Maternal-fetal medicine (Wolters Kluwer Health, Inc.)最新文献

{"title":"Severe Intrauterine Adhesions Following Modified B-Lynch Procedure.","authors":"Ye Feng, Hui Bi","doi":"10.1097/FM9.0000000000000274","DOIUrl":"https://doi.org/10.1097/FM9.0000000000000274","url":null,"abstract":"","PeriodicalId":74121,"journal":{"name":"Maternal-fetal medicine (Wolters Kluwer Health, Inc.)","volume":"7 3","pages":"184-185"},"PeriodicalIF":1.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12846858/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146095097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Balancing Breastfeeding and HIV Management in Africa: Addressing the Challenges of Mother-to-Child Transmission.","authors":"Patrick Ashinze, Egbunu Emmanuel, Eniola Obafemi, Eniola Akande, Elelu Muhammed, Aremu Sikiru, Bonu Innocent, Ifuekosa Uhumuavbi, Nelson Mafua, Ndubuisi Joyce, Onwuasoeze Chigozie, Jonathan Adeola, Oluwadamilare Olatunbosun, Esele Ekuaze, Ahmed Adeshina","doi":"10.1097/FM9.0000000000000289","DOIUrl":"https://doi.org/10.1097/FM9.0000000000000289","url":null,"abstract":"","PeriodicalId":74121,"journal":{"name":"Maternal-fetal medicine (Wolters Kluwer Health, Inc.)","volume":"7 3","pages":"190-192"},"PeriodicalIF":1.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12846857/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146094456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic Analysis of Prenatal Renal Abnormalities in 17q12 Microdeletion Syndrome.","authors":"Yongmei Shen, Yaqi Li, Xiaomin Zhao, Lei Zhang, Liying Yao, Jiasong Cao, Qimei Lin, Hefei Wang, Maolin Nie, Rongxin Wei, Ying Chang","doi":"10.1097/FM9.0000000000000287","DOIUrl":"https://doi.org/10.1097/FM9.0000000000000287","url":null,"abstract":"<p><strong>Objective: </strong>To analyze fetal renal abnormality genetic features and the prenatal characteristics of the 17q12 microdeletion syndrome.</p><p><strong>Methods: </strong>This prospective cohort study examined prenatal ultrasound findings of renal abnormalities in pregnant women who underwent single nucleotide polymorphism (SNP) array or copy number variation sequencing (CNV-seq) testing on amniotic fluid or fetal tissue at Tianjin Central Obstetrics and Gynecology Hospital between January 2016 and August 2022. The study cohort comprised women with advanced maternal age, fetal ultrasound anomalies, high-risk non-invasive prenatal testing results, or suspected 17q12 microdeletion syndrome. Comprehensive clinical data, including maternal age, detailed ultrasound findings, and pregnancy outcomes, were systematically collected. SNP-array analysis was conducted using an Affymetrix CytoScan 750 K Array Chip to identify CNVs and loss of heterozygosity, while CNV-seq was performed on the Illumina HiSeq 2000 platform. Detected variants were classified according to the American College of Medical Genetics and Genomics guidelines. Statistical analyses were performed using SPSS version 27.0.</p><p><strong>Results: </strong>Abnormal renal development was identified in 141 patients, among whom 26 exhibited hyperechogenic kidneys (HCK). Of these, 12 cases were associated with 17q12 microdeletion syndrome, while the remaining 14 were linked to other chromosomal abnormalities. When excluding patients with HCK, those diagnosed with polycystic kidney disease demonstrated a higher prevalence of chromosomal abnormalities compared to those with multicystic dysplastic kidney and renal dysplasia. Although isolated conditions such as horseshoe kidney, hydronephrosis, ectopic kidney, and unilateral kidney typically presented with normal chromosomal findings, the incidence of chromosomal abnormalities increased when these conditions coexisted with other anomalies. A detailed analysis of the correlation between 17q12 microdeletion syndrome and HCK revealed that 12 out of the 14 patients diagnosed with 17q12 microdeletion syndrome exhibited HCK. Genetic testing confirmed the syndrome in seven patients, with five cases attributed to novel mutations and two cases resulting from inherited mutations.</p><p><strong>Conclusion: </strong>Fetal HCK was closely associated with the 17q12 microdeletion syndrome, and polycystic kidney disease showed a higher rate of chromosomal abnormalities. Chromosome test results were mostly normal in patients with other renal abnormalities, such as kidney dysplasia, horseshoe kidneys, hydronephrosis, kidney deficiency, and ectopic kidneys. Prenatal diagnosis is recommended, especially in cases of non-isolated fetal renal abnormalities. This study provides strong evidence supporting a link between fetal renal abnormalities and genetic syndromes.</p>","PeriodicalId":74121,"journal":{"name":"Maternal-fetal medicine (Wolters Kluwer Health, Inc.)","volume":"7 3","pages":"151-156"},"PeriodicalIF":1.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12846862/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146095062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Traumatic Spinal Cord Injury Combined With Pregnancy.","authors":"Ye Feng, Huixia Yang, Yu Sun","doi":"10.1097/FM9.0000000000000244","DOIUrl":"10.1097/FM9.0000000000000244","url":null,"abstract":"","PeriodicalId":74121,"journal":{"name":"Maternal-fetal medicine (Wolters Kluwer Health, Inc.)","volume":"7 2","pages":"112-115"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12222986/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144577176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors Behind Decreased Red Cell Antibody and Hemolytic Disease of Fetus and Newborn Rates: Single Center Experience.","authors":"Slavica Dajak, Anet Papazovska, Jelena Lukacevic, Ivica Bradaric, Paula Odak, Dejana Bogdanic","doi":"10.1097/FM9.0000000000000279","DOIUrl":"10.1097/FM9.0000000000000279","url":null,"abstract":"","PeriodicalId":74121,"journal":{"name":"Maternal-fetal medicine (Wolters Kluwer Health, Inc.)","volume":"7 2","pages":"97-99"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12222987/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144577164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reassessment of <i>MTRR</i> rs1801394 Polymorphism and Neural Tube Defects Risk.","authors":"Jethendra Kumar Muruganantham, Ramakrishnan Veerabathiran","doi":"10.1097/FM9.0000000000000282","DOIUrl":"10.1097/FM9.0000000000000282","url":null,"abstract":"","PeriodicalId":74121,"journal":{"name":"Maternal-fetal medicine (Wolters Kluwer Health, Inc.)","volume":"7 2","pages":"123-124"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12222988/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144577174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ibuprofen Oral Administration Protocols for Analgesia After Cesarean Delivery: A Prospective Randomized Controlled Study.","authors":"Shuang Li, Ju Bao, Yuan Qu, Bo Zhang, Xinni Cao, Yanping Huang, Zhe Liu","doi":"10.1097/FM9.0000000000000266","DOIUrl":"10.1097/FM9.0000000000000266","url":null,"abstract":"<p><strong>Objective: </strong>To compare the analgesic effects of ibuprofen administered orally via two modes combined with a conventional, patient-controlled intravenous analgesia pump on maternal pain after cesarean section (CS).</p><p><strong>Methods: </strong>This prospective, randomized, controlled study enrolled females who underwent CS from August 2022 to August 2023 at Peking University First Hospital, Beijing, China. Participants were randomly assigned to either an as-needed ibuprofen group (300 mg orally upon request) or a scheduled ibuprofen group (300 mg every 12 hours for 48 hours). The primary outcomes assessed were postoperative pain levels using the Wong-Baker Faces Pain Scale-Revised and cumulative oxycodone consumption at multiple time points up to 48 hours post-delivery. Secondary outcomes included recovery parameters (time to first flatus, ambulation, and lactation initiation), patient satisfaction with pain control, and postpartum depression scores evaluated by the Edinburgh Postnatal Depression Scale on postoperative day 3. Normally distributed data analyzed with <i>t</i>-tests; non-normal data with Mann-Whitney U tests; categorical variables with chi-square or Fisher's exact tests (SPSS 26.0, <i>P</i> < 0.05).</p><p><strong>Results: </strong>After excluding 61 non-eligible cases, 339 patients were included (171 as-needed <i>vs.</i> 168 scheduled). The scheduled group showed significantly better pain control at 12 hours (4.00 (2.00-5.50) <i>vs.</i> 4.00 (4.00-6.00), <i>P</i> < 0.001), 24 hours (4.00 (2.00-4.00) <i>vs.</i> 4.00 (2.00-6.00), <i>P</i> < 0.001), and 36 hours (2.00 (2.00-4.00) <i>vs.</i> 4.00 (2.00-4.00), <i>P</i> < 0.001), and 48 hours (2.00 (2.00-4.00) <i>vs.</i> 2.00 (2.00-4.00), <i>P</i> = 0.004) post-delivery and lower levels of oxycodone consumption at 36 hours (10.20 (8.20-13.35) <i>vs.</i> 11.00 (8.80-14.40), <i>P</i> = 0.042) and 48 hours (12.40 (10.40-15.95) <i>vs.</i> 13.80 (11.00-16.00), <i>P</i> = 0.020) postpartum compared with those in the as-needed group. Additionally, the time to the return of bowel movements was shorter in the scheduled group than in the as-needed group (23.50 (16.94, 31.47) <i>vs.</i> 27.00 (19.88, 35.97), <i>P</i> = 0.004). Differences in post-delivery ambulation, lactation initiation, satisfaction levels, and depression scores were not significantly different between the two groups.</p><p><strong>Conclusion: </strong>The results of this study promote the use of ibuprofen (scheduled oral administration) combined with a conventional, patient-controlled intravenous analgesia pump for achieving better post-CS pain control than an as-needed dosage regimen.</p><p><strong>Registration: </strong>Chinese Clinical Trial Registry, ChiCTR2400082474.</p>","PeriodicalId":74121,"journal":{"name":"Maternal-fetal medicine (Wolters Kluwer Health, Inc.)","volume":"7 2","pages":"69-75"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12222979/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144577166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Managing the Unknown: A Case of Listeria Monocytogenes in Pregnancy.","authors":"Megan E Kalata, Ashley Pak","doi":"10.1097/FM9.0000000000000269","DOIUrl":"10.1097/FM9.0000000000000269","url":null,"abstract":"","PeriodicalId":74121,"journal":{"name":"Maternal-fetal medicine (Wolters Kluwer Health, Inc.)","volume":"7 2","pages":"119-120"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12222992/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144577168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding Anemia and Predictors of Adverse Maternal and Neonatal Outcomes: A Multicenter Prospective Cohort Study in Southern Ethiopia.","authors":"Sisay Moges, Sintayehu Kussa, Ashebir Endale, Bereket Aberham Lajore, Dejene Ermias Mekango","doi":"10.1097/FM9.0000000000000281","DOIUrl":"10.1097/FM9.0000000000000281","url":null,"abstract":"<p><strong>Objective: </strong>To assess the adverse maternal and neonatal outcomes of anemia among pregnant women in primary hospitals in Southern Ethiopia.</p><p><strong>Methods: </strong>This institution-based prospective cohort study was conducted from March 1 to October 30, 2022, in three primary hospitals in the Hadiya zone of Southern Ethiopia. Participants were categorized into exposed (Hb < 11 g/dL) and non-exposed (Hb ≥ 11 g/dL) groups based on hemoglobin levels measured before delivery. Baseline characteristics were comparable between groups. Maternal and neonatal complications were considered as outcomes. Data were analyzed using STATA version 15. Descriptive statistics summarized baseline characteristics, and Chi-square tests assessed associations. Generalized linear models with a log link calculated adjusted relative risks (a<i>RR</i>s) with 95% <i>CI</i>s. Statistical significance was set at <i>P</i> < 0.05. Multivariable models adjusted for confounders, and sensitivity analyses evaluated robustness using multiple imputations for missing data.</p><p><strong>Results: </strong>A total of 490 participants were enrolled in the study, with 245 in each of the exposed and non-exposed groups. Due to loss to follow-up, 220 participants in the exposed group and 239 in the non-exposed group were assessed for outcomes. Prolonged labor (adjusted <i>RR</i> (a<i>RR</i>) = 3.235; 95% <i>CI</i>: 1.658, 6.312; <i>P</i> = 0.003) and postpartum hemorrhage (a<i>RR</i> = 2.901; 95% <i>CI</i>: 1.202, 7.910; <i>P = 0.045</i>) were identified as adverse maternal pregnancy outcomes of anemia. We observed low birth weight (a<i>RR</i> = 3.020; 95% <i>CI</i>: 1.233, 6.010; <i>P</i> = 0.002) and respiratory distress syndrome (a<i>RR</i> = 4.820; 95% <i>CI</i>: 2.901, 9.012; <i>P</i> = 0.001) as neonatal complications. Furthermore, having no previous history of anemia reduced the risk of prolonged labor (a<i>RR</i> = 0.078; 95% <i>CI</i>: 0.033, 0.188; <i>P</i> = 0.015) and low birth weight (a<i>RR</i> = 0.480; 95% <i>CI</i>: 0.370, 0.592; <i>P</i> = 0.001).</p><p><strong>Conclusion: </strong>Mothers who have experienced maternal anemia in the past or present face serious consequences for both themselves and their children. Preventing anemia should thus start before conception and continue through pregnancy.</p>","PeriodicalId":74121,"journal":{"name":"Maternal-fetal medicine (Wolters Kluwer Health, Inc.)","volume":"7 2","pages":"76-84"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12222984/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144577177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How to Develop Leadership in Academic Medicine: Lessons From the PAWLHS Program.","authors":"Lian Chen","doi":"10.1097/FM9.0000000000000273","DOIUrl":"10.1097/FM9.0000000000000273","url":null,"abstract":"","PeriodicalId":74121,"journal":{"name":"Maternal-fetal medicine (Wolters Kluwer Health, Inc.)","volume":"7 2","pages":"67-68"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12223007/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144577165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}