Mycobacterial diseases : tuberculosis & leprosy最新文献_第9页

Primary Tubercular Osteomyelitis of Manubrio Sternal Joint: A Case Report 原发性胸骨关节结核性骨髓炎1例

Mycobacterial diseases : tuberculosis & leprosy Pub Date : 2015-07-23 DOI: 10.4172/2161-1068.1000188

Monika Gupta, M. Mittal, A. Agarwal, B. Thukral

引用次数: 1

Clinical Characteristics and Diagnostic Delay in Spinal Tuberculosis Patients in The Netherlands 荷兰脊柱结核患者的临床特征和诊断延迟

Mycobacterial diseases : tuberculosis & leprosy Pub Date : 2015-07-15 DOI: 10.4172/2161-1068.1000187

D. Ijdema, C. Magis-Escurra, Horsting Pp, C. Erkens, R. Aarnoutse, M. Boeree

{"title":"Clinical Characteristics and Diagnostic Delay in Spinal Tuberculosis Patients in The Netherlands","authors":"D. Ijdema, C. Magis-Escurra, Horsting Pp, C. Erkens, R. Aarnoutse, M. Boeree","doi":"10.4172/2161-1068.1000187","DOIUrl":"https://doi.org/10.4172/2161-1068.1000187","url":null,"abstract":"Introduction: With declining TB incidences diagnostic delays, especially in extra-pulmonary TB, may increase. We describe the patient and clinical characteristics of patients with spinal TB and assessed the course of diagnostic delays of spinal TB from 2000-2011 in The Netherlands. \u0000Methods: Data from the Netherlands Tuberculosis Registry were studied, completed with basic demographic data and data considering patients-, doctors- and total diagnostic delay retrieved from the patient records at the public municipal health services. \u0000Results: A total of 274 cases were studied. Median diagnostic delay was five months and stable during this period. Sex and age groups were associated with significant differences in diagnostic delay (male 4.5 vs female 5.5 months), and 4.5-5 months in the youngest age group and persons>65 years but 5.75 months in patients aged 35-64 years. No difference was observed between origin of patients, patients presenting with TB risk factors or with neurological symptoms. Typical TB symptoms at presentation lead, surprisingly, to significantly increased doctors’ delay (typical symptoms 4.0 vs no typical symptoms 2.0 months, p=0.05). \u0000Conclusion: Considering spinal TB diagnosis and act expeditious is necessary to limit the time to diagnosis in spinal TB. Refresher courses should be offered both to family physicians and clinical specialists in The Netherlands","PeriodicalId":74235,"journal":{"name":"Mycobacterial diseases : tuberculosis & leprosy","volume":"5 1","pages":"1000187"},"PeriodicalIF":0.0,"publicationDate":"2015-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70581175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Clinical Evaluation of IP-10 and MIG for the Diagnosis of Active Tuberculosis Disease IP-10和MIG对活动性肺结核诊断的临床评价

Mycobacterial diseases : tuberculosis & leprosy Pub Date : 2015-06-05 DOI: 10.4172/2161-1068.1000185

Y. Kobashi, K. Mouri, Shigeki Kato, M. Oka

{"title":"Clinical Evaluation of IP-10 and MIG for the Diagnosis of Active Tuberculosis Disease","authors":"Y. Kobashi, K. Mouri, Shigeki Kato, M. Oka","doi":"10.4172/2161-1068.1000185","DOIUrl":"https://doi.org/10.4172/2161-1068.1000185","url":null,"abstract":"Background: The aim of this study was to evaluate the clinical potential of IP-10 and MIG as biomarkers of tuberculosis (TB) infection adding a comparison with IGRAs (QFT and T-SPOT.TB). \u0000Materials and Methods: The subjects consisted of 52 patients with active TB disease and 86 patients with non-TB disease. We measured two IGRAs using peripheral blood (PB), and IP-10 and MIG using the supernatant from whole blood stimulated with MTB (Mycobacterium tuberculosis)-specific antigens. \u0000Results: In the patient group with active TB disease, while the positive response rates of QFT and T-SPOT.TB were 81% and 87%, that of IP-10 using the supernatant was 88% and that of MIG was 85%. In the patient group with non-TB disease, the positive response rate of QFT was 13%, and that of T-SPOT.TB was 14%, IP-10 using the supernatant was 14%, and that of MIG was 14%. The IP-10 and MIG levels of the patients with active TB disease using the supernatant were significantly higher than those of the patients with non-TB disease. The combination of four diagnostic methods using the supernatant increased the positive response rate to 94%. \u0000Conclusion: IP-10 and MIG using a supernatant stimulated with MTB-specific antigens showed similar results to IGRAs. Therefore, these tests can be used as alternatives for the diagnosis of active TB disease.","PeriodicalId":74235,"journal":{"name":"Mycobacterial diseases : tuberculosis & leprosy","volume":"5 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2015-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/2161-1068.1000185","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70581528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Detection of Mycobacterium ulcerans in Mastomys natalensis and PotentialTransmission in Buruli ulcer Endemic Areas in CÃÂ´te d'Ivoire 科特迪瓦CÃÂ布鲁里溃疡流行区的溃疡分枝杆菌检测及潜在传播

Mycobacterial diseases : tuberculosis & leprosy Pub Date : 2015-05-28 DOI: 10.4172/2161-1068.1000184

C. Dassi, L. Mosi, B. Akpatou, Charles Akugbey Narh, Charles Quaye, D. O. Konan, J. Djaman, B. Bonfoh

{"title":"Detection of Mycobacterium ulcerans in Mastomys natalensis and PotentialTransmission in Buruli ulcer Endemic Areas in CÃÂ´te d'Ivoire","authors":"C. Dassi, L. Mosi, B. Akpatou, Charles Akugbey Narh, Charles Quaye, D. O. Konan, J. Djaman, B. Bonfoh","doi":"10.4172/2161-1068.1000184","DOIUrl":"https://doi.org/10.4172/2161-1068.1000184","url":null,"abstract":"The endemicity of Buruli ulcer (BU), a non-tuberculous mycobacteria infection, has significantly increased in Cote d'Ivoire. The exact transmission mode remains unknown but DNA based evidence of Mycobacterium ulcerans, the causative agent, have implicated potential environmental reservoirs, similar to those suspected in the transmission to humans. The role of small mammals in transmission has recently received some research attention. Based on the hypothesis that the overlapping ecology of human and animal habitats would favour mycobacteria transmission, the study aimed to identify BU like infections in small mammals living in close proximity to humans, in endemic communities. One hundred and eleven animals were trapped within five communities in two major endemic areas, Daloa and Tabbo. Majority of trapped small mammals were mice, Mastomys natalensis, of which 8 animals had external lesions. PCR on organ and lesion samples identified, predominantly, mycobacterium spp, of which five mice were positive for IS2404. IS2404 sequencing confirmed infection in two mice as M. ulcerans strain Agy99. Our findings suggest that small terrestrial mammals could be susceptible to mycobacteria, particularly, M. ulcerans, within endemic communities in Cote d’Ivoire. It also consolidates earlier evidence asserting their role as potential environmental reservoirs of M. ulcerans in endemic communities. The potential public health threat from these small mammals warrants an “OneHealth” approach to investigating the ecology and transmission of M. ulcerans in endemic countries.","PeriodicalId":74235,"journal":{"name":"Mycobacterial diseases : tuberculosis & leprosy","volume":"31 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2015-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70581249","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Outcome of Tuberculosis Treatment on Measures of Obesity and Adiposity Indices Among the Tribals of Northeast India 印度东北部部落结核病治疗对肥胖和肥胖指数测量的影响

Mycobacterial diseases : tuberculosis & leprosy Pub Date : 2015-05-25 DOI: 10.4172/2161-1068.1000182

M. Tungdim, Heemanshu Aurora, S. Kapoor

引用次数: 2

Cloning, Expression and Characterization of Fusion Proteins Based on Peptides of Rv1980c Disrupting Rv3019c Sequence and Evaluation of its Potential Immunoreactivity in Pulmonary Tuberculosis Sera Rv1980c干扰Rv3019c序列多肽融合蛋白的克隆、表达和鉴定及其在肺结核血清中的潜在免疫反应性评价

Mycobacterial diseases : tuberculosis & leprosy Pub Date : 2015-05-20 DOI: 10.4172/2161-1068.1000183

I. G. Sardella, Ana Carla de Paulo Mulinari, L. Fonseca, M. Saad

{"title":"Cloning, Expression and Characterization of Fusion Proteins Based on Peptides of Rv1980c Disrupting Rv3019c Sequence and Evaluation of its Potential Immunoreactivity in Pulmonary Tuberculosis Sera","authors":"I. G. Sardella, Ana Carla de Paulo Mulinari, L. Fonseca, M. Saad","doi":"10.4172/2161-1068.1000183","DOIUrl":"https://doi.org/10.4172/2161-1068.1000183","url":null,"abstract":"Mycobacterium tuberculosis-specific antigens (Ag) would be of important value in developing immunodiagnostic test for tuberculosis (TB), however human heterogeneous recognition of Ag epitopes may result in specificity variation of the test. In this work, we described the construction of two fusion proteins, based on two peptides from MPT-64 disrupting MT-10 Ag, F1-MT10.3 (1M-40S):CE15 (173G-187A):MT10.3 (41S-96) and F2- MT10.3 (1M-40S):MPT64 (91L-205A):MT10.3 (41S-96), and their potential immunoreactivity in TB sera. These fusion genes were cloned in expression vector, inserted in E. coli, and their proteins were expressed and purified. Using ELISA technique purified fused proteins and single full antigens were evaluated for IgA, IgM and IgG in sera from individuals diagnosed with pulmonary tuberculosis (TB) and controls with other pulmonary disease. The F1 construction generated a new peptide and F2 generate two modified peptides compared with the single full proteins. Testing of the tuberculosis human sera, the constructions were recognized by all antibodies types but the best results was obtained for ELISA-IgA which predominantly recognized the F2 (66.7%) and F1 (58.3%), follow by full single antigens MT10.3 (41.7%) and MPT64 (16.7%) keeping the highest specificity (95.5%), hitherto being unnoticed. Reactivity of IgG-F1 and IgM-F2 showed higher UAC than full MT10.2 and MPT64. The data demonstrated the viability of the constructions and the usefulness of molecule modification for obtains potential immune reactivity improvement, deserving further immunological characterization.","PeriodicalId":74235,"journal":{"name":"Mycobacterial diseases : tuberculosis & leprosy","volume":"5 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2015-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70581154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

A Case of Severe Mycobacterium kansasii Infection Complicated with the Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH) 严重堪萨斯分枝杆菌感染合并抗利尿激素分泌不当综合征1例

Mycobacterial diseases : tuberculosis & leprosy Pub Date : 2015-05-02 DOI: 10.4172/2161-1068.1000181

Billie Caceda, J. Garrós, U. Mj, M. Sada, M. Machó, R. Cisterna

{"title":"A Case of Severe Mycobacterium kansasii Infection Complicated with the Syndrome of Inappropriate Antidiuretic Hormone Secretion (SIADH)","authors":"Billie Caceda, J. Garrós, U. Mj, M. Sada, M. Machó, R. Cisterna","doi":"10.4172/2161-1068.1000181","DOIUrl":"https://doi.org/10.4172/2161-1068.1000181","url":null,"abstract":"We present a case of severe Mycobacterium kansasii infection due to the clinical and radiological progression and complicated with syndrome of inappropriate antidiuretic hormone secretion (SIADH). This 54-year-old male alcoholic and heavy smoker as predisposing factors presented severe anorexia, asthenia and cachexia. Abundant acid-fast bacilli (AFB) were observed in the patient’s sputum and pleural fluid after Ziehl-Neelsen (ZN) staining. The strain was identified as M. kansasii by culture. A treatment with isoniazid, pyrazinamide, ethambutol, clarithromycin and moxifloxacin were then initiated. The course of the illness includes impaired consciousness, behavioural disturbances and agitation; we believe was a consequence of SIADH, because of the severe hyponatremia with low serum osmolality condition. Also, generalized or local infections are important and unregarded causes of SIADH. Multiple infectious diseases are associated with this syndrome [1]. An awareness of this www.omicsonline.org/open-access/pathogenicity-of-entamoeba-species-depends-on-cell-line-conversiongenome-reprogramming-and-epigenetic-gene-regulation-2157-7013-1000245.phppathogen with clinical, radiologic, and microbiologic parameters are all needed to establish the diagnosis of this infection and the eradication of disease requires prolonged combination drug therapy.","PeriodicalId":74235,"journal":{"name":"Mycobacterial diseases : tuberculosis & leprosy","volume":"5 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2015-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70581381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fluorescein Diacetate Staining- A Strategy of Laboratories Capacity Building for Efficient Management of Mycobacterium Infections Treatment in Resource Limited Settings 双醋酸荧光素染色——在资源有限的环境中有效管理分枝杆菌感染治疗的实验室能力建设策略

Mycobacterial diseases : tuberculosis & leprosy Pub Date : 2015-04-21 DOI: 10.4172/2161-1068.1000180

D. Zingué

引用次数: 2

Renal Tuberculosis: The Enigma Continues 肾结核:谜题继续

Mycobacterial diseases : tuberculosis & leprosy Pub Date : 2015-01-01 DOI: 10.4172/2161-1068.1000186

R. Khan, S. Quaiser, A. Viswanath

引用次数: 3

Mycobacterium kumamotonense, another Member of the Mycobacterium terrae Complex Unusually Carrying Two Copies of the Ribosomal RNA Operon 熊原分枝杆菌，另一个异常携带两个核糖体RNA操纵子副本的地状分枝杆菌复合体的成员

Mycobacterial diseases : tuberculosis & leprosy Pub Date : 2014-12-07 DOI: 10.4172/2161-1068.1000176

M. Menéndez, M. Jiménez, J. Yubero, M. J. García

引用次数: 5