Leah M Thornton Hampton, Dana Briggs Wyler, Bethanie Carney Almroth, Scott Coffin, Win Cowger, Darragh Doyle, Eden K Hataley, Sara J Hutton, Magdalena M Mair, Ezra L Miller, Laura Monclús, Emma E Sharpe, Siddiqui Samreen, Kazi Towsif Ahmed, Quinn P V Allamby, Ana L Antonio Vital, Davide Asnicar, Jennifer L Bare, Andrew Barrick, Katherine Berreman, Lidwina Bertrand, Virginia Boone, Agathe Bour, Julian Brehm, Victor Carrasco-Navarro, Travis Cook, Garth A Covernton, Patricia Cubanski, Pedro M C Da Silva, Luan de Souza Leite, Sam M Gene, Ludovic Hermabessiere, Asta Hooge, Yuichi Iwasaki, Natasha Klasios, Christine M Knauss, Azora König Kardgar, Philipp Kropf, Isaac B Kudu, Anna Kukkola, Christian Laforsch, Stephanie B Kennedy, Frederic D L Leusch, Lucy Wei Li, Hsuan-Cheng Lu, Judd Mahan, Uddin Md Saif, Simona Mondellini, John P Norman, Zacharias Pandelides, Tove Petersson, Danielle A Philibert, Elina Kvist, Anja F R M Ramsperger, Gabrielle Rigutto, Sven Ritschar, Monica H Sandgaard, Jona Schmitt, Matthias Schott, Michael Schwarzer, Katryna J Seabrook, Teresa M Seifried, Rohan Sepahi, Mariella Siña, Alex N Testoff, Maaike Vercauteren, Colleen M Wardlaw, Andrew Yeh, Rachel Zajac-Fay, Alvine C Mehinto
{"title":"The Toxicity of Microplastics Explorer (ToMEx) 2.0.","authors":"Leah M Thornton Hampton, Dana Briggs Wyler, Bethanie Carney Almroth, Scott Coffin, Win Cowger, Darragh Doyle, Eden K Hataley, Sara J Hutton, Magdalena M Mair, Ezra L Miller, Laura Monclús, Emma E Sharpe, Siddiqui Samreen, Kazi Towsif Ahmed, Quinn P V Allamby, Ana L Antonio Vital, Davide Asnicar, Jennifer L Bare, Andrew Barrick, Katherine Berreman, Lidwina Bertrand, Virginia Boone, Agathe Bour, Julian Brehm, Victor Carrasco-Navarro, Travis Cook, Garth A Covernton, Patricia Cubanski, Pedro M C Da Silva, Luan de Souza Leite, Sam M Gene, Ludovic Hermabessiere, Asta Hooge, Yuichi Iwasaki, Natasha Klasios, Christine M Knauss, Azora König Kardgar, Philipp Kropf, Isaac B Kudu, Anna Kukkola, Christian Laforsch, Stephanie B Kennedy, Frederic D L Leusch, Lucy Wei Li, Hsuan-Cheng Lu, Judd Mahan, Uddin Md Saif, Simona Mondellini, John P Norman, Zacharias Pandelides, Tove Petersson, Danielle A Philibert, Elina Kvist, Anja F R M Ramsperger, Gabrielle Rigutto, Sven Ritschar, Monica H Sandgaard, Jona Schmitt, Matthias Schott, Michael Schwarzer, Katryna J Seabrook, Teresa M Seifried, Rohan Sepahi, Mariella Siña, Alex N Testoff, Maaike Vercauteren, Colleen M Wardlaw, Andrew Yeh, Rachel Zajac-Fay, Alvine C Mehinto","doi":"10.1186/s43591-025-00145-6","DOIUrl":"10.1186/s43591-025-00145-6","url":null,"abstract":"<p><p>In 2021 the Toxicity of Microplastics Explorer (ToMEx, https://microplastics.sccwrp.org) was released as an open source, open access database and web application for microplastics toxicity. Since then, it has been utilized by the microplastic research community for the exploration, visualization, and analysis of toxicity data for both hazard characterization and risk assessment. The peer-reviewed literature has continued to grow exponentially, making ToMEx out-of-date. To ensure the continued utility of ToMEx, an international crowd-sourcing approach was utilized to update ToMEx by extracting data from additional studies published since the original release. Through this process, both the aquatic and human health ToMEx databases roughly doubled in size, and modest increases in data diversity (e.g., number of species represented, types of test particles) were observed in the aquatic organisms database. However, most trends (e.g., greater toxicities observed with smaller particle sizes, lack of dose-response data etc.) observed in the first iteration of ToMEx remained constant. A previously developed framework for deriving ecological health-based microplastic thresholds using species sensitivity distributions was reapplied to determine how thresholds and their associated uncertainty intervals would change following the database update. Twelve new studies passed minimum screening criteria and were deemed fit for the purpose of threshold derivation. The addition of new data allowed for the separation of freshwater and marine compartments which had previously been combined due to a lack of applicable toxicity data for freshwater species. When molecular and cellular level endpoints were included, freshwater thresholds were comparable or increased from values calculated using previous data (-5 to 2.5-fold change) whereas marine thresholds dramatically decreased (-5000 to -29-fold change). However, when endpoints were restricted to organism and above, marine and freshwater thresholds were comparable to those calculated previously (-20 to 14-fold change). Confidence intervals for both marine and freshwater thresholds remained wide. The doubling of the database increases the value of ToMEx for researchers, particularly those focused on characterizing hazards associated with microplastics. Its utility remains limited for environmental managers as 89% of studies in ToMEx 2.0 failed to meet minimum screening criteria for threshold derivation, highlighting the need to generate fit-for-purpose toxicity data for threshold development. However, ToMEx continues to be a useful research tool, and future iterations could become even more powerful through novel artificial intelligence applications to streamline data curation and even predict toxicological outcomes.</p><p><strong>Supplementary information: </strong>The online version contains supplementary material available at 10.1186/s43591-025-00145-6.</p>","PeriodicalId":74190,"journal":{"name":"Microplastics and nanoplastics","volume":"5 1","pages":"38"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12474654/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145187794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Faith Chebet Tumwet, Anne Richter, Tomas Kleint, T. Scheytt
{"title":"Vertical movement of microplastics by roots of wheat plant (Triticum aestivum) and the plant response in sandy soil","authors":"Faith Chebet Tumwet, Anne Richter, Tomas Kleint, T. Scheytt","doi":"10.1186/s43591-024-00092-8","DOIUrl":"https://doi.org/10.1186/s43591-024-00092-8","url":null,"abstract":"","PeriodicalId":74190,"journal":{"name":"Microplastics and nanoplastics","volume":"33 46","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141924839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kristian Syberg, B. C. Almroth, M. Fernandez, Juan Baztan, Melanie Bergmann, Richard C. Thompson, Sedat Gündoğdu, Doris Knoblauch, Alessio Gomiero, Laura Monclús, Jane Muncke, Justin M. Boucher, Patricia Villarrubia Gomez, Trisia Farrelly
{"title":"Informing the Plastic Treaty negotiations on science - experiences from the Scientists’ Coalition for an Effective Plastic Treaty","authors":"Kristian Syberg, B. C. Almroth, M. Fernandez, Juan Baztan, Melanie Bergmann, Richard C. Thompson, Sedat Gündoğdu, Doris Knoblauch, Alessio Gomiero, Laura Monclús, Jane Muncke, Justin M. Boucher, Patricia Villarrubia Gomez, Trisia Farrelly","doi":"10.1186/s43591-024-00091-9","DOIUrl":"https://doi.org/10.1186/s43591-024-00091-9","url":null,"abstract":"","PeriodicalId":74190,"journal":{"name":"Microplastics and nanoplastics","volume":" 93","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141824808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Emily A. Christopher, Yvette Christopher-de Vries, Anitha Devadoss, L. Mandemaker, Jeske van Boxel, Helena M. Copsey, Hanna M. Dusza, Juliette Legler, Florian Meirer, Jane Muncke, Tim S. Nawrot, N. Saenen, B. Scholz-Böttcher, Lang Tran, Bert M Weckhuysen, Runyu Zou, Lisa Zimmermann, K. Galea, Roel Vermeulen, M. Boyles
{"title":"Impacts of micro- and nanoplastics on early-life health: a roadmap towards risk assessment","authors":"Emily A. Christopher, Yvette Christopher-de Vries, Anitha Devadoss, L. Mandemaker, Jeske van Boxel, Helena M. Copsey, Hanna M. Dusza, Juliette Legler, Florian Meirer, Jane Muncke, Tim S. Nawrot, N. Saenen, B. Scholz-Böttcher, Lang Tran, Bert M Weckhuysen, Runyu Zou, Lisa Zimmermann, K. Galea, Roel Vermeulen, M. Boyles","doi":"10.1186/s43591-024-00089-3","DOIUrl":"https://doi.org/10.1186/s43591-024-00089-3","url":null,"abstract":"","PeriodicalId":74190,"journal":{"name":"Microplastics and nanoplastics","volume":"8 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141685968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Emily Lena Tran, S. Bevers, Casey Smith, Stephanie Brown, Nathan Malone, D. H. Fairbrother, J. Ranville
{"title":"Use of metal-tagged environmentally representative micro- and nanoplastic particles to investigate transport and retention through porous media using single particle ICP-MS","authors":"Emily Lena Tran, S. Bevers, Casey Smith, Stephanie Brown, Nathan Malone, D. H. Fairbrother, J. Ranville","doi":"10.1186/s43591-024-00087-5","DOIUrl":"https://doi.org/10.1186/s43591-024-00087-5","url":null,"abstract":"","PeriodicalId":74190,"journal":{"name":"Microplastics and nanoplastics","volume":"42 19","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140981190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. L. Dawson, Utpal Bose, Dongdong Ni, Joost Laurus Dinant Nelis
{"title":"Unravelling protein corona formation on pristine and leached microplastics","authors":"A. L. Dawson, Utpal Bose, Dongdong Ni, Joost Laurus Dinant Nelis","doi":"10.1186/s43591-024-00086-6","DOIUrl":"https://doi.org/10.1186/s43591-024-00086-6","url":null,"abstract":"","PeriodicalId":74190,"journal":{"name":"Microplastics and nanoplastics","volume":" 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140692085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Patrizia Pfohl, Markus Rueckel, Lars Meyer, Glauco Battagliarin, Andreas Künkel, Thorsten Hüffer, Michael Zumstein, Thilo Hofmann, Wendel Wohlleben
{"title":"Influence of plastic shape on interim fragmentation of compostable materials during composting","authors":"Patrizia Pfohl, Markus Rueckel, Lars Meyer, Glauco Battagliarin, Andreas Künkel, Thorsten Hüffer, Michael Zumstein, Thilo Hofmann, Wendel Wohlleben","doi":"10.1186/s43591-024-00084-8","DOIUrl":"https://doi.org/10.1186/s43591-024-00084-8","url":null,"abstract":"","PeriodicalId":74190,"journal":{"name":"Microplastics and nanoplastics","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140223873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
David Vanavermaete, Amy Lusher, Jakob Strand, Esteban Abad, Marinella Farré, Emilie Kallenbach, Michael Dekimpe, K. Verlé, Sebastian Primpke, Stefano Aliani, Bavo De Witte
{"title":"Plastics in biota: technological readiness level of current methodologies","authors":"David Vanavermaete, Amy Lusher, Jakob Strand, Esteban Abad, Marinella Farré, Emilie Kallenbach, Michael Dekimpe, K. Verlé, Sebastian Primpke, Stefano Aliani, Bavo De Witte","doi":"10.1186/s43591-024-00083-9","DOIUrl":"https://doi.org/10.1186/s43591-024-00083-9","url":null,"abstract":"","PeriodicalId":74190,"journal":{"name":"Microplastics and nanoplastics","volume":"15 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140239224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Farm animals as a critical link between environmental and human health impacts of micro-and nanoplastics","authors":"H. Aardema, A. Vethaak, J. Kamstra, J. Legler","doi":"10.1186/s43591-024-00082-w","DOIUrl":"https://doi.org/10.1186/s43591-024-00082-w","url":null,"abstract":"","PeriodicalId":74190,"journal":{"name":"Microplastics and nanoplastics","volume":"16 32","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140240681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nelle Meyers, Kathrin Kopke, Natalja Buhhalko, Karin Mattsson, Colin R. Janssen, Gert Everaert, B. De Witte
{"title":"Value for money: a cost-effectiveness analysis of microplastic analytics in seawater","authors":"Nelle Meyers, Kathrin Kopke, Natalja Buhhalko, Karin Mattsson, Colin R. Janssen, Gert Everaert, B. De Witte","doi":"10.1186/s43591-024-00081-x","DOIUrl":"https://doi.org/10.1186/s43591-024-00081-x","url":null,"abstract":"","PeriodicalId":74190,"journal":{"name":"Microplastics and nanoplastics","volume":" 528","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139787363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}