{"title":"冠状动脉粥样硬化在管腔斑块及其他部位的空间转录组图谱。","authors":"Paul Cheng, Thomas Quertermous","doi":"10.1038/s44161-024-00568-z","DOIUrl":null,"url":null,"abstract":"Single-cell transcriptomic studies have primarily focused on cell-autonomous mechanisms in coronary atherosclerosis. A study mapping the spatial transcriptome of cells in the diseased coronary artery elucidates the co-localization of vascular cell lineages, suggesting cell–cell communications in the neointima and in vascular adventitia.","PeriodicalId":74245,"journal":{"name":"Nature cardiovascular research","volume":"4 1","pages":"8-10"},"PeriodicalIF":9.4000,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Spatial transcriptomic mapping of coronary atherosclerosis in the luminal plaque and beyond\",\"authors\":\"Paul Cheng, Thomas Quertermous\",\"doi\":\"10.1038/s44161-024-00568-z\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Single-cell transcriptomic studies have primarily focused on cell-autonomous mechanisms in coronary atherosclerosis. A study mapping the spatial transcriptome of cells in the diseased coronary artery elucidates the co-localization of vascular cell lineages, suggesting cell–cell communications in the neointima and in vascular adventitia.\",\"PeriodicalId\":74245,\"journal\":{\"name\":\"Nature cardiovascular research\",\"volume\":\"4 1\",\"pages\":\"8-10\"},\"PeriodicalIF\":9.4000,\"publicationDate\":\"2025-01-02\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature cardiovascular research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.nature.com/articles/s44161-024-00568-z\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature cardiovascular research","FirstCategoryId":"1085","ListUrlMain":"https://www.nature.com/articles/s44161-024-00568-z","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
Spatial transcriptomic mapping of coronary atherosclerosis in the luminal plaque and beyond
Single-cell transcriptomic studies have primarily focused on cell-autonomous mechanisms in coronary atherosclerosis. A study mapping the spatial transcriptome of cells in the diseased coronary artery elucidates the co-localization of vascular cell lineages, suggesting cell–cell communications in the neointima and in vascular adventitia.
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