Medicine internationalPub Date : 2026-05-18eCollection Date: 2026-07-01DOI: 10.3892/mi.2026.323
Efthymia Thanasa, Anna Thanasa, Emmanouil Xydias, Ioannis Paraoulakis, Evangelos Kamaretsos, Apostolos Ziogas, Ioannis Thanasas
{"title":"Management of post-cesarean pelvic abscess in the uterine scar: A case report and mini-review of the literature.","authors":"Efthymia Thanasa, Anna Thanasa, Emmanouil Xydias, Ioannis Paraoulakis, Evangelos Kamaretsos, Apostolos Ziogas, Ioannis Thanasas","doi":"10.3892/mi.2026.323","DOIUrl":"10.3892/mi.2026.323","url":null,"abstract":"<p><p>Cesarean section is among the most frequently performed surgical procedures worldwide. In recent years, the increasing rate of cesarean deliveries has led to an increased incidence of post-operative complications. The present case report describes a rare case of a post-operative pelvic abscess located at the uterine scar following a cesarean section, managed successfully via laparotomy. The patient, a 17-year-old woman, was admitted 1 week after undergoing a cesarean delivery. She presented with abdominal pain, fever and chills. Blood tests revealed elevated inflammatory markers and a mild coagulation disorder, consistent with an ongoing infectious process. The results of urinalysis did not reveal any notable findings. A transvaginal ultrasound and an abdominal computed tomography scan revealed a large, mixed echogenic mass with irregular borders and the presence of intralesional air bubbles, localized at the uterine scar anterior to the bladder. Given the persistence of clinical symptoms, supportive imaging and laboratory findings, and the failure of conservative management of the post-operative intra-abdominal infection, surgical intervention was deemed necessary. A laparotomy was performed through the previous cesarean incision. Intraoperatively, an abscess was identified at the site of the uterine scar and was surgically drained. Samples were collected for aerobic and anaerobic cultures, and the cavity was irrigated thoroughly to remove purulent and hemorrhagic material. A drainage tube was placed before closure. The postoperative course of the patient was uneventful, with complete clinical resolution. Following the case presentation, a brief review of the current diagnostic and therapeutic strategies for this uncommon post-operative complication is also provided. On the whole, the present case report underscores the importance of timely surgical intervention via laparotomy when image-guided drainage or laparoscopy is not feasible.</p>","PeriodicalId":74161,"journal":{"name":"Medicine international","volume":"6 4","pages":"39"},"PeriodicalIF":0.0,"publicationDate":"2026-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13216849/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148138942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Ultrasonographic whirlpool sign in ovarian torsion with dual mature teratomas: A case report and literature review.","authors":"Fani-Niki Varra, Apostolos Fasoulopoulos, Eleni Spathi, Ourania Tzirou, Viktoria-Konstantina Varra, Michail Varras","doi":"10.3892/mi.2026.322","DOIUrl":"10.3892/mi.2026.322","url":null,"abstract":"<p><p>Adnexal torsion is a gynecological emergency resulting from the partial or complete rotation of the ovary, often involving the fallopian tube, around its vascular pedicle. Prompt diagnosis is crucial to prevent ischemic injury and preserve ovarian function. Mature cystic ovarian teratomas are common benign neoplasms and represent a frequent cause of torsion due to their size, mobility and mass effect. The present case report describes the case of a 36-year-old woman (gravida 2, para 2) who presented several hours following the sudden onset of right lower abdominal pain, initially accompanied by nausea, both of which had resolved by the time of evaluation. A transvaginal ultrasonography revealed a right ovarian mass measuring 6.13x5.20 cm, containing two mature cystic teratomas. Gray-scale and color Doppler imaging clearly demonstrated the characteristic whirlpool sign, indicating torsion of the adnexal vascular pedicle. An emergency laparoscopy revealed the quadruple torsion of the adnexa (fallopian tube and ovary), and a right salpingo-oophorectomy was performed, as the patient had completed her family. The post-operative course of the patient was uneventful. A post-operative pathological examination confirmed the torsion of mature ovarian teratomas with associated hemorrhagic necrosis. On the whole, the present study demonstrates that the ultrasonographic whirlpool sign is a highly specific pre-operative marker for adnexal torsion, particularly in cases with multiple mature cystic teratomas. Early recognition facilitates prompt surgical intervention, minimizes ischemic injury, and may preserve ovarian function. Incorporating the focused assessment of the whirlpool sign into routine ultrasonography for acute pelvic pain enhances diagnostic accuracy and guides timely operative management.</p>","PeriodicalId":74161,"journal":{"name":"Medicine international","volume":"6 4","pages":"38"},"PeriodicalIF":0.0,"publicationDate":"2026-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13199951/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148038463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Medicine internationalPub Date : 2026-05-12eCollection Date: 2026-07-01DOI: 10.3892/mi.2026.321
Konstantinos-Antonios Kostopoulos-Kanitakis, Jean Kanitakis
{"title":"Acrokeratosis verruciformis of Hopf: Genetic, clinicopathologic and therapeutic features (Review).","authors":"Konstantinos-Antonios Kostopoulos-Kanitakis, Jean Kanitakis","doi":"10.3892/mi.2026.321","DOIUrl":"10.3892/mi.2026.321","url":null,"abstract":"<p><p>Acrokeratosis verruciformis of Hopf (AVH) is a rare genodermatosis belonging to the group of epidermal differentiation diseases. It is due to the heterozygous missense mutation p.(Pro602Leu) in the ATPase sarcoplasmic/endoplasmic reticulum Ca<sup>2+</sup> transporting 2 (<i>ATP2A2</i>) gene, which is also involved in Darier disease (DD), and is therefore considered an allelic form of DD. AVH is usually transmitted as an autosomal dominant trait with variable penetrance, although several sporadic cases have been reported. The disease manifests clinically with flat, wart-like papules with a verrucous surface that develop predominantly on the dorsum of the hands and feet, and appear early in life or, in sporadic cases, in adulthood. The lesions exhibit characteristic microscopic changes (verrucous epidermal hyperplasia with a 'church-spire-like' surface), which allow differentiation from DD. The course of the disease is chronic and the outcome as a rule benign, although rare cases of malignant transformation have been reported. Treatment is not necessary; it can be attempted at the request of the patient, knowing that no standardized treatment exists. Treatments that have been tested include topical agents (namely keratolytics, retinoids and cryotherapy) and systemic retinoids; however, the results are often modest. The present brief narrative review aimed to summarize the etiopathogenic, clinical, histopathological and therapeutic features of AVH.</p>","PeriodicalId":74161,"journal":{"name":"Medicine international","volume":"6 4","pages":"37"},"PeriodicalIF":0.0,"publicationDate":"2026-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13204314/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148044932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Neurochagas: Experimental and human literature of an uncommon entity (Review).","authors":"Jamir Pitton Rissardo, Hossam Tharwat Ali, Vishnu Vardhan Byroju, Ana Leticia Fornari Caprara","doi":"10.3892/mi.2026.320","DOIUrl":"10.3892/mi.2026.320","url":null,"abstract":"<p><p>Neurochagas, the neurological manifestation of Chagas disease, presents a challenge to global health, affecting millions of individuals worldwide. Despite significant progress being made in the understanding of the pathogenesis and clinical presentation of neurochagas, numerous gaps persist in the literature, hindering effective diagnosis and management. The present review discusses the relevant experimental and human literature regarding neurochagas and its epidemiology, pathophysiology, clinical manifestations, diagnostic approaches, treatment strategies and future directions for research. Neurochagas includes a broad spectrum of neurological manifestations, including meningoencephalitis, stroke-like syndromes, cognitive impairment, movement disorders, peripheral neuropathy and autonomic dysfunction, resulting from <i>Trypanosoma cruzi</i> invasion and neuroinflammatory responses. Diagnosing this neurozoonotic disease relies on a multidimensional approach, incorporating clinical evaluation, serological testing, neuroimaging studies, cerebrospinal fluid analysis and ancillary tests. Treatment strategies for neurochagas focus on antiparasitic therapy, symptomatic management, immunomodulation and supportive care. However, available clinical evidence and evidence of proper nervous system penetration is limited, particularly for advanced neurological complications. Future studies are required in order to advance the understanding of the disease mechanisms, identifying biomarkers for early diagnosis and treatment response assessment, developing novel therapeutic interventions, implementing precision medicine approaches, and strengthening global health initiatives to reduce the burden of neurochagas.</p>","PeriodicalId":74161,"journal":{"name":"Medicine international","volume":"6 4","pages":"36"},"PeriodicalIF":0.0,"publicationDate":"2026-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13201984/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148044991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Medicine internationalPub Date : 2026-05-06eCollection Date: 2026-07-01DOI: 10.3892/mi.2026.319
Isra Omar, Ahmed Alakhras, Mona Ahmad, Samahir Mutwali
{"title":"Systemic lupus erythematosus in pregnancy: Maternal and fetal outcomes and management strategies (Review).","authors":"Isra Omar, Ahmed Alakhras, Mona Ahmad, Samahir Mutwali","doi":"10.3892/mi.2026.319","DOIUrl":"10.3892/mi.2026.319","url":null,"abstract":"<p><p>Systemic lupus erythematosus (SLE) is a chronic, multisystem, autoimmune disease that predominantly affects women during their reproductive years. Pregnancy in women with SLE is no longer considered uniformly prohibitive; however, it remains a high-risk clinical scenario due to maternal disease activity, lupus nephritis, antiphospholipid antibodies, chronic organ damage, and treatment-related factors that can adversely affect both maternal and fetal outcomes. Current evidence indicates that the risk of flare is highest in women who conceive with an active disease, discontinue effective therapy, or have a history of major organ involvement. At the same time, pregnancy introduces diagnostic complexity due to physiological gestational changes which may mimic lupus activity, particularly in hematological, renal and vascular domains. Maternal complications include preeclampsia, thromboembolism, infection, lupus nephritis exacerbation and postpartum flare, whereas fetal complications include miscarriage, fetal growth restriction, prematurity, neonatal lupus and congenital heart block in anti-Ro/SSA- or anti-La/SSB-positive pregnancies. Optimal management begins prior to conception and requires multidisciplinary care, risk stratification, medication optimization and structured maternal-fetal surveillance throughout pregnancy and the puerperium. The present narrative review summarizes contemporary evidence on the immunopathogenesis, preconception assessment, maternal and fetal risks, and therapeutic management of SLE in pregnancy, with an emphasis on clinically applicable strategies that improve patient outcomzes.</p>","PeriodicalId":74161,"journal":{"name":"Medicine international","volume":"6 4","pages":"35"},"PeriodicalIF":0.0,"publicationDate":"2026-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13172969/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147965847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Medicine internationalPub Date : 2026-04-24eCollection Date: 2026-05-01DOI: 10.3892/mi.2026.318
Shin Zaw, Lucas Douridas, Rodrigo Murillo Alvarez, Vania Zayat
{"title":"Radiological concern for liposarcoma unmasked as extra-adrenal myelolipoma: A case report.","authors":"Shin Zaw, Lucas Douridas, Rodrigo Murillo Alvarez, Vania Zayat","doi":"10.3892/mi.2026.318","DOIUrl":"10.3892/mi.2026.318","url":null,"abstract":"<p><p>Extra-adrenal myelolipomas (EAMLs) are rare, benign tumors composed of mature adipose tissue and trilineage hematopoiesis, most commonly arising in the retroperitoneum. When large or radiographically atypical, they can mimic malignant entities, such as well-differentiated liposarcomas, often necessitating tissue diagnosis. The present case report describes the case of a 79-year-old male patient with a history of pituitary adenoma treated with resection and radiation, resulting in secondary adrenal insufficiency and central hypothyroidism, who presented with progressive weakness, recurrent falls, and an unintentional weight loss of 18-20 lb. The laboratory evaluation did not reveal any notable findings, apart from known endocrine abnormalities. Non-contrast computed tomography (CT) revealed a heterogeneous, fat-containing left retroperitoneal mass, measuring 6.3x7.0x8.8 cm, with apparent ureteral encasement, concerning for liposarcoma. Surgical intervention was deferred due to comorbidities. A CT-guided biopsy demonstrated mature adipose tissue with trilineage hematopoietic elements, positive for CD45, MPO, CD71 and CD61, with flow cytometry excluding a clonal process, confirming EAML. EAMLs are exceedingly rare, with <100 cases reported, and definitive diagnosis relies on histopathology. The case described herein is notable for its association with remote Cushing's disease, supporting a potential link between chronic endocrine stimulation and EAML pathogenesis. EAML should be considered in the differential diagnosis of fat-containing retroperitoneal masses with atypical imaging features.</p>","PeriodicalId":74161,"journal":{"name":"Medicine international","volume":"6 3","pages":"34"},"PeriodicalIF":0.0,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13158900/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147936050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Unveiling the potential use of bioprinting materials in directing stem cell fate for cartilage regeneration: Focusing on induced pluripotent stem cells and enhanced lubrication (Review).","authors":"Gunasekara Wijesinghege Nimanthi Kaushalya, Sanath Rajapakse","doi":"10.3892/mi.2026.317","DOIUrl":"10.3892/mi.2026.317","url":null,"abstract":"<p><p>Cartilage is a strong, yet flexible, type of connective tissue found in various parts of the body. Cartilage that covers the ends of bones in joints, referred to as articular cartilage, is frequently damaged during injuries and osteoarthritis (OA). Lack of blood vessels and nerves in the cartilage limits its self-renewal capacity, rendering cartilage regeneration a critical challenge. Three-dimensional (3D) bioprinting provides a promising approach for cartilage regeneration by depositing bioink layer by layer to create a 3D structure of more complex tissues such as cartilage, with clinically relevant sizes and mimicking the native shape and natural microenvironment. The present review discusses the potential of bioprinting materials to direct the fate of induced pluripotent stem cells (iPSCs) towards chondrocytes, while simultaneously enhancing lubrication. This will be achieved by incorporating iPSCs, natural polymers, synthetic polymers and lubricants such as lubricin, growth factors and signaling molecules that are involved in chondrogenesis. By optimizing bioink formulation and other parameters in bioprinters, the production of tissues in a precisely controlled manner is ensured, and limitations in current treatments for degenerative diseases such as OA can be avoided. Researchers have developed various complex and functional tissues and organs using bioprinting with successful animal trials, and are in the process of developing patient-specific iPSCs to generate personalized cartilage grafts having high and prolonged regenerative ability with further enhanced lubrication. The present review aimed to provide hope for patients suffering from cartilage degeneration by demonstrating the potential of 3D bioprinting for effective cartilage regeneration.</p>","PeriodicalId":74161,"journal":{"name":"Medicine international","volume":"6 3","pages":"33"},"PeriodicalIF":0.0,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13158841/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147936013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Medicine internationalPub Date : 2026-04-16eCollection Date: 2026-05-01DOI: 10.3892/mi.2026.316
Saime Paydas, Alpay Turan Sezgin
{"title":"Acute kidney injury secondary to overtreatment of hypertension in an elderly patient undergoing combined cardiovascular surgery: A case report.","authors":"Saime Paydas, Alpay Turan Sezgin","doi":"10.3892/mi.2026.316","DOIUrl":"10.3892/mi.2026.316","url":null,"abstract":"<p><p>The present case report describes the case of a 76-year-old diabetic female patient operated on for ischemic heart disease and aortic valve stenosis. The patient suffered from acute kidney injury related to hypotension secondary to the use of anti-hypertensive drugs. The present case report also discusses the need for greater caution in treating hypertension in elderly patients with diabetes and cardiovascular disease, drawing on the available literature. Patients should be encouraged to measure their blood pressure at home, and written blood pressure target values should be provided to both the patient and their caregivers. It is important to note that hypotension, similar to hypertension, may lead to complications such as falls, acute kidney injury and hospitalization. Furthermore, the adverse events that develop following simultaneous coronary artery bypass graft and surgical aortic valve replacement surgery in the elderly are discussed in an aim to provide further insight on this matter.</p>","PeriodicalId":74161,"journal":{"name":"Medicine international","volume":"6 3","pages":"32"},"PeriodicalIF":0.0,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13158927/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147936043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Medicine internationalPub Date : 2026-04-14eCollection Date: 2026-05-01DOI: 10.3892/mi.2026.315
Basem Fouda, Matthew Laffey, Usama Al-Abri, Yuriy Dovhan, Tariq Al-Saadi
{"title":"Use of neuroendoscopy in metastatic brain tumours: A systematic review.","authors":"Basem Fouda, Matthew Laffey, Usama Al-Abri, Yuriy Dovhan, Tariq Al-Saadi","doi":"10.3892/mi.2026.315","DOIUrl":"10.3892/mi.2026.315","url":null,"abstract":"<p><p>Neuroendoscopy allows the performance of biopsy and the resection of metastatic brain lesions using a minimally invasive approach. The present systematic review aimed to survey the existing evidence surrounding the use of neuroendoscopic techniques in the setting of metastatic brain lesions. A systematic search of the available literature was performed using the approach outlined by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) method. The search identified 34 studies that enrolled 150 participants. The average age of the patients was 57 years (range, 37-80 years), and the female-to-male ratio was 51 to 54. The most common primary sites were the lung (42/113), breast (18/113) and melanoma (16/113). Supratentorial tumours represented 93 of the 115 cases. Of the 34 included studies, the goal of the procedure was resection in 23 studies, biopsy in six studies (with ventriculostomy in 3), and both in five studies. The degree of resection was reported for 93 participants, in which a gross, near and subtotal resection was achieved in 60, 13 and 20 cases, respectively. Overall, 13 studies encompassing 34 participants reported that 28 (82%) patients demonstrated post-operative symptomatic improvement following resection. The overall survival was reported for 50 patients following resection across four studies, yielding a weighted average of 12.8 months. To the best of our knowledge, the present study represents the first comprehensive systematic assessment of the existing evidence surrounding the role of neuroendoscopy for brain metastases. The findings presented herein demonstrate promise for the role of neuroendoscopy in this setting; however, the quality and quantity of evidence limit the drawing of strong conclusions.</p>","PeriodicalId":74161,"journal":{"name":"Medicine international","volume":"6 3","pages":"31"},"PeriodicalIF":0.0,"publicationDate":"2026-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13111978/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147791354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Medicine internationalPub Date : 2026-04-03eCollection Date: 2026-05-01DOI: 10.3892/mi.2026.314
Malvina Eleftheriou, Dimitrios Ampazis, Abraham Pouliakis, Michael Doulberis, Konstantinos Toutouzas, Georgios Zografos, Dimitrios Theodorou, Tania Triantafyllou
{"title":"Recent evidence on quality of life following total gastrectomy for gastric cancer: A scoping review.","authors":"Malvina Eleftheriou, Dimitrios Ampazis, Abraham Pouliakis, Michael Doulberis, Konstantinos Toutouzas, Georgios Zografos, Dimitrios Theodorou, Tania Triantafyllou","doi":"10.3892/mi.2026.314","DOIUrl":"10.3892/mi.2026.314","url":null,"abstract":"<p><p>As survival rates improve following total gastrectomy for gastric cancer, quality of life (QoL) has become a critical assessment outcome alongside traditional oncological metrics. Both the short- and long-term course of recovery can be affected by post-gastrectomy syndromes and other post-operative outcomes; however, QoL remains underreported and underutilised in clinical evaluations. Herein, a scoping review of studies published after 2020 that assessed QoL following total gastrectomy for gastric cancer was performed, focusing on curative resections without additional major organ removal. Articles were identified through the PubMed, Scopus and EMBASE databases using combinations of key words related to gastrectomy, QoL and validated patient-reported outcome instruments. A total of nine studies met the inclusion criteria. The majority of functional outcomes (physical, role and emotional functioning) consistently declined at an early stage following the surgery, with recovery typically beginning after ~6 months. Key symptoms, particularly reflux and eating restrictions, remained variable and could persist for up to 2 years. Global QoL improved over time despite ongoing symptoms, suggesting a degree of psychosocial adjustment. Surgical approach and anastomotic technique had limited long-term impact, though minimally invasive methods have been reported to show modest short-term advantages. Despite its clinical importance, QoL remains an underused primary outcome in gastric cancer surgery. A stronger focus on standardised, patient-centred assessment could bridge the gap between technical success and meaningful recovery. Identifying the distinct course of QoL following total gastrectomy may facilitate its integration into surgical planning and care. To the best of our knowledge, this is the first scoping review to focus exclusively on QoL following total gastrectomy in the era of updated surgical guidelines, providing an up-to-date framework for improving patient outcomes.</p>","PeriodicalId":74161,"journal":{"name":"Medicine international","volume":"6 3","pages":"30"},"PeriodicalIF":0.0,"publicationDate":"2026-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13093132/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147791431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}