American Journal of Kidney Diseases最新文献_第9页

Transplanting Identities 移植身份。

IF 9.4 1区医学

American Journal of Kidney Diseases Pub Date : 2024-07-17 DOI: 10.1053/j.ajkd.2024.01.528

Tarek Zieneldien BS

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Antioxidants for Adults With CKD: Editorial Summary of a Cochrane Review 成人慢性肾脏病患者的抗氧化剂。

IF 9.4 1区医学

American Journal of Kidney Diseases Pub Date : 2024-07-11 DOI: 10.1053/j.ajkd.2023.12.026

Julia M.T. Colombijn, Robin W.M. Vernooij

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Clonal Hematopoiesis and Acute Kidney Injury Risk: Inflammatory Macrophages Implicated 克隆性造血与急性肾损伤风险：炎症性巨噬细胞参与其中

IF 9.4 1区医学

American Journal of Kidney Diseases Pub Date : 2024-07-10 DOI: 10.1053/j.ajkd.2024.06.007

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Revisiting Antioxidants in CKD: Still No Consensus 重新审视慢性肾脏病中的抗氧化剂：仍未达成共识。

IF 9.4 1区医学

American Journal of Kidney Diseases Pub Date : 2024-07-10 DOI: 10.1053/j.ajkd.2024.06.009

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Use of Pragmatic Trials to Improve Implementation of Best Practices for CKD 利用实用性试验改进慢性肾脏病最佳治疗方法的实施。

IF 9.4 1区医学

American Journal of Kidney Diseases Pub Date : 2024-07-10 DOI: 10.1053/j.ajkd.2024.06.008

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Humanizing Nephrology: The Power of Social History. 人性化肾脏病学：社会历史的力量。

IF 9.4 1区医学

American Journal of Kidney Diseases Pub Date : 2024-07-04 DOI: 10.1053/j.ajkd.2024.04.014

Rajiv Agarwal

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Mitigating the Disparate Impacts of Longevity Matching of Kidney Transplants 减轻肾移植长寿匹配的不同影响。

IF 9.4 1区医学

American Journal of Kidney Diseases Pub Date : 2024-07-04 DOI: 10.1053/j.ajkd.2024.06.002

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Sex and the Risk of Atheromatous and Nonatheromatous Cardiovascular Disease in CKD: Findings From the CKD-REIN Cohort Study 性别与慢性肾脏病患者罹患动脉粥样硬化性和非动脉粥样硬化性心血管疾病的风险：CKD-REIN 队列研究的发现。

IF 9.4 1区医学

American Journal of Kidney Diseases Pub Date : 2024-06-24 DOI: 10.1053/j.ajkd.2024.04.013

{"title":"Sex and the Risk of Atheromatous and Nonatheromatous Cardiovascular Disease in CKD: Findings From the CKD-REIN Cohort Study","authors":"","doi":"10.1053/j.ajkd.2024.04.013","DOIUrl":"10.1053/j.ajkd.2024.04.013","url":null,"abstract":"<div><h3>Rationale & Objective</h3><div>Sex differences in cardiovascular disease (CVD) are well established, but whether chronic kidney disease (CKD) modifies these risk differences and whether they differ between atheromatous CVD (ACVD) and nonatheromatous CVD (NACVD) is unknown. Assessing this interaction was the principal goal of this study.</div></div><div><h3>Study Design</h3><div>Prospective cohort study.</div></div><div><h3>Setting & Participants</h3><div>Adults enrolled in the CKD-REIN (CKD-Renal Epidemiology and Information Network) cohort, a nationally representative sample of 40 nephrology clinics in France, from 2013 to 2020.</div></div><div><h3>Exposure</h3><div>Sex.</div></div><div><h3>Outcomes</h3><div>Fatal and nonfatal composite ACVD events (ischemic coronary, cerebral, and peripheral artery disease) and composite NACVD events (heart failure, hemorrhagic stroke, and arrhythmias).</div></div><div><h3>Analytical Approach</h3><div>Multivariable cause-specific Cox proportional hazards models.</div></div><div><h3>Results</h3><div>1,044 women and 1,976 men with moderate to severe CKD (median age, 67 vs 69y; mean estimated glomerular filtration rate [eGFR], 32±12 vs 33±12mL/min/1.73m<sup>2</sup>) were studied. During a median follow-up of 5.0 (IQR, 4.8-5.2) years, the ACVD rate (per 100 patient-years) was significantly lower in women than in men, at 2.1 (95% CI, 1.6-2.5) versus 3.6 (3.2-4.0; <em>P</em>  =0.55). NACVD had a steeper relationship with eGFR than did ACVD. There was an interaction (<em>P</em>      <!-->m<sup>2</sup>. In contrast, the NACVD hazard did not differ between sexes across the eGFR range studied.</div></div><div><h3>Limitations</h3><div>Cardiovascular biomarkers and sex hormones were not assessed.</div></div><div><h3>Conclusions</h3><div>This study shows how the lower risk of ACVD among women versus men attenuates fully with kidney disease progression. The equal risk of NACVD between sexes across CKD stages and its steeper association with eGFR suggest an important contribution of CKD to the development of this CVD type.</div></div><div><h3>Plain-Language Summary</h3><div>Sex differences in the risks of atheromatous and nonatheromatous cardiovascular disease (CVD) are well established in the general population. If or how chronic kidney disease (CKD) might modify these risks is unknown. In this large cohort of 3,010 patients with CKD, women had a lower risk than men of atheromatous CVDs such as coronary artery disease or strok","PeriodicalId":7419,"journal":{"name":"American Journal of Kidney Diseases","volume":"84 5","pages":"Pages 546-556.e1"},"PeriodicalIF":9.4,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141454520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Social Isolation, Loneliness, and Risk of Microvascular Complications Among Individuals With Type 2 Diabetes Mellitus 2 型糖尿病患者的社会隔离、孤独感与微血管并发症风险。

IF 9.4 1区医学

American Journal of Kidney Diseases Pub Date : 2024-06-24 DOI: 10.1053/j.ajkd.2024.05.004

{"title":"Social Isolation, Loneliness, and Risk of Microvascular Complications Among Individuals With Type 2 Diabetes Mellitus","authors":"","doi":"10.1053/j.ajkd.2024.05.004","DOIUrl":"10.1053/j.ajkd.2024.05.004","url":null,"abstract":"<div><h3>Rationale & Objective</h3><div>Social disconnection has been associated with poor cardiometabolic health. This study sought to investigate the associations of social isolation and loneliness with diabetic microvascular complications (DMCs) among individuals with type 2 diabetes mellitus (T2DM) and compare these associations versus those related to traditional risk factors.</div></div><div><h3>Study Design</h3><div>Prospective cohort study.</div></div><div><h3>Setting & Participants</h3><div>A total of 24,297 UK Biobank participants with T2DM and no DMCs at baseline.</div></div><div><h3>Exposure</h3><div>Social isolation and loneliness were measured using self-reported questionnaires.</div></div><div><h3>Outcome</h3><div>The incidence of DMCs defined as a composite of diabetic kidney disease, diabetic retinopathy, or diabetic neuropathy.</div></div><div><h3>Analytical Approach</h3><div>Multivariable cause-specific hazards regression. To compare the relative importance of social disconnection with other established factors, the <em>R</em><sup>2</sup> values of the Cox models were calculated.</div></div><div><h3>Results</h3><div>During a median follow-up of 12.6 years, 5,530 patients were documented to experience DMCs (3,458 with diabetic kidney disease, 2,255 with diabetic retinopathy, and 1,146 with diabetic neuropathy). The highest level of social isolation was associated with an increased risk of any DMC component (most vs least: HR, 1.13; 95% CI, 1.05-1.22), especially diabetic kidney disease (HR, 1.14; 95% CI, 1.04-1.25) and neuropathy (HR, 1.31; 95% CI, 1.11-1.53). Any level of loneliness was associated with an increased risk of any DMC component (HR, 1.12; 95% CI, 1.02-1.23) and diabetic kidney disease (HR, 1.16; 95% CI, 1.03-1.30). Social isolation and loneliness exhibited associations with DMCs comparable to those of other conventional risk factors, including smoking, blood pressure, and physical activity.</div></div><div><h3>Limitations</h3><div>Limited generalizability related to the composition of participants in the UK Biobank Study.</div></div><div><h3>Conclusions</h3><div>Social isolation and loneliness were independently associated with a higher risk of incident DMCs among individuals with T2DM, with comparable importance to other traditional risk factors. These findings underscore social isolation and loneliness as novel and potentially modifiable risk factors for DMCs.</div></div><div><h3>Plain-Language Summary</h3><div>Social isolation and loneliness are important social determinants that are associated with adverse cardiometabolic health. Individuals with diabetes are particularly vulnerable to social isolation and loneliness. However, the relationship of social isolation or loneliness with diabetic microvascular complications (DMCs) remains unclear. Our study used the UK Biobank study data to investigate the associations of social isolation and loneliness with the development of DMCs. We found that social isola","PeriodicalId":7419,"journal":{"name":"American Journal of Kidney Diseases","volume":"84 5","pages":"Pages 557-566.e1"},"PeriodicalIF":9.4,"publicationDate":"2024-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141454521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Smoking Timing, Healthy Diet, and Risk of Incident CKD Among Smokers: Findings From UK Biobank 吸烟时间、健康饮食与吸烟者罹患慢性肾脏病的风险：英国生物库的研究结果。

IF 9.4 1区医学

American Journal of Kidney Diseases Pub Date : 2024-06-22 DOI: 10.1053/j.ajkd.2024.04.011

{"title":"Smoking Timing, Healthy Diet, and Risk of Incident CKD Among Smokers: Findings From UK Biobank","authors":"","doi":"10.1053/j.ajkd.2024.04.011","DOIUrl":"10.1053/j.ajkd.2024.04.011","url":null,"abstract":"<div><h3>Rationale & Objective</h3><div>Although smoking is a recognized risk factor for chronic kidney disease (CKD), the relationship between the time smoking is initiated after awakening each day and CKD remains largely unstudied. This study examined the association between this timing and the risk of CKD, and the potential interactions of smoking timing with other risk factors for the occurrence of CKD.</div></div><div><h3>Study Design</h3><div>Observational cohort study.</div></div><div><h3>Setting & Participants</h3><div>A total of 32,776 participants in the UK Biobank with complete data on the time from waking to the first cigarette and free of prevalent CKD were included.</div></div><div><h3>Exposure</h3><div>Time from waking to the first cigarette.</div></div><div><h3>Outcome</h3><div>Incident CKD cases.</div></div><div><h3>Analytical Approach</h3><div>Cox proportional hazards regression was used to investigate the associations between the time smoking is initiated each day and the risk of CKD. The potential interactions of smoking timing with risk factors in relationship to CKD risk were assessed on both multiplicative and additive scales.</div></div><div><h3>Results</h3><div>During a median follow-up period of 12 years, 940 incident CKD cases occurred. Shorter durations of time from waking to the first cigarette were associated with a higher risk of incident CKD (<em>P</em> trend=0.01). Compared with>120 minutes, the adjusted hazard ratio (HR) associated with smoking timing was 1.28 (95% CI, 0.92–1.80) for 61-120 minutes, 1.48 (95% CI, 1.11-1.96) for 30-60 minutes, 1.36 (95% CI, 1.01-1.88) for 5-15 minutes, and 1.70 (95% CI, 1.22-2.37) for<5 minutes, respectively. Furthermore, there was a significant additive interaction and multiplicative interactions between the timing of smoking and a healthy diet score (<em>P</em> for additive interaction=0.01; <em>P</em> for multiplicative interaction = 0.004).</div></div><div><h3>Limitations</h3><div>Generalizability, possible residual confounding, limiting causal inference.</div></div><div><h3>Conclusions</h3><div>These findings reveal a significant association between the shorter time from waking to the first cigarette and a higher CKD risk. The magnitude of these associations was greater in the setting of an unhealthy diet.</div></div><div><h3>Plain-Language Summary</h3><div>This study explored the association of the daily timing of first cigarette smoking and the occurrence of kidney disease. Further, we addressed whether this association was influenced by the quality of the diet. The study found that smoking very soon after waking, especially when combined with a poorer quality diet, was associated with a significantly increased risk of developing chronic kidney disease. This research emphasizes the value of healthier lifestyle choices for kidney health.</div></div>","PeriodicalId":7419,"journal":{"name":"American Journal of Kidney Diseases","volume":"84 5","pages":"Pages 593-600.e1"},"PeriodicalIF":9.4,"publicationDate":"2024-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141441942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0