MedComm - Future medicine最新文献_第2页

Digital Phenotyping of Physical Activity and Mortality in Cancer Survivors 癌症幸存者身体活动与死亡率的数字表型分析

MedComm - Future medicine Pub Date : 2026-07-01 DOI: 10.1002/mef2.70064

Yuanyou Li, Tianchen Niu, Zhongzheng Xiang, Junhan Zhao, Junjie Zhang, Lingjie Fan

{"title":"Digital Phenotyping of Physical Activity and Mortality in Cancer Survivors","authors":"Yuanyou Li, Tianchen Niu, Zhongzheng Xiang, Junhan Zhao, Junjie Zhang, Lingjie Fan","doi":"10.1002/mef2.70064","DOIUrl":"https://doi.org/10.1002/mef2.70064","url":null,"abstract":"Physical activity is central to cancer survivorship care, yet the prognostic value of its multiple dimensions remains poorly characterized. We aimed to define multidimensional, wearable-derived digital phenotypes of physical activity; determine their independent associations with all-cause mortality; identify dose–response thresholds for survival benefit; and evaluate their utility in machine learning mortality prediction among cancer survivors. This observational cohort study analyzed 9379 National Health and Nutrition Examination Survey (2011–2014) participants with wrist accelerometry and mortality follow-up, including 864 cancer survivors. Three Monitor-Independent Movement Summary (MIMS) phenotypes were derived: Volume, Intensity, and Variability. In fully adjusted Cox models, vigorous versus light patterns were associated with lower mortality (hazard ratios 0.33, 0.22, and 0.29 for Volume, Intensity, and Variability, respectively). Dose–response thresholds for survival benefit were identified (Intensity > 24, Volume > 4945, and Variability > 2.4). Protective associations were stronger in survivors with low functional limitation. Machine learning models discriminated well (Random Survival Forest AUC = 0.799), with external validation confirming generalizability (AUC = 0.773). Multidimensional digital phenotypes, particularly for peak intensity and variability, are independent mortality predictors, supporting their integration into precision cancer survivorship care. Interpretation is limited by the absence of cancer staging and treatment data.","PeriodicalId":74135,"journal":{"name":"MedComm - Future medicine","volume":"5 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mef2.70064","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148358026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Promotive Role of Dominant-Negative Fas-Associated Death Domain Protein Mutants in Anti-CD3 Antibody-Induced Murine Hyperacute Enteritis 显性阴性fas相关死亡结构域蛋白突变体在抗cd3抗体诱导的小鼠超急性肠炎中的促进作用

MedComm - Future medicine Pub Date : 2026-06-29 DOI: 10.1002/mef2.70063

Huangru Xu, Jiaqi Xu, Yubing Zhang, Yuanhao Tan, Shengyun Zhu, Na Han, Yicheng Lv, Mengyun Wang, Yuchen Liu, Junyi Ren, Hongqin Zhuang, Zi-Chun Hua

{"title":"Promotive Role of Dominant-Negative Fas-Associated Death Domain Protein Mutants in Anti-CD3 Antibody-Induced Murine Hyperacute Enteritis","authors":"Huangru Xu, Jiaqi Xu, Yubing Zhang, Yuanhao Tan, Shengyun Zhu, Na Han, Yicheng Lv, Mengyun Wang, Yuchen Liu, Junyi Ren, Hongqin Zhuang, Zi-Chun Hua","doi":"10.1002/mef2.70063","DOIUrl":"https://doi.org/10.1002/mef2.70063","url":null,"abstract":"Inflammatory bowel disease (IBD) represents a prevalent chronic intestinal inflammatory disorder governed by multifactorial regulation, in which aberrant activation and dysregulation of the intestinal immune system exert pivotal roles. Previous studies have demonstrated that intraperitoneal administration of anti-CD3 antibody in mice elicits acute intestinal inflammation and diarrhea, accompanied by elevated expression of pro-inflammatory cytokine transcripts, tissue edema, and expansion of intraepithelial lymphocytes (IELs). However, the molecular mechanisms by which death domain adaptor proteins regulate intestinal immune homeostasis and inflammatory responses remain incompletely understood. In this study, we identified Fas-associated death domain protein (FADD) as a critical modulator in anti-CD3 antibody-induced hyperacute colitis. Our data revealed that anti-CD3 antibody triggered ultra-rapid intestinal injury characterized by vascular congestion and mucosal edema in wild-type mice. Notably, the tissue damage induced by anti-CD3 antibody was predominantly localized to the small intestine, with the jejunum being the most severely affected segment. Intriguingly, mice harboring a dominant-negative mutant form of FADD (FADD-DN) exhibited significantly exacerbated mucosal edema during the acute injury phase upon anti-CD3 antibody challenge, indicating that FADD-DN mice are more susceptible to anti-CD3-induced intestinal inflammation. Collectively, these findings establish FADD as a potential key molecular target for the therapeutic intervention of inflammatory bowel disease.","PeriodicalId":74135,"journal":{"name":"MedComm - Future medicine","volume":"5 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mef2.70063","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148386932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Coronary Blood Flow Dynamics During Continuous Flow Left Ventricular Assist Device Support: Insights From a Virtual Cohort and In-Silico Simulations 连续血流左心室辅助装置支持期间的冠状动脉血流动力学：来自虚拟队列和计算机模拟的见解

MedComm - Future medicine Pub Date : 2026-06-22 DOI: 10.1002/mef2.70062

Selim Bozkurt

{"title":"Coronary Blood Flow Dynamics During Continuous Flow Left Ventricular Assist Device Support: Insights From a Virtual Cohort and In-Silico Simulations","authors":"Selim Bozkurt","doi":"10.1002/mef2.70062","DOIUrl":"https://doi.org/10.1002/mef2.70062","url":null,"abstract":"Understanding the interaction between the Continuous Flow Left Ventricular Assist Device (CF-LVAD) and physiological mechanisms regulating coronary blood flow may help optimize CF-LVAD support. A virtual cohort for patients implanted with HeartMate3 CF-LVAD was created by generating datasets. The datasets consist of the cardiac and coronary parameters in a numerical model simulating cardiac function, blood flow in the circulatory system, blood flow rate regulatory mechanisms, and HeartMate3 CF-LVAD support. Sensitivity and correlation analyses were performed to evaluate the influence of the cardiac and coronary parameters on the average left and right coronary blood flow rates. Interdependencies between the hemodynamic data in the coronary circulation during HeartMate3 support were evaluated as well. Simulation results and statistical analyses showed that the left coronary blood flow rate is highly influenced by the blood flow regulatory mechanisms, whereas the right coronary blood flow rate is highly influenced by the CF-LVAD operating speed and left ventricular elastance. Left coronary blood flow rate is not strongly correlated with hemodynamic, physiological, and CF-LVAD parameters. However, right coronary blood flow rate is strongly correlated with mean aortic pressure and coronary perfusion pressure during partial CF-LVAD support and flow rate through HeartMate3 is an additional factor during full support.","PeriodicalId":74135,"journal":{"name":"MedComm - Future medicine","volume":"5 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mef2.70062","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148323986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in Research on the Anti-Tuberculosis Effects of Active Components in Chinese Herbal Medicine 中药有效成分抗结核作用的研究进展

MedComm - Future medicine Pub Date : 2026-06-15 DOI: 10.1002/mef2.70061

Qianqian Zhang, Siqi Lin, Juan Liu, Huani Wu, Xiaodan Lin, Jiawen He, Qiaoyu Yang, Jiang Pi, Fen Yang

{"title":"Advances in Research on the Anti-Tuberculosis Effects of Active Components in Chinese Herbal Medicine","authors":"Qianqian Zhang, Siqi Lin, Juan Liu, Huani Wu, Xiaodan Lin, Jiawen He, Qiaoyu Yang, Jiang Pi, Fen Yang","doi":"10.1002/mef2.70061","DOIUrl":"https://doi.org/10.1002/mef2.70061","url":null,"abstract":"Tuberculosis (TB) remains a critical global health challenge, associated with significant morbidity and mortality. Traditional therapeutic regimens have largely remained unchanged for decades, but their effectiveness has decreased due to the emergence of drug-resistant Mycobacterium tuberculosis strains. This rise in drug resistance complicates disease management and facilitates further transmission, highlighting the urgent need for novel and effective therapeutic agents. Traditional Chinese herbal medicines have shown promise in TB treatment by enhancing host immunity, inhibiting drug-resistant strains of Mycobacterium tuberculosis, and reducing inflammation. However, there is currently no comprehensive and systematic review detailing the specific active ingredients of these herbal medicines and their mechanisms against TB. This paper focuses on four medicinal herbs, Astragalus membranaceus, Forsythia suspensa, Hedyotis diffusa, and Ganoderma lucidum, which contain bioactive compounds with significant anti-TB properties. We systematically analyze current research to elucidate how these active substances inhibit Mycobacterium tuberculosis growth and modulate host immune responses. The review aims to provide insights that could inform the development of herbal-based anti-TB therapies and proposes future research directions to enhance the rational design and clinical application of traditional Chinese medicine (TCM) in TB treatment.","PeriodicalId":74135,"journal":{"name":"MedComm - Future medicine","volume":"5 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mef2.70061","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148281901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From Barriers to Competence: Multi-Institutional Exploratory Study of Perceived Competence, Attitudes, and Barriers in E-Patient Communication Among Chinese Medical Students 从障碍到能力：中国医学生电子病人沟通感知能力、态度和障碍的多机构探索性研究

MedComm - Future medicine Pub Date : 2026-06-15 DOI: 10.1002/mef2.70060

Fangyi Li, Chu Liu, Yonghong Qing, Yingying Zhu, Haifeng Wang, Xiaole Lu, Yiming Lai, Jinzhuo Ning, Li Sun, Mo Zhang, Bolin Pan, Doudou Li, Ziqi Wang, Caicong Wu, Jianda Ma, Xu Chen

{"title":"From Barriers to Competence: Multi-Institutional Exploratory Study of Perceived Competence, Attitudes, and Barriers in E-Patient Communication Among Chinese Medical Students","authors":"Fangyi Li, Chu Liu, Yonghong Qing, Yingying Zhu, Haifeng Wang, Xiaole Lu, Yiming Lai, Jinzhuo Ning, Li Sun, Mo Zhang, Bolin Pan, Doudou Li, Ziqi Wang, Caicong Wu, Jianda Ma, Xu Chen","doi":"10.1002/mef2.70060","DOIUrl":"https://doi.org/10.1002/mef2.70060","url":null,"abstract":"Second-generation E-patients producing personal health data demand new clinical communication competencies, but the readiness of medical students—frontline doctors—remains unclear. This 17-institutional cross-sectional study of 310 Chinese medical students evaluated perceived competence, attitudes, barriers, and explored relationships via Structural Equation Modeling (SEM). Respondent profiles shifted toward male (70.32% vs. 48.70%), postgraduate (60.32% vs. 44.50%), Double First-Class university (63.55% vs. 47.06%), and eastern (64.19% vs. 52.94%) students, reflecting heightened issue saliency and professional leverage. While 78.71% of the students held positive attitudes and 55.16% reported high overall competence, granular assessments revealed profound proficiency deficits, specifically in digital clinical data interpretation (proficiency < 30.00%), alongside pervasive situational barriers. Multivariable modeling confirmed positive attitudes as the principal predictor of high competence (OR = 2.282, 95% CI: 1.292–4.032, p = 0.004). SEM further revealed a challenge-oriented pathway in which acute barrier awareness was positively related to attitudes (β = 0.394) and subsequent proficiency (β = 0.439). Despite small sample size limitations, the results underscore a significant mismatch between future physicians' digital health awareness and actual competence. We propose a model-driven framework to deconstruct communication barriers to catalyze attitudinal elevation and subsequent competence acquisition, preparing such digital-pioneer students for the data-rich E-patient landscape.","PeriodicalId":74135,"journal":{"name":"MedComm - Future medicine","volume":"5 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mef2.70060","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148281900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Peptide-Based Composite Hydrogels Loaded With Chlorogenic Acid for Diabetic Wound Healing 载绿原酸肽基复合水凝胶用于糖尿病伤口愈合

MedComm - Future medicine Pub Date : 2026-05-29 DOI: 10.1002/mef2.70059

Siqi Lin, Xiaomin Zhang, Qianqian Zhang, Juan Liu, Bojie Lin, Jiayi Yang, Jun-Fa Xu, Yongdui Ruan, Ting Li, Jiang Pi, Daina Zhao, Fen Yang

{"title":"Peptide-Based Composite Hydrogels Loaded With Chlorogenic Acid for Diabetic Wound Healing","authors":"Siqi Lin, Xiaomin Zhang, Qianqian Zhang, Juan Liu, Bojie Lin, Jiayi Yang, Jun-Fa Xu, Yongdui Ruan, Ting Li, Jiang Pi, Daina Zhao, Fen Yang","doi":"10.1002/mef2.70059","DOIUrl":"https://doi.org/10.1002/mef2.70059","url":null,"abstract":"Chlorogenic acid (CGA) aids diabetic wound healing via antioxidant, antibacterial, and pro-migration effects, but poor stability and low membrane permeability limit its use in chronic diabetes. Therefore, we employed a one-pot method to mix naphthalene-modified diphenylalanine (FF) and hyaluronic acid (HA) to prepare an injectable composite hydrogel capable of delivering CGA to inflamed wounds and enabling sustained-release drug delivery, thereby promoting the healing of diabetic wounds. We evaluated it through the rheological and morphological properties, as well as the in vitro biocompatibility of the hydrogel. Structurally, the hydrogel exhibits a uniform nanofiber network, conferring enhanced mechanical strength and stable drug-loading capacity. In a mouse wound model, it reduced wound area to 7.99% ± 0.73% after 12 days of treatment, with increased granulation tissue, collagen deposition, and microvascular density compared with the normal saline group. Collectively, these findings indicate that the peptide-based composite hydrogel promotes local angiogenesis and vascular maturation, thereby accelerating the healing process of chronic diabetic wounds. This system represents a promising strategy for the development of bioactive wound dressings. Nevertheless, the underlying molecular mechanisms remain to be fully elucidated, and further validation in large animal models is required prior to clinical translation.","PeriodicalId":74135,"journal":{"name":"MedComm - Future medicine","volume":"5 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mef2.70059","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148166978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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MedComm - Future medicine Pub Date : 2026-05-17

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MedComm - Future medicine Pub Date : 2026-05-10

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MedComm - Future medicine Pub Date : 2026-04-26

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Immunotherapy in Advanced Gastric Cancer: Advancing Precision Medicine and Emerging Therapeutic Strategies 晚期胃癌的免疫治疗：推进精准医学和新兴治疗策略

MedComm - Future medicine Pub Date : 2026-03-27 DOI: 10.1002/mef2.70051

Li Zhang, Qihua Zhang, Xueliang Zhang, Aihong Mao, Yuhua Liu, Huiyan Luo

{"title":"Immunotherapy in Advanced Gastric Cancer: Advancing Precision Medicine and Emerging Therapeutic Strategies","authors":"Li Zhang, Qihua Zhang, Xueliang Zhang, Aihong Mao, Yuhua Liu, Huiyan Luo","doi":"10.1002/mef2.70051","DOIUrl":"https://doi.org/10.1002/mef2.70051","url":null,"abstract":"Advanced gastric cancer (GC) continues to pose a substantial global health burden, with traditional treatment modalities providing only modest clinical benefit. In recent years, immunotherapy has emerged as a transformative strategy, and immune checkpoint inhibitors (ICIs) have revolutionized the treatment of numerous cancers, including hematologic malignancies, melanoma, and lung cancer. Clinical studies have established that immunotherapy also improves survival in advanced GC, yet critical issues remain regarding the identification of optimal candidates, the clarification of efficacy for monotherapy or combination strategies, and the exploration of potential biomarkers for immunotherapy. This review delineates therapeutic strategies involving ICIs for advanced GC, including single-agent, combination therapy, and dual-ICI approaches. The review also provides a critical appraisal of the utility of biomarkers for predicting therapeutic response, a summary of the current state of CAR-T cell therapy, and an overview of ongoing investigations into cancer vaccines. A strategic framework for the selection of immunotherapy in advanced GC is also proposed. Precision-based strategies have potential in enhancing treatment efficacy and reducing the financial burden of the patient. Despite the paradigm shift brought by immunotherapy in advanced GC, immune-related adverse events (irAEs) remain a significant clinical hurdle. A detailed discussion of these events is beyond the scope of this review due to space constraints.","PeriodicalId":74135,"journal":{"name":"MedComm - Future medicine","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mef2.70051","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147615310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0