American Journal of Kidney Diseases最新文献

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Methods for Diagnosing Proteinuria: When to Use Which Test, and Why. 蛋白尿的诊断方法:何时使用哪一种测试,以及为什么使用。
IF 9.4 1区 医学
American Journal of Kidney Diseases Pub Date : 2024-12-18 DOI: 10.1053/j.ajkd.2024.09.017
Nikolai Carl Hodel, Katharina M Rentsch, Daniel Henry Paris, Michael Mayr
{"title":"Methods for Diagnosing Proteinuria: When to Use Which Test, and Why.","authors":"Nikolai Carl Hodel, Katharina M Rentsch, Daniel Henry Paris, Michael Mayr","doi":"10.1053/j.ajkd.2024.09.017","DOIUrl":"https://doi.org/10.1053/j.ajkd.2024.09.017","url":null,"abstract":"<p><p>Proteinuria plays a central role in the diagnosis of kidney disease and has a high prognostic value. The test methods used differ considerably regarding impact on test accuracy, sensitivity, and specificity. Therefore, knowledge of the methodology is crucial for the interpretation of the results. In addition to the distinction between semi-quantitative and quantitative tests, there are also relevant differences within the two methods. In general, semi-quantitative tests are easy to handle but have limitations such as: i) incomplete quantification, ii) a lack of specificity regarding the type of proteinuria, iii) a high rate of false positive tests with the need for re-testing with a quantitative method for verification. In contrast, quantitative methods, especially immunoassays, have the advantages of: i) high test accuracy, ii) the possibility of targeted detection of specific protein molecules in addition to albumin. However, these methods are more expensive and require access to a laboratory or an electronic point of care device. In this review, the different types of tests for proteinuria, their underlying methodologies and their strengths and weaknesses are discussed in detail to allow a rational decision of use and a correct interpretation of the results depending on the clinical context.</p>","PeriodicalId":7419,"journal":{"name":"American Journal of Kidney Diseases","volume":" ","pages":""},"PeriodicalIF":9.4,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142870974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Patient Education for CKD and Decision Support in Primary Care: Findings From the EPIK Pilot Study. 初级保健中的CKD患者教育和决策支持:来自EPIK试点研究的发现。
IF 9.4 1区 医学
American Journal of Kidney Diseases Pub Date : 2024-12-14 DOI: 10.1053/j.ajkd.2024.10.005
Julie Wright Nunes, Eve Kerr, Akinlolu Ojo, Corey Powell, Audrey Fan, F John Brinley, Anita Devine, Tammy Ellies, Katie Grzyb, Luis Garcia-Guzman, Tejpreet Nakai, Andrea Oliverio, Emily Chen, Angela Fagerlin
{"title":"Patient Education for CKD and Decision Support in Primary Care: Findings From the EPIK Pilot Study.","authors":"Julie Wright Nunes, Eve Kerr, Akinlolu Ojo, Corey Powell, Audrey Fan, F John Brinley, Anita Devine, Tammy Ellies, Katie Grzyb, Luis Garcia-Guzman, Tejpreet Nakai, Andrea Oliverio, Emily Chen, Angela Fagerlin","doi":"10.1053/j.ajkd.2024.10.005","DOIUrl":"10.1053/j.ajkd.2024.10.005","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Rationale & objective: &lt;/strong&gt;Chronic kidney disease (CKD) affects millions of people in the United States, yet effective interventions to address gaps in patient knowledge and engagement are not well-established. We developed and pilot tested a brief educational decision aid for patients with CKD who are being treated in primary care settings.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Study design: &lt;/strong&gt;Pilot quality improvement (QI) study of a decision aid intervention.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Setting & participants: &lt;/strong&gt;The decision aid was introduced and used in 1 of 2 general internal medicine primary care clinics for adult patients with CKD.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Exposure: &lt;/strong&gt;An electronic medical record-based patient educational decision aid called the Encounter Decision Intervention (EDI) developed using QI methods and with input from patients and clinicians for use during primary care visits to address a CKD diagnosis and engage patients in their clinical management.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Outcome: &lt;/strong&gt;Perceived and objective CKD knowledge, CKD-specific stress, and patient satisfaction measured in both primary care clinics as assessed using validated surveys.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Analytical approach: &lt;/strong&gt;Fisher exact tests, t tests, and Kruskal-Wallis tests were used to detect univariable associations of outcomes with use of the EDI across primary care clinics.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Seventy-four patients completed the study (37 in each clinic). There were no statistically significant differences in patient characteristics between the clinics. The group treated in the clinic that used the EDI had statistically significantly higher satisfaction with their clinicians, with clinician communication, and with their overall care. The patients reported high satisfaction with the EDI, and the clinicians reported favorable usability.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Limitations: &lt;/strong&gt;A nonrandomized comparison, small sample size, and possible differences across practice settings.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;A new integrated educational decision aid was successfully implemented in a primary care setting. Pilot testing suggested that the EDI was associated with higher patient satisfaction with their primary care provider, with their clinician's communication, and with their overall care.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Plain-language summary: &lt;/strong&gt;Most patients who have chronic kidney disease (CKD) are not aware of their illness. Few studies have explored whether patient education can increase patients' knowledge about CKD or influence patients' satisfaction with the care or communication they receive from their physicians. This study tested whether a short CKD education intervention implemented by the patient's physician was associated with patients' greater awareness of their CKD as well as their satisfaction with care and communication. This pilot study found that a decision aid for patients with CKD was implementable in a primary care setting. Patients who received CKD education ","PeriodicalId":7419,"journal":{"name":"American Journal of Kidney Diseases","volume":" ","pages":""},"PeriodicalIF":9.4,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142826926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Significance of Incident Osteoporotic Fractures After Kidney Transplantation: A National Korean Cohort Study. 肾移植后发生骨质疏松性骨折的临床意义:韩国全国队列研究
IF 9.4 1区 医学
American Journal of Kidney Diseases Pub Date : 2024-12-12 DOI: 10.1053/j.ajkd.2024.09.014
Yunyoung Jang, Ji Eun Kim, Jina Park, Jeongin Song, Sehoon Park, Yong Chul Kim, Dong Ki Kim, Kwon Wook Joo, Yon Su Kim, Minsu Park, Hajeong Lee, Eunjeong Kang
{"title":"Clinical Significance of Incident Osteoporotic Fractures After Kidney Transplantation: A National Korean Cohort Study.","authors":"Yunyoung Jang, Ji Eun Kim, Jina Park, Jeongin Song, Sehoon Park, Yong Chul Kim, Dong Ki Kim, Kwon Wook Joo, Yon Su Kim, Minsu Park, Hajeong Lee, Eunjeong Kang","doi":"10.1053/j.ajkd.2024.09.014","DOIUrl":"https://doi.org/10.1053/j.ajkd.2024.09.014","url":null,"abstract":"<p><strong>Rationale & objective: </strong>Recipients of kidney allografts are at risk for osteoporotic fractures (OF), but their association with patient and allograft outcomes remains uncertain due to common coexisting risks and complex medical conditions. This study sought to assess if overall incidence of OF among recipients of kidney allografts compared to patients receiving maintenance dialysis for kidney failure.</p><p><strong>Study design: </strong>A national retrospective cohort study.</p><p><strong>Setting: </strong>& Participants: 145,090 Korean patients with newly diagnosed kidney failure between 2009 and 2019.</p><p><strong>Exposure: </strong>Kidney transplantation vs dialysis for the outcome of OF. OF for the outcome of death.</p><p><strong>Outcomes: </strong>Incident osteoporotic fractures, overall and by site (hip, spine, forearm, and humerus); death.</p><p><strong>Analytical approach: </strong>Comparison of patients receiving maintenance dialysis to recipients of kidney allografts matched for age, sex, year of new index date, duration of dialysis, and presence of hypertension and diabetes mellitus. Cause-specific Cox proportional hazards regression models estimated the association between modality of kidney replacement therapy and OF. Cox models incorporating OF as a time-updated covariate were used to estimate the association of OF and mortality.</p><p><strong>Results: </strong>A total of 11,413 pairs were matched, and the rates of incident OF in allograft recipients and the matched dialysis comparators were 5.2% and 5.6%, respectively. After 5.5 years of follow-up, the risk of incident OF was lower in KT recipients compared to matched dialysis comparators (adjusted hazard ratio[aHR] 0.73; 95% confidence interval [CI], 0.64-0.84; P<0.001). Differences in the rates of fracture were principally due to differences in hip fractures. Incident OF was associated with increased mortality risk (aHR 2.18; 95% CI, 1.57-3.02; P<0.001), and death-censored allograft failure (aHR 1.42; 95% CI 1.02-1.97; P=0.040).</p><p><strong>Limitations: </strong>No data on bone mineral density or hyperparathyroidism, and the definition of OFs used encompassed traumatic fractures. Use of claims data.</p><p><strong>Conclusions: </strong>Kidney allograft recipients have a lower incidence of incident OF compared to dialysis patients, but when they occur OF was associated with a higher rate of death and allograft loss.</p>","PeriodicalId":7419,"journal":{"name":"American Journal of Kidney Diseases","volume":" ","pages":""},"PeriodicalIF":9.4,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Glomerular Filtration of Creatinine: Validation of a Novel Index of Muscle Mass Among Older Adults. 肾小球滤过肌酐:验证老年人肌肉质量的新指标
IF 9.4 1区 医学
American Journal of Kidney Diseases Pub Date : 2024-12-12 DOI: 10.1053/j.ajkd.2024.09.013
Tatsufumi Oka, Lesley A Inker, Juhi Chaudhari, Hocine Tighiouart, Erin P Flanagin, Kristin Siggeirsdottir, Olafur S Indridason, Runolfur Palsson, Vilmundur G Gudnason, Andrew S Levey
{"title":"Glomerular Filtration of Creatinine: Validation of a Novel Index of Muscle Mass Among Older Adults.","authors":"Tatsufumi Oka, Lesley A Inker, Juhi Chaudhari, Hocine Tighiouart, Erin P Flanagin, Kristin Siggeirsdottir, Olafur S Indridason, Runolfur Palsson, Vilmundur G Gudnason, Andrew S Levey","doi":"10.1053/j.ajkd.2024.09.013","DOIUrl":"10.1053/j.ajkd.2024.09.013","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Rationale & objective: &lt;/strong&gt;Low muscle mass is common among older adults and associated with poor prognosis. Quantifying muscle mass is challenging in routine clinical practice. We hypothesized that glomerular filtration of creatinine (GF&lt;sub&gt;cr&lt;/sub&gt;) reflects muscle mass, and previously proposed estimated GF&lt;sub&gt;cr&lt;/sub&gt; (eGF&lt;sub&gt;cr&lt;/sub&gt;), as a practical index of muscle mass in older adults. This study investigated whether measured GF&lt;sub&gt;cr&lt;/sub&gt; (mGF&lt;sub&gt;cr&lt;/sub&gt;) and eGF&lt;sub&gt;cr&lt;/sub&gt; are similarly associated with the direct measure of muscle mass, the thigh total muscle lean area (TTMLA).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Study design: &lt;/strong&gt;Cross-sectional analysis of a community-based prospective cohort.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Setting & participants: &lt;/strong&gt;A total of 794 older adults with measured glomerular filtration rate (mGFR) and TTMLA in the AGES-Reykjavik Study.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Exposure: &lt;/strong&gt;Measured GF&lt;sub&gt;cr&lt;/sub&gt;, the product of serum creatinine (Scr) and mGFR obtained using plasma iohexol clearance and eGF&lt;sub&gt;cr&lt;/sub&gt;, the product of Scr and estimated glomerular filtration rate using serum cystatin C (Scys).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Outcome: &lt;/strong&gt;TTMLA measured using computed tomography.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Analytical approach: &lt;/strong&gt;Sex-specific Pearson's correlation and linear regression analyses using continuous and categorical mGF&lt;sub&gt;cr&lt;/sub&gt; and eGF&lt;sub&gt;cr&lt;/sub&gt;. Covariates included demographic, behavioral, and clinical variables, and comorbid conditions.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The mean age and mGFR were 80.3±4.0 (SD) years and 62.3±16.5 (SD) mL/min/1.73m&lt;sup&gt;2&lt;/sup&gt;, respectively. The lowest sex-specific tertile of mGF&lt;sub&gt;cr&lt;/sub&gt;, compared with the highest tertile, was associated with a 14.6 (95% CI, 11.5-17.6) cm&lt;sup&gt;2&lt;/sup&gt;/1.73m&lt;sup&gt;2&lt;/sup&gt; lower TTMLA in men, and a 7.9 (95% CI, 5.5-10.2) cm&lt;sup&gt;2&lt;/sup&gt;/1.73m&lt;sup&gt;2&lt;/sup&gt; lower TTMLA in women. Significant associations were observed between eGF&lt;sub&gt;cr&lt;/sub&gt; and TTMLA. Correlations of eGF&lt;sub&gt;cr&lt;/sub&gt; with TTMLA were generally as strong or stronger than correlations of alternative indices derived from Scr and Scys.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Limitations: &lt;/strong&gt;Residual confounding by measured and unmeasured variables.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;These findings support the validity of GF&lt;sub&gt;cr&lt;/sub&gt; as an index of muscle mass among older adults and the use of eGF&lt;sub&gt;cr&lt;/sub&gt; as a practical alternative to mGF&lt;sub&gt;cr&lt;/sub&gt; in the clinical setting.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Plain-language summary: &lt;/strong&gt;Low muscle mass is common among older adults and is associated with poor clinical outcomes. Quantifying muscle mass is challenging in routine clinical practice. We evaluated whether glomerular filtration of creatinine (GF&lt;sub&gt;cr&lt;/sub&gt;) could serve as an index of muscle mass. We performed a cross-sectional study including 794 older adults who underwent computed tomography for thigh muscle lean area as a directly measured indicator of total body muscle mass. Significant positive associatio","PeriodicalId":7419,"journal":{"name":"American Journal of Kidney Diseases","volume":" ","pages":""},"PeriodicalIF":9.4,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142824010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
When a Loved One Faces Kidney Disease. 当你所爱的人面临肾脏疾病。
IF 9.4 1区 医学
American Journal of Kidney Diseases Pub Date : 2024-12-06 DOI: 10.1053/j.ajkd.2024.08.006
Swetha R Kanduri
{"title":"When a Loved One Faces Kidney Disease.","authors":"Swetha R Kanduri","doi":"10.1053/j.ajkd.2024.08.006","DOIUrl":"https://doi.org/10.1053/j.ajkd.2024.08.006","url":null,"abstract":"","PeriodicalId":7419,"journal":{"name":"American Journal of Kidney Diseases","volume":" ","pages":""},"PeriodicalIF":9.4,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142799026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acute Kidney Injury in Care Transitions (ACT): A Randomized Controlled Feasibility Trial. 护理过渡中的急性肾损伤(ACT):一项随机对照可行性试验。
IF 9.4 1区 医学
American Journal of Kidney Diseases Pub Date : 2024-12-06 DOI: 10.1053/j.ajkd.2024.08.005
Erin F Barreto, Heather P May, Kristin C Cole, Joan M Griffin, Joseph R Herges, Kianoush B Kashani, Andrea G Kattah, Caroline B Ledet, Rozalina G McCoy, Angeliki G Tinaglia, Andrew D Rule
{"title":"Acute Kidney Injury in Care Transitions (ACT): A Randomized Controlled Feasibility Trial.","authors":"Erin F Barreto, Heather P May, Kristin C Cole, Joan M Griffin, Joseph R Herges, Kianoush B Kashani, Andrea G Kattah, Caroline B Ledet, Rozalina G McCoy, Angeliki G Tinaglia, Andrew D Rule","doi":"10.1053/j.ajkd.2024.08.005","DOIUrl":"https://doi.org/10.1053/j.ajkd.2024.08.005","url":null,"abstract":"","PeriodicalId":7419,"journal":{"name":"American Journal of Kidney Diseases","volume":" ","pages":""},"PeriodicalIF":9.4,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142798911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Establishing Research Priorities in Geriatric Nephrology: A Delphi Study of Clinicians and Researchers. 确定老年肾脏病学的研究重点:临床医生和研究人员的德尔菲研究。
IF 9.4 1区 医学
American Journal of Kidney Diseases Pub Date : 2024-11-26 DOI: 10.1053/j.ajkd.2024.09.012
Catherine R Butler, Akanksha Nalatwad, Katharine L Cheung, Mary F Hannan, Melissa D Hladek, Emily A Johnston, Laura Kimberly, Christine K Liu, Devika Nair, Semra Ozdemir, Fahad Saeed, Jennifer S Scherer, Dorry L Segev, Anoop Sheshadri, Karthik K Tennankore, Tiffany R Washington, Dawn Wolfgram, Nidhi Ghildayal, Rasheeda Hall, Mara McAdams-DeMarco
{"title":"Establishing Research Priorities in Geriatric Nephrology: A Delphi Study of Clinicians and Researchers.","authors":"Catherine R Butler, Akanksha Nalatwad, Katharine L Cheung, Mary F Hannan, Melissa D Hladek, Emily A Johnston, Laura Kimberly, Christine K Liu, Devika Nair, Semra Ozdemir, Fahad Saeed, Jennifer S Scherer, Dorry L Segev, Anoop Sheshadri, Karthik K Tennankore, Tiffany R Washington, Dawn Wolfgram, Nidhi Ghildayal, Rasheeda Hall, Mara McAdams-DeMarco","doi":"10.1053/j.ajkd.2024.09.012","DOIUrl":"10.1053/j.ajkd.2024.09.012","url":null,"abstract":"<p><strong>Rationale & objective: </strong>Despite substantial growth of the population of older adults with kidney disease, there remains a lack of evidence to guide clinical care for this group. The Kidney Disease and Aging Research Collaborative conducted a Delphi study to build consensus on research priorities for clinical geriatric nephrology.</p><p><strong>Study design: </strong>Asynchronous modified Delphi study.</p><p><strong>Setting & participants: </strong>Clinicians and researchers in the United States and Canada with clinical experience and/or research expertise in geriatric nephrology.</p><p><strong>Outcome: </strong>Research priorities in geriatric nephrology.</p><p><strong>Analytical approach: </strong>In the first Delphi round, participants submitted free-text descriptions of research priorities considered important for improving the clinical care of older adults with kidney disease. Delphi moderators used inductive content analysis to group concepts into categories. In the second and third rounds, participants iteratively reviewed topics, selected their top 5 priorities, and offered comments used to revise categories.</p><p><strong>Results: </strong>Among 121 who were invited, 57 participants (47%) completed the first Delphi round and 48 (84% of enrolled participants) completed all rounds. After 3 rounds, the 5 priorities with the highest proportion of agreement were (1) communication and decision-making about treatment options for older adults with kidney failure (69% agreement), (2) quality of life, symptom management, and palliative care (67%), (3) frailty and physical function (54%), (4) tailoring therapies for kidney disease to specific needs of older adults (42%), and (5) caregiver and social support (35%). Health equity and person-centricity were identified as cross-cutting features that informed all topics.</p><p><strong>Limitations: </strong>Relatively low response rate and limited participation by private practitioners and older clinicians and researchers.</p><p><strong>Conclusions: </strong>Experts in geriatric nephrology identified clinical research priorities with the greatest potential to improve care for older adults with kidney disease. These findings provide a road map for the geriatric nephrology community to harmonize and maximize the impact of research efforts.</p>","PeriodicalId":7419,"journal":{"name":"American Journal of Kidney Diseases","volume":" ","pages":""},"PeriodicalIF":9.4,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142738040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Treatment Effect Heterogeneity in Acute Kidney Injury Incidence Following Intravenous Antihypertensive Administration for Severe Blood Pressure Elevation During Hospitalization. 住院期间严重血压升高静脉注射降压药后急性肾损伤发生率的治疗效果异质性
IF 9.4 1区 医学
American Journal of Kidney Diseases Pub Date : 2024-11-22 DOI: 10.1053/j.ajkd.2024.09.011
Lama Ghazi, Xinyuan Chen, Michael O Harhay, Liangyuan Hu, Aditya Biswas, Aldo J Peixoto, Fan Li, F Perry Wilson
{"title":"Treatment Effect Heterogeneity in Acute Kidney Injury Incidence Following Intravenous Antihypertensive Administration for Severe Blood Pressure Elevation During Hospitalization.","authors":"Lama Ghazi, Xinyuan Chen, Michael O Harhay, Liangyuan Hu, Aditya Biswas, Aldo J Peixoto, Fan Li, F Perry Wilson","doi":"10.1053/j.ajkd.2024.09.011","DOIUrl":"10.1053/j.ajkd.2024.09.011","url":null,"abstract":"<p><strong>Rationale & objective: </strong>Severe hypertension (HTN) that develops after hospital admission is prevalent in 10% of patients admitted for reasons other than HTN. Severe HTN is commonly treated with intravenous (IV) antihypertensives and is associated with a greater risk of acute kidney injury (AKI). We explored whether there is heterogeneity in IV antihypertensives' effect on AKI incidence among patients who develop severe HTN during hospitalization.</p><p><strong>Study design: </strong>Heterogeneity of treatment effect analysis.</p><p><strong>Settings & participants: </strong>Patients who developed severe HTN, defined as systolic blood pressure (BP)>180 or diastolic BP>110mm Hg, during hospitalization and did not have kidney failure.</p><p><strong>Exposure: </strong>Treatment with IV antihypertensives within 3 hours of BP elevation.</p><p><strong>Outcome: </strong>Time to developing AKI.</p><p><strong>Analytical approach: </strong>An accelerated failure time Bayesian additive regression trees (BART) model to capture the association between the time to develop AKI and predictors. Individual treatment effects were estimated for each participant using a counterfactual outcome framework, and these estimates were used to identify patient characteristics associated with treatment effect heterogeneity in response to IV antihypertensives.</p><p><strong>Results: </strong>We included 11,951 patients who developed severe HTN, 741 were treated with IV antihypertensives, and 11,210 were not, of whom 18% and 13% developed AKI, respectively. Most patients would have been harmed from IV antihypertensive treatment except for a small subset of 317 patients who were White, had a systolic BP on admission≥156mm Hg, an estimated glomerular filtration rate of≥70.7mL/min/1.73m<sup>2</sup>, and a serum bicarbonate of<21.7mmol/L.</p><p><strong>Limitations: </strong>Data-driven, hypothesis-generating approach. Findings were not validated with external data sources.</p><p><strong>Conclusions: </strong>These exploratory findings suggest that most patients who develop severe HTN will not benefit from IV antihypertensive treatment. Future studies should assess for heterogeneity when identifying treatment options, if any are needed, for severe HTN.</p><p><strong>Plain-language summary: </strong>Patients who develop severe blood pressure elevation during hospitalization are commonly treated with intravenous antihypertensives; however, this could lead to acute kidney injury (AKI). We wanted to assess whether this is consistent across all patients, using a new statistical approach that predicts what would happen if patients who were treated had not been treated and those who were not treated had been. We found that most patients will develop AKI, and only a small subset of patients might not. This exploratory study can help inform future studies on the treatment of hypertension that develops during hospitalization.</p>","PeriodicalId":7419,"journal":{"name":"American Journal of Kidney Diseases","volume":" ","pages":""},"PeriodicalIF":9.4,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142695188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In Reply to "ACGME Accreditation for Transplant Nephrology Training: Clarifying Why This Is a Step in the Right Direction". ACGME 对移植肾脏病学培训的认证:明确为什么这是朝着正确方向迈出的一步。
IF 9.4 1区 医学
American Journal of Kidney Diseases Pub Date : 2024-11-22 DOI: 10.1053/j.ajkd.2024.11.001
Samira S Farouk, Matthew A Sparks, Fasika Tedla, Roslyn B Mannon
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引用次数: 0
A Young Woman With Nephrotic Syndrome: A Quiz 一名患有肾病综合征的年轻女性:小测验
IF 9.4 1区 医学
American Journal of Kidney Diseases Pub Date : 2024-11-20 DOI: 10.1053/j.ajkd.2024.05.020
Niloufar Ebrahimi , William Whittier , Yan Chen Wongworawat , Orhan Efe , Michifumi Yamashita , Amir Abdipour , Sahibzadi Mahrukh Noor , Lakshmi Ganesan , Sayna Norouzi
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引用次数: 0
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