Medicines (Basel, Switzerland)最新文献_第7页

Evaluating Cataract Surgical Rate through Smart Partnership between Ministry of Health, Malaysia and Federal Territory Islamic Religious Council. 通过马来西亚卫生部和联邦领土伊斯兰宗教委员会之间的明智伙伴关系评估白内障手术率。

Medicines (Basel, Switzerland) Pub Date : 2023-01-12 DOI: 10.3390/medicines10010012

Nor Fariza Ngah, Nor Asiah Muhamad, Roslin Azni Abdul Aziz, Elias Hussein, Mohammad Aziz Salowi, Zabri Kamarudin, Noor Hisham Abdullah, Tahir Aris

{"title":"Evaluating Cataract Surgical Rate through Smart Partnership between Ministry of Health, Malaysia and Federal Territory Islamic Religious Council.","authors":"Nor Fariza Ngah, Nor Asiah Muhamad, Roslin Azni Abdul Aziz, Elias Hussein, Mohammad Aziz Salowi, Zabri Kamarudin, Noor Hisham Abdullah, Tahir Aris","doi":"10.3390/medicines10010012","DOIUrl":"https://doi.org/10.3390/medicines10010012","url":null,"abstract":"Introduction: Cataract is the leading cause of blindness. About 90% of cataract blindness occurs in low- and middle-income countries. The prevalence of blindness and low vision in any country depends on the socioeconomic status, the availability of medical and healthcare facilities, and the literacy of the population.Aim: This paper aims to estimate the cataract surgery rate (CSR) at Pusat Pembedahan Katarak, MAIWP-Hospital Selayang (Cataract Operation Centre), and provide descriptive assessments of the patients who received eye treatments in the center.Methods: The data were retrieved from the clinical database from 2013 to 2016. Information on the patient's sociodemographic and clinical and treatment history was collected.Results: The cataract surgery rate for 2013 was about 27 and increased to 37.3 in 2014. However, it declined to 25 in 2015 before it resumed to 36 in 2016. For female patients who received eye treatments at Pusat Pembedahan Katarak, MAIWP-Hospital Selayang, the rate was higher (53.7%) compared to male patients (46.3%). The mean duration of cataract surgery from 2013 to 2016 was 21.25 ± 11.071 min.Conclusion: The increased cataract surgery rate for MAIWP-HS through smart partnerships for day care cataract surgery proved that better accessibility makes the short- and long-term strategies for the reduction and prevention of blindness in Malaysia possible to achieve.","PeriodicalId":74162,"journal":{"name":"Medicines (Basel, Switzerland)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9860600/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9140458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Choroidal Melanoma: A Mini Review. 脉络膜黑色素瘤:一个小回顾。

Medicines (Basel, Switzerland) Pub Date : 2023-01-05 DOI: 10.3390/medicines10010011

Noha Soliman, Diaa Mamdouh, Aisha Elkordi

引用次数: 0

Disseminated MAI in an HIV Patient-An Unusual Presentation. HIV患者弥散性MAI -一种不寻常的表现。

Medicines (Basel, Switzerland) Pub Date : 2023-01-05 DOI: 10.3390/medicines10010010

Joshni Simon, Joella Lambert, Jose Mosco-Guzman, Kaitlyn Dittmer, Alison Stern-Harbutte, Weston Connelly

引用次数: 0

First-in-Human Study to Investigate the Safety Assessment of Peri-Implant Soft Tissue Regeneration with Micronized-Gingival Connective Tissue: A Pilot Case Series Study. 用微粉化牙龈结缔组织进行种植体周围软组织再生安全性评估的首次人体研究:一项试点病例系列研究。

Medicines (Basel, Switzerland) Pub Date : 2023-01-04 DOI: 10.3390/medicines10010009

Takashi I, Sawako Noda, Seigo Ohba, Izumi Asahina, Yoshinori Sumita

{"title":"First-in-Human Study to Investigate the Safety Assessment of Peri-Implant Soft Tissue Regeneration with Micronized-Gingival Connective Tissue: A Pilot Case Series Study.","authors":"Takashi I, Sawako Noda, Seigo Ohba, Izumi Asahina, Yoshinori Sumita","doi":"10.3390/medicines10010009","DOIUrl":"https://doi.org/10.3390/medicines10010009","url":null,"abstract":"Background: We have recently proposed an alternative strategy of free gingival graft (FGG) and connective tissue graft (CTG) using micronized-gingival connective tissues (MGCTs). The advantage of this strategy is that MGCTs from a small piece of maxillary tuberosity can regenerate the keratinized tissue band. However, safety and efficacy have not yet been established in patients. This clinical study was a pilot case series, and the objective was to assess the safety and the preliminary efficacy of MGCTs on peri-implant mucosa regeneration. Methods: This was a pilot interventional, single-center, first-in-human (FIH), open (no masking), uncontrolled, and single-assignment study. A total of 4 patients who needed peri-implant soft tissues reconstruction around dental implants received transplantation of atelocollagen-matrix with MGCTs micronized by the tissue disruptor technique. The duration of intervention was 4 weeks after surgery. Results: This first clinical study demonstrated that using MGCTs did not cause any irreversible adverse events, and it showed the preliminary efficacy for peri-implant soft tissues reconstruction in dental implant therapy. Conclusions: Though further studies are needed on an appropriate scale, as an alternative strategy of FGG or CTG, MGCTs might be promising for peri-implant mucosa reconstruction without requiring a high level of skills and morbidity to harvest graft tissues.","PeriodicalId":74162,"journal":{"name":"Medicines (Basel, Switzerland)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9865433/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10551271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel Polyethylene Terephthalate Screw Sleeve Implant: Salvage Treatment in a Case of Spine Instability after Vertebroplasty Failure. 新型聚对苯二甲酸乙二醇酯螺钉套植入物:椎体成形术失败后脊柱不稳定的抢救治疗一例。

Medicines (Basel, Switzerland) Pub Date : 2022-12-30 DOI: 10.3390/medicines10010006

Giacomo Drago, Giulia Pastorello, Paolo Gallinaro, Roberto Zanata, Jacopo Del Verme, Altin Stafa, Enrico Giordan

{"title":"Novel Polyethylene Terephthalate Screw Sleeve Implant: Salvage Treatment in a Case of Spine Instability after Vertebroplasty Failure.","authors":"Giacomo Drago, Giulia Pastorello, Paolo Gallinaro, Roberto Zanata, Jacopo Del Verme, Altin Stafa, Enrico Giordan","doi":"10.3390/medicines10010006","DOIUrl":"https://doi.org/10.3390/medicines10010006","url":null,"abstract":"Introduction: The management of osteoporotic fractures is sometimes rather challenging for spinal surgeons, and considering the longer life expectancy induced by improved living conditions, their prevalence is expected to increase. At present, the approaches to osteoporotic fractures differ depending on their severity, location, and the patient's age. State-of-the-art treatments range from vertebroplasty/kyphoplasty to hardware-based spinal stabilization in which screw augmentation with cement is the gold standard.Case presentation: We describe the case of a 74-year-old man with an L5 osteoporotic fracture. The patient underwent a vertebroplasty (VP) procedure, which was complicated by a symptomatic cement leakage in the right L4-L5 neuroforamen. We urgently decompressed the affected pedicle via hemilaminectomy. At that point, the column required stability. The extravasation of cement had ruled out the use of cement-augmented pedicle screws but leaving the pedicular screws alone was not considered sufficient to achieve stability. We decided to cover the screws with a polyethylene terephthalate sleeve (OGmend®) to avoid additional cement leakage and to reinforce the screw strength required by the poor bone quality.Conclusion: In the evolving technologies used for spinal surgery, screws sleeve implants such as OGmend® are a useful addition to the surgeon's armamentarium when an increased pull-out strength is required and other options are not available.","PeriodicalId":74162,"journal":{"name":"Medicines (Basel, Switzerland)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9861514/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9140454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Safety and Evaluation of the Immune Response of Coronavirus Nosode (BiosimCovex) in Healthy Volunteers: A Preliminary Study Extending the Homeopathic Pathogenetic Trial. 在健康志愿者中使用冠状病毒 Nosode（BiosimCovex）的安全性和免疫反应评估：顺势疗法病原体试验的初步扩展研究。

Medicines (Basel, Switzerland) Pub Date : 2022-12-30 DOI: 10.3390/medicines10010008

Paul Herscu, Gitanjali Talele, Shashikant Vaidya, Rajesh Shah

{"title":"Safety and Evaluation of the Immune Response of Coronavirus Nosode (BiosimCovex) in Healthy Volunteers: A Preliminary Study Extending the Homeopathic Pathogenetic Trial.","authors":"Paul Herscu, Gitanjali Talele, Shashikant Vaidya, Rajesh Shah","doi":"10.3390/medicines10010008","DOIUrl":"10.3390/medicines10010008","url":null,"abstract":"Objectives: Regulatory clinical Phase I studies are aimed at establishing the human safety of an active pharmaceutical agent to be later marketed as a drug. Since homeopathic medicines are prepared by a potentizing method using alcohol, past a certain dilution, their toxicity/infectivity is assumed to be unlikely. We aimed to develop a bridge study between homeopathic pathogenetic trials and clinical trials. The primary purpose was to evaluate the safety of a nosode, developed from clinical samples of a COVID-19 patient. The secondary objectives were to explore whether a nosode developed for a specific clinical purpose, such as use during an epidemic, may elicit laboratory signals worthy of further exploration. Methods: An open-label study was designed to evaluate the safety and immune response of the Coronavirus nosode BiosimCovex, given orally on three consecutive days to ten healthy volunteers. Clinical examinations, laboratory safety and immune parameters were established. Interferon-gamma, Interleukin-6, and CD 4 were measured. (CTRI registration number: CTRI/2020/05/025496). Results: No serious/fatal adverse events were reported. Laboratory tests to measure safety were unchanged. Three subjects showed elevated Interleukin-6 (IL-6) on day 17 in comparison to the baseline, and ten subjects showed elevated IL-6 on day 34. A significant difference between IL-6 observations, calculated by repeated measures ANOVA, was found to be highly significant. On day 60, the IL-6 values of nine subjects were found to return to normal. Corresponding CD4 cell elevation was observed on day 60, when compared to day 34. Conclusions: HPT may potentially extend into physiological changes with regards to immune response and should encourage future studies.","PeriodicalId":74162,"journal":{"name":"Medicines (Basel, Switzerland)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9865918/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10551270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Prospective Study of Mid-Trimester MCP-1 Levels as a Predictor of Preterm Delivery. 妊娠中期MCP-1水平作为早产预测因子的前瞻性研究。

Medicines (Basel, Switzerland) Pub Date : 2022-12-30 DOI: 10.3390/medicines10010007

Mirjana A Bogavac, Dejan D Ćelić, Tamara M Perić

{"title":"A Prospective Study of Mid-Trimester MCP-1 Levels as a Predictor of Preterm Delivery.","authors":"Mirjana A Bogavac, Dejan D Ćelić, Tamara M Perić","doi":"10.3390/medicines10010007","DOIUrl":"https://doi.org/10.3390/medicines10010007","url":null,"abstract":"Background: The prevention of preterm delivery (PTD) represents one of the major topics in modern obstetrics. The aim was to design a prospective study and investigate if mid-trimester serum and amniotic fluid levels of MCP-1 could predict the occurence of spontaneous PTD. Methods: The study involved 198 women who underwent genetic amniocentesis and blood sampling in the middle of their trimester. After applying the criteria for inclusion in the study, there were 16 respondents in the study group, and 38 respondents in the control group. Level of MCP-1 in amniotic fluid and serum was measured with commercially available enzyme-linked immunosorbent assays (ELISA) and statistical analysis was conducted. Results: There was no statistically significant difference in serum or amniotic fluid MCP1 levels between PTD and the control groups. Conclusion: The results suggest that MCP-1 is probably not the most relevant marker for predicting PTD. This study provides new normative data for MCP-1 levels in amniotic fluid and maternal sera and is a valuable tool for future diagnostic and comparative studies.","PeriodicalId":74162,"journal":{"name":"Medicines (Basel, Switzerland)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9866850/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9073348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Use of Traditional Mongolian Medicine in Children with Concussion. 蒙药在儿童脑震荡中的应用。

Medicines (Basel, Switzerland) Pub Date : 2022-12-30 DOI: 10.3390/medicines10010005

Orgilbayar Ganbat, Oyuntugs Byambasukh, Tserendagva Dalkh, Byambasuren Dagvajantsan

{"title":"Use of Traditional Mongolian Medicine in Children with Concussion.","authors":"Orgilbayar Ganbat, Oyuntugs Byambasukh, Tserendagva Dalkh, Byambasuren Dagvajantsan","doi":"10.3390/medicines10010005","DOIUrl":"https://doi.org/10.3390/medicines10010005","url":null,"abstract":"(1) Background: There is no specific treatment for concussion in modern medicine, and existing treatment is only limited to resting and restoring cognition. For centuries, Mongolians have used traditional Mongolian medicine (TMM) methods to treat a variety of diseases such as Baria zasal. In this study, we aimed to explore the treatment parents and guardians seek when their children have suffered a concussion. (2) Methods: In this study, we used an online questionnaire. The study participants (n = 400) were randomly selected parents and guardians. The definition of bariachi is an advanced practitioner of baria zasal, which covers most of the massage therapy techniques mentioned in this study. (3) Results: In total, 72% of the parents and guardians went to a bariachi when their children suffered a concussion, while only 10.3% chose western medical hospitals. When asked what they did after the initial treatment was not effective, 47.8% of the participants responded that they went to the bariachi. Based on the days of treatment result, 11.8% reported on the beneficial effects of the treatment appearing in one day, and 60.3% in 1−3 days, which shows that the participants suffered a healing effect of the baria zasal shortly after application to their children. In the regression analysis, visiting a Bariachi was independent of age, gender, or even religion. (4) Conclusions: Although Western medicine is highly developed in Mongolia, the baria zasal of TMM has not lost its appeal in treating concussion. This suggests that baria zasal could be a unique method of concussion treatment even today. This also suggests that the techniques of Baria zasal should be further studied, and as in modern medicine.","PeriodicalId":74162,"journal":{"name":"Medicines (Basel, Switzerland)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9863045/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9073349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

DNA Damage as a Mechanistic Link between Air Pollution and Obesity? DNA损伤是空气污染与肥胖之间的机制联系?

Medicines (Basel, Switzerland) Pub Date : 2022-12-29 DOI: 10.3390/medicines10010004

Abdelaziz Ghanemi, Mayumi Yoshioka, Jonny St-Amand

引用次数: 1

Potential of Mesenchymal Stem Cells and Their Secretomes in Decreasing Inflammation Markers in Polycystic Ovary Syndrome Treatment: A Systematic Review. 间充质干细胞及其分泌组在多囊卵巢综合征治疗中降低炎症标志物的潜力:系统综述。

Medicines (Basel, Switzerland) Pub Date : 2022-12-23 DOI: 10.3390/medicines10010003

Gunawan Dwi Prayitno, Keri Lestari, Cynthia Retna Sartika, Tono Djuwantono, Andi Widjaya, R Muharam, Yudi Mulyana Hidayat, Dewi Wulandari, Rima Haifa, Nabilla Farah Naura, Kristin Talia Marbun, Annisah Zahrah

{"title":"Potential of Mesenchymal Stem Cells and Their Secretomes in Decreasing Inflammation Markers in Polycystic Ovary Syndrome Treatment: A Systematic Review.","authors":"Gunawan Dwi Prayitno, Keri Lestari, Cynthia Retna Sartika, Tono Djuwantono, Andi Widjaya, R Muharam, Yudi Mulyana Hidayat, Dewi Wulandari, Rima Haifa, Nabilla Farah Naura, Kristin Talia Marbun, Annisah Zahrah","doi":"10.3390/medicines10010003","DOIUrl":"https://doi.org/10.3390/medicines10010003","url":null,"abstract":"Background: Polycystic ovary syndrome (PCOS) is a chronic disorder and is one of the most common endocrine disorders in women of a reproductive age. The prevalence of PCOS is growing globally; 52% of women in Southeast Asia alone suffer from this disorder. This disorder is caused by chronic hyperandrogenism, which hinders folliculogenesis. There is also a close relationship between hyperandrogenism and hyperinsulinemia/insulin resistance (IR), and it is estimated that 40-80% of PCOS patients suffer from insulin resistance (IR). Mesenchymal stem cells (MSCs) and their secretomes have been shown to alleviate PCOS symptoms by decreasing IR and androgen secretion by reducing inflammation. This study aimed to systematically review the literature to study the reported potential of MSCs and their secretomes in decreasing inflammation markers in PCOS treatment. Methods: A systematic literature search was performed on EMBASE, PubMed (MEDLINE), and the Cochrane Library with the terms insulin-resistant PCOS, mesenchymal stem cells, and secretome or conditioned medium as the search keywords. A total of 317 articles were reviewed. Four articles were identified as relevant for this systematic review. Results: The results of this study supported the use of mesenchymal stem cells and their secretions in decreasing inflammatory markers in the treatment of polycystic ovary syndrome. Conclusions: This review provided evidence that treatment with mesenchymal stem cells and their secretomes has the potential to treat PCOS due to its ability to downregulate androgen levels and increase insulin sensitivity, which thereby lowers the level of proinflammatory factors.","PeriodicalId":74162,"journal":{"name":"Medicines (Basel, Switzerland)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9864810/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9140453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2