American Journal of Kidney Diseases最新文献

{"title":"Living With a Rare Glomerular Disease: A Call to Action for Early Diagnosis and Innovation in Treatment","authors":"","doi":"10.1053/j.ajkd.2024.01.525","DOIUrl":"10.1053/j.ajkd.2024.01.525","url":null,"abstract":"","PeriodicalId":7419,"journal":{"name":"American Journal of Kidney Diseases","volume":null,"pages":null},"PeriodicalIF":9.4,"publicationDate":"2024-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0272638624006723/pdfft?md5=7e4596148c70796fe54df72b3711898e&pid=1-s2.0-S0272638624006723-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140849965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Defining Risk in APOL1-Associated Kidney Disease: The Story is Evolving!","authors":"","doi":"10.1053/j.ajkd.2024.03.016","DOIUrl":"10.1053/j.ajkd.2024.03.016","url":null,"abstract":"","PeriodicalId":7419,"journal":{"name":"American Journal of Kidney Diseases","volume":null,"pages":null},"PeriodicalIF":9.4,"publicationDate":"2024-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S027263862400742X/pdfft?md5=ac05150f8afea623f803f13e6612ffab&pid=1-s2.0-S027263862400742X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140856272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How Low Can You Go With Dose of Continuous Kidney Replacement Therapy? Is That the Right Question to Ask?","authors":"","doi":"10.1053/j.ajkd.2024.03.007","DOIUrl":"10.1053/j.ajkd.2024.03.007","url":null,"abstract":"","PeriodicalId":7419,"journal":{"name":"American Journal of Kidney Diseases","volume":null,"pages":null},"PeriodicalIF":9.4,"publicationDate":"2024-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0272638624006747/pdfft?md5=844c14a30f484a53330b78fea69dd42a&pid=1-s2.0-S0272638624006747-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140855294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Safety of Iptacopan in Patients with Iga Nephropathy (IGAN): Interim Analysis (IA) of The Phase 3 Applause-Igan Study:","authors":"","doi":"10.1053/j.ajkd.2024.03.005","DOIUrl":"https://doi.org/10.1053/j.ajkd.2024.03.005","url":null,"abstract":"","PeriodicalId":7419,"journal":{"name":"American Journal of Kidney Diseases","volume":null,"pages":null},"PeriodicalIF":13.2,"publicationDate":"2024-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140618903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2 Treatment with Chlorthalidone vs Hydrochlorothiazide and Renal Outcomes: The Diuretic Comparison Project (DCP):","authors":"","doi":"10.1053/j.ajkd.2024.03.004","DOIUrl":"https://doi.org/10.1053/j.ajkd.2024.03.004","url":null,"abstract":"","PeriodicalId":7419,"journal":{"name":"American Journal of Kidney Diseases","volume":null,"pages":null},"PeriodicalIF":13.2,"publicationDate":"2024-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140618902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypertension and Proteinuria in a Pregnancy: A Quiz","authors":"Massimo Torreggiani , Maria Rita Stancanelli , Linda Njandjo , Antioco Fois , Giorgina Barbara Piccoli","doi":"10.1053/j.ajkd.2023.10.019","DOIUrl":"https://doi.org/10.1053/j.ajkd.2023.10.019","url":null,"abstract":"","PeriodicalId":7419,"journal":{"name":"American Journal of Kidney Diseases","volume":null,"pages":null},"PeriodicalIF":13.2,"publicationDate":"2024-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140619170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"1 Matching-Adjusted Indirect Comparisons of Egfr Slopes in The Protect Study With UK Radar Iga Nephropathy Population and The Control Arm of Nefigard:","authors":"","doi":"10.1053/j.ajkd.2024.03.003","DOIUrl":"https://doi.org/10.1053/j.ajkd.2024.03.003","url":null,"abstract":"","PeriodicalId":7419,"journal":{"name":"American Journal of Kidney Diseases","volume":null,"pages":null},"PeriodicalIF":13.2,"publicationDate":"2024-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140618901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"National Kidney Foundation 2024 Spring Clinical Meeting Late-Breaking Abstracts May 14-18, 2024","authors":"","doi":"10.1053/j.ajkd.2024.03.001","DOIUrl":"https://doi.org/10.1053/j.ajkd.2024.03.001","url":null,"abstract":"","PeriodicalId":7419,"journal":{"name":"American Journal of Kidney Diseases","volume":null,"pages":null},"PeriodicalIF":13.2,"publicationDate":"2024-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140619224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peritoneal Dialysis Technique Survival: A Cohort Study","authors":"","doi":"10.1053/j.ajkd.2024.03.012","DOIUrl":"10.1053/j.ajkd.2024.03.012","url":null,"abstract":"<div><h3>Rationale &amp; Objective</h3><p>Reasons for transfer from peritoneal dialysis<span> (PD) to hemodialysis (HD) remain incompletely understood. Among incident and prevalent patients receiving PD, we evaluated the association of clinical factors, including prior treatment with HD, with PD technique survival.</span></p></div><div><h3>Study Design</h3><p>Retrospective cohort study.</p></div><div><h3>Setting &amp; Participants</h3><p>Adults who initiated PD at a Dialysis Clinic, Inc (DCI) outpatient facility between January 1, 2010, and September 30, 2019.</p></div><div><h3>Exposure</h3><p>The primary exposure of interest was timing of PD start, categorized as PD-first, PD-early, or PD-late. Other covariates included demographics, clinical characteristics, and routine laboratory results.</p></div><div><h3>Outcome</h3><p>Modality switch from PD to HD sustained for more than 90 days.</p></div><div><h3>Analytical Approach</h3><p>Multivariable Fine-Gray models with competing risks and time-varying covariates, stratified at 9 months to account for lack of proportionality.</p></div><div><h3>Results</h3><p>Among 5,224 patients who initiated PD at a DCI facility, 3,174 initiated dialysis with PD (“PD-first”), 942 transitioned from HD to PD within 90 days (“PD-early”), and 1,108 transitioned beyond 90 days (“PD-late”); 1,472 (28%) subsequently transferred from PD to HD. The PD-early and PD-late patients had a higher risk of transfer to HD as compared with PD-first patients (in the first 9 months: adjusted hazard ratio [AHR], 1.51 [95% CI, 1.17-1.96] and 2.41 [95% CI, 1.94-3.00], respectively; and after 9 months: AHR, 1.16 [95% CI, 0.99-1.35] and AHR, 1.43 [95% CI, 1.24-1.65], respectively). More peritonitis<span> episodes, fewer home visits, lower serum albumin levels, lower residual kidney function, and lower peritoneal clearance calculated with weekly Kt/V were additional risk factors for PD-to-HD transfer.</span></p></div><div><h3>Limitations</h3><p>Missing data on dialysis adequacy and residual kidney function, confounded by short PD technique survival.</p></div><div><h3>Conclusions</h3><p>Initiating dialysis with PD is associated with greater PD technique survival, though many of those who initiate PD-late in their dialysis course still experience substantial time on PD. Peritonitis, lower serum albumin, and lower Kt/V are risk factors for PD-to-HD transfer that may be amenable to intervention.</p></div><div><h3>Plain-Language Summary</h3><p>Peritoneal dialysis (PD) is an important kidney replacement modality with several potential advantages compared with in-center hemodialysis (HD). However, a substantial number of patients transfer to in-center HD early on, without having experienced the quality-of-life and other benefits that come with sustained maintenance of PD. Using retrospective data from a midsize national dialysis provider, we found that initiating dialysis with PD is associated with longer maintenance of PD, compared with initiating d","PeriodicalId":7419,"journal":{"name":"American Journal of Kidney Diseases","volume":null,"pages":null},"PeriodicalIF":9.4,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140856273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of Blood Mitochondrial DNA Copy Number With Risk of Acute Kidney Injury After Cardiac Surgery.","authors":"Vasantha Jotwani, Heather Thiessen-Philbrook, Dan E Arking, Stephanie Y Yang, Eric McArthur, Amit X Garg, Ronit Katz, Gregory J Tranah, Joachim H Ix, Steve Cummings, Sushrut S Waikar, Mark J Sarnak, Michael G Shlipak, Samir M Parikh, Chirag R Parikh","doi":"10.1053/j.ajkd.2024.03.013","DOIUrl":"10.1053/j.ajkd.2024.03.013","url":null,"abstract":"","PeriodicalId":7419,"journal":{"name":"American Journal of Kidney Diseases","volume":null,"pages":null},"PeriodicalIF":9.4,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140849962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}