Nature cardiovascular research最新文献_第9页

Targeting atherosclerosis beyond cholesterol reduction 除降低胆固醇外，还针对动脉粥样硬化。

IF 10.8

Nature cardiovascular research Pub Date : 2025-05-07 DOI: 10.1038/s44161-025-00662-w

Gerburg Schwaerzer

引用次数: 0

Preclinical mouse models of immune checkpoint inhibitor-associated myocarditis 免疫检查点抑制剂相关性心肌炎的临床前小鼠模型。

IF 10.8

Nature cardiovascular research Pub Date : 2025-05-07 DOI: 10.1038/s44161-025-00640-2

Reilly G. Fankhauser, Douglas B. Johnson, Javid J. Moslehi, Justin M. Balko

{"title":"Preclinical mouse models of immune checkpoint inhibitor-associated myocarditis","authors":"Reilly G. Fankhauser, Douglas B. Johnson, Javid J. Moslehi, Justin M. Balko","doi":"10.1038/s44161-025-00640-2","DOIUrl":"10.1038/s44161-025-00640-2","url":null,"abstract":"In this Review, we present a comprehensive analysis of preclinical models used to study immune checkpoint inhibitor-associated myocarditis (hereafter ICI-myocarditis), a potentially lethal immune-related adverse event. We begin by providing an overview of immune checkpoint inhibitors, highlighting how their efficacy in cancer treatment is counterbalanced by their predisposition to cause immune-related adverse events. Next, we draw from human data to identify disease features that an effective mouse model should ideally mimic. After that, we present a critical evaluation of a wide variety of existing mouse models including genetic, pharmacological and humanized models. We summarize insights gathered about the underlying mechanisms of ICI-myocarditis and the role of mouse models in these discoveries. We conclude with a perspective on the future of preclinical models, highlighting potential model improvements and research directions that could strengthen our understanding of ICI-myocarditis, ultimately improving patient outcomes. Fankhauser et al. provide an in-depth review of preclinical mouse models used to study immune checkpoint inhibitor-associated myocarditis (ICI-myocarditis). They discuss potential improvements to the field that could, in the future, strengthen our understanding of ICI-myocarditis.","PeriodicalId":74245,"journal":{"name":"Nature cardiovascular research","volume":"4 5","pages":"526-538"},"PeriodicalIF":10.8,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144009110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ARID5A orchestrates cardiac aging and inflammation through MAVS mRNA stabilization ARID5A通过MAVS mRNA稳定调控心脏老化和炎症。

IF 10.8

Nature cardiovascular research Pub Date : 2025-04-29 DOI: 10.1038/s44161-025-00635-z

Yanling Fan, Yandong Zheng, Yiyuan Zhang, Gang Xu, Chun Liu, Jianli Hu, Qianzhao Ji, Shuo Zhang, Shuaiqi Fang, Jinghui Lei, Lan-Zhu Li, Xing Wang, Xi Xu, Cui Wang, Si Wang, Shuai Ma, Moshi Song, Wenjian Jiang, Junming Zhu, Yijia Feng, Jiangang Wang, Ying Yang, Guodong Zhu, Xiao-Li Tian, Hongjia Zhang, Weihong Song, Jiayin Yang, Yan Yao, Guang-Hui Liu, Jing Qu, Weiqi Zhang

{"title":"ARID5A orchestrates cardiac aging and inflammation through MAVS mRNA stabilization","authors":"Yanling Fan, Yandong Zheng, Yiyuan Zhang, Gang Xu, Chun Liu, Jianli Hu, Qianzhao Ji, Shuo Zhang, Shuaiqi Fang, Jinghui Lei, Lan-Zhu Li, Xing Wang, Xi Xu, Cui Wang, Si Wang, Shuai Ma, Moshi Song, Wenjian Jiang, Junming Zhu, Yijia Feng, Jiangang Wang, Ying Yang, Guodong Zhu, Xiao-Li Tian, Hongjia Zhang, Weihong Song, Jiayin Yang, Yan Yao, Guang-Hui Liu, Jing Qu, Weiqi Zhang","doi":"10.1038/s44161-025-00635-z","DOIUrl":"10.1038/s44161-025-00635-z","url":null,"abstract":"Elucidating the regulatory mechanisms of human cardiac aging remains a great challenge. Here, using human heart tissues from 74 individuals ranging from young (≤35 years) to old (≥65 years), we provide an overview of the histological, cellular and molecular alterations underpinning the aging of human hearts. We decoded aging-related gene expression changes at single-cell resolution and identified increased inflammation as the key event, driven by upregulation of ARID5A, an RNA-binding protein. ARID5A epi-transcriptionally regulated Mitochondrial Antiviral Signaling Protein (MAVS) mRNA stability, leading to NF-κB and TBK1 activation, amplifying aging and inflammation phenotypes. The application of gene therapy using lentiviral vectors encoding shRNA targeting ARID5A into the myocardium not only mitigated the inflammatory and aging phenotypes but also bolstered cardiac function in aged mice. Altogether, our study provides a valuable resource and advances our understanding of cardiac aging mechanisms by deciphering the ARID5A-MAVS axis in post-transcriptional regulation. Through multimodal analyses of human cardiac tissues across different ages, Fan, Zheng, Zhan, Xu, Liu and colleagues reveal that RNA-binding protein ARID5A drives inflammaging by stabilizing the MAVS mRNA and activating the NF-κB–TBK1 pathway, and show that inactivating myocardial ARID5A attenuates cardiac senescence and functional decline.","PeriodicalId":74245,"journal":{"name":"Nature cardiovascular research","volume":"4 5","pages":"602-623"},"PeriodicalIF":10.8,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144032220","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ARID5A promotes inflammation and fibrosis during cardiac aging ARID5A在心脏老化过程中促进炎症和纤维化。

IF 10.8

Nature cardiovascular research Pub Date : 2025-04-29 DOI: 10.1038/s44161-025-00621-5

Shoval Miyara, Eldad Tzahor

引用次数: 0

Single-cell spatial transcriptomics of tertiary lymphoid organ-like structures in human atherosclerotic plaques 人类动脉粥样硬化斑块中三级淋巴样器官样结构的单细胞空间转录组学。

IF 10.8

Nature cardiovascular research Pub Date : 2025-04-28 DOI: 10.1038/s44161-025-00639-9

Zhichao Lai, Deqiang Kong, Qingsong Li, Yue Wang, Kang Li, Xiaohan Duan, Jiang Shao, Yiyun Xie, Junye Chen, Tianjing Zhang, Yuyao Feng, Haohao Deng, Jiaxian Wang, Chaonan Wang, Keqiang Shu, Hongmei Zhao, Hanze Du, Congwei Jia, Huanyu Dai, Lizhi Xie, Jianlin Liu, Xujiao Luo, Lin Wang, Leyin Xu, Zhan Zhu, Xiangling Lei, Yuru Wang, Yixuan Yang, Yanan Liu, Yuyu Liang, Yang Yang, Jun Xie, Bao Liu, Ziqing Deng, Xin Liu

{"title":"Single-cell spatial transcriptomics of tertiary lymphoid organ-like structures in human atherosclerotic plaques","authors":"Zhichao Lai, Deqiang Kong, Qingsong Li, Yue Wang, Kang Li, Xiaohan Duan, Jiang Shao, Yiyun Xie, Junye Chen, Tianjing Zhang, Yuyao Feng, Haohao Deng, Jiaxian Wang, Chaonan Wang, Keqiang Shu, Hongmei Zhao, Hanze Du, Congwei Jia, Huanyu Dai, Lizhi Xie, Jianlin Liu, Xujiao Luo, Lin Wang, Leyin Xu, Zhan Zhu, Xiangling Lei, Yuru Wang, Yixuan Yang, Yanan Liu, Yuyu Liang, Yang Yang, Jun Xie, Bao Liu, Ziqing Deng, Xin Liu","doi":"10.1038/s44161-025-00639-9","DOIUrl":"10.1038/s44161-025-00639-9","url":null,"abstract":"Tertiary lymphoid organs have been identified in the arterial adventitia in both mouse models of atherosclerosis and patients with atherosclerosis, yet their role in the disease remains insufficiently explored. Here we present a spatially resolved single-cell transcriptome atlas of human atherosclerotic plaques, identifying 14 distinct cell types and providing evidence of plaque tertiary lymphoid organs (PTLOs). The development of PTLOs was associated with the expression of lymphangiogenic chemokine genes and the adhesion molecule gene in fibroblast-like smooth muscle cells. PTLOs harbor abundant B cells with expanded and diversified B cell receptors, suggesting substantial immune involvement. We also observed that B cells may be exchanged between PTLOs and perivascular adipose tissues. The presence of PTLO-like structures correlates with cerebrovascular events, which may be mediated by PTLO-derived IgG antibodies enhancing macrophage functional activity. Our findings suggest the existence and characteristics of PTLOs in human atherosclerosis, elucidating their cellular functions and clinical implications and offering avenues for understanding, diagnosing and treating this condition. Lai et al. present a spatially resolved atlas of human atherosclerotic plaques, revealing cellular heterogeneity and identifying lymphoid structures and their potential functions and implications.","PeriodicalId":74245,"journal":{"name":"Nature cardiovascular research","volume":"4 5","pages":"547-566"},"PeriodicalIF":10.8,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144060123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tertiary lymphoid organs in human atherosclerotic plaques 人类动脉粥样硬化斑块的三级淋巴器官。

IF 10.8

Nature cardiovascular research Pub Date : 2025-04-28 DOI: 10.1038/s44161-025-00645-x

Devadatta Gosavi, Klaus Ley

引用次数: 0

Stochastic virtual heart model predictions 随机虚拟心脏模型预测。

IF 10.8

Nature cardiovascular research Pub Date : 2025-04-23 DOI: 10.1038/s44161-025-00641-1

Martin J. Bishop, Gernot Plank

引用次数: 0

Reply to: Stochastic virtual heart model predictions 回复：随机虚拟心脏模型预测。

IF 10.8

Nature cardiovascular research Pub Date : 2025-04-23 DOI: 10.1038/s44161-025-00642-0

Eric Sung, Adityo Prakosa, Natalia Trayanova

引用次数: 0

Lymphatic mysteries unzipped 淋巴的奥秘解开了。

IF 10.8

Nature cardiovascular research Pub Date : 2025-04-18 DOI: 10.1038/s44161-025-00643-z

Tatiana V. Petrova, Gwendalyn J. Randolph

引用次数: 0

Synthetic generation of cardiac tissue motion from surface electrocardiograms 从表面心电图合成心脏组织运动。

IF 10.8

Nature cardiovascular research Pub Date : 2025-04-14 DOI: 10.1038/s44161-025-00629-x

Aditya Radhakrishnan, Naveena Yanamala, Ankush Jamthikar, Yanting Wang, Sasha-Ann East, Yasmin Hamirani, Kameswari Maganti, Partho P. Sengupta

{"title":"Synthetic generation of cardiac tissue motion from surface electrocardiograms","authors":"Aditya Radhakrishnan, Naveena Yanamala, Ankush Jamthikar, Yanting Wang, Sasha-Ann East, Yasmin Hamirani, Kameswari Maganti, Partho P. Sengupta","doi":"10.1038/s44161-025-00629-x","DOIUrl":"10.1038/s44161-025-00629-x","url":null,"abstract":"Cardiac tissue motion is a sensitive biomarker for detecting early myocardial damage. Here, we show the similarity, interpretability and diagnostic accuracy of synthetic tissue Doppler imaging (TDI) waveforms generated from surface electrocardiograms (ECGs). Prospectively collected ECG and TDI data were cross-matched as 9,144 lateral and 8,722 septal TDI–ECG pairs (463 patients) for generating synthetic TDI across every 1% interval of the cardiac cycle. External validation using 816 lateral and 869 septal TDI–ECG pairs (314 patients) demonstrated strong correlation (repeated-measures r = 0.90, P < 0.0001), cosine similarity (0.89, P < 0.0001) and no differences during a randomized visual Turing test. Synthetic TDI correlated with clinical parameters (585 patients) and detected diastolic and systolic dysfunction with an area under the curve of 0.80 and 0.81, respectively. Furthermore, synthetic TDI systolic and early diastolic measurements generated from an external ECG dataset (233,647 patients) were associated with all-cause mortality during both sinus rhythm and atrial fibrillation, underscoring their potential for personalized cardiac care. Radhakrishnan, Yanamala et al. report the diagnostic accuracy of synthetic tissue Doppler imaging waveforms generated from surface electrocardiograms and their correlation with cardiac function and clinical outcomes.","PeriodicalId":74245,"journal":{"name":"Nature cardiovascular research","volume":"4 4","pages":"445-457"},"PeriodicalIF":10.8,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144042670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0