MedComm - Future medicine最新文献_第10页

RNA modification pattern-based subtypes reveal heterogenous clinical outcomes and tumor immunity of clear cell renal cell carcinoma 基于RNA修饰模式的亚型揭示了透明细胞肾细胞癌的异质临床结果和肿瘤免疫

MedComm - Future medicine Pub Date : 2023-01-04 DOI: 10.1002/mef2.30

Aimin Jiang, Zijun Xu, Xiao Fang, Di Gu, Kai Dong, Zhenjie Wu, Xinxin Gan, Bing Liu, Silun Ge, Le Qu, Peng Luo, Anbang Wang, Linhui Wang

{"title":"RNA modification pattern-based subtypes reveal heterogenous clinical outcomes and tumor immunity of clear cell renal cell carcinoma","authors":"Aimin Jiang, Zijun Xu, Xiao Fang, Di Gu, Kai Dong, Zhenjie Wu, Xinxin Gan, Bing Liu, Silun Ge, Le Qu, Peng Luo, Anbang Wang, Linhui Wang","doi":"10.1002/mef2.30","DOIUrl":"10.1002/mef2.30","url":null,"abstract":"RNA methylation plays a key role across biological processes, which could be utilized as new weapons for cancer management. However, the implication of RNA methylation regulators in cancers, especially in clear cell renal cell cancer (ccRCC), remains largely unknown. We investigated the multiomics profile of RNA methylation regulators at the pan-cancer level. We found most RNA methylation regulators were dysregulated in cancers, which might be explained by genomic mutation and copy number variation. A novel subtype of ccRCC, RNA modification cancer subtype 2 (RMCS2), was identified and verified among different ccRCC cohorts. RMCS2 led to a shortened overall survival and had an activated state of PI3K-AKT-mTOR, KRAS, and retinoic acid metabolism signals, which resulted in an immune exhausted phenotype. In summary, our findings demonstrated that the aberrance of RNA methylation regulators was a common biological phenomenon pan-cancer. Dysregulated RNA methylation patterns could reshape tumor immunity thus impacting patients' prognosis and therapeutic response, and could function as a promising tool for ccRCC patients.","PeriodicalId":74135,"journal":{"name":"MedComm - Future medicine","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mef2.30","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42039057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Mesenchymal stem cell culture in aligned porous hydroxyapatite scaffolds using a multiwell plate bioreactor for bone tissue engineering 骨组织工程中多孔羟基磷灰石支架间充质干细胞的多孔板生物反应器培养

MedComm - Future medicine Pub Date : 2022-09-10 DOI: 10.1002/mef2.17

Gayathry G., Athira R. K., Anju M. S., Anil Kumar P. R., Harikrishna Varma P. R., Naresh Kasoju, Manoj Komath

{"title":"Mesenchymal stem cell culture in aligned porous hydroxyapatite scaffolds using a multiwell plate bioreactor for bone tissue engineering","authors":"Gayathry G., Athira R. K., Anju M. S., Anil Kumar P. R., Harikrishna Varma P. R., Naresh Kasoju, Manoj Komath","doi":"10.1002/mef2.17","DOIUrl":"10.1002/mef2.17","url":null,"abstract":"Regeneration of bone lost by trauma, diseases and aging, and restoration of its load-bearing function are major clinical challenges. Hydroxyapatite (HA) is a clinically proven scaffold material for bone grafting, but the random-pore structure limits the homing of the cells inside the graft and the bone regeneration progresses with the resorption of the graft material. This work is based on the hypothesis that aligned through pores in the graft will lead to a faster healing by homing the local cells inside and provide a better environment for new bone formation through the graft structure. The investigation was done using aligned porous HA scaffolds seeded with human Wharton's jelly-derived mesenchymal stem cells (hWJ-MSCs) and cultured in a multiwell format bioreactor setup. The cell adhesion was studied by microscopy, cell proliferation was evaluated by Alamar blue assay and osteogenic differentiation was confirmed by biochemical and molecular assays. The results indicate that the hWJ-MSCs infiltrated through the aligned porous network of the scaffold, proliferated well when cultured in the expansion medium, and differentiated into osteogenic lineage when cultured in the differentiation medium.","PeriodicalId":74135,"journal":{"name":"MedComm - Future medicine","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/mef2.17","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46924692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Artificial intelligence revolution in structure prediction for entire proteomes 人工智能在整个蛋白质组结构预测中的革命

MedComm - Future medicine Pub Date : 2022-09-01 DOI: 10.1002/mef2.19

Jun Zou

引用次数: 1

Autophagy‐independent mitochondrial quality control: Mechanisms and disease associations 自噬-独立线粒体质量控制:机制和疾病关联

MedComm - Future medicine Pub Date : 2022-09-01 DOI: 10.1002/mef2.25

Feixiang Bao, Jiahui Xiao, Lingyan Zhou, Yanhua Xie, Yueqiao Li, Yi Wu, Xingguo Liu

引用次数: 1

Sodium Danshensu mediates human T lymphocyte activation via NF‐κB and MAPK pathway regulation 丹参素钠通过NF-κB和MAPK通路调节介导人T淋巴细胞活化

MedComm - Future medicine Pub Date : 2022-09-01 DOI: 10.1002/mef2.21

Yanan Chen, Rongrong Tian, Jin Xue, Jie Yu, Haibo Wang

引用次数: 0

In vivo gene therapy with CRISPR–Cas9: A promising therapeutic strategy to cure inherited diseases CRISPR–Cas9体内基因治疗：一种治疗遗传性疾病的有前景的策略

MedComm - Future medicine Pub Date : 2022-09-01 DOI: 10.1002/mef2.26

Fei Li, Taorui Wang, Qiang Cheng

引用次数: 0

Implementation of deep learning in drug design 深度学习在药物设计中的应用

MedComm - Future medicine Pub Date : 2022-09-01 DOI: 10.1002/mef2.18

Bo Yang, Kan Li, Xiuqin Zhong, Jun Zou

引用次数: 3

A novel computational framework for integrating multidimensional data to enhance accuracy in predicting the prognosis of colorectal cancer 一种整合多维数据的新型计算框架，以提高预测结直肠癌预后的准确性

MedComm - Future medicine Pub Date : 2022-09-01 DOI: 10.1002/mef2.27

Qinran Zhang, Yuhong Xu, Shiyang Kang, Junquan Chen, Zhihao Yao, Haitao Wang, Qi-Nian Wu, Qi Zhao, Qihua Zhang, Ruifeng Xu, Xiufen Zou, Hui‐yan Luo

引用次数: 0

Changing clinical features of the 2022 monkeypox global health emergency 2022年猴痘全球突发卫生事件的临床特征变化

MedComm - Future medicine Pub Date : 2022-09-01 DOI: 10.1002/mef2.24

D. Baptista‐Hon, Gabriel João W. Fesalbon, Olivia Monteiro

引用次数: 1

SARS-CoV-2 modulation of RIG-I-MAVS signaling: Potential mechanisms of impairment on host antiviral immunity and therapeutic approaches. SARS-CoV-2调节RIG-I-MAVS信号:损害宿主抗病毒免疫的潜在机制和治疗方法

MedComm - Future medicine Pub Date : 2022-09-01 Epub Date: 2022-12-11 DOI: 10.1002/mef2.29

Mingming Wang, Yue Zhao, Juan Liu, Ting Li

{"title":"SARS-CoV-2 modulation of RIG-I-MAVS signaling: Potential mechanisms of impairment on host antiviral immunity and therapeutic approaches.","authors":"Mingming Wang, Yue Zhao, Juan Liu, Ting Li","doi":"10.1002/mef2.29","DOIUrl":"10.1002/mef2.29","url":null,"abstract":"The coronavirus disease 2019 (COVID-19) is a global infectious disease aroused by RNA virus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Patients may suffer from severe respiratory failure or even die, posing a huge challenge to global public health. Retinoic acid-inducible gene I (RIG-I) is one of the major pattern recognition receptors, function to recognize RNA viruses and mediate the innate immune response. RIG-1 and melanoma differentiation-associated gene 5 contain an N-terminal caspase recruitment domain that is activated upon detection of viral RNA in the cytoplasm of virus-infected cells. Activated RIG-I and mitochondrial antiviral signaling (MAVS) protein trigger a series of corresponding immune responses such as the production of type I interferon against viral infection. In this review, we are summarizing the role of the structural, nonstructural, and accessory proteins from SARS-CoV-2 on the RIG-I-MAVS pathway, and exploring the potential mechanism how SARS-CoV-2 could evade the host antiviral response. We then proposed that modulation of the RIG-I-MAVS signaling pathway might be a novel and effective therapeutic strategy to against COVID-19 as well as the constantly mutating coronavirus.","PeriodicalId":74135,"journal":{"name":"MedComm - Future medicine","volume":"1 2","pages":"e29"},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9878249/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9913151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3