Medical sciences (Basel, Switzerland)最新文献

{"title":"Comprehensive Geriatric Care in Older Adults: Walking Ability after an Acute Fracture.","authors":"Ulrich Niemöller,&nbsp;Andreas Arnold,&nbsp;Thomas Stein,&nbsp;Martin Juenemann,&nbsp;Damir Erkapic,&nbsp;Josef Rosenbauer,&nbsp;Karel Kostev,&nbsp;Marco Meyer,&nbsp;Christian Tanislav","doi":"10.3390/medsci11020040","DOIUrl":"https://doi.org/10.3390/medsci11020040","url":null,"abstract":"<p><strong>Background/objectives: </strong>Comprehensive Geriatric Care (CGC) is a specific multimodal treatment for older patients. In the current study, we aimed to investigate walking performance after CGC in medically ill patients versus those with fractures.</p><p><strong>Methods: </strong>The timed up and go test (TuG), a 5-grade scale assessment (1 = no walking impairment to 5 = no walking ability at all) for evaluating individual walking ability was performed in all patients who underwent CGC prior to and after treatment. Factors associated with improvement in walking ability were analyzed in the subgroup of patients with fractures.</p><p><strong>Results: </strong>Out of 1263 hospitalized patients, 1099 underwent CGC (median age: 83.1 years (IQR 79.0-87.8 years); 64.1% were female). Patients with fractures (<i>n</i> = 300) were older than those without (<i>n</i> = 799), (median 85.6 versus 82.4 years, <i>p</i> = 0.001). Improvement in TuG after CGC was found in 54.2% of the fracture patients compared to just 45.9% of those without fractures. In fracture group patients, TuG improved from median 5 on admission to median 3 on discharge (<i>p</i> = 0.001). In fracture patients, improvement in walking ability was associated with higher Barthel index values on admission (median 45 (IQR: 35-55) versus 35 (IQR: 20-50): <i>p</i> = 0.001) and Tinetti assessment scores (median 9 (IQR: 4-14.25) versus 5 (IQR: 0-13); <i>p</i> = 0.001) and was negatively associated with the diagnosis of dementia (21.4% versus 31.5%; <i>p</i> = 0.058).</p><p><strong>Conclusion: </strong>CGC improved walking ability in more than half of all patients examined. Older patients in particular might benefit from undergoing the procedure after an acute fracture. A better initial functional status favors a positive result following the treatment.</p>","PeriodicalId":74152,"journal":{"name":"Medical sciences (Basel, Switzerland)","volume":"11 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10301278/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10078201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying Activities from an Intervention to Promote Sleep in Hospitalised Patients Using the Focus Mapping Technique.","authors":"Manuel Armayones Ruiz,&nbsp;Noemí Robles,&nbsp;Iolanda Graupera Diez,&nbsp;Raimon Camps Salat,&nbsp;Joan Escarrabill Sanglas,&nbsp;Elena Salas Marco","doi":"10.3390/medsci11020039","DOIUrl":"https://doi.org/10.3390/medsci11020039","url":null,"abstract":"<p><strong>Background: </strong>Sleep is an essential element for patients' recovery during a period of hospitalisation. Hospital Clínic de Barcelona has developed the ClíNit project to promote patients' sleep by identifying elements that affect the quality of sleep and implementing actions to improve rest at night.</p><p><strong>Objective: </strong>Our aim is to select actions to improve sleep quality.</p><p><strong>Methods: </strong>The study population included night-shift nurses from two clinical units where the pilot actions were to be carried out (n: 14). The nurses prioritised actions to improve sleep quality using the methodology proposed by Fogg: clarification, magic wand, crispification, and the focus-mapping technique.</p><p><strong>Results: </strong>Two sessions were organised for each unit and 32 actions considered high impact and easy to implement were proposed, of which 43.75% (14/32) were directly dependent on nurses. It was then agreed to implement four of these pilot studies.</p><p><strong>Conclusions: </strong>One aspect worth highlighting is that using prioritization techniques such as the Fogg technique is a good strategy to implement the general objectives of intervention programmes in large organizations in an easy way.</p>","PeriodicalId":74152,"journal":{"name":"Medical sciences (Basel, Switzerland)","volume":"11 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10302051/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10096467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medical Treatment in Heart Failure with Reduced Ejection Fraction: A Proposed Algorithm Based on the Patient's Electrolytes and Congestion Status.","authors":"Ioannis Paraskevaidis,&nbsp;Andrew Xanthopoulos,&nbsp;Nikolaos Karamichalakis,&nbsp;Filippos Triposkiadis,&nbsp;Elias Tsougos","doi":"10.3390/medsci11020038","DOIUrl":"10.3390/medsci11020038","url":null,"abstract":"<p><p>In heart failure (HF) with reduced ejection fraction (HFrEF), four classes of drugs (β-blockers, angiotensin-converting enzyme inhibitors/angiotensin receptor neprilysin inhibitors, mineralocorticoid receptor antagonists, and the most recent Sodium-Glucose Co-Transporters 2 Inhibitors) have demonstrated positive results in randomized controlled trials (RCTs). Nevertheless, the latest RCTs are not proper for comparison since they were carried out at various times with dissimilar background therapies and the patients enrolled did not have the same characteristics. The difficulty of extrapolating from these trials and proposing a common framework appropriate for all cases is thus obvious. Despite the fact that these four agents are now the fundamental pillars of HFrEF treatment, the built-up algorithm of initiation and titration is a matter of debate. Electrolyte disturbances are common in HFrEF patients and can be attributed to several factors, such as the use of diuretics, renal impairment, and neurohormonal activation. We have identified several HFrEF phenotypes according to their sodium (Na⁺) and potassium (K⁺) status in a \"real world\" setting and suggest an algorithm on how to introduce the most appropriate drug and set up therapy based on the patients' electrolytes and the existence of congestion.</p>","PeriodicalId":74152,"journal":{"name":"Medical sciences (Basel, Switzerland)","volume":"11 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10302950/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10096472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender Effects on Left Ventricular Responses and Survival in Patients with Severe Aortic Regurgitation: Results from a Cohort of 756 Patients with up to 22 Years of Follow-Up.","authors":"Padmini Varadarajan,&nbsp;Ramdas G Pai","doi":"10.3390/medsci11020036","DOIUrl":"https://doi.org/10.3390/medsci11020036","url":null,"abstract":"<p><strong>Objectives: </strong>We sought to evaluate the effect of gender on biology, therapeutic decisions, and survival in patients with severe aortic regurgitation (AR).</p><p><strong>Background: </strong>Gender affects adaptive response to the presence of valvular heart diseases and therapeutic decisions. The impact of these on survival in severe AR patients is not known.</p><p><strong>Methods: </strong>This observational study was compiled from our echocardiographic database which was screened (1993-2007) for patients with severe AR. Detailed chart reviews were performed. Mortality data were obtained from the Social Security Death Index and analyzed as a function of gender.</p><p><strong>Results: </strong>Of the 756 patients with severe AR, 308 (41%) were women. Over a follow-up of up to 22 years, there were 434 deaths. Women compared to men were older (64 ± 18 vs. 59 ± 17 years, <i>p</i> = 0.0002). Women also had smaller left ventricular (LV) end diastolic dimension (5.2 ± 1.1 vs. 6.0 ± 1.0 cm, <i>p</i> < 0.0001), higher EF (56% ± 17% vs. 52% ± 18%, <i>p</i> = 0.003), higher prevalence of diabetes mellitus (18% vs. 11%, <i>p</i> = 0.006), and higher prevalence of ≥2+ mitral regurgitation (52% vs. 40%, <i>p</i> = 0.0008) despite a smaller LV size. Women were also less likely to receive aortic valve replacement (AVR) (24% vs. 48%, <i>p</i> < 0.0001) compared to men and had a lower survival on univariate analysis (<i>p</i> = 0.001). However, after adjusting for group differences including AVR rates, gender was not an independent predictor of survival. However, the survival benefit associated with AVR was similar in both women and men.</p><p><strong>Conclusions: </strong>This study strongly suggests that female gender is associated with different biological responses to AR compared to men. There is also a lower AVR rate in women, but women derive similar survival benefit as men with AVR. Gender does not seem to affect survival in an independent fashion in patients with severe AR after adjusting for group differences and AVR rates.</p>","PeriodicalId":74152,"journal":{"name":"Medical sciences (Basel, Switzerland)","volume":"11 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10303455/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10096469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient Dietary Supplements Use: Do Results from Natural Language Processing of Clinical Notes Agree with Survey Data?","authors":"Douglas Redd,&nbsp;Terri Elizabeth Workman,&nbsp;Yijun Shao,&nbsp;Yan Cheng,&nbsp;Senait Tekle,&nbsp;Jennifer H Garvin,&nbsp;Cynthia A Brandt,&nbsp;Qing Zeng-Treitler","doi":"10.3390/medsci11020037","DOIUrl":"https://doi.org/10.3390/medsci11020037","url":null,"abstract":"<p><p>There is widespread use of dietary supplements, some prescribed but many taken without a physician's guidance. There are many potential interactions between supplements and both over-the-counter and prescription medications in ways that are unknown to patients. Structured medical records do not adequately document supplement use; however, unstructured clinical notes often contain extra information on supplements. We studied a group of 377 patients from three healthcare facilities and developed a natural language processing (NLP) tool to detect supplement use. Using surveys of these patients, we investigated the correlation between self-reported supplement use and NLP extractions from the clinical notes. Our model achieved an F1 score of 0.914 for detecting all supplements. Individual supplement detection had a variable correlation with survey responses, ranging from an F1 of 0.83 for calcium to an F1 of 0.39 for folic acid. Our study demonstrated good NLP performance while also finding that self-reported supplement use is not always consistent with the documented use in clinical records.</p>","PeriodicalId":74152,"journal":{"name":"Medical sciences (Basel, Switzerland)","volume":"11 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10304046/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10096466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metaplastic Carcinoma of the Breast: Case Series of a Single Institute and Review of the Literature.","authors":"Alkistis Papatheodoridi,&nbsp;Eleni Papamattheou,&nbsp;Spyridon Marinopoulos,&nbsp;Ioannis Ntanasis-Stathopoulos,&nbsp;Constantine Dimitrakakis,&nbsp;Aris Giannos,&nbsp;Maria Kaparelou,&nbsp;Michalis Liontos,&nbsp;Meletios-Athanasios Dimopoulos,&nbsp;Flora Zagouri","doi":"10.3390/medsci11020035","DOIUrl":"https://doi.org/10.3390/medsci11020035","url":null,"abstract":"<p><p>Metaplastic carcinoma of the breast (MpBC) is a very rare and aggressive type of breast cancer. Data focusing on MpBC are limited. The aim of this study was to describe the clinicopathological features of MpBC and evaluate the prognosis of patients with MpBC. Eligible articles about MpBC were identified by searching CASES SERIES gov and the MEDLINE bibliographic database for the period of 1 January 2010 to 1 June 2021 with the keywords metaplastic breast cancer, mammary gland cancer, neoplasm, tumor, and metaplastic carcinoma. In this study, we also report 46 cases of MpBC stemming from our hospital. Survival rates, clinical behavior, and pathological characteristics were analyzed. Data from 205 patients were included for analysis. The mean age at diagnosis was 55 (14.7) years. The TNM stage at diagnosis was mostly stage II (58.5%) and most tumors were triple negative. The median overall survival was 66 (12-118) months, and the median disease-free survival was 56.8 (11-102) months. Multivariate Cox regression analysis revealed that surgical treatment was associated with decreased risk of death (hazard ratio 0.11, 95% confidence interval 0.02-0.54, <i>p</i> = 0.01) while advanced TNM stage was associated with increased risk of death (hazard ratio 1.5, 95% confidence interval 1.04-2.28, <i>p</i> = 0.03). Our results revealed that surgical treatment and TNM stage were the only independent risk factors related to patients' overall survival.</p>","PeriodicalId":74152,"journal":{"name":"Medical sciences (Basel, Switzerland)","volume":"11 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10204473/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9516156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cervical Artery Dissection and Patent Foramen Ovale in Juvenile Stroke: Causality or Casuality? A Familiar Case Report.","authors":"Francesca Antonia Arcadi,&nbsp;Rosa Morabito,&nbsp;Silvia Marino,&nbsp;Caterina Formica,&nbsp;Rocco Salvatore Calabrò","doi":"10.3390/medsci11020034","DOIUrl":"https://doi.org/10.3390/medsci11020034","url":null,"abstract":"<p><p>Cervical artery dissection (CAD) and Patent Foramen Ovale (PFO) are important causes of stroke in young patients. Although PFO is considered an independent risk factor for cerebral infarction in young adults with cryptogenic stroke, other concomitant causes may be necessary to cause brain injury. PFO could be a predisposing factor of stroke through several mechanisms including paradoxical embolism from a venous source, thrombus formation in atrial septum, or atrial arrhythmias causing cerebral thromboembolism. The pathophysiology of CAD is poorly understood and includes both constitutional and environmental factors. A causal association is often difficult to establish, as other predisposing factors may also play a role in CAD etiopathogenesis. We present a family with ischemic stroke (a father and his three daughters), in which the two different stroke causes are present. We hypothesized that a paradoxical embolism caused by PFO, associated with arterial wall disease, in the presence of a procoagulant state, could produce arterial dissection and then stroke.</p>","PeriodicalId":74152,"journal":{"name":"Medical sciences (Basel, Switzerland)","volume":"11 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10204567/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9516157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gender Disparities after Transcatheter Aortic Valve Replacement with Newer Generation Transcatheter Heart Valves: A Systematic Review and Meta-Analysis.","authors":"Angkawipa Trongtorsak,&nbsp;Sittinun Thangjui,&nbsp;Pabitra Adhikari,&nbsp;Biraj Shrestha,&nbsp;Jakrin Kewcharoen,&nbsp;Leenhapong Navaravong,&nbsp;Somsupha Kanjanauthai,&nbsp;Steve Attanasio,&nbsp;Hammad A Saudye","doi":"10.3390/medsci11020033","DOIUrl":"https://doi.org/10.3390/medsci11020033","url":null,"abstract":"<p><p>Previous studies have demonstrated gender disparities in mortality and vascular complications after transcatheter aortic valve replacement (TAVR) with early generation transcatheter heart valves (THVs). It is unclear, however, whether gender-related differences persist with the newer generation THVs. We aim to assess gender disparities after TAVR with newer generation THVs. The MEDLINE and Embase databases were thoroughly searched from inception to April 2023 to identify studies that reported gender-specific outcomes after TAVR with newer generation THVs (Sapien 3, Corevalve Evolut R, and Evolut Pro). The outcomes of interest included 30-day mortality, 1-year mortality, and vascular complications. In total, 5 studies (4 databases) with a total of 47,933 patients (21,073 females and 26,860 males) were included. Ninety-six percent received TAVR via the transfemoral approach. The females had higher 30-day mortality rates (odds ratio (OR) = 1.53, 95% confidence interval (CI) 1.31-1.79, <i>p</i>-value (<i>p</i>) < 0.001) and vascular complications (OR = 1.43, 95% CI 1.23-1.65, <i>p</i> < 0.001). However, one-year mortality was similar between the two groups (OR = 0.78, 95% CI 0.61-1.00, <i>p</i> = 0.28). The female gender continues to be associated with higher 30-day mortality rates and vascular complications after TAVR with newer generation transcatheter heart valves, while there was no difference in 1-year mortality between the genders. More data is needed to explore the causes and whether we can improve TAVR outcomes in females.</p>","PeriodicalId":74152,"journal":{"name":"Medical sciences (Basel, Switzerland)","volume":"11 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10204443/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9508988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interaction between Age and Primary Site on Survival Outcomes in Primary GI Melanoma over the Past Decade.","authors":"Ayrton Bangolo,&nbsp;Pierre Fwelo,&nbsp;Sowmya Sagireddy,&nbsp;Harin Shah,&nbsp;Chinmay Trivedi,&nbsp;John Bukasa-Kakamba,&nbsp;Rutvij Patel,&nbsp;Luke Bharane,&nbsp;Manraj K Randhawa,&nbsp;Vignesh K Nagesh,&nbsp;Shraboni Dey,&nbsp;Hannah Terefe,&nbsp;Gagan Kaur,&nbsp;Nicholas Dinko,&nbsp;Fatma Lina Emiroglu,&nbsp;Ahmed Mohamed,&nbsp;Mark A Fallorina,&nbsp;David Kosoy,&nbsp;Danish Waqar,&nbsp;Ankita Shenoy,&nbsp;Kareem Ahmed,&nbsp;Anvit Nanavati,&nbsp;Amritpal Singh,&nbsp;Anthony Willie,&nbsp;Diego M C Gonzalez,&nbsp;Deblina Mukherjee,&nbsp;Jayadev Sajja,&nbsp;Tracy Proverbs-Singh,&nbsp;Sameh Elias,&nbsp;Simcha Weissman","doi":"10.3390/medsci11020032","DOIUrl":"https://doi.org/10.3390/medsci11020032","url":null,"abstract":"<p><strong>Background: </strong>Primary malignant melanomas of the Gastrointestinal mucosa are uncommon. Most cases of gastrointestinal (GI) melanomas are secondary, arising from metastasis at distant sites. The purpose of this study is to assess to what extent the interaction between independent prognostic factors (age and tumor site) of primary GI melanoma influence survival. Furthermore, we also aimed to investigate the clinical characteristics, survival outcomes, and independent prognostic factors of patients with primary GI melanoma in the past decade.</p><p><strong>Methods: </strong>A total of 399 patients diagnosed with primary GI melanoma, between 2008 and 2017, were enrolled in our study by retrieving data from the Surveillance, Epidemiology, and End Results (SEER) database. We analyzed demographics, clinical characteristics, and overall mortality (OM) as well as cancer-specific mortality (CSM) of primary GI melanoma. Variables with a <i>p</i> value < 0.1 in the univariate Cox regression were incorporated into the multivariate Cox model (model 1) to determine the independent prognostic factors, with a hazard ratio (HR) of greater than 1 representing adverse prognostic factors. Furthermore, we analyzed the effect of the interaction between age and primary location on mortality (model 2).</p><p><strong>Results: </strong>Multivariate cox proportional hazard regression analyses revealed higher OM in age group 80+ (HR = 5.653, 95% CI 2.212-14.445, <i>p</i> = 0), stomach location of the tumor (HR = 2.821, 95% CI 1.265-6.292, <i>p</i> = 0.011), regional lymph node involvement only (HR = 1.664, 95% CI 1.051-2.635, <i>p</i> < 0.05), regional involvement by both direct extension and lymph node involvement (HR = 1.755, 95% CI 1.047-2.943, <i>p</i> < 0.05) and distant metastases (HR = 4.491, 95% CI 3.115-6.476, <i>p</i> = 0), whereas the lowest OM was observed in patients with small intestine melanoma (HR = 0.383, 95% CI 0.173-0.846, <i>p</i> < 0.05). Multivariate cox proportional hazard regression analyses of CSM also revealed higher mortality of the same groups and lower CSM in small intestine and colon melanoma excluding the rectum. For model 2, considering the interaction between age and primary site on mortality, higher OM was found in age group 80+, followed by age group 40-59 then age group 60-79, regional lymph node involvement only, regional involvement by both direct extension and lymph node involvement and distant metastases. The small intestine had a lower OM. The rectum as primary location and the age range 40-59 interacted to lower the OM (HR = 0.14, 95% CI 0.02-0.89, <i>p</i> = 0.038). Age and primary gastric location did not interact to affect the OM. For the CSM, taking into account the interaction between age and the primary location, higher mortality was found in the same groups and the colon location. The primary colon location also interacted with the age group 40-59 to increase the CSM (HR = 1.38 × 10⁹, 95% CI 7.80 ×","PeriodicalId":74152,"journal":{"name":"Medical sciences (Basel, Switzerland)","volume":"11 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10204572/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9516153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential Anti-Tumor Effects of IFN-Inducible Chemokines CXCL9, CXCL10, and CXCL11 on a Mouse Squamous Cell Carcinoma Cell Line.","authors":"Ari Matsumoto,&nbsp;Miki Hiroi,&nbsp;Kazumasa Mori,&nbsp;Nobuharu Yamamoto,&nbsp;Yoshihiro Ohmori","doi":"10.3390/medsci11020031","DOIUrl":"https://doi.org/10.3390/medsci11020031","url":null,"abstract":"<p><p>Chemokines are a group of cytokines involved in the mobilization of leukocytes, which play a role in host defense and a variety of pathological conditions, including cancer. Interferon (IFN)-inducible chemokines C-X-C motif ligand 9 (CXCL), CXCL10, and CXCL11 are anti-tumor chemokines; however, the differential anti-tumor effects of IFN-inducible chemokines are not completely understood. In this study, we investigated the anti-tumor effects of IFN-inducible chemokines by transferring chemokine expression vectors into a mouse squamous cell carcinoma cell line, SCCVII, to generate a cell line stably expressing chemokines and transplanted it into nude mice. The results showed that CXCL9- and CXCL11-expressing cells markedly inhibited tumor growth, whereas CXCL10-expressing cells did not inhibit growth. The NH₂-terminal amino acid sequence of mouse CXCL10 contains a cleavage sequence by dipeptidyl peptidase 4 (DPP4), an enzyme that cleaves the peptide chain of chemokines. IHC staining indicated DPP4 expression in the stromal tissue, suggesting CXCL10 inactivation. These results suggest that the anti-tumor effects of IFN-inducible chemokines are affected by the expression of chemokine-cleaving enzymes in tumor tissues.</p>","PeriodicalId":74152,"journal":{"name":"Medical sciences (Basel, Switzerland)","volume":"11 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10204432/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9516160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}