心肌细胞增殖和心脏再生。

IF 9.4

Nature cardiovascular research Pub Date : 2025-01-02 DOI: 10.1038/s44161-024-00588-9

Mara Bouwman, Dennis E. M. de Bakker, Hessel Honkoop, Alexandra E. Giovou, Danielle Versteeg, Arie R. Boender, Phong D. Nguyen, Merel Slotboom, Daniel Colquhoun, Marta Vigil-Garcia, Lieneke Kooijman, Rob Janssen, Ingeborg B. Hooijkaas, Marie Günthel, Kimberly J. Visser, Mischa Klerk, Lorena Zentilin, Mauro Giacca, Jan Kaslin, Gerard J. J. Boink, Eva van Rooij, Vincent M. Christoffels, Jeroen Bakkers

{"title":"Cross-species comparison reveals that Hmga1 reduces H3K27me3 levels to promote cardiomyocyte proliferation and cardiac regeneration","authors":"Mara Bouwman, Dennis E. M. de Bakker, Hessel Honkoop, Alexandra E. Giovou, Danielle Versteeg, Arie R. Boender, Phong D. Nguyen, Merel Slotboom, Daniel Colquhoun, Marta Vigil-Garcia, Lieneke Kooijman, Rob Janssen, Ingeborg B. Hooijkaas, Marie Günthel, Kimberly J. Visser, Mischa Klerk, Lorena Zentilin, Mauro Giacca, Jan Kaslin, Gerard J. J. Boink, Eva van Rooij, Vincent M. Christoffels, Jeroen Bakkers","doi":"10.1038/s44161-024-00588-9","DOIUrl":"10.1038/s44161-024-00588-9","url":null,"abstract":"In contrast to adult mammalian hearts, the adult zebrafish heart efficiently replaces cardiomyocytes lost after injury. Here we reveal shared and species-specific injury response pathways and a correlation between Hmga1, an architectural non-histone protein, and regenerative capacity, as Hmga1 is required and sufficient to induce cardiomyocyte proliferation and required for heart regeneration. In addition, Hmga1 was shown to reactivate developmentally silenced genes, likely through modulation of H3K27me3 levels, poising them for a pro-regenerative gene program. Furthermore, AAV-mediated Hmga1 expression in injured adult mouse hearts led to controlled cardiomyocyte proliferation in the border zone and enhanced heart function, without cardiomegaly and adverse remodeling. Histone modification mapping in mouse border zone cardiomyocytes revealed a similar modulation of H3K27me3 marks, consistent with findings in zebrafish. Our study demonstrates that Hmga1 mediates chromatin remodeling and drives a regenerative program, positioning it as a promising therapeutic target to enhance cardiac regeneration after injury. Bouwman et al. identify Hmga1-mediated chromatin remodeling as the fundamental regulator of zebrafish cardiac regeneration and reveal the potential of Hmga1 to restore heart repair in mice by reactivating developmental genes, suggesting potential therapeutic applications.","PeriodicalId":74245,"journal":{"name":"Nature cardiovascular research","volume":"4 1","pages":"64-82"},"PeriodicalIF":9.4,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44161-024-00588-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142924165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mechanical regulation of macrophage metabolism by allograft inflammatory factor 1 leads to adverse remodeling after cardiac injury 同种异体移植物炎症因子1对巨噬细胞代谢的机械调节导致心脏损伤后的不良重构。

IF 9.4

Nature cardiovascular research Pub Date : 2025-01-02 DOI: 10.1038/s44161-024-00585-y

Matthew DeBerge, Kristofor Glinton, Connor Lantz, Zhi-Dong Ge, David P. Sullivan, Swapna Patil, Bo Ryung Lee, Minori I. Thorp, Adam Mullick, Steve Yeh, Shuling Han, Anja M. van der Laan, Hans W. M. Niessen, Xunrong Luo, Nicholas E. S. Sibinga, Edward B. Thorp

{"title":"Mechanical regulation of macrophage metabolism by allograft inflammatory factor 1 leads to adverse remodeling after cardiac injury","authors":"Matthew DeBerge, Kristofor Glinton, Connor Lantz, Zhi-Dong Ge, David P. Sullivan, Swapna Patil, Bo Ryung Lee, Minori I. Thorp, Adam Mullick, Steve Yeh, Shuling Han, Anja M. van der Laan, Hans W. M. Niessen, Xunrong Luo, Nicholas E. S. Sibinga, Edward B. Thorp","doi":"10.1038/s44161-024-00585-y","DOIUrl":"10.1038/s44161-024-00585-y","url":null,"abstract":"Myocardial infarction (MI) mobilizes macrophages, the central protagonists of tissue repair in the infarcted heart. Although necessary for repair, macrophages also contribute to adverse remodeling and progression to heart failure. In this context, specific targeting of inflammatory macrophage activation may attenuate maladaptive responses and enhance cardiac repair. Allograft inflammatory factor 1 (AIF1) is a macrophage-specific protein expressed in a variety of inflammatory settings, but its function after MI is unknown. Here we identify a maladaptive role for macrophage AIF1 after MI in mice. Mechanistic studies show that AIF1 increases actin remodeling in macrophages to promote reactive oxygen species–dependent activation of hypoxia-inducible factor (HIF)-1α. This directs a switch to glycolytic metabolism to fuel macrophage-mediated inflammation, adverse ventricular remodeling and progression to heart failure. Targeted knockdown of Aif1 using antisense oligonucleotides improved cardiac repair, supporting further exploration of macrophage AIF1 as a therapeutic target after MI. DeBerge, Glinton et al. demonstrate that allograft inflammatory factor 1 promotes inflammatory glycolytic reprogramming in cardiac macrophages, leading to adverse remodeling and progression to heart failure after myocardial infarction.","PeriodicalId":74245,"journal":{"name":"Nature cardiovascular research","volume":"4 1","pages":"83-101"},"PeriodicalIF":9.4,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142924180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Social isolation negatively affects oxytocin production and accelerates atherosclerosis 社交孤立会对催产素产生负面影响，加速动脉粥样硬化。

IF 9.4

Nature cardiovascular research Pub Date : 2025-01-02 DOI: 10.1038/s44161-024-00602-0

Elisa Martini

引用次数: 0

Paraxial mesoderm as a direct gateway to lymphatic endothelial cells 旁轴中胚层作为淋巴内皮细胞的直接通道。

IF 9.4

Nature cardiovascular research Pub Date : 2025-01-02 DOI: 10.1038/s44161-024-00583-0

Tatiana V. Petrova, Valeria V. Orlova

引用次数: 0

Association between genetically predicted leisure and social activities and cardiovascular disease and other health outcomes 基因预测的休闲和社会活动与心血管疾病和其他健康结果之间的关系。

IF 9.4

Nature cardiovascular research Pub Date : 2025-01-02 DOI: 10.1038/s44161-024-00581-2

Soyeon Kim, Hyunwoong Ko, Woojae Myung, Joohyun Yoon, Kiwon Kim, Sang-Hyuk Jung, Injeong Shim, Soojin Cha, Beomsu Kim, Jae Myeong Kang, Woong-Yang Park, Pradeep Natarajan, Ron Do, Hong-Hee Won

{"title":"Association between genetically predicted leisure and social activities and cardiovascular disease and other health outcomes","authors":"Soyeon Kim, Hyunwoong Ko, Woojae Myung, Joohyun Yoon, Kiwon Kim, Sang-Hyuk Jung, Injeong Shim, Soojin Cha, Beomsu Kim, Jae Myeong Kang, Woong-Yang Park, Pradeep Natarajan, Ron Do, Hong-Hee Won","doi":"10.1038/s44161-024-00581-2","DOIUrl":"10.1038/s44161-024-00581-2","url":null,"abstract":"Participation in leisure and social activities (LSA) is associated with better health outcomes and lower mortality1–3. Previous observational studies demonstrated a relationship between engagement in LSA and both mental and physical health4,5. Although several studies6 examined the association between LSA and health outcomes, including cardiovascular disease, their possible causal relationship has not been studied. In this study, we investigated the causal relationship between LSA and various health outcomes, including cardiovascular disease, using data from genome-wide association study summary statistics (sample size = 63,926–1,557,411) and a Mendelian randomization approach. Genetically predicted LSA were associated with a reduced risk of several health outcomes, including coronary artery disease and coronary atherosclerosis. Mediation analysis indicated that these effects were partly mediated by modifiable risk factors, such as body mass index, smoking and lipid levels. These findings highlight the importance of LSA in disease prevention and health promotion. In a genetic study, Kim, Ko et al. demonstrate that participating in leisure and social activities reduces the risk of various diseases, including cardiovascular disease.","PeriodicalId":74245,"journal":{"name":"Nature cardiovascular research","volume":"4 1","pages":"15-25"},"PeriodicalIF":9.4,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142924162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spatial transcriptomic mapping of coronary atherosclerosis in the luminal plaque and beyond 冠状动脉粥样硬化在管腔斑块及其他部位的空间转录组图谱。

IF 9.4

Nature cardiovascular research Pub Date : 2025-01-02 DOI: 10.1038/s44161-024-00568-z

Paul Cheng, Thomas Quertermous

引用次数: 0

Encompassing view of spatial and single-cell RNA sequencing renews the role of the microvasculature in human atherosclerosis 空间和单细胞RNA测序的综合观点更新了微血管在人类动脉粥样硬化中的作用。

IF 9.4

Nature cardiovascular research Pub Date : 2024-12-23 DOI: 10.1038/s44161-024-00582-1

Tore Bleckwehl, Anne Babler, Merel Tebens, Sidrah Maryam, Michael Nyberg, Markus Bosteen, Maurice Halder, Isaac Shaw, Susanne Fleig, Charles Pyke, Henning Hvid, Louise Marie Voetmann, Jaap D. van Buul, Judith C. Sluimer, Vivek Das, Simon Baumgart, Rafael Kramann, Sikander Hayat

{"title":"Encompassing view of spatial and single-cell RNA sequencing renews the role of the microvasculature in human atherosclerosis","authors":"Tore Bleckwehl, Anne Babler, Merel Tebens, Sidrah Maryam, Michael Nyberg, Markus Bosteen, Maurice Halder, Isaac Shaw, Susanne Fleig, Charles Pyke, Henning Hvid, Louise Marie Voetmann, Jaap D. van Buul, Judith C. Sluimer, Vivek Das, Simon Baumgart, Rafael Kramann, Sikander Hayat","doi":"10.1038/s44161-024-00582-1","DOIUrl":"10.1038/s44161-024-00582-1","url":null,"abstract":"Atherosclerosis is a pervasive contributor to ischemic heart disease and stroke. Despite the advance of lipid-lowering therapies and anti-hypertensive agents, the residual risk of an atherosclerotic event remains high, and developing therapeutic strategies has proven challenging. This is due to the complexity of atherosclerosis with a spatial interplay of multiple cell types within the vascular wall. In this study, we generated an integrative high-resolution map of human atherosclerotic plaques combining single-cell RNA sequencing from multiple studies and spatial transcriptomics data from 12 human specimens with different stages of atherosclerosis. Here we show cell-type-specific and atherosclerosis-specific expression changes and spatially constrained alterations in cell–cell communication. We highlight the possible recruitment of lymphocytes via ACKR1 endothelial cells of the vasa vasorum, the migration of vascular smooth muscle cells toward the lumen by transforming into fibromyocytes and cell–cell communication in the plaque region, indicating an intricate cellular interplay within the adventitia and the subendothelial space in human atherosclerosis. Bleckwehl et al. present a spatial transcriptomic map of atherosclerotic plaques across disease stages, revealing cellular recruitment and migration patterns and intercellular communication dynamics as a valuable resource for future research.","PeriodicalId":74245,"journal":{"name":"Nature cardiovascular research","volume":"4 1","pages":"26-44"},"PeriodicalIF":9.4,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142883830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0