American Journal of Kidney Diseases最新文献

{"title":"Peripheral Neuropathy Presenting With Hypereosinophilia: A Quiz","authors":"Rex K. Siu , Alexandra C. Hardy , Faaiq N. Aslam , Induja R. Nimma , Sehreen Mumtaz , Sam T. Albadri , Nancy Dawson , Lyle W. Baker","doi":"10.1053/j.ajkd.2025.01.017","DOIUrl":"10.1053/j.ajkd.2025.01.017","url":null,"abstract":"","PeriodicalId":7419,"journal":{"name":"American Journal of Kidney Diseases","volume":"86 1","pages":"Pages A13-A16"},"PeriodicalIF":9.4,"publicationDate":"2025-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144320893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Reply to \"Clarification on Existing Opportunities for POCUS Certifications for Nephrologists\".","authors":"Abhilash Koratala,Amir Kazory","doi":"10.1053/j.ajkd.2025.04.016","DOIUrl":"https://doi.org/10.1053/j.ajkd.2025.04.016","url":null,"abstract":"","PeriodicalId":7419,"journal":{"name":"American Journal of Kidney Diseases","volume":"13 1","pages":""},"PeriodicalIF":13.2,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144319817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Why Do Creatinine- and Cystatin C-Based Estimated GFR Values Often Differ?","authors":"Antoine Créon,Andrew S Levey,Juan J Carrero","doi":"10.1053/j.ajkd.2025.05.002","DOIUrl":"https://doi.org/10.1053/j.ajkd.2025.05.002","url":null,"abstract":"","PeriodicalId":7419,"journal":{"name":"American Journal of Kidney Diseases","volume":"5 1","pages":""},"PeriodicalIF":13.2,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clarification on Existing Opportunities for POCUS Certifications for Nephrologists.","authors":"Daniel W Ross,Andrew A Moses,Adina S Voiculescu,Vandana Dua Niyyar","doi":"10.1053/j.ajkd.2025.04.015","DOIUrl":"https://doi.org/10.1053/j.ajkd.2025.04.015","url":null,"abstract":"","PeriodicalId":7419,"journal":{"name":"American Journal of Kidney Diseases","volume":"145 1","pages":""},"PeriodicalIF":13.2,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144319816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Financial Nephrotoxicity: Prevention Is Better Than Cure.","authors":"Simon Sawhney, Nicole Scholes-Robertson","doi":"10.1053/j.ajkd.2025.05.001","DOIUrl":"https://doi.org/10.1053/j.ajkd.2025.05.001","url":null,"abstract":"","PeriodicalId":7419,"journal":{"name":"American Journal of Kidney Diseases","volume":" ","pages":""},"PeriodicalIF":9.4,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144281957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reframing Risk in CKD: Inflammation at the Center Stage.","authors":"Peter Stenvinkel","doi":"10.1053/j.ajkd.2025.04.010","DOIUrl":"https://doi.org/10.1053/j.ajkd.2025.04.010","url":null,"abstract":"","PeriodicalId":7419,"journal":{"name":"American Journal of Kidney Diseases","volume":" ","pages":""},"PeriodicalIF":9.4,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144273946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"To Stay or to Fold: Biomarkers and the Management of Potentially Hemodynamic Acute Kidney Injury.","authors":"Justin M Belcher","doi":"10.1053/j.ajkd.2025.04.006","DOIUrl":"https://doi.org/10.1053/j.ajkd.2025.04.006","url":null,"abstract":"","PeriodicalId":7419,"journal":{"name":"American Journal of Kidney Diseases","volume":" ","pages":""},"PeriodicalIF":9.4,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144273947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mortality on Hemodiafiltration Compared to High-Flux Hemodialysis: A Brazilian Cohort Study.","authors":"Jorge Paulo Strogoff-de-Matos, Maria Eugenia F Canziani, Ana Beatriz L Barra","doi":"10.1053/j.ajkd.2025.04.013","DOIUrl":"https://doi.org/10.1053/j.ajkd.2025.04.013","url":null,"abstract":"<p><strong>Rationale & objective: </strong>Hemodiafiltration (HDF) has been associated with better survival than high flux hemodialysis (HD), but these studies were mainly conducted in developed countries. This study examined the mortality risk among Brazilian patients with kidney failure, comparing treatment with HDF to treatment with high-flux HD.</p><p><strong>Study design: </strong>Observational cohort study.</p><p><strong>Setting & participants: </strong>All adult patients on maintenance dialysis (high-flux HD and HDF) at 29 dialysis facilities in Brazil between January 1, 2022 and December 31, 2023.</p><p><strong>Exposure: </strong>Treatment with HDF patients versus high-flux HD.</p><p><strong>Outcome: </strong>All-cause mortality and cause-specific mortality attributed to cardiovascular/cerebrovascular and infection-related diseases.</p><p><strong>Analytical approach: </strong>Multivariable Cox proportional hazards regression in which dialysis modality was considered a time-updated exposure.</p><p><strong>Results: </strong>8,391 patients were included in the study: 6,787 receiving only high-flux HD, 2,836 receiving HDF, among whom 1,222 had migrated from high-flux HD to HDF during the follow-up period. The two-year survival rates in these groups were 81.2% and 77.9%, respectively (p < 0.001). A significantly lower adjusted death risk was observed among patients receiving HDF versus HD (HR 0.73; 95% confidence interval [CI], 0.63-0.85) in a time-updated analysis. HDF treatment was also associated with the reduction of cardiovascular mortality risk, but not of infection-related death. In the subgroup analysis, the reduction in mortality risk associated with HDF was consistent across subgroups, with a more pronounced effect observed in patients under the age of 65 (HR, 0.56; 95% CI, 0.42-0.77) than for those aged 65 or more (HR, 0.82; 95% CI, 0.70-0.96). In a sensitivity analysis, including only HD and HDF as starting therapy and data censored at the time of dialysis modality change, treatment with HDF was associated with a lower death risk (HR 0.73; 95% CI, 0.62-0.85).</p><p><strong>Limitations: </strong>The retrospective design and a relatively small follow-up period.</p><p><strong>Conclusions: </strong>In this large cohort study conducted in Brazil, patients treated with HDF, compared to those on conventional high-flux HD, exhibited a lower risk of all-cause and cardiovascular mortality.</p>","PeriodicalId":7419,"journal":{"name":"American Journal of Kidney Diseases","volume":" ","pages":""},"PeriodicalIF":9.4,"publicationDate":"2025-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144273945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systemic Inflammation and the Risks of Adverse Kidney Outcomes in Adults With Atherosclerotic Cardiovascular Disease.","authors":"Faizan Mazhar, Edouard L Fu, Anne-Laure Faucon, Paul Hjemdahl, Jimmi Mathisen, Iram Faqir Muhammad, Oscar Plunde, Vlado Perkovic, Katherine R Tuttle, Juan-Jesus Carrero","doi":"10.1053/j.ajkd.2025.04.011","DOIUrl":"https://doi.org/10.1053/j.ajkd.2025.04.011","url":null,"abstract":"<p><strong>Rationale & objective: </strong>Inflammasome activation is involved in the pathogenesis of both atherosclerotic cardiovascular disease (ASCVD) and chronic kidney disease (CKD). This study investigated whether systemic inflammation, measured by C-reactive protein (CRP), is associated with adverse kidney outcomes in adults with ASCVD.</p><p><strong>Study design: </strong>Retrospective cohort study.</p><p><strong>Setting & participants: </strong>83,928 adults with ASCVD in Stockholm, Sweden, who underwent routine CRP testing between 2007 and 2021.</p><p><strong>Exposure(s): </strong>CRP was defined as the geometric mean of serum CRP levels within a 3-month ascertainment window, excluding CRP values potentially associated with an acute inflammatory process.</p><p><strong>Outcome(s): </strong>AKI (based on diagnosis code or KDIGO serum creatinine criteria) and a composite kidney outcome defined as sustained >30% decline in eGFR or kidney failure.</p><p><strong>Analytical approach: </strong>Cause-specific Cox proportional hazards regression.</p><p><strong>Results: </strong>54% of the cohort was male, with mean age of 71 years. 59% of participants had systemic inflammation (CRP ≥2 mg/L). Over a median follow-up of 6.4 years (interquartile range, 3.1-9.8 years), 8371 kidney events, 10,757 AKI events, and 24,954 deaths were recorded. Compared with CRP <1 mg/L, higher CRP categories were associated with increased risks of both outcomes. Compared to a CRP of 1 or less, the adjusted HRs for the composite kidney outcome were 1.16 (95% CI, 1.09-1.23) for CRP >1-3 mg/L, 1.24 (1.17-1.32) for CRP >3-10 mg/L, and 1.35 (1.25-1.46) for CRP >10-20 mg/L. For AKI, the HRs were 1.18 (1.12-1.25), 1.34 (1.27-1.42), and 1.37 (1.28-1.47), respectively.</p><p><strong>Limitations: </strong>Unmeasured confounding inherent to observational studies.</p><p><strong>Conclusions: </strong>In this large cohort of adults with ASCVD, elevated CRP levels were associated with higher risks of adverse kidney outcomes.</p>","PeriodicalId":7419,"journal":{"name":"American Journal of Kidney Diseases","volume":" ","pages":""},"PeriodicalIF":9.4,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144245733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transplant Staff Awareness of Gender Disparities and the Evaluation of Women for Kidney Transplantation.","authors":"Annika Gompers, Jade Buford, Rachel E Patzer, Stephen O Pastan, Ana Rossi, Jessica L Harding","doi":"10.1053/j.ajkd.2025.03.027","DOIUrl":"https://doi.org/10.1053/j.ajkd.2025.03.027","url":null,"abstract":"","PeriodicalId":7419,"journal":{"name":"American Journal of Kidney Diseases","volume":" ","pages":""},"PeriodicalIF":9.4,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144245734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}