Medicines (Basel, Switzerland)最新文献_第10页

Post-Traumatic-Related Technical Errors in Orthopantomographic Imaging. 骨科断层成像中创伤后相关技术错误。

Medicines (Basel, Switzerland) Pub Date : 2022-12-09 DOI: 10.3390/medicines9120063

Oana Almășan, Raluca Ancuța Roman, Mihaela Hedeşiu, Simion Bran, Sara Roman, Bianca Petric, Cristian Dinu

{"title":"Post-Traumatic-Related Technical Errors in Orthopantomographic Imaging.","authors":"Oana Almășan, Raluca Ancuța Roman, Mihaela Hedeşiu, Simion Bran, Sara Roman, Bianca Petric, Cristian Dinu","doi":"10.3390/medicines9120063","DOIUrl":"https://doi.org/10.3390/medicines9120063","url":null,"abstract":"Background: This study aimed at identifying errors encountered in orthopantomography (OPG) in post-traumatic patients caused by limitations in performing a correct technique. Methods: A retrospective observational study was performed. Diagnosis, exposure/processing mistakes, positioning-related errors, and bimaxillary immobilization were evaluated. Results: Thirty panoramic radiographs with mandible fractures were examined. Twelve error types were encountered: errors in exposure or processing, air radiolucency in the palatoglossal space, errors in the alignment of the Frankfort horizontal plane: head in flexion, with a joyful expression or head extended, with a somber appearance, errors towards the mid-sagittal plane (lateral head inclination, deviation, or rotation), errors caused by the non-use of the bite-block or inappropriate position on the device, errors caused by positioning outside the focal plane, artifacts/shadow images produced by post-operative metal plates, and bimaxillary immobilization errors. The number of errors per radiograph ranged from two to a maximum of five. The most dominant ones were inappropriate alignment in the focal plane and lateral rotation of the head in over 70% of cases. Lateral deviation and palatoglossal air were present in more than 50% of images. Conclusions: In trauma cases, technical difficulties in obtaining a proper OPG image are common and often insurmountable, limiting the diagnosis.","PeriodicalId":74162,"journal":{"name":"Medicines (Basel, Switzerland)","volume":"9 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9785702/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10423379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Antimicrobial and Toxic Effects of Boswellia serrata Roxb. and Mentha piperita Linn. Essential Oils on Vaginal Inhabitants. 乳香（Boswellia serrata Roxb.）和薄荷（Mentha piperita Linn.精油对阴道居民的抗菌和毒性作用。

Medicines (Basel, Switzerland) Pub Date : 2022-12-09 DOI: 10.3390/medicines9120062

Mirjana A Bogavac, Tamara M Perić, Jovana Mišković, Maja Karaman

{"title":"Antimicrobial and Toxic Effects of Boswellia serrata Roxb. and Mentha piperita Linn. Essential Oils on Vaginal Inhabitants.","authors":"Mirjana A Bogavac, Tamara M Perić, Jovana Mišković, Maja Karaman","doi":"10.3390/medicines9120062","DOIUrl":"10.3390/medicines9120062","url":null,"abstract":"Commercial essential oils (EOs) of incense, Boswellia serrata Roxb, and mint, Mentha piperita L., were investigated against vaginal bacterial and Candida albicans isolates for antimicrobial potential and safety use. The antimicrobial activity of EOs was investigated through a double-dilution micro-plate assay. A brine shrimp assay was used for the determination of toxicity, while the determination of the chemical composition of EOs was carried out using GS-MS. Obtained minimal inhibitory (MIC) and minimal bactericidal concentration (MBC) point to the activity of mint essential oil (EO) against the multi-resistant P. aeruginosa isolate (MIC/MBC at 6.25 µL/mL), while MIC and MBC values for other isolates were reached at higher concentrations (25-50 µL/mL). According to the toxicity assay, the incense EO reached the LC50 value at 3.07 µL/mL, while mint EO showed higher toxicity at lower concentrations (0.5 µL/mL) and the LC50 could not be determined. The highest antimicrobial potential was obtained for incense against P. aeruginosa. Although the toxicity assay showed high toxicity of mint EO to the eggs of aquatic crustaceans Artemia salina, further testing of EO toxicity is proposed, for example on healthy cell-lines. According to the GC/MS spectrometry, the most represented components of mint EO were the oxygenated hydrocarbons L-menthone (20.86%) and menthol (31.86%), and they could be proposed for further antimicrobial and toxicity investigation.","PeriodicalId":74162,"journal":{"name":"Medicines (Basel, Switzerland)","volume":"9 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9784983/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10433597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Salvage of Hindfoot Charcot with Osteomyelitis and Ulceration: A Case Report. 后足骨髓炎及溃疡的抢救1例。

Medicines (Basel, Switzerland) Pub Date : 2022-12-02 DOI: 10.3390/medicines9120061

Khalid Hasan, Sreenivasulu Metikala, Madana Mohana R Vallem

引用次数: 0

Group Medical Visits for Addressing Weight and Blood Pressure in an Underserved Population. 在服务不足人群中解决体重和血压问题的团体医疗访问。

Medicines (Basel, Switzerland) Pub Date : 2022-12-01 DOI: 10.3390/medicines9120060

Amit Algotar, Stephanie Trofymenko, Myra Muramoto, Amy Howerter, Randa Kutob

引用次数: 0

The Incidence and Risk Factors of Urinary Tract Infection in Patients with Type 2 Diabetes Mellitus Using SGLT2 Inhibitors: A Real-World Observational Study. 使用SGLT2抑制剂的2型糖尿病患者尿路感染的发生率和危险因素:一项真实世界的观察性研究

Medicines (Basel, Switzerland) Pub Date : 2022-11-22 DOI: 10.3390/medicines9120059

Suriyon Uitrakul, Krittika Aksonnam, Pimchanok Srivichai, Sorawit Wicheannarat, Supatcha Incomenoy

{"title":"The Incidence and Risk Factors of Urinary Tract Infection in Patients with Type 2 Diabetes Mellitus Using SGLT2 Inhibitors: A Real-World Observational Study.","authors":"Suriyon Uitrakul, Krittika Aksonnam, Pimchanok Srivichai, Sorawit Wicheannarat, Supatcha Incomenoy","doi":"10.3390/medicines9120059","DOIUrl":"https://doi.org/10.3390/medicines9120059","url":null,"abstract":"Background: The incidence and risk of urinary tract infection (UTI) in patients with type 2 diabetes mellitus (T2DM) who use sodium glucose co-transporter-2 (SGLT2) inhibitors are still controversial. Therefore, this study aimed to investigate the incidence and risk factors of using SGLT2 inhibitors, particularly in Thai patients. Methods: Electronic medication records of all patients, who started the treatment of T2DM between 1 January 2019 and 30 June 2021 at a tertiary hospital in Thailand, were reviewed. The patients were divided into SGLT2 inhibitor and non-SGLT2 inhibitor groups to compare the incidence of UTI. Results: The overall incidence rate of UTI was 33.49% in the SGLT2 inhibitor group and 11.72% in the non-SGLT2 inhibitor group. The incidence rates of UTI were not different between dapagliflozin and empagliflozin treatment (34.00% and 33.03%, respectively). Patients treated with SGLT2 inhibitors had a 3.70 higher risk of UTI compared with those treated with non-SGLT2 inhibitors (95%CI 2.60-5.29). Moreover, the significant risk factors for UTI found in this study were gender, age, and occupation. Conclusions: This study highlighted the high incidence of UTI in patients using dapagliflozin and empagliflozin compared with non-SGLT2 inhibitors. Additionally, patients of female gender and older age had a significantly higher risk of UTI when treated with SGLT2 inhibitors, whereas those with permanent jobs had a lower risk.","PeriodicalId":74162,"journal":{"name":"Medicines (Basel, Switzerland)","volume":"9 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9785475/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10426014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Zulfiqar Frailty Scale (ZFS): Concordance Study with the Clinical Frailty Scale (CFS). Zulfiqar衰弱量表(ZFS):与临床衰弱量表(CFS)的一致性研究。

Medicines (Basel, Switzerland) Pub Date : 2022-11-18 DOI: 10.3390/medicines9110058

Abrar-Ahmad Zulfiqar, Léo Martin, Perla Habchi, Delwende Noaga Damien Massimbo, Ibrahima Amadou Dembele, Emmanuel Andres

{"title":"Zulfiqar Frailty Scale (ZFS): Concordance Study with the Clinical Frailty Scale (CFS).","authors":"Abrar-Ahmad Zulfiqar, Léo Martin, Perla Habchi, Delwende Noaga Damien Massimbo, Ibrahima Amadou Dembele, Emmanuel Andres","doi":"10.3390/medicines9110058","DOIUrl":"https://doi.org/10.3390/medicines9110058","url":null,"abstract":"Introduction: We designed a new scale for the rapid detection of frailty for use in primary care, referred to as the Zulfiqar Frailty Scale (ZFS). Objective: To evaluate the performance of the “ZFS” tool to screen for frailty as defined in the Clinical Frailty Scale (CFS) criteria in an ambulatory population of patients at least 75 years old. Method: A prospective study conducted in Alsace, France, for a duration of 6 months that included patients aged 75 and over was judged to be autonomous with an ADL (Activity of Daily Living) > 4/6. Results: In this ambulatory population of 124 patients with an average age of 79 years, the completion time for our scale was less than two minutes, and the staff required no training beforehand. Sensibility was 67%, while specificity was 87%. The positive predictive value was 80%, and the negative predictive value was 77%. The Youden index was 59.8%. In our study, we have a moderate correlation between CFS and ZFS (r = 0.674 with 95%CI = [0.565; 0.760]; p-value < 2.2 × 10−16 < 0.05). The Pearson correlations between these two geriatric scores were all strong and roughly equivalent to each other. The kappa of Cohen (k) = 0.46 (Unweighted), moderate concordance between the ZFS and CFS scales according to Fleiss classification. Conclusion: The “ZFS” tool makes it possible to screen for frailty with a high level of specificity and positive/negative predictive value.","PeriodicalId":74162,"journal":{"name":"Medicines (Basel, Switzerland)","volume":"9 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9695739/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10842930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The Role of Equilibrium between Free Radicals and Antioxidants in Depression and Bipolar Disorder. 抑郁症和双相情感障碍中自由基和抗氧化剂平衡的作用。

Medicines (Basel, Switzerland) Pub Date : 2022-11-14 DOI: 10.3390/medicines9110057

Anastasia Kotzaeroglou, Ioannis Tsamesidis

{"title":"The Role of Equilibrium between Free Radicals and Antioxidants in Depression and Bipolar Disorder.","authors":"Anastasia Kotzaeroglou, Ioannis Tsamesidis","doi":"10.3390/medicines9110057","DOIUrl":"https://doi.org/10.3390/medicines9110057","url":null,"abstract":"Background: Increasing evidence suggests that the presence of oxidative stress and disorders of the antioxidant defense system are involved in a wide range of neuropsychiatric disorders, such as bipolar disorder, schizophrenia and major depression, but the exact mechanism remains unknown. This review focuses on a better appreciation of the contribution of oxidative stress to depression and bipolar disorder. Methods: This review was conducted by extracting information from other research and review studies, as well as other meta-analyses, using two search engines, PubMed and Google Scholar. Results: As far as depression is concerned, there is agreement among researchers on the association between oxidative stress and antioxidants. In bipolar disorder, however, most of them observe strong lipid peroxidation in patients, while regarding antioxidant levels, opinions are divided. Nevertheless, in recent years, it seems that on depression, there are mainly meta-analyses and reviews, rather than research studies, unlike on bipolar disorder. Conclusions: Undoubtedly, this review shows that there is an association among oxidative stress, free radicals and antioxidants in both mental disorders, but further research should be performed on the exact role of oxidative stress in the pathophysiology of these diseases.","PeriodicalId":74162,"journal":{"name":"Medicines (Basel, Switzerland)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9694953/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40509579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Antidiabetic Actions of Ethanol Extract of Camellia sinensis Leaf Ameliorates Insulin Secretion, Inhibits the DPP-IV Enzyme, Improves Glucose Tolerance, and Increases Active GLP-1 (7-36) Levels in High-Fat-Diet-Fed Rats. 茶树叶乙醇提取物改善高脂饮食大鼠胰岛素分泌、抑制DPP-IV酶、改善葡萄糖耐量和增加活性GLP-1(7-36)水平的降糖作用

Medicines (Basel, Switzerland) Pub Date : 2022-11-11 DOI: 10.3390/medicines9110056

Prawej Ansari, J M A Hannan, Samara T Choudhury, Sara S Islam, Abdullah Talukder, Veronique Seidel, Yasser H A Abdel-Wahab

{"title":"Antidiabetic Actions of Ethanol Extract of Camellia sinensis Leaf Ameliorates Insulin Secretion, Inhibits the DPP-IV Enzyme, Improves Glucose Tolerance, and Increases Active GLP-1 (7-36) Levels in High-Fat-Diet-Fed Rats.","authors":"Prawej Ansari, J M A Hannan, Samara T Choudhury, Sara S Islam, Abdullah Talukder, Veronique Seidel, Yasser H A Abdel-Wahab","doi":"10.3390/medicines9110056","DOIUrl":"https://doi.org/10.3390/medicines9110056","url":null,"abstract":"Camellia sinensis (green tea) is used in traditional medicine to treat a wide range of ailments. In the present study, the insulin-releasing and glucose-lowering effects of the ethanol extract of Camellia sinensis (EECS), along with molecular mechanism/s of action, were investigated in vitro and in vivo. The insulin secretion was measured using clonal pancreatic BRIN BD11 β cells, and mouse islets. In vitro models examined the additional glucose-lowering properties of EECS, and 3T3L1 adipocytes were used to assess glucose uptake and insulin action. Non-toxic doses of EECS increased insulin secretion in a concentration-dependent manner, and this regulatory effect was similar to that of glucagon-like peptide 1 (GLP-1). The insulin release was further enhanced when combined with isobutylmethylxanthine (IBMX), tolbutamide or 30 mM KCl, but was decreased in the presence of verapamil, diazoxide and Ca2+ chelation. EECS also depolarized the β-cell membrane and elevated intracellular Ca2+, suggesting the involvement of a KATP-dependent pathway. Furthermore, EECS increased glucose uptake and insulin action in 3T3-L1 cells and inhibited dipeptidyl peptidase IV (DPP-IV) enzyme activity, starch digestion and protein glycation in vitro. Oral administration of EECS improved glucose tolerance and plasma insulin as well as inhibited plasma DPP-IV and increased active GLP-1 (7-36) levels in high-fat-diet-fed rats. Flavonoids and other phytochemicals present in EECS could be responsible for these effects. Further research on the mechanism of action of EECS compounds could lead to the development of cost-effective treatments for type 2 diabetes.","PeriodicalId":74162,"journal":{"name":"Medicines (Basel, Switzerland)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9698069/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40509578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Estimating Worldwide Impact of Low Physical Activity on Risk of Developing Ischemic Heart Disease-Related Disability: An Updated Search in the 2019 Global Health Data Exchange (GHDx). 估计低体力活动对缺血性心脏病相关残疾风险的全球影响:2019年全球健康数据交换(GHDx)中的最新搜索

Medicines (Basel, Switzerland) Pub Date : 2022-11-03 DOI: 10.3390/medicines9110055

Giuseppe Lippi, Fabian Sanchis-Gomar, Camilla Mattiuzzi, Carl J Lavie

{"title":"Estimating Worldwide Impact of Low Physical Activity on Risk of Developing Ischemic Heart Disease-Related Disability: An Updated Search in the 2019 Global Health Data Exchange (GHDx).","authors":"Giuseppe Lippi, Fabian Sanchis-Gomar, Camilla Mattiuzzi, Carl J Lavie","doi":"10.3390/medicines9110055","DOIUrl":"https://doi.org/10.3390/medicines9110055","url":null,"abstract":"We provide here updated analysis of the impact of physical inactivity on risk of developing ischemic heart disease (IHD)-related disability along with the latest 10-year progression. We collected data through an electronic search in the 2019 Global Health Data Exchange (GHDx) database using the keywords \"low physical activity\", complemented with the additional epidemiologic variables \"disability-adjusted life years\" (DALYs; number); \"ischemic heart disease\"; \"socio-demographic index\" (SDI); \"age\"; \"sex\" and \"year\", for calculating volume of DALYs lost due to physical activity (PA)-related disability after IHD (LPA-IHD impairment). Based on this search, the overall LPA-IHD impairment was estimated at 7.6 million DALYs in 2019 (3.9 and 3.7 million DALYs in males and females, respectively), thus representing nearly 50% of all PA-related disabilities. The highest impact of LPA-IHD impairment was observed in middle SDI countries, being the lowest in low SDI countries. The LPA-IHD DALYs increased by 17.5% in both sexes during the past 10 years (19.2% in males, and 15.8% in females, respectively), though this trend was dissimilar among different SDI areas, especially during the past two years. In high and high-middle SDI countries, the LPA-IHD grew during the past 2 years, whilst the trend remained stable or declined in other regions. In conclusion, LPA-IHD impairment remains substantial worldwide, leading the way to reinforce current policies aimed at increasing PA volume in the population.","PeriodicalId":74162,"journal":{"name":"Medicines (Basel, Switzerland)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9693065/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40690799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Postpartum Spinal Cord Infarction: A Case Report and Review of the Literature. 产后脊髓梗死1例报告及文献复习。

Medicines (Basel, Switzerland) Pub Date : 2022-10-31 DOI: 10.3390/medicines9110054

Jung-Lung Hsu, Shy-Chyi Chin, Ming-Huei Cheng, Yih-Ru Wu, Aileen Ro, Long-Sun Ro

{"title":"Postpartum Spinal Cord Infarction: A Case Report and Review of the Literature.","authors":"Jung-Lung Hsu, Shy-Chyi Chin, Ming-Huei Cheng, Yih-Ru Wu, Aileen Ro, Long-Sun Ro","doi":"10.3390/medicines9110054","DOIUrl":"https://doi.org/10.3390/medicines9110054","url":null,"abstract":"Background: Postpartum spinal cord infarction is a very rare disease. Only two cases have been reported in the English literature. Methods: We reported a 26 year old female who received second doses of the mRNA-1273 vaccine 52 days before delivery. She presented as sudden onset of paraplegia, sensory level, and sphincter incontinence at postpartum period. No history of heparin exposure was noted. Imaging findings confirmed the T10-11 level infarction and her anti-human heparin platelet factor 4 (anti-PF4) antibody was positive. After 7 days of dexamethasone therapy, her paraplegia and urinary incontinence gradually improved. Results: The CT angiography (CTA) of the artery of Adamkiewicz (Aka) showed tandem narrowing, most conspicuous at the T10-11 level, which was presumably due to partial occlusion of the arteriolar lumen. The thoracolumbar spine magnetic resonance imaging with contrast medium showed owl's eyes sign at the T10 and T11 levels. We compared our case with two other case reports from the literature. Conclusions: Post-partum spinal cord infarction with positive anti-PF4 antibody and relatively thrombocytopenia are the characteristics of our case.","PeriodicalId":74162,"journal":{"name":"Medicines (Basel, Switzerland)","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9698876/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40690798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0