Medical review (Berlin, Germany)最新文献_第7页

Site-specific genome editing in treatment of inherited diseases: possibility, progress, and perspectives. 位点特异性基因组编辑在遗传性疾病治疗中的应用：可能性、进展和前景。

Medical review (Berlin, Germany) Pub Date : 2022-11-11 eCollection Date: 2022-10-01 DOI: 10.1515/mr-2022-0029

Chao Huang, Qing Li, Jinsong Li

引用次数: 2

Developmental origins of adult diseases. 成人疾病的发育起源。

Medical review (Berlin, Germany) Pub Date : 2022-11-11 eCollection Date: 2022-10-01 DOI: 10.1515/mr-2022-0027

Jiaying Mo, Xuanqi Liu, Yutong Huang, Renke He, Yu Zhang, Hefeng Huang

{"title":"Developmental origins of adult diseases.","authors":"Jiaying Mo, Xuanqi Liu, Yutong Huang, Renke He, Yu Zhang, Hefeng Huang","doi":"10.1515/mr-2022-0027","DOIUrl":"10.1515/mr-2022-0027","url":null,"abstract":"The occurrence and mechanisms of developmental adult diseases have gradually attracted attention in recent years. Exposure of gametes and embryos to adverse environments, especially during plastic development, can alter the expression of certain tissue-specific genes, leading to increased susceptibility to certain diseases in adulthood, such as diabetes, cardiovascular disease, neuropsychiatric, and reproductive system diseases, etc. The occurrence of chronic disease in adulthood is partly due to genetic factors, and the remaining risk is partly due to environmental-dependent epigenetic information alteration, including DNA methylation, histone modifications, and noncoding RNAs. Changes in this epigenetic information potentially damage our health, which has also been supported by numerous epidemiological and animal studies in recent years. Environmental factors functionally affect embryo development through epimutation, transmitting diseases to offspring and even later generations. This review mainly elaborated on the concept of developmental origins of adult diseases, and revealed the epigenetic mechanisms underlying these events, discussed the theoretical basis for the prevention and treatment of related diseases.","PeriodicalId":74151,"journal":{"name":"Medical review (Berlin, Germany)","volume":"2 5","pages":"450-470"},"PeriodicalIF":0.0,"publicationDate":"2022-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/80/62/mr-2-5-mr-2022-0027.PMC10388800.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10658303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Organoid research on human early development and beyond. 人类早期发育及以后的类器官研究。

Medical review (Berlin, Germany) Pub Date : 2022-10-31 eCollection Date: 2022-10-01 DOI: 10.1515/mr-2022-0028

Lu Wen, Fuchou Tang

引用次数: 0

Ultrasound contrast agents from microbubbles to biogenic gas vesicles. 超声造影剂从微泡到生物气泡。

Medical review (Berlin, Germany) Pub Date : 2022-10-19 eCollection Date: 2023-02-01 DOI: 10.1515/mr-2022-0020

Wenlong Zeng, Xiuli Yue, Zhifei Dai

{"title":"Ultrasound contrast agents from microbubbles to biogenic gas vesicles.","authors":"Wenlong Zeng, Xiuli Yue, Zhifei Dai","doi":"10.1515/mr-2022-0020","DOIUrl":"10.1515/mr-2022-0020","url":null,"abstract":"Microbubbles have been the earliest and most widely used ultrasound contrast agents by virtue of their unique features: such as non-toxicity, intravenous injectability, ability to cross the pulmonary capillary bed, and significant enhancement of echo signals for the duration of the examination, resulting in essential preclinical and clinical applications. The use of microbubbles functionalized with targeting ligands to bind to specific targets in the bloodstream has further enabled ultrasound molecular imaging. Nevertheless, it is very challenging to utilize targeted microbubbles for molecular imaging of extravascular targets due to their size. A series of acoustic nanomaterials have been developed for breaking free from this constraint. Especially, biogenic gas vesicles, gas-filled protein nanostructures from microorganisms, were engineered as the first biomolecular ultrasound contrast agents, opening the door for more direct visualization of cellular and molecular function by ultrasound imaging. The ordered protein shell structure and unique gas filling mechanism of biogenic gas vesicles endow them with excellent stability and attractive acoustic responses. What's more, their genetic encodability enables them to act as acoustic reporter genes. This article reviews the upgrading progresses of ultrasound contrast agents from microbubbles to biogenic gas vesicles, and the opportunities and challenges for the commercial and clinical translation of the nascent field of biomolecular ultrasound.","PeriodicalId":74151,"journal":{"name":"Medical review (Berlin, Germany)","volume":"3 1","pages":"31-48"},"PeriodicalIF":0.0,"publicationDate":"2022-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/78/00/mr-3-1-mr-2022-0020.PMC10471104.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10363192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trimethylamine-N-oxide is an important target for heart and brain diseases. 三甲胺-N-氧化物是心脑疾病的重要靶点。

Medical review (Berlin, Germany) Pub Date : 2022-09-22 eCollection Date: 2022-08-01 DOI: 10.1515/mr-2022-0026

Shusi Ding, Jing Xue, Qi Zhang, Lemin Zheng

引用次数: 0

The polarizable and reprogrammable identity of Kupffer cells in Nonalcoholic Steatohepatitis. Kupffer细胞在非酒精性脂肪性肝炎中的可极化和可重编程特性。

Medical review (Berlin, Germany) Pub Date : 2022-09-20 eCollection Date: 2022-08-01 DOI: 10.1515/mr-2022-0023

Tarik Zahr, Kevin Sun, Li Qiang

引用次数: 0

Crosstalk between bone and other organs. 骨骼和其他器官之间的串扰。

Medical review (Berlin, Germany) Pub Date : 2022-09-15 eCollection Date: 2022-08-01 DOI: 10.1515/mr-2022-0018

Wanqiong Yuan, Chunli Song

引用次数: 3

Proteomics research of SARS-CoV-2 and COVID-19 disease. SARS-CoV-2和新冠肺炎疾病的蛋白质组学研究。

Medical review (Berlin, Germany) Pub Date : 2022-09-14 eCollection Date: 2022-08-01 DOI: 10.1515/mr-2022-0016

Nan Zhang, Siyuan Wang, Catherine C L Wong

引用次数: 0

Hypothalamic GABAergic neurocircuitry in the regulation of energy homeostasis and sleep/wake control. 下丘脑GABA能神经回路在能量稳态调节和睡眠/觉醒控制中的作用。

Medical review (Berlin, Germany) Pub Date : 2022-09-14 eCollection Date: 2022-10-01 DOI: 10.1515/mr-2022-0022

Hong Jiang

引用次数: 1

Fibroblast growth factor 21 and dietary interventions: what we know and what we need to know next. 成纤维细胞生长因子21和饮食干预：我们所知道的和接下来需要知道的。

Medical review (Berlin, Germany) Pub Date : 2022-09-13 eCollection Date: 2022-10-01 DOI: 10.1515/mr-2022-0019

Tianru Jin

{"title":"Fibroblast growth factor 21 and dietary interventions: what we know and what we need to know next.","authors":"Tianru Jin","doi":"10.1515/mr-2022-0019","DOIUrl":"10.1515/mr-2022-0019","url":null,"abstract":"Dietary interventions include the change of dietary styles, such as fasting and dietary or nutrient restrictions; or the addition of plant-derived compounds (such as polyphenols known as curcumin, resveratrol, or anthocyanin, or other nutraceuticals) into the diet. During the past a few decades, large number of studies have demonstrated therapeutic activities of these dietary interventions on metabolic and other diseases in human subjects or various animal models. Mechanisms underlying those versatile therapeutic activities, however, remain largely unclear. Interestingly, recent studies have shown that fibroblast growth factor 21 (FGF21), a liver-derived hormone or hepatokine, mediates metabolic beneficial effects of certain dietary polyphenols as well as protein restriction. Here I have briefly summarized functions of FGF21, highlighted related dietary interventions, and presented literature discussions on role of FGF21 in mediating function of dietary polyphenol intervention and protein restriction. This is followed by presenting my perspective view, with the involvement of gut microbiota. It is anticipated that further breakthroughs in this field in the near future will facilitate conceptual merge of classical medicine and modern medicine.","PeriodicalId":74151,"journal":{"name":"Medical review (Berlin, Germany)","volume":"2 5","pages":"524-530"},"PeriodicalIF":0.0,"publicationDate":"2022-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c9/49/mr-2-5-mr-2022-0019.PMC10388781.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10657921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0